Differential effects on cognitive functioning in 9- to 12-year olds prenatally exposed to cigarettes and marihuana
Abstract
Cognitive performance was examined in 131 9-12-year-old children for whom prenatal marihuana and cigarette exposure had been ascertained. The subjects, participants in an ongoing longitudinal study, were from a low-risk, predominantly middle class sample. The tasks included the WISC-III and a series of tests assessing aspects of cognition subsumed under the rubric of executive function. Consistent with results obtained at earlier ages, discriminant function analysis revealed a dose-dependent association, which remained after controlling for potential confounds (including secondhand smoke), between prenatal cigarette exposure and lower global intelligence scores with the verbal subtests of the WISC maximally discriminating among levels of in utero exposure. In contrast, prenatal marihuana exposure was not associated with global intelligence or the verbal subtests. Rather, this drug was negatively associated with the executive function tasks that require impulse control and visual analysis/hypothesis testing and with a number of WISC subtests requiring the same abilities. The interpretation of these results is discussed in terms of executive function and is related to earlier observations of this sample and to the extant prefrontal and general marihuana literature.
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Central processing of auditory stimuli appears to be highly sensitive to disruption by gestational tobacco exposure.
“In particular, central processing of auditory stimuli appears to be highly sensitive to disruption by gestational tobacco exposure.”
From Impaired auditory discrimination learning following perinatal nicotine exposure or β2 nicotinic acetylcholine receptor subunit deletion (2012) · cites this paper as [16]
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- Authors
- Fried, P. A., Watkinson, B., & Gray, R.
- Affiliations
- Carleton University (CA)
- Corresponding author
- Fried, Peter A.
- ORCID
- Fried, Peter A.
- Venue
- Neurotoxicology and Teratology
- Publisher
- Elsevier BV
- Published
- 1998-05
- Volume
- 20
- Issue
- 3
- Pages
- 293-306
- ISSN
- 0892-0362 (ISSN-L)
- OpenAlex
- W4247502122
- Cited by
- 235
- References
- 51
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 11 · 2023: 12 · 2022: 11 · 2021: 7 · 2020: 10 · 2019: 8 · 2018: 10 · 2017: 8 · 2016: 5 · 2015: 11 · 2014: 9 · 2013: 7 · 2012: 10
- FWCI
- 7.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurotoxicology and Teratology (publishedVersion)
- Funders
- National Institute on Drug Abuse
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Keywords
- prenatal drug exposure, prenatal cannabis exposure, cognitive function, executive function, intelligence, children, dose-response relationship, impulse control, hypothesis testing, passive smoking, WISC-III
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