The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
PDGFRβ Signaling Regulates Mural Cell Plasticity and Inhibits Fat Development
Open accessAbstract
SUMMARY Mural cells (pericytes and vascular smooth muscle cells) provide trophic and structural support to blood vessels. Vascular smooth muscle cells alternate between a synthetic/proliferative state and a differentiated/contractile state, but the dynamic states of pericytes are poorly understood. To explore the cues that regulate mural cell differentiation and homeostasis, we have generated conditional knock-in mice with activating mutations at the PDGFRβ locus. We show that increased PDGFRβ signaling drives cell proliferation and downregulates differentiation genes in aortic vascular smooth muscle. Increased PDGFRβ signaling also induces a battery of immune response genes in pericytes and mesenchymal cells, and inhibits differentiation of white adipocytes. Mural cells are emerging as multipotent progenitors of pathophysiological importance, and we identify PDGFRβ signaling as an important in vivo regulator of their progenitor potential.
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Self-citationPericytes regulate vascular immune homeostasis in the CNS
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Metadata
- Authors
- Olson, L. E., & Soriano, P.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 20
- Issue
- 6
- Pages
- 815-826
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2038198824
- Cited by
- 194
- References
- 9
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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