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Cited by 1,078

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

The Hippo Signaling Pathway Components Lats and Yap Pattern Tead4 Activity to Distinguish Mouse Trophectoderm from Inner Cell Mass

Open access
Nishioka, Noriyuki, Inoue, Ken-ichi, Adachi, Kenjiro, Kiyonari, Hiroshi, Ota, Mitsunori, Ralston, Amy, Yabuta, Norikazu, Hirahara, Shino, Stephenson, Robert O., Ogonuki, Narumi, Makita, Ryosuke, Kurihara, Hiroki, Morin-Kensicki, Elizabeth M., Nojima, Hiroshi, Rossant, Janet, Nakao, Kazuki, Niwa, Hitoshi, Sasaki, Hiroshi·2009·Developmental Cell
DOI 10.1016/j.devcel.2009.02.003
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Abstract

Outside cells of the preimplantation mouse embryo form the trophectoderm (TE), a process requiring the transcription factor Tead4. Here, we show that transcriptionally active Tead4 can induce Cdx2 and other trophoblast genes in parallel in embryonic stem cells. In embryos, the Tead4 coactivator protein Yap localizes to nuclei of outside cells, and modulation of Tead4 or Yap activity leads to changes in Cdx2 expression. In inside cells, Yap is phosphorylated and cytoplasmic, and this involves the Hippo signaling pathway component Lats. We propose that active Tead4 promotes TE development in outside cells, whereas Tead4 activity is suppressed in inside cells by cell contact- and Lats-mediated inhibition of nuclear Yap localization. Thus, differential signaling between inside and outside cell populations leads to changes in cell fate specification during TE formation.

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Metadata

Authors
Nishioka, N., Inoue, K.-I., Adachi, K., Kiyonari, H., Ota, M., Ralston, A., Yabuta, N., Hirahara, S., Stephenson, R. O., Ogonuki, N., Makita, R., Kurihara, H., Morin-Kensicki, E. M., Nojima, H., Rossant, J., Nakao, K., Niwa, H., & Sasaki, H.
Venue
Developmental Cell
Publisher
Elsevier BV
Published
2009-03
Volume
16
Issue
3
Pages
398-410
ISSN
1534-5807 (ISSN-L)
DOI
10.1016/j.devcel.2009.02.003
OpenAlex
W2004102023
Cited by
1,078
References
6
FWCI
20.00
Type
journal article
Language
en
Open access
bronze

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