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Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics

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Puchalska, Patrycja, Crawford, Peter A.·2017·Cell Metabolism
DOI 10.1016/j.cmet.2016.12.022
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Abstract

Ketone body metabolism is a central node in physiological homeostasis. In this review, we discuss how ketones serve discrete fine-tuning metabolic roles that optimize organ and organism performance in varying nutrient states, and protect from inflammation and injury in multiple organ systems. Traditionally viewed as metabolic substrates enlisted only in carbohydrate restriction, recent observations underscore the importance of ketone bodies as vital metabolic and signaling mediators when carbohydrates are abundant. Complementing a repertoire of known therapeutic options for diseases of the nervous system, prospective roles for ketone bodies in cancer have arisen, as have intriguing protective roles in heart and liver, opening therapeutic options in obesity-related and cardiovascular disease. Controversies in ketone metabolism and signaling are discussed to reconcile classical dogma with contemporary observations.

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200 of 327 shown

Cited by

Metadata

Authors
Puchalska, P., & Crawford, P. A.
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2017-02
Volume
25
Issue
2
Pages
262-284
ISSN
1550-4131 (ISSN-L)
DOI
10.1016/j.cmet.2016.12.022
OpenAlex
W2587156779
Cited by
1,610
References
45
FWCI
63.35
Type
journal article
Language
en
Open access
bronze
Licence
Funders
National Institutes of Health (DK091538)

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