Involvement of the prelimbic prefrontal cortex on cannabidiol-induced attenuation of contextual conditioned fear in rats
Abstract
Rationale Systemic administration of cannabidiol (CBD), a non-psychotomimetic component of Cannabis sativa, is able to attenuate cardiovascular and behavioral (freezing) changes induced by re-exposure to a context that had been previously paired with footshocks. The brain sites mediating this effect, however, remain unknown. The medial prefrontal cortex (mPFC) has been related to contextual fear conditioning.Objectives (1) To verify, using c-Fos immunocytochemistry, if the mPFC is involved in the attenuation of contextual fear induced by systemic administration of CBD; (2) to investigate if direct microinjections of CBD into mPFC regions would also attenuate contextual fear.Results Confirming previous results systemic administration of CBD (10mg/kg) decreased contextual fear and associated c-Fos expression in the prefrontal cortex (prelimbic and infralimbic regions). The drug also attenuated c-Fos expression in the bed nucleus of the stria terminalis (BNST). Direct CBD (30 nmol) microinjection into the PL prefrontal cortex reduced freezing induced by re-exposure to the aversively conditioned context. In the infralimbic (IL) prefrontal cortex, however, CBD (30 nmol) produced an opposite result, increasing the expression of contextual fear conditioning. This result was confirmed by an additional experiment where the conditioning session was performed under a less aversive protocol.Conclusion These results suggest that the PL prefrontal cortex may be involved in the attenuation of contextual fear induced by systemic injection of CBD. They also support the proposition that the IL and PL play opposite roles in fear conditioning. A possible involvement of the BNST in CBD effects needs to be further investigated.
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CBD induced acute anxiolytic effects when injected into the dPAG and BNST.
“As shown in Figure 2, CBD induced acute anxiolytic effects when injected into the dPAG and BNST (21, 37–41).”
From Translational investigation of the therapeutic potential of Cannabidiol (CBD): Toward a new age (2018) · cites this paper as [41]
CBD modified anxiety-like behaviors in the mPFC, preventing the expression of contextual fear conditioning.
“CBD also modified anxiety-like behaviors in the mPFC, preventing the expression of contextual fear conditioning (41).”
From Translational investigation of the therapeutic potential of Cannabidiol (CBD): Toward a new age (2018) · cites this paper as [41]
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- Authors
- Lemos, J. I., Resstel, L. B., & Guimarães, F. S.
- Affiliations
- Universidade de São Paulo (BR)
- Corresponding author
- Guimarães, Francisco Silveira
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 207
- Issue
- 1
- Pages
- 105-111
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2003968300
- Cited by
- 146
- References
- 82
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- FWCI
- 6.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- cannabidiol, contextual fear conditioning, fear extinction, prelimbic cortex, infralimbic cortex, bed nucleus of the stria terminalis, Fos expression, microinjection, freezing behavior, aversive conditioning, medial prefrontal cortex
- MeSH terms
- Animals, Behavior, Animal, Cannabidiol, Conditioning, Classical, Dose-Response Relationship, Drug, Electroshock, Exploratory Behavior, Fear, Hypothalamus, Immunohistochemistry, Male, Neurons, Spatial Behavior, Proto-Oncogene Proteins c-fos, Rats, Wistar, Prefrontal Cortex, Rats
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