Cited by 308Substance Abuse Treatment and OutcomesPersonality Disorders and PsychopathologyNeural and Behavioral Psychology Studies

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The role of affective dysregulation in drug addiction

Cheetham, Ali, Allen, Nicholas B., Yücel, Murat, Lubman, Dan I.·2010·Clinical Psychology Review

DOI 10.1016/j.cpr.2010.04.005

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Abstract

Although affective and substance use disorders frequently co-occur, the role of affective dysregulation in addiction is often overlooked. This paper reviews the role of affective dysregulation in the initiation and maintenance of substance use disorders (SUDs), presenting evidence for a relationship between SUD and three biologically-based dimensions of affective temperament and behaviour: negative affect (NA), positive affect (PA), and effortful control (EC). High NA, low EC, and both high and low PA were each found to play a role in conferring risk and maintaining substance use behaviours, although the strength of their influence differed depending on stage of illness (i.e., early onset use through to addiction). Given these findings, we argue that future research should explicitly consider how changes within affective systems may underlie the development of SUDs. A better understanding of the role of affective dysregulation in addiction will aid in clarifying how risk is conferred, as well as how addictive behaviours are maintained, thereby informing the development of preventative strategies and novel treatments. Future studies should continue to examine the role of high NA in SUDs, and further examine the respective roles of high PA, low PA, and low EC, as well as identifying the affective characteristics that predispose high-risk individuals to later substance use problems.

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“Our findings are similar to other studies showing an association between DESR and cigarette smoking or SUD (Aguilar de Arcos et al., 2008; Cheetham et al., 2010; Dorard et al., 2008; Gonzalez et al., 2008).”
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Authors: Cheetham, A., Allen, N. B., Yücel, M., & Lubman, D. I.
Affiliations: The University of Melbourne (AU)
Corresponding author: Lubman, Dan I.
ORCID: Cheetham, Ali
Allen, Nicholas B.
Yücel, Murat
Lubman, Dan I.
Venue: Clinical Psychology Review
Publisher: Elsevier BV
Published: 2010-08
Volume: 30
Issue: 6
Pages: 621-634
ISSN: 0272-7358 (ISSN-L)
DOI: 10.1016/j.cpr.2010.04.005
OpenAlex: W1977593884
Cited by: 308
References: 180
Citations by year: 2026: 10 · 2025: 11 · 2024: 14 · 2023: 17 · 2022: 20 · 2021: 22 · 2020: 29 · 2019: 28 · 2018: 21 · 2017: 23 · 2016: 26 · 2015: 26 · 2014: 18 · 2013: 20 · 2012: 14
FWCI: 1.47
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Clinical Psychology Review (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: emotional dysregulation, substance use disorders, drug addiction, affective temperament, negative affect, positive affect, effortful control, addiction risk, early onset of substance use, prevention
MeSH terms: Affective Symptoms, Emotions, Humans, Temperament, Behavior, Addictive, Diagnosis, Dual (Psychiatry), Substance-Related Disorders

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The role of affective dysregulation in drug addiction

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