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NADPH oxidase- and mitochondria-derived reactive oxygen species in proinflammatory microglial activation: a bipartisan affair?
Open accessAbstract
Microglia are the resident immune cells of the brain and play major roles in central nervous system development, maintenance, and disease. Brain insults cause microglia to proliferate, migrate, and transform into one or more activated states. Classical M1 activation triggers the production of proinflammatory factors such as tumor necrosis factor-α, interleukin-1β (IL-1β), nitric oxide, and reactive oxygen species (ROS), which, in excess, can exacerbate brain injury. The mechanisms underlying microglial activation are not fully understood, yet reactive oxygen species are increasingly implicated as mediators of microglial activation. In this review, we highlight studies linking reactive oxygen species, in particular hydrogen peroxide derived from NADPH oxidase-generated superoxide, to the classical activation of microglia. In addition, we critically evaluate controversial evidence suggesting a specific role for mitochondrial reactive oxygen species in the activation of the NLRP3 inflammasome, a multiprotein complex that mediates the production of IL-1β and IL-18. Finally, the limitations of common techniques used to implicate mitochondrial ROS in microglial and inflammasome activation, such as the use of the mitochondrially targeted ROS indicator MitoSOX and the mitochondrially targeted antioxidant MitoTEMPO, are also discussed.
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“However, the selectivity of mitoTEMPO as a mitochondrial-targeted antioxidant has been questioned, especially at higher concentrations [159].”
From ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease (2020) · cites this paper as [159]
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Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80434-1 · Cited by 7,289
A role for mitochondria in nlrp3 inflammasome activation
Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602
Microglia: a sensor for pathological events in the CNS
Kreutzberg, G. W. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10049-7 · Cited by 4,396
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
Block, M. L., Zecca, L., & Hong, J.-S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2038 · Cited by 4,110
Chronic systemic pesticide exposure reproduces features of Parkinson's disease
Betarbet, R. S., Sherer, T., MacKenzie, G. M., Garcia‐Osuna, M., Panov, A. V., & Greenamyre, J. T. (2000) · Nature Neuroscience · doi:10.1038/81834 · Cited by 3,777
Bauernfeind, F. G., Horvath, G. L., Stutz, A., Alnemri, E. S., MacDonald, K. L., Speert, D. P., Fernandes‐Alnemri, T., Wu, J., Monks, B. G., Fitzgerald, K. A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901363 · Cited by 3,087
Hornung, V., Bauernfeind, F., Halle, A., Samstad, E. O., Kono, H., Rock, K. L., Fitzgerald, K. A., & Latz, E. (2008) · Nature Immunology · doi:10.1038/ni.1631 · Cited by 3,065
Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049
NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
Heneka, M. T., Kummer, M. P., Stutz, A., Delekate, A., Schwartz, S., Vieira-Saecker, A., Griep, A., Axt, D., Remus, A., Tzeng, T.-C., et al. (2013) · Nature · doi:10.1038/nature11729 · Cited by 2,898
Thioredoxin-interacting protein links oxidative stress to inflammasome activation
Zhou, R., Tardivel, A., Thorens, B., Choi, I., & Tschopp, J. (2010) · Nature Immunology · doi:10.1038/ni.1831 · Cited by 2,708
Research works printed but not linked: 2
- Kumar, 2012, Neuroinflammation after traumatic brain injury: opportunities for therapeutic intervention, Brain Behav. Immun., 26, 1191, 10.1016/j.bbi.2012.06.008 · DOI · Paper page
- Kurland, 2013, 6, 1287
Cited by
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Simpson, D. S. A., & Oliver, P. L. (2020) · Antioxidants · doi:10.3390/antiox9080743 · Cited by 1,044
Tan, H.-Y., Wang, N., Li, S., Hong, M., Wang, X., & Feng, Y. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/2795090 · Cited by 657
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von Bernhardi, R., Eugenín-von Bernhardi, L., & Eugenín, J. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00124 · Cited by 556
Zhao, Y., Zhang, J., Zheng, Y., Zhang, Y., Zhang, X. J., Wang, H., Du, Y., Guan, J., Wang, X., & Fu, J. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02250-8 · Cited by 362
Sarkar, S., Malovic, E., Harischandra, D. S., Ghaisas, S., Panicker, N., Charli, A., Palanisamy, B. N., Rokad, D., Jin, H., Anantharam, V., et al. (2017) · npj Parkinson s Disease · doi:10.1038/s41531-017-0032-2 · Cited by 288
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Recent Advances of the NLRP3 Inflammasome in Central Nervous System Disorders
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Sarkar, S., Rokad, D., Malovic, E., Luo, J., Harischandra, D. S., Jin, H., Anantharam, V., Huang, X., Lewis, M., Kanthasamy, A., et al. (2019) · Science Signaling · doi:10.1126/scisignal.aat9900 · Cited by 171
Haslund‐Vinding, J., McBean, G., Jaquet, V, & Vilhardt, F. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13425 · Cited by 169
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Clayton, K. A., Enoo, A. A. V., & Ikezu, T. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00680 · Cited by 137
Brand, M. D. (2020) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2020.1828258 · Cited by 123
Michalak, K. P., & Michalak, A. Z. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1558263 · Cited by 148
Mongan, D., Ramesar, M., Föcking, M., Cannon, M., & Cotter, D. (2020) · Early Intervention in Psychiatry · doi:10.1111/eip.12859 · Cited by 123
Ghosh, A., Langley, M. R., Harischandra, D. S., Neal, M. P., Jin, H., Anantharam, V., Joseph, J., Brenza, T. M., Narasimhan, B., Kanthasamy, A., et al. (2016) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-016-9650-4 · Cited by 107
Han, Y., Liu, X., Jin, M., Sun, H., & Kwon, T. (2023) · Inflammation Research · doi:10.1007/s00011-023-01790-4 · Cited by 114
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Bozic, I., Savic, D., Laketa, D., Bjelobaba, I., Milenkovic, I., Pekovic, S., Nedeljkovic, N., & Lavrnja, I. (2015) · PLOS ONE · doi:10.1371/journal.pone.0118372 · Cited by 101
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Jodeiri Farshbaf, M., Ghaedi, K., Megraw, T. L., Curtiss, J., Shirani Faradonbeh, M., Vaziri, P., & Nasr-Esfahani, M. H. (2016) · NeuroMolecular Medicine · doi:10.1007/s12017-015-8370-x · Cited by 101
Huang, J., Wang, X., Li, N., Fan, W., Li, X., Qian, Z., Liu, J., Li, W., Zhang, Z., Liu, X., et al. (2024) · Advanced Science · doi:10.1002/advs.202308031 · Cited by 102
Ye, J., Jiang, Z., Chen, X., Liu, M., Li, J., & Liu, N. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14042 · Cited by 96
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Jia, J., Jin, H., Nan, D., Yu, W., & Huang, Y. (2021) · APOPTOSIS · doi:10.1007/s10495-021-01661-5 · Cited by 97
Qi, G., Mi, Y., Fan, R., Li, R., Liu, Z., & Liu, X. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b00133 · Cited by 95
Jung, J., Choi, M., Lee, Y., Moon, B., Park, J., & Kim, H.-S. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b05147 · Cited by 92
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Kalsbeek, M. J. T., Mulder, L., & Yi, C. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.09.028 · Cited by 93
Roelofs, B. A., Ge, S. X., Studlack, P. E., & Polster, B. M. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.05.032 · Cited by 92
Self-citationSchilling, S., Chausse, B., Dikmen, H. O., Almouhanna, F., Hollnagel, J., Lewen, A., & Kann, O. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.05.013 · Cited by 91
Pozzo, E. D., Tremolanti, C., Costa, B., Giacomelli, C., Milenkovic, V. M., Bader, S. M., Wetzel, C. H., Rupprecht, R., Taliani, S., Settimo, F. D., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184467 · Cited by 89
Mendiratta, S., hussein, M., Nasser, H. A., & Ali, A. (2019) · Particle & Particle Systems Characterization · doi:10.1002/ppsc.201900195 · Cited by 89
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Lowry, J. R., & Klegeris, A. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.02.014 · Cited by 77
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Ye, J., Jiang, Z., Chen, X., Liu, M., Li, J., & Liu, N. (2015) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.10.026 · Cited by 76
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Li, J., Xu, L., Deng, X., Jiang, C., Pan, C., Chen, L., Han, Y., Dai, W., Hu, L., Zhang, G., et al. (2016) · Pain · doi:10.1097/j.pain.0000000000000575 · Cited by 71
Park, J., Choi, H., Kim, B., Chae, U., Lee, D. G., Lee, S.-R., Lee, S., Lee, H., & Lee, D. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.08.030 · Cited by 71
Ladwig, A., Walter, H. L., Hucklenbroich, J., Willuweit, A., Langen, K., Fink, G. R., Rueger, M. A., & Schroeter, M. (2017) · Mediators of Inflammation · doi:10.1155/2017/7189421 · Cited by 64
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Pap, R., Pandur, E., Jánosa, G., Sipos, K., Agócs, A., & Deli, J. (2021) · Antioxidants · doi:10.3390/antiox10030363 · Cited by 64
Miyamoto, S., Zhang, G., Hall, D., Oates, P. J., Maity, S., Madesh, M., Han, X., & Sharma, K. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.011110 · Cited by 60
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Hara‐Chikuma, M., Tanaka, M., Verkman, A. S., & Yasui, M. (2020) · Nature Communications · doi:10.1038/s41467-020-19491-5 · Cited by 52
Oka, S., Leon, J., Sakumi, K., Abolhassani, N., Sheng, Z., Tsuchimoto, D., LaFerla, F. M., & Nakabeppu, Y. (2021) · Scientific Reports · doi:10.1038/s41598-021-84640-9 · Cited by 51
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Mrvová, N., Škandík, M., Kuniaková, M., & Račková, L. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.09.005 · Cited by 50
Huang, P., Zhang, L., Tan, Y., & Chen, S. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00337-1 · Cited by 54
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Nadjar, A. (2018) · Prostaglandins, Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2018.07.006 · Cited by 49
Sirabella, R., Sisalli, M. J., Costa, G., Omura, K. M., Ianniello, G., Pinna, A., Morelli, M., Renzo, G. D., Annunziato, L., & Scorziello, A. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0775-7 · Cited by 48
Alvariño, R., Alonso, E., Lacret, R., Oves‐Costales, D., Genilloud, O., Reyes, F., Alfonso, A., & Botana, L. M. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b01090 · Cited by 48
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Strogulski, N. R., Portela, L. V., Polster, B. M., & Loane, D. J. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15959 · Cited by 49
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Tamtaji, O. R., Behnam, M., Pourattar, M. A., Jafarpour, H., & Asemi, Z. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28871 · Cited by 44
Morris, G., Puri, B. K., Maes, M. H. J., OLIVE, L. S., Berk, M., & Carvalho, A. F. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109858 · Cited by 42
Sousa, N. A., de Oliveira, G. A. L., de Oliveira, A. P., Lopes, A. L. F., Iles, B., Nogueira, K. D. M., Araújo, T. S. L., de Souza, L. K. M., de Araújo, A. R., Ramos‐Jesus, J., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-59665-1 · Cited by 42
Yosri, H., El‐Kashef, D. H., El‐Sherbiny, M., Said, E., & Salem, H. A. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113758 · Cited by 42
Zha, Z., Liu, S., Liu, Y., Li, C., & Wang, L. (2022) · Antioxidants · doi:10.3390/antiox11081495 · Cited by 44
Benfotiamine upregulates antioxidative system in activated BV-2 microglia cells
Bozic, I. D., Savić, D. Z., Stevanović, I. D., Peković, S., Nedeljković, N., & Lavrnja, I. C. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00351 · Cited by 44
O'Brien, J. A., & Austin, P. J. (2019) · Biomolecules · doi:10.3390/biom9080381 · Cited by 41
Brain organoids: A promising model to assess oxidative stress‐induced central nervous system damage
Oyefeso, F. A., Muotri, A. R., Wilson, C. G., & Pecaut, M. J. (2021) · Developmental Neurobiology · doi:10.1002/dneu.22828 · Cited by 44
Recent Progress in Autocatalytic Ceria Nanoparticles-Based Translational Research on Brain Diseases
Choi, S. W., & Kim, J. (2020) · ACS Applied Nano Materials · doi:10.1021/acsanm.9b02243 · Cited by 39
Electroconvulsive stimulation attenuates chronic neuroinflammation
Goldfarb, S., Fainstein, N., & Ben‐Hur, T. (2020) · JCI Insight · doi:10.1172/jci.insight.137028 · Cited by 41
Wang, W., Tam, K. C., Ng, T. C., Goit, R. K., Chan, K. L.-S., & Lo, A. (2020) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2020-001519 · Cited by 39
Nanomaterials as novel agents for amelioration of Parkinson’s disease
Wu, J., Cui, X., Ke, P. C., Mortimer, M., Wang, X., Bao, L., & Chen, C. (2021) · Nano Today · doi:10.1016/j.nantod.2021.101328 · Cited by 38
Barnett, D., Zimmer, T. S., Booraem, C., Palaguachi, F., Meadows, S. M., Xiao, H., Wong, M. Y., Luo, W., Gan, L., Chouchani, E. T., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01390-y · Cited by 41
Tylek, K., Trojan, E., Leśkiewicz, M., Regulska, M., Bryniarska, N., Curzytek, K., Lacivita, E., Leopoldo, M., & Basta‐Kaim, A. (2021) · Cells · doi:10.3390/cells10092373 · Cited by 37
Crous, A., & Abrahamse, H. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10142-w · Cited by 38
Zhang, H., Yang, S., Lu, Y., Zhou, L., Dong, M., Chu, Y., Pang, X., Chen, L., Xu, L., Zhang, L., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103473 · Cited by 38
Pilipović, K., Župan, Ž., Dolenec, P., Mršić‐Pelčić, J., & Župan, G. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.01.003 · Cited by 35
Yu, S., Fu, J., Wang, J., Zhao, Y., Liu, B., Wei, J., Yan, X., & Su, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010135 · Cited by 34
Bastioli, G., Piccirillo, S., Graciotti, L., Carone, M., Sprega, G., Taoussi, O., Preziuso, A., & Castaldo, P. (2024) · Cells · doi:10.3390/cells13151301 · Cited by 38
Mayer, A. M. S., Murphy, J., Macadam, D., Osterbauer, C., Baseer, I., Hall, M. L. M., Fehér, D., & Williams, P. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv251 · Cited by 34
Pampuščenko, K., Morkūnienė, R., Krasauskas, L., Smirnovas, V., Brown, G. C., & Borutaitė, V. (2023) · Scientific Reports · doi:10.1038/s41598-023-37887-3 · Cited by 31
Cheng, C., Cui, J. Z., Ji, X., & Yao, L. (2020) · Future Medicinal Chemistry · doi:10.4155/fmc-2019-0311 · Cited by 32
PapRIV, a BV-2 microglial cell activating quorum sensing peptide
Janssens, Y., Debunne, N., Spiegeleer, A. D., Wynendaele, E., Planas, M., Feliu, L., Quarta, A., Claes, C., Dam, D. V., Deyn, P. P. D., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-90030-y · Cited by 33
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Metadata
- Authors
- Bordt, E. A., & Polster, B. M.
- Affiliations
- University of Maryland, Baltimore (US)
- Corresponding author
- Polster, Brian M.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 76
- Pages
- 34-46
- ISSN
- 0891-5849 (ISSN-L)
- PMC
- PMC4252610
- OpenAlex
- W1971167579
- Cited by
- 202
- References
- 163
- Citations by year
- 2026: 15 · 2025: 15 · 2024: 17 · 2023: 14 · 2022: 19 · 2021: 24 · 2020: 16 · 2019: 18 · 2018: 20 · 2017: 16 · 2016: 15 · 2015: 12 · 2014: 1
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R01 NS085165)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- microglial activation, reactive oxygen species, NADPH oxidase, mitochondrial reactive oxygen species, hydrogen peroxide, superoxide, M1 macrophage polarization, NLRP3 inflammasome, IL-1β, IL-18, MitoSOX, MitoTEMPO, neuroinflammation, brain injury
- MeSH terms
- Animals, Humans, Mitochondria, Reactive Oxygen Species, Microglia, Inflammation Mediators, NADPH Oxidases
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