Gut microbiota diversity across ethnicities in the United States
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Abstract
Composed of hundreds of microbial species, the composition of the human gut microbiota can vary with chronic diseases underlying health disparities that disproportionally affect ethnic minorities. However, the influence of ethnicity on the gut microbiota remains largely unexplored and lacks reproducible generalizations across studies. By distilling associations between ethnicity and differences in two US-based 16S gut microbiota data sets including 1,673 individuals, we report 12 microbial genera and families that reproducibly vary by ethnicity. Interestingly, a majority of these microbial taxa, including the most heritable bacterial family, Christensenellaceae, overlap with genetically associated taxa and form co-occurring clusters linked by similar fermentative and methanogenic metabolic processes. These results demonstrate recurrent associations between specific taxa in the gut microbiota and ethnicity, providing hypotheses for examining specific members of the gut microbiota as mediators of health disparities.
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The human gut contains several discrete, ecologically balanced communities (microbiotypes) that are resilient but can be changed by diet, drugs, and lifestyle.
“The human gut microbiome includes multiple discrete ecologically balanced communities—hereafter referred to as ‘enteric microbiotypes’—that are resilient although still modifiable by diet, drugs and lifestyle47–52.”
From Intestinal microbiota signatures of clinical response and immune-related adverse events in melanoma patients treated with anti-PD-1 (2022) · cites this paper as [48]
Enteric microbiotypes differ by geographical area, as the gut microbiome is influenced by ethnicity and geographical origin.
“Enteric microbiotypes are distinctive of different geographical areas, as the human gut microbiome is affected by ethnicity and geographical origin48,49,52.”
From Intestinal microbiota signatures of clinical response and immune-related adverse events in melanoma patients treated with anti-PD-1 (2022) · cites this paper as [48]
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- Authors
- Brooks, A. W., Priya, S., Blekhman, R., & Bordenstein, S. R.
- Affiliations
- Vanderbilt University (US)
- University of Minnesota (US)
- Corresponding author
- Bordenstein, Seth R.
- Venue
- PLOS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2018-12-04
- Volume
- 16
- Issue
- 12
- Pages
- e2006842
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- PMC
- PMC6279019
- OpenAlex
- W2949947154
- Cited by
- 304
- References
- 82
- Citations by year
- 2026: 24 · 2025: 38 · 2024: 28 · 2023: 48 · 2022: 37 · 2021: 54 · 2020: 52 · 2019: 23
- FWCI
- 11.41
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS Biology (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Alfred P. Sloan Foundation
- Vanderbilt University
- University of Minnesota
- National Institutes of Health
- National Institute of General Medical Sciences (GM128716, T32GM080178, R35GM128716)
- National Institute on Minority Health and Health Disparities
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut microbiota, ethnicity, health disparities, ethnic minorities, Christensenellaceae, microbial genera, 16S rRNA, microbial co-occurrence, methanogenesis, fermentation, genetic association
- MeSH terms
- Gastrointestinal Microbiome, Bacteria, Ethnicity, Feces, Humans, RNA, Ribosomal, 16S, United States, Genetic Variation, Microbiota
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