Cited by 837Gut microbiota and healthOral microbiology and periodontitis researchInflammatory Bowel Disease

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Meta‐analyses of human gut microbes associated with obesity and IBD

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Walters, William A., Xu, Zech, Knight, Rob·2014·FEBS Letters

DOI 10.1016/j.febslet.2014.09.039PMC PMC5050012

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Abstract

Recent studies have linked human gut microbes to obesity and inflammatory bowel disease, but consistent signals have been difficult to identify. Here we test for indicator taxa and general features of the microbiota that are generally consistent across studies of obesity and of IBD, focusing on studies involving high‐throughput sequencing of the 16S rRNA gene (which we could process using a common computational pipeline). We find that IBD has a consistent signature across studies and allows high classification accuracy of IBD from non‐IBD subjects, but that although subjects can be classified as lean or obese within each individual study with statistically significant accuracy, consistent with the ability of the microbiota to experimentally transfer this phenotype, signatures of obesity are not consistent between studies even when the data are analyzed with consistent methods. The results suggest that correlations between microbes and clinical conditions with different effect sizes (e.g. the large effect size of IBD versus the small effect size of obesity) may require different cohort selection and analysis strategies.

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Authors: Walters, W. A., Xu, Z., & Knight, R.
Affiliations: University of Colorado Boulder (US)
Howard Hughes Medical Institute (US)
Corresponding author: Knight, Rob
ORCID: Walters, William A.
Knight, Rob
Venue: FEBS Letters
Publisher: Wiley
Published: 2014-10-13
Volume: 588
Issue: 22
Pages: 4223-4233
ISSN: 0014-5793 (ISSN-L)
1873-3468
DOI: 10.1016/j.febslet.2014.09.039
PMC: PMC5050012
OpenAlex: W2037279825
Cited by: 836
References: 54
Citations by year: 2026: 27 · 2025: 42 · 2024: 66 · 2023: 65 · 2022: 84 · 2021: 96 · 2020: 98 · 2019: 92 · 2018: 91 · 2017: 78 · 2016: 64 · 2015: 32 · 2014: 1
FWCI: 5.49
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: FEBS Letters (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
Funders: National Institutes of Health
Crohns and Colitis Foundation of America
Howard Hughes Medical Institute
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Keywords: gut microbiota, obesity, inflammatory bowel disease, 16S rRNA gene, indicator taxa, microbiota transfer, effect size, cohort selection
MeSH terms: Animals, Feces, Humans, Obesity, Inflammatory Bowel Diseases, Sequence Analysis, RNA, Gastrointestinal Tract

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Meta‐analyses of human gut microbes associated with obesity and IBD

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