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Cancer-on-a-chip systems at the frontier of nanomedicine
Open accessAbstract
Nanomedicine provides a unique opportunity for promoting drug efficacy through enhanced delivery mechanisms. However, its translation into the clinics has been relatively slow compared with the large amount of research occurring in laboratory settings. Given the limitations of conventional cell culture models and preclinical animal models, we discuss the potential utility of recently developed cancer-on-a-chip platforms, which maximally replicate the pathophysiology of the human tumor microenvironments, as alternatives for effective evaluation of nanomedicine. We begin with a brief discussion of nanomedicine, then chart the history of organ-on-a-chip platform development and their recent evolution as tools for modeling different cancers for assessing nanomedicine efficacy, concluding with future perspectives for the field.
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“Today, tumor-on-chip systems are the most promising embodiment of in vitro platforms capable of faithfully recapitulation of relevant aspects of the biochemical complexity and dynamics of the tumor niche in a controlled environment (i.e., with much lower variability than is associated with in vivo systems [8,54,113]).”
From The Tumor-on-Chip: Recent Advances in the Development of Microfluidic Systems to Recapitulate the Physiology of Solid Tumors (2019) · cites this paper as [113]
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“Patient-on-chip platforms including engineered in vitro tissue models associated with patient derived cells (i.e. individual- and disease-specific hiPSCs) have the potential to revolutionize the drug discovery paradigm, and bring us closer towards the reality of personalized medicine [160,359,412].”
From Cardiovascular disease models: A game changing paradigm in drug discovery and screening (2019) · cites this paper as [412]
In the citing paper
“Furthermore, microfluidic systems can link different organs-on-a-chip to potentially simulate the complexity of multiorgan drug metabolism and pharmacokinetics9,47,50,68–71.”
From Tumor-on-a-chip: from bioinspired design to biomedical application (2021) · cites this paper as [47]
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“Organ-on-a-chip devices possess good performance and improved recapitulation of the native microenvironment, and they allow high‐throughput tests with decreased cost, ethical advantages and enhanced reproducibility47,55–57.”
From Tumor-on-a-chip: from bioinspired design to biomedical application (2021) · cites this paper as [47]
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Metadata
- Authors
- Zhang, Y. S., Zhang, Y.-N., & Zhang, W.
- Affiliations
- Brigham and Women's Hospital (US)
- Fudan University (CN)
- Corresponding author
- Zhang, Yu Shrike
- Zhang, Weijia
- Venue
- Drug Discovery Today
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 22
- Issue
- 9
- Pages
- 1392-1399
- ISSN
- 1359-6446 (ISSN-L)
- PMC
- PMC5610924
- OpenAlex
- W2604347510
- Cited by
- 127
- References
- 73
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 16 · 2023: 11 · 2022: 13 · 2021: 19 · 2020: 14 · 2019: 19 · 2018: 17 · 2017: 8
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Drug Discovery Today (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (K99CA201603)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- organ-on-a-chip, nanomedicine, tumor microenvironment, drug delivery, preclinical models, microfluidic model
- MeSH terms
- Animals, Humans, Models, Biological, Neoplasms, Biomimetic Materials, Nanomedicine
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