The Effect of Four Immeasurables Meditations on Depressive Symptoms: A Systematic Review and Meta-Analysis
Abstract
The Four Immeasurables Meditations (FIM) intervention have been shown as a promising intervention for reducing depressive symptoms. The current study is a systematic review of FIM intervention effects on depressive symptoms. Among 192 empirical research articles on FIM published before May 2019, 40 independent trials from 35 records measured depressive symptoms. The meta-analysis included 21 randomized controlled trials (RCT; n = 1468) and 16 uncontrolled trials (n = 376). The results supported overall effectiveness of FIM on depressive symptoms (d = 0.38 for RCT and d = 0.87 for uncontrolled trials). Moderator analysis indicated the effects differed across protocols, and effects were smaller in RCT using active control groups. No significant differences were observed for participant type, measures, intervention length, or intervention components. Individual studies found no direct association between meditation practice time and effects, and mindfulness and self-compassion were widely supported as mechanisms of change. Current evidence supports FIM as an effective intervention for reducing depressive symptoms, but additional studies with more rigorous designs using active control groups are needed. Further investigation should be encouraged regarding specific protocols and participants, the contribution of meditation practice, and other mechanisms such as positive emotions.
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Mindfulness techniques can reduce symptoms of both anxiety and depression that are related to somatic symptoms.
“Studies concerning mindfulness-based interventions, for instance, mindfulness-based stress reduction (MBSR) [24] or mindfulness-based cognitive therapy (MBCT) [25], have brought evidence that mindfulness techniques can reduce symptoms of both anxiety [26,27] and depression [28,29] that are related to somatic symptoms [30] such as cardiovascular disease [31] or cancer [32].”
Kindness-based meditation has a moderate effect in reducing depressive symptoms, anxiety and stress, and increases compassion, self-compassion, and positive emotions of practitioners, compared to no intervention.
“4 meta-analyses of 22, 21, 19, and 10 randomised controlled trials show that in comparison to no intervention, kindness-based meditation has a moderate effect in reducing depressive symptoms, anxiety and stress, and increases compassion and self-compassion, and positive emotions of kindness-practitioners 22 – 25 .”
From Kindness as a public health action (2025) · cites this paper as [23]
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Kury, M., Fredrickson, B. L., Cappellen, P. V., & Don, B. P. (2026) · Mindfulness · doi:10.1007/s12671-026-02803-z
Studies on the impact of meditation on mental health: A critical review
Popadić, K. (2026) · Psychiatria Danubina · doi:10.24869/psyd.2026.4
Asplund, T., & Dobrin, P. (2026) · Sustainability Science · doi:10.1007/s11625-026-01884-y
- Authors
- Lv, J., Liu, Q., Zeng, X., Oei, T. P. S., Liu, Y., Xu, K., Sun, W., Hou, H., & Liu, J.
- Affiliations
- East China Normal University (CN)
- Beijing Normal University (CN)
- The University of Queensland (AU)
- The University of Melbourne (AU)
- Capital Medical University (CN)
- Corresponding author
- Zeng, Xianglong
- Venue
- Clinical Psychology Review
- Publisher
- Elsevier BV
- Published
- 2020-03
- Volume
- 76
- Pages
- 101814
- ISSN
- 0272-7358 (ISSN-L)
- OpenAlex
- W2998813575
- Cited by
- 44
- References
- 64
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 5 · 2023: 7 · 2022: 10 · 2021: 7 · 2020: 3
- FWCI
- 0.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Psychology Review (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fundamental Research Funds for the Central Universities
- Topics
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Social Sciences › Health › Religion, Spirituality, and Psychology
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Keywords
- depressive symptoms, compassion meditation, mindfulness, self-compassion, mechanisms of change, active control groups, positive emotions
- MeSH terms
- Depression, Empathy, Humans, Meditation, Mindfulness
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