Microglia: Multitasking Specialists of the Brain
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Microglia are the resident macrophage population of the central nervous system that perform functions required for typical development, homeostasis, plasticity, immunity and repair.
“Microglia are the resident macrophage population of the central nervous system (CNS) that perform functions required for typical development, as well as homeostasis, plasticity, immunity and repair (1–5).”
From An environment-dependent transcriptional network specifies human microglia identity (2017) · cites this paper as [5]
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An environment-dependent transcriptional network specifies human microglia identity
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“1 as an essential lineagedetermining transcription factor (LDTF) (21, 22), highly efficient phagocytic and tissue debris clearance abilities (2, 5), and the ability to quickly trigger an inflammatory response following detection of pathogens or tissue damage (23).”
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The Lifespan and Turnover of Microglia in the Human Brain
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Microglia affect α-synuclein cell-to-cell transfer in a mouse model of Parkinson’s disease
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<i>Cx3cr1-</i> deficient microglia exhibit a premature aging transcriptome
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“They support brain development and adult CNS homeostasis, functions which are often dysregulated in acute or chronic neurological conditions (Xavier et al, 2014; Casano & Peri, 2015; Ransohoff, 2016; Hickman et al, 2018; Thion et al, 2018b).”
Microglial Function during Glucose Deprivation: Inflammatory and Neuropsychiatric Implications
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- Authors
- Casano, A. M., & Peri, F.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 32
- Issue
- 4
- Pages
- 469-477
- ISSN
- 1534-5807
- Cited by
- 192
- References
- 34
- Language
- en
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