Cannabidiol administration into the bed nucleus of the stria terminalis alters cardiovascular responses induced by acute restraint stress through 5-HT1A receptor
Abstract
Systemic administration of cannabidiol (CBD) is able to attenuate cardiovascular responses to acute restraint stress through activation of 5-HT1A receptors. Previous results from our group suggest that the bed nucleus of the stria terminalis (BNST) is involved in the antiaversive effects of the CBD. Moreover, it has been proposed that synapses within the BNST influence restraint-evoked cardiovascular changes, in particular by an inhibitory influence on the tachycardiac response associated to restraint stress. Thus, the present work investigated the effects of CBD injected into the BNST on cardiovascular changes induced by acute restraint stress and if these effects would involve the local activation of 5-HT1A receptors. The exposition to restraint stress increased both blood pressure and heart rate (HR). The microinjection of CBD (30 and 60 nmol) into the BNST enhanced the restraint-evoked HR increase, in a dose-dependent manner, without affecting the pressor response. The selective 5-HT1A receptor antagonist WAY100635 by itself did not change the cardiovascular responses to restraint stress, but blocked the effects of CBD. These results showed that CBD microinjected into the BNST enhanced the HR increase associated with acute restraint stress without affecting the blood pressure response. Although these results are not in agreement with those observed after systemic administration of CBD, they are similar to effects observed after reversible inactivation of the BNST. Moreover, similar to the effects observed after systemic administration, CBD effects in the BNST seem to depend on activation of 5-HT1A receptors.
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The anxiolytic-like effects produced by CBD injections into rat infralimbic or prelimbic cortices, BNST, and dPAG are attenuated by concomitant 5-HT1A-R antagonism.
“The anxiolytic-like effects produced by CBD injections into the rat infralimbic (Marinho et al., 2015) or prelimbic (Fogaca et al., 2014) cortices, BNST (Gomes et al., 2013; Gomes et al., 2012; Gomes et al., 2011) and dPAG (Campos et al., 2013a) are attenuated by concomitant 5-HT1A-R antagonism.”
From The endocannabinoid system as a target for novel anxiolytic drugs (2017) · cites this paper as Gomes et al., 2013
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“…↓MBP and HR Martin-Santos et al., 2012 Human Healthy volunteers 600mg Oral Pre-test Pre-drug and Hourly interval for 3 h post-drug No changes on BP or HR Gomes et al., 2013 Rats Stress (restraint) 15, 30 or 60 nmol BNST Pre-stress Pre-stress and during 60 min post-stress Enhanced the HR…”
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- Authors
- Gomes, F. V., Alves, F. H. F., Guimarães, F. S., Correa, F. M. A., Resstel, L. B. M., & Crestani, C. C.
- Affiliations
- Universidade de São Paulo (BR)
- ORCID
- Venue
- European Neuropsychopharmacology
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 23
- Issue
- 9
- Pages
- 1096-1104
- ISSN
- 0924-977X (ISSN-L)
- OpenAlex
- W2169981366
- Cited by
- 27
- References
- 53
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 3 · 2020: 6 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 5 · 2014: 1 · 2013: 1
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista) (submittedVersion)
- UNESP Institutional Repository (São Paulo State University) (submittedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo (2011/07332-3, 2010/16192-8, 2007/03685-3)
- Fundação para o Desenvolvimento da UNESP (00923/10-DFP)
- Conselho Nacional de Desenvolvimento CientÃfico e Tecnológico (501323/2010-4, 305996/2008-8, 474177/2010-6)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- cannabidiol, bed nucleus of the stria terminalis, 5-HT1A receptor, acute restraint stress, cardiovascular response, heart rate, blood pressure, WAY-100635, microinjection
- MeSH terms
- Acute Disease, Animals, Blood Pressure, Cannabidiol, Dose-Response Relationship, Drug, Heart Rate, Male, Restraint, Physical, Septal Nuclei, Stress, Psychological, Rats, Wistar, Receptor, Serotonin, 5-HT1A, Rats, Infusions, Intraventricular
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