Source Memory in the Rat
Open accessAbstract
Source memory is a representation of the origin (source) of information. When source information is bound together, it makes a memory episodic, allowing us to differentiate one event from another. Here, we asked whether rats remember the source of encoded information. Rats foraged for distinctive flavors of food that replenished (or failed to replenish) at its recently encountered location according to a source-information rule. To predict replenishment, rats needed to remember where they had encountered a preferred food type (chocolate) with self-generated (walking along a runway encountering chocolate) or experimenter-generated (placement of the rat at the chocolate site by an experimenter) cues. Three lines of evidence implicate the presence of source memory. First, rats selectively adjusted revisits to the chocolate location based on source information, under conditions in which familiarity of events could not produce successful performance. Second, source memory was dissociated from location memory by different decay rates. Third, temporary inactivation of the CA3 region of the hippocampus with lidocaine selectively eliminated source memory, suggesting that source memory is dependent upon an intact hippocampus. Development of an animal model of source memory may be valuable to probe the biological underpinnings of memory disorders marked by impairments in source memory.
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Source memory is a characteristic component of episodic memory in humans.
“as source memories are embedded within episodic memories, they are a characteristic component of episodic memory in humans [99,101,103,104].”
From Is episodic-like memory <i>like</i> episodic memory? (2024) · cites this paper as [99]
Rats are able to discriminate between self- or experimenter-generated information, a form of source memory known as reality monitoring.
“Furthermore, rats were shown to be able to discriminate between self- or experimenter-generated information [99]; a form of source memory known as reality monitoring [100].”
From Is episodic-like memory <i>like</i> episodic memory? (2024) · cites this paper as [99]
Intra-CA3 infusion of lidocaine impaired performance of rats tested by a task of source memory.
“Intra-CA3 infusion of lidocaine also impaired the performance of rats tested by a task of source memory”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Crystal et al., 2013
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- Authors
- Crystal, J. D., Alford, W. T., Zhou, W., & Hohmann, A. G.
- Affiliations
- Indiana University Bloomington (US)
- Corresponding author
- Crystal, Jonathon D.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 23
- Issue
- 5
- Pages
- 387-391
- ISSN
- 0960-9822 (ISSN-L)
- PMC
- PMC3595394
- OpenAlex
- W2101704980
- Cited by
- 82
- References
- 36
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 11 · 2023: 3 · 2022: 7 · 2021: 5 · 2020: 8 · 2019: 6 · 2018: 5 · 2017: 10 · 2016: 5 · 2015: 5 · 2014: 4 · 2013: 6
- FWCI
- 3.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH080052)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- source memory, episodic memory, rats, hippocampus, CA3, lidocaine inactivation, location memory, memory decay, memory disorders
- MeSH terms
- Animals, Cues, Hippocampus, Male, Spatial Behavior, Rats, Long-Evans, Rats, Memory, Episodic
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