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A comprehensive meta-analysis of interpretation biases in depression
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Interpretation biases have long been theorized to play a central role in depression. Yet, the strength of the empirical evidence for this bias remains a topic of debate. This meta-analysis aimed to estimate the overall effect size and to identify moderators relevant to theory and methodology. PsycINFO, Embase, Web of Science, Scopus, PubMed, and dissertation databases were searched. A random-effects meta-analysis was performed on 87 studies (N=9443). Results revealed a medium overall effect size (g=0.72, 95%-CI:[0.62;0.82]). Equivalent effect sizes were observed for patients diagnosed with clinical depression (g=0.60, 95%-CI:[0.37;0.75]), patients remitted from depression (g=0.59, 95%-CI:[0.33;0.86]), and undiagnosed individuals reporting elevated depressive symptoms (g=0.66, 95%-CI:[0.47;0.84]). The effect size was larger for self-referential stimuli (g=0.90, 95%-CI[0.78;1.01]), but was not modified by the presence (g=0.74, 95%-CI[0.59;0.90]) or absence (g=0.72, 95%-CI[0.58;0.85]) of mental imagery instructions. Similar effect sizes were observed for a negative interpretation bias (g=0.58, 95%-CI:[0.40;0.75]) and lack of a positive interpretation bias (g=0.60, 95%-CI:[0.36;0.85]). The effect size was only significant when interpretation bias was measured directly (g=0.88, 95%-CI[0.77;0.99]), but not when measured indirectly (g=0.04, 95%-CI[-0.14;0.22]). It is concluded that depression is associated with interpretation biases, but caution is necessary because methodological factors shape conclusions. Implications and recommendations for future research are outlined.
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“This linkage across negative beliefs, subsequent psychopathology, and examining and restructuring these beliefs to reduce depression is well established (e.g., Everaert et al., 2017; Diehle et al., 2014).”
From I've Seen Enough: Measuring the Toll of Content Moderation on Mental Health (2025) · cites this paper as Everaert et al., 2017
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D’Avanzato, C. (2013) · Cited by 2
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Research works printed but not linked: 1
- Dickson, 2015, Investigating the role of cognitive biases as a risk factor for depression (Dissertation Abstracts International)
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Mental illness and well‐being: an affect regulation perspective
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Distorted Cognitive Processes in Major Depression: A Predictive Processing Perspective
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Dolcos, F., Katsumi, Y., Moore, M., Berggren, N., de Gelder, B., Derakshan, N., Hamm, A. O., Koster, E. H. W., Ladouceur, C. D., Okon‐Singer, H., et al. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.08.017 · Cited by 247
Self-citationBoemo, T., Nieto, I., Vazquez, C., & Sanchez-Lopez, A. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104747 · Cited by 191
Uusberg, A., Taxer, J. L., Yih, J., Uusberg, H., & Gross, J. J. (2019) · Emotion Review · doi:10.1177/1754073919862617 · Cited by 220
Metadata
- Authors
- Everaert, J., Podina, I. R., & Koster, E. H. W.
- Affiliations
- Ghent University (BE)
- University of Bucharest (RO)
- Corresponding author
- Everaert, Jonas
- Venue
- Clinical Psychology Review
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 58
- Pages
- 33-48
- ISSN
- 0272-7358 (ISSN-L)
- OpenAlex
- W2756528888
- Cited by
- 378
- References
- 133
- Citations by year
- 2026: 59 · 2025: 35 · 2024: 41 · 2023: 49 · 2022: 42 · 2021: 34 · 2020: 79 · 2019: 28 · 2018: 10 · 2017: 1
- FWCI
- 5.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Clinical Psychology Review (publishedVersion, other-oa)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion, other-oa)
- Funders
- Yale University
- Universiteit Gent
- Universitatea din București
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Psychological Treatments and Assessments
- Keywords
- interpretation bias, depression, cognitive biases, negative interpretation bias, mental imagery, depression remission, depressive symptoms
- MeSH terms
- Depression, Depressive Disorder, Humans, Thinking
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