Blockchain in healthcare and health sciences—A scoping review
Open accessAbstract
BACKGROUND: Blockchain can be described as an immutable ledger, logging data entries in a decentralized manner. This new technology has been suggested to disrupt a wide range of data-driven domains, including the health domain. OBJECTIVE: The purpose of this study was to systematically review, assess and synthesize peer-reviewed publications utilizing/proposing to utilize blockchain to improve processes and services in healthcare, health sciences and health education. METHOD: A structured literature search on the topic was conducted in October 2018 relevant bibliographic databases. RESULT: 39 publications fulfilled the inclusion criteria. The result indicates that Electronic Health Records and Personal Health Records are the most targeted areas using blockchain technology. Access control, interoperability, provenance and data integrity are all issues that are meant to be improved by blockchain technology in this field. Ethereum and Hyperledger fabric seem to be the most used platforms/frameworks in this domain. CONCLUSION: This study shows that the endeavors of using blockchain technology in the health domain are increasing exponentially. There are areas within the health domain that potentially could be highly impacted by blockchain technology.
AI snapshot
Written from the paper’s full text.
TL;DR
This scoping review systematically assessed 39 peer-reviewed publications on blockchain in healthcare, health sciences, and health education. It found that EHRs and PHRs are the most targeted areas, consortium blockchains and Ethereum/Hyperledger are common, but the field remains early and lacks evidence of real-world effects and regulatory compliance.
Key findings
- Of 39 included publications, 43% targeted electronic health records, 15% personal health records, and 5% clinical trial support systems; 62% addressed some process of sharing health data.
- Blockchain was proposed to improve access control in 35% of publications, interoperability in 27%, data integrity in 28%, and provenance in 12%.
- Consortium blockchain was the preferred type (38%); Ethereum was used in 28%, Hyperledger Fabric in 10%, and Exonum in 4%; 36% developed a new blockchain and 21% did not specify a platform. PoW was the most frequent consensus algorithm (21%), PBFT was 15%, 41% did not state a consensus protocol, and 38% used smart contracts.
- The average citation count was 21 ± 40 (up to March 2019); publications by year were 2016 (n = 4), 2017 (n = 11), and 2018 (n = 23); most studies were associated with Chinese (42%) or USA (20%) research institutes. Quality assessment total mean score was 5.7 ± 1.8, with a range of 1–9.
Methods
- A structured literature search was conducted in October 2018 in MEDLINE, Embase, Cochrane Library, Scopus, Google Scholar, Compendex, Inspec, ACM, and IEEE, searching for “blockchain” combined with “health” and using backward/forward snowballing.
- Titles, abstracts, and full articles were screened by reviewer 1, with doubtful cases reviewed by three additional reviewers; disagreements were resolved by discussion. Data were extracted into a pre-developed matrix and analyzed in Microsoft Excel.
- Quality assessment used a tool adapted from Hölbl et al.; no papers were excluded in this process. All included papers were categorized as Proof-of-Concept design, and eleven were considered a hybrid between Proof-of-Concept and case-study design.
Limitations
- The paper states that the review does not capture the whole picture, especially promising private-sector developments not covered in the included publications, such as genome management and medical credential systems.
- The paper states that none of the included publications described how their blockchain-based solution complied with GDPR, HIPAA, or other national health data laws and regulations.
- Evident from the text: many included publications failed to define their blockchain type, platform/framework, or consensus protocol, limiting comparability and feasibility assessment; the search was last updated in October 2018, so later work is not included.
Model-written summary. Check it against the paper before relying on it.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
0 of 32 cited sources checked · 0 supported · 0 flagged
- Findingown data
Thirty-nine publications fulfilled the inclusion criteria.
“39 publications fulfilled the inclusion criteria.”
- Also stated in: § 4. Results · plain
“The following section presents a summary of the extracted data from the included papers (n = 39).”
Quote in the paperSubstantial claim - Also stated in: § 4. Results · plain
- Findingown data
More than half of the publications (62%) addressed some processes of sharing health data.
“More than half of the publications (62 %) addressed some processes of sharing health data.”
Quote in the paperNot a substantial claim - Findingown data
The most frequently targeted system was EHR, with 43% of the publications addressing this topic.
“The most frequently targeted system was EHR, with 43 % of the publications addressing this topic.”
Quote in the paperNot a substantial claim - Findingown data
Electronic Health Records and Personal Health Records are the most targeted areas using blockchain technology in the health domain.
“The result indicates that Electronic Health Records and Personal Health Records are the most targeted areas using blockchain technology.”
- Also stated in: § 4.1.1. Summary of proposed solutions · plain
“The most frequently targeted system was EHR, with 43 % of the publications addressing this topic.Other systems of focus were PHR (15 %) and clinical trial support systems (5 %).”
Quote in the paperSubstantial claim - Also stated in: § 4.1.1. Summary of proposed solutions · plain
- Findingown data
Many of the PHRs were proposed as patient-controlled and not tethered to a particular health institution or system.
“Many of the PHRs were proposed as patient-controlled and not tethered to a particular health institution or system (Table 6).”
Quote in the paperNot a substantial claim
- Findingown data
Ethereum and Hyperledger fabric are the most used platforms/frameworks in the health domain.
“Ethereum and Hyperledger fabric seem to be the most used platforms/frameworks in this domain.”
Quote in the paperNot a substantial claim - Findingown data
The endeavors of using blockchain technology in the health domain are increasing exponentially.
“This study shows that the endeavors of using blockchain technology in the health domain are increasing exponentially.”
- Also stated in: § Quality Assessment Query · plain
“The included papers were published during the following years; 2016 (n = 4), 2017 (n = 11) and 2018 (n = 23).”
Quote in the paperSubstantial claim - Also stated in: § Quality Assessment Query · plain
- Findingown data
Several papers (26%) failed to define their blockchain approach.
“Although several of the papers failed to define their approach (26 %), private-(10 %) and public blockchains (15 %) appears to be less used in the health domain (Fig. 4).”
Quote in the paperNot a substantial claim - Findingown data
Blockchain solutions for interoperability challenges were discussed in 27% of the included publications.
“Blockchain solutions for the interoperability challenges were discussed in several papers (27 %) (Table 5).”
Quote in the paperNot a substantial claim - Findingown data
Eight (21%) of the included studies failed to specify a platform or framework for their concept.
“Eight (21 %) of the included studies failed to specify a platform or framework for their concept (Fig. 4).”
Quote in the paperNot a substantial claim - Findingown data
Private and public blockchains appear to be less used in the health domain than consortium blockchains.
“Although several of the papers failed to define their approach (26 %), private-(10 %) and public blockchains (15 %) appears to be less used in the health domain (Fig. 4).”
Quote in the paperNot a substantial claim - Findingreasoning
Data integrity was generally maintained by the immutability property of the blockchain.
“Generally, the data integrity was maintained by the immutability property of the blockchain (2.1.1 -Key characteristics).”
Quote in the paperNot a substantial claim - Findingcitation
In clinical trials, data integrity was maintained by using smart contracts and integration with trusted IoT devices.
“Another approach for using blockchain to maintain data integrity was found within clinical trials where smart contracts and integration with trusted IoT devices are used [44,46].”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [44]
Not checked in the free run.
- cites [46]
Not checked in the free run.
- Findingown data
The most frequent used consensus algorithm in the included publications was PoW, accounting for 21% of the cases.
“The most frequent used consensus algorithm in the included publications were PoW, accounting for 21 % of the cases.”
Quote in the paperNot a substantial claim - Findingown data
A consortium blockchain was the preferred type among the included publications, at 38%.
“A consortium blockchain (38 %) was the preferred type among the included publications.”
- Also stated in: § 5. Discussion · hedged
“Furthermore, a consortium blockchain appears to be the preferred design choice when it comes to type of blockchain.”
Quote in the paperNot a substantial claim - Also stated in: § 5. Discussion · hedged
- Findingown data
A variety of consensus algorithms are used for blockchain concepts in the health domain.
“The summarized results indicate that a variety of consensus algorithms are used for blockchain concepts in the health domain (Table 7).”
Quote in the paperNot a substantial claim - Findingcitation
Data integrity was enhanced by storing hashed medical data or a hash pointer on chain.
“Data integrity was enhanced by storing hashed medical data or hash pointer on chain [49,41,38].”
Quote in the paperSubstantial claim0 of 3 sources checked - Findingown data
Hyperledger Fabric was utilized four times (10%) in the included publications.
“Ethereum was utilized in eleven (28 %) of the 39 included publications, Hyperledger Fabric four times (10 %) and Exonum once (4 %) (Fig. 4).”
Quote in the paperNot a substantial claim - Findingown data
The second most frequent used consensus algorithm was PBTF (15%).
“The second most frequent used consensus algorithm was PBTF (15 %).”
Quote in the paperNot a substantial claim - Findingown data
Average scores for Q1 (1.0 ± 0.7), Q2 (0.9 ± 0.7) and Q3 (1.0 ± 0.5) appear lower than Q4 (1.6 ± 0.6) and Q5 (1.2 ± 0.6).
“The average score for Q1 (1.0 ± 0.7), Q2 (0.9 ± 0.7) and Q3 (1.0 ± 0.5) appears to be lower than Q4 (1.6 ± 0.6) and Q5 (1.2 ± 0.6).”
Quote in the paperNot a substantial claim - Findingown data
The remaining studies did not define whether smart contracts were a feature or not.
“In several of the proposed concepts, smart contracts were a feature: 38 % of the included studies used smart contracts for some functionality; the remaining studies did not define if smart contracts were a feature or not (Table 7).”
Quote in the paperNot a substantial claim - Findingown data
The average quality of the included publications increased in papers published in 2018 compared to 2016 and 2017.
“As shown in Fig. 5, the average quality increased in papers published in 2018 compared to 2016 and 2017.”
- Also stated in: § 5. Discussion · plain
“The quality of the papers is also on the rise (Fig. 5).”
Quote in the paperNot a substantial claim - Also stated in: § 5. Discussion · plain
- Findingown data
Blockchain was suggested as an improvement to access control in 35% of the included publications.
“As illustraded in Table 5, blockchain was suggested as an improvement to access control in 35 % of the included publications.”
Quote in the paperNot a substantial claim - Findingcitation
In a blockchain concept for medical supply chains, data provenance was enhanced by the use of trusted IoT devices that execute smart contracts on the blockchain.
“In a blockchain concept for medical supply chains, data provenance was enhanced by the use of trusted IoT devices that execute smart contracts on the blockchain [43].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [43]
Not checked in the free run.
- Findingown data
Private blockchains accounted for 10% of the included publications.
“Although several of the papers failed to define their approach (26 %), private-(10 %) and public blockchains (15 %) appears to be less used in the health domain (Fig. 4).”
Quote in the paperNot a substantial claim - Findingcitation
In concepts addressing clinical trials, data provenance issues were targeted by providing a tracking system of data used in the trials.
“Other examples were found in the concepts addressing clinical trials, where data provenance issues are targeted by providing a tracking system of data used in the trials [44,46].”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [44]
Not checked in the free run.
- cites [46]
Not checked in the free run.
- Findingown data
38% of the included studies used smart contracts for some functionality.
“In several of the proposed concepts, smart contracts were a feature: 38 % of the included studies used smart contracts for some functionality; the remaining studies did not define if smart contracts were a feature or not (Table 7).”
Quote in the paperNot a substantial claim - Findingown data
Many researchers explore the use of smart contracts on the Ethereum platform, organized as a consortium blockchain.
“Many researchers explore the use of Smart-contracts on the Ethereum platform, organized as a consortium blockchain.”
Quote in the paperNot a substantial claim - Findingown data
Several (41%) of the publications failed to state which consensus protocol their concept intended to apply.
“Several (41 %) of the publications failed to state which consensus protocol their concept intended to apply.”
Quote in the paperNot a substantial claim - Findingown data
The ability to improve provenance was targeted in 12% of the included publications.
“The ability to improve provenance was targeted in 12 % of the included publications (Table 5).”
Quote in the paperNot a substantial claim - Findingown data
Public blockchains accounted for 15% of the included publications.
“Although several of the papers failed to define their approach (26 %), private-(10 %) and public blockchains (15 %) appears to be less used in the health domain (Fig. 4).”
Quote in the paperNot a substantial claim - Findingown data
14 studies (36%) developed a new blockchain for their respective concepts.
“14 studies (36 %) developed a new blockchain for their respective concepts.”
Quote in the paperNot a substantial claim - Findingown data
Ethereum was utilized in eleven (28%) of the 39 included publications.
“Ethereum was utilized in eleven (28 %) of the 39 included publications, Hyperledger Fabric four times (10 %) and Exonum once (4 %) (Fig. 4).”
Quote in the paperNot a substantial claim - Findingown data
To increase data integrity, a blockchain solution was proposed in 28% of the included publications.
“To increase data integrity a blockchain solution was proposed in 28 % of the included publications in this review (Table 5).”
Quote in the paperNot a substantial claim - Findingown data
No publications were found on the use of blockchain for reimbursement purposes.
“Also, we found no publications on the use of blockchain for reimbursement purposes.”
Quote in the paperNot a substantial claim - Findingown data
Neither of the included publications described how their blockchain-based solution was compliant with GDPR, HIPAA or other national health data laws and regulations.
“Furthermore, neither of the included publications described how their blockchain-based solution was compliant with GDPR, HIPAA or other national health data laws and regulations.”
Quote in the paperSubstantial claim - Findingnone given
Most of the proposed solutions are implemented in institution-controlled EHRs, in Personal health record systems (PHRs) or in the mHealth domain.
“Most of the proposed solutions are implemented in Institution-controlled EHRs, in Personal health record systems (PHRs) or in the mHealth domain.”
Quote in the paperNot a substantial claim - Findingown data
None of the included papers contained evidence that smart contracts make health informatic processes more efficient.
“However, none of the included papers contained evidence of such effect”
Quote in the paperSubstantial claim - Findingcitation
Two publications explored the use of blockchain in clinical trial systems.
“Also, two publications explored the use of blockchain in clinical trial systems [44,46].”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [44]
Not checked in the free run.
- cites [46]
Not checked in the free run.
- Findingcitation
Four publications proposed to use blockchain for building a personal health record system that could bridge the gap between the patient and institution-specific EHRs.
“Four publications [25,27,28,48] proposed to use blockchain for building a personal health record system that could bridge the gap between the patient and institutionspecific EHRs.”
Quote in the paperNot a substantial claim0 of 4 sources checked - Findingown data
Most papers envisioned the use of blockchain in health record systems (EHRs and PHRs).
“Most papers envisioned the use of blockchain in health record systems (EHRs and PHRs) (Table 6).”
Quote in the paperNot a substantial claim - Findingreasoning
Within health record systems, the use of blockchain to build functionality for sharing of data within clinical teams and between clinicians and researchers were the most targeted use cases.
“Within these, the use of blockchain to build functionality for sharing of data within clinical teams and between clinicians and researchers were the most targeted use cases.”
Quote in the paperNot a substantial claim - Findingreasoning
Hyperledger was a popular platform/framework used in the included publications.
“In addition to Ethereum, Hyperledger was a popular platform/framework used in the included publications.”
Quote in the paperNot a substantial claim - Findingown data
Several other health information system domains are under-explored, as few if any publications were found on Knowledge infrastructures, Picture archiving and communications systems, Automated diagnostic service for patients, Administrative systems, Population health management system and Pharma supplychains.
“Several other health information system domains are under-explored as we found few if any publications on Knowledge infrastructures, Picture archiving and communications systems, Automated diagnostic service for patients, Administrative systems, Population health management system and Pharma supplychains.”
Quote in the paperSubstantial claim - Findingnone given
The five included publications on m-health do not provide enough collective evidence that blockchain may be superior to existing solutions.
“Although these five included publications do not provide enough collective evidence that blockchain may be superior to existing solutions, they provide an insight into an interesting use-case for several reasons;”
Quote in the paperSubstantial claim - Findingcitation
Three papers addressed the sharing of clinical data for use in non-clinical contexts.
“Three papers addressed the sharing of clinical data for use in non-clinical contexts [29,32,47].”
Quote in the paperNot a substantial claim0 of 3 sources checked - Findingown data
No publications were found on the use of blockchain in the context of interaction between patients and healthcare students in healthcare education and training.
“We found no publications on the use of blockchain in the context of interaction between patients and healthcare students in the context of healthcare education and training.”
Quote in the paperNot a substantial claim - Findingown data
The frontier of research, as portrayed in this review, shows that blockchain-based solutions currently are being explored in a few EHR, PHR and clinical trial system use cases.
“The frontier of research, as portrayed in this review, show that blockchain-based solutions currently are being explored in a few EHR, PHR and Clinical trial system use cases.”
Quote in the paperSubstantial claim - Findingcitation
Five publications addressed the m-health domain and patient-controlled collection, storage and sharing of sensor data.
“Five of the publications addressed the m-health domain and patientcontrolled collection, storage and sharing of sensor data [23,27,35,39,32].”
Quote in the paperNot a substantial claim0 of 5 sources checked - Findingown data
Most of the use cases for sharing clinical data in non-clinical contexts were related to biomedical research.
“Most of the use cases were related to biomedical research.”
Quote in the paperNot a substantial claim - Interpretationreasoning
There are areas within the health domain that potentially could be highly impacted by blockchain technology.
“There are areas within the health domain that potentially could be highly impacted by blockchain technology.”
Quote in the paperSubstantial claim - Premisecitation
Healthcare institutions currently experience an increased demand of real-world data from industry and research organizations.
“Healthcare institutions currently experience an increased demand of real-world data from industry and research organizations [16].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [16]
Not checked in the free run.
- Premisecitation
The traditional way of achieving access control commonly assumes trust between the owner of the data and the entities storing them.
“The traditional way of achieving access control commonly assumes trust between the owner of the data and the entities storing them.These entities are often servers fully entrusted for defining and enforcing access control policies [14].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [14]
Not checked in the free run.
- Interpretationreasoning
The use of blockchain to build better support for basic and translational biomedical research appears to be a well-recognized problem.
“Hence, the use of blockchain to build better support for basic and translational biomedical research appear to be a well-recognized problem.”
Quote in the paperNot a substantial claim - Interpretationreasoning
The utilization of smart contracts partly explains why Ethereum is the mostly used platform for the proposed concepts.
“The utilization of smart-contracts partly explains why Ethereum is the mostly used platform for the proposed concepts (Fig. 4).”
Quote in the paperNot a substantial claim
- Classified as probably not a substantial claim. 25
- May combine two claims. 17
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Findingown dataThe included papers were published in 2016 (n = 4), 2017 (n = 11), and 2018 (n = 23).
“The included papers were published during the following years; 2016 (n = 4), 2017 (n = 11) and 2018 (n = 23).”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataMost studies were associated with Chinese research institutes or research groups (42%), followed by institutes and groups in the USA (20%).
“Most studies were associated with Chinese research institutes or research groups (42 %) followed by institutes and groups in the USA (20 %).”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataAccess control, interoperability, provenance and data integrity are issues that are meant to be improved by blockchain technology in the health domain.
“Access control, interoperability, provenance and data integrity are all issues that are meant to be improved by blockchain technology in this field.”
- Also stated in: § 4.1.2. Challenges which blockchain aims to improve · plain
“As illustraded in Table 5, blockchain was suggested as an improvement to access control in 35 % of the included publications.”
- Also stated in: § Health Information system · plain
“Blockchain solutions for the interoperability challenges were discussed in several papers (27 %) (Table 5).”
Quote in the paperSubstantial claim- Also stated in: § 4.1.2. Challenges which blockchain aims to improve · plain
Probably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataThe papers had an average citation count of 21 ± 40 (up to March 2019).
“The papers had an average citation count of 21 ± 40 (up to March 2019).”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataThe included publications are evenly distributed between journal publications and conference proceedings.
“As shown in Table 4, the included publications seem to be evenly distributed between journal publications and conference proceedings.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataA large proportion of included publications proposed a structural design (54%) as main contribution, followed by proposals including new algorithms or protocols (38%).
“A large proportion proposed a structural design (54 %) as main contribution, followed by proposals including new algorithms or protocols (38 %) (Table 4).”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Findingown dataIEEE Access with five papers and The Journal of Medical Systems with six papers represented the journals with most included publications.
“IEEE Access with five papers and The Journal of Medical Systems with six papers represented the journals with most included publications.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataOther systems of focus were PHR (15%) and clinical trial support systems (5%).
“Other systems of focus were PHR (15 %) and clinical trial support systems (5 %).”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingnone givenEleven of the included papers could be considered as a hybrid between a Proof-of-Concept and a Case-study design.
“In addition, eleven of the included papers could be considered as a hybrid between a Proof-of-Concept and a Casestudy design.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing), S4 (based).
Findingnone givenNot all concepts that are built using the Ethereum platform or Ethereum protocols used PoW.
“In addition, it is also noteworthy that not all concepts that are built using the Ethereum platform or Ethereum protocols used PoW.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataExonum was utilized once (4%) in the included publications.
“Ethereum was utilized in eleven (28 %) of the 39 included publications, Hyperledger Fabric four times (10 %) and Exonum once (4 %) (Fig. 4).”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe quality of the included publications varies with a standard deviation of 1.8 for the total mean score and a range of 1-9.
“The quality of the included publications varies with a standard deviation of 1.8 for the total mean score and a range of 1-9.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationEthereum and Hyperledger are so far the most popular existing blockchain frameworks/platforms.
“Ethereum (decentralized platform) (5) and Hyperledger (framework) [9] are so far the most popular, and both allow developers to build new blockchain applications onto existing blockchains and to create new test-nets using their protocols.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [9]
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductown dataData extraction was mainly done by reviewer 1 and later re-examined by reviewers 2-4.
“Data was extracted from the included papers in a pre-development matrix.The data extraction was mainly done by reviewer 1 [AH] and later re-examined by reviewers 2-4 [AF, KK and DG].”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductown dataTitles, abstracts and full articles were screened by reviewer 1 applying inclusion and exclusion criteria, with publications meeting criteria or in doubt reviewed a second time by three additional reviewers, and disagreements resolved by discussion among all four reviewers.
“Titles, abstracts and full articles were subsequently screened by reviewer 1 [AH] applying the inclusion and exclusion criteria (Appendix B -Protocol).Publications meeting the inclusive criteria, and those for which the first reviewer was in doubt, were reviewed a second time by three additional reviewers [AF, KK and DG].In cases of disagreement, a discussion between all four reviewers determined”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim. May combine two claims.
Premisenone givenAccess control, provenance, data integrity and interoperability are crucial to both maintain patient privacy and exchange data with other institutions in the healthcare ecosystem.
“To both maintain the patient's privacy and exchange data with other institutions in the healthcare ecosystem, access control, provenance, data integrity and interoperability are crucial.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationEthereum is at this date the largest facilitator of smart contracts on blockchain.
“The blockchain Ethereum is at this date the largest facilitator of smart contracts on blockchain [5].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [5]
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationBitcoin represents a solid use-case that blockchain technology works.
“Bitcoin, with close to 400 million completed transactions (March 19, 2019) [2], represents a solid use-case that blockchain technology works.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [2]
Not checked in the free run.
Probably not a substantial claim: may not pass S2 (checkable).
InterpretationreasoningBlockchain technology has many appealing properties that could be utilized to improve and obtain a higher level of interoperability, information sharing, access control, provenance and data integrity among stakeholders.
“With some of its key attributes such as decentralization, distribution and data integrity, and without any necessary third party, blockchain technology has many appealing properties that could be utilized to improve and obtain a higher level of interoperability, information sharing, access control, provenance and data integrity among the mentioned stakeholders, thereby moving towards a new”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim.
PremisecitationBlockchain technology is considered to have potential for real improvement of health information systems.
“Although blockchain technology is considered to have potential for real improvement of health information systems [3], the recent hype surrounding this technology similarly entails unrealistic proposals and ideas and current literature provides little overview of applications that have been developed, tested and/or deployed.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [3]
Not checked in the free run.
May combine two claims.
Interpretationown dataResearch on the explorative use of blockchain in healthcare is an academic research topic in its infancy, but the number of research groups, approaches and proposed solutions is currently growing exponentially.
“In this scoping literature review, we have found that the research on the explorative use of blockchain in healthcare is an academic research topic in its infancy but that the number of research groups approaches and proposed solutions currently is growing exponentially.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing), S4 (based).
InterpretationreasoningA smart-contract function, which often has the purpose of reducing third party interaction, has the potential of making health informatic processes more efficient.
“A smart-contract function, which often has the purpose of reducing third party interaction, has the potential of making health informatic processes more efficient.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S2 (checkable). May combine two claims.
Study design and conductreasoningThe strength of this publication is its stringent inclusion criteria and the quality assessment approach.
“The strength of this publication is its stringent inclusion criteria and the quality assessment approach.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S2 (checkable). May combine two claims.
Study design and conductreasoningAlthough this study provides a good overview of what has recently been investigated in an academic peer-reviewed setting, the review does not capture the whole picture of the development in the area.
“Although this study provides a good overview of what has recently been investigated in an academic (peer-reviewed) setting, the review does not capture the whole picture of the development in the area.”
Quote in the paperNot a substantial claim- Rests on an assumption: There are promising developments in the private sector in other areas of the health sector that are not covered in the included publications for this review, for example genome management and medical credential systems.
Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based).
Interpretationown dataJudged from the number of blockchain-related publications on Google Scholar, the inauguration and growth of blockchain in healthcare as an academic field is in line with those in other academic sectors.
“Judged from the number of blockchain-related publications on Google Scholar, the inauguration and growth of blockchain in healthcare as an academic field is in line with those in other academic sectors.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim.
InterpretationcitationA consortium blockchain may be more appropriate than a public permissionless or private blockchain to ensure that data are not accessible by those without view rights and to comply with current health data regulations.
“Since HIS deals with highly sensitive data [18], which usually entails that a limited number of entities should have access, a consortium blockchain may be more appropriate than a public permissionless and private to ensure that data are not accessible by those who have no view rights and also to comply with current health data regulations.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [18]
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationWith stronger emphasis on team-based care and continuity of care across institutional borders, and identity management and access control across different health systems, the processes of sharing become important.
“With stronger emphasis on team-based care and continuity of care across institutional borders, and identity management and access control across different health systems, the processes of sharing becomes important [58].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [58] source
Not checked in the free run.
Classified as probably not a substantial claim.
PremisecitationHealth information systems deal with highly sensitive data.
“Since HIS deals with highly sensitive data [18], which usually entails that a limited number of entities should have access, a consortium blockchain may be more appropriate than a public permissionless and private to ensure that data are not accessible by those who have no view rights and also to comply with current health data regulations.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [18]
Not checked in the free run.
May combine two claims.
Interpretationown dataResearch on the use of blockchain in healthcare is now established as an academic field, and the number and quality of publications are increasing rapidly.
“Research on the use of blockchain in healthcare is now established as an academic field, and the number and quality of publications are increasing rapidly.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim. May combine two claims.
InterpretationreasoningThe evidence collected in this review gives a clear indication that blockchain-enhanced solutions for m-health have promising potential and need to be explored further.
“The evidence collected in this review gives a clear indication that blockchain enhanced solutions for this area of the health system have a promising potential and needs to be explored further.”
Quote in the paperSubstantial claim- The authors state this as an assumption: M-health will increase at a rapid pace in the coming years.
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
InterpretationcitationUsing blockchain for personal health records is an alternative take on using health information to fix a broken healthcare system and improve continuity of care, building on the patient in a more empowered and controlling role.
“This is an alternative take on the use of health information to fix a broken healthcare system and improve the continuity of care [59] which builds on the patient in a more empowered and controlling role.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [59] source
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based).
InterpretationreasoningThe popularity of Hyperledger in the included publications correlates well with the overall popularity of blockchain platforms.
“This correlates well with the overall popularity of blockchain platforms.”
Quote in the paperNot a substantial claim
The paper relies on this without support.
Current literature provides little overview of applications that have been developed, tested and/or deployed.
“current literature provides little overview of applications that have been developed, tested and/or deployed.”
The authors state this as an assumption.
M-health will increase at a rapid pace in the coming years.
“There is a reasonable assumption that m-health will increase at a rapid pace in the coming years and the need to verify and access m-health generated data by the health systems becomes crucial for the continued development of HIS and to insure that these data-driven systems stay up to date.”
The paper relies on this without support.
Healthcare institutions are in critical demand for new and improved trust-preserving solutions.
“Due to the over-arching importance of maintaining trust while satisfying an ever-increasing demand for exchange of data within the healthcare ecosystem, healthcare institutions are in critical demand for new and improved trust-preserving solutions.”
The paper relies on this without support.
M-health is a rather new field and lacks a common data infrastructure and, to some degree, lacks common regulation around dealing with health data and getting the data accepted by the established health system.
“M-health is a rather new field and lacks a common data infrastructure and, to some degree, lacks common regulation around dealing with health data and getting the data accepted by the established health system.”
The paper relies on this without support.
There are promising developments in the private sector in other areas of the health sector that are not covered in the included publications for this review, for example genome management and medical credential systems.
“There are promising developments in the private sector in other areas of the health sector that are not covered in the included publications for this review; for example, genome management and medical credential systems.”
The paper relies on this without support.
The blockchain technology market in the global healthcare industrial sector is expected to cross $500 million by 2022.
“This trend is also noticeable in the global healthcare industrial sector, where the blockchain technology market is expected to cross $500 million by 2022.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Prior systematic literature reviews on blockchain in healthcare have focused primarily on synthesizing or delineating trends and areas of blockchain application.
“While these SLRs have contributed to the extant body of knowledge, their focus has primarily been on synthesizing or delineating trends (e.g.Hasselgren et al., 2020) and areas of blockchain application (see Risius & Spohrer, 2017;Hölbl et al. 2018;Agbo et al. 2019;Jaoude & Saade, 2019).”
From Blockchain in healthcare: A systematic literature review, synthesizing framework and future research agenda (2020) · cites this paper as Hasselgren et al., 2020
Data breaches of wearable data are expected as an eventuality rather than a mere possibility.
“Given the sensitivity of wearable data, next-generation cybersecurity tools, such as blockchain111, should be considered because data breaches are expected as an eventuality rather than a mere possibility and because the data constantly move from one platform to another.”
From Smart wearable devices in cardiovascular care: Where we are and how to move forward (2021) · cites this paper as [111]
Blockchain has proved its success in healthcare and biomedical applications with promising performances in terms of healthcare data security, secure data management, and transparent medical data storage.
“Up to date, blockchain has proved its success in healthcare and biomedical applications with promising performances in terms of healthcare data security [49], secure data management [50], [51], and transparent medical data storage [52], [53].”
From Blockchain and AI-Based Solutions to Combat Coronavirus (COVID-19)-Like Epidemics: A Survey (2021) · cites this paper as [49]
In one study, 72% of patients were willing to share their health data with their physician, but fewer were willing to share with their health insurer or manufacturing companies (53%).
“In one study, patients who were willing to share their health data with their physician (72%) but fewer with their health insurer or manufacturing companies (53%).57”
From Unlocking Tomorrow’s Health Care: Expanding the Clinical Scope of Wearables by Applying Artificial Intelligence (2024) · cites this paper as [57]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Table 6 category counts do not reach its grand total
MajorThe counts in Table 6 sum to 33, not the reported grand total of 39. This leaves six included publications unaccounted for in the table's categorization.
Reported 39 · recomputed 33
“| Grand Total | 39 |”
Exonum proportion is incorrect
MinorOne of 39 publications is about 2.56%, or 3% rounded to the nearest integer, rather than 4%.
Reported 4 · recomputed 2.564103
“Exonum once (4 %)”
Quality-assessment criterion Q5 has conflicting definitions
MinorThe quality-assessment query defines Q5 as solution feasibility, whereas Table 8 labels Q5 as problem-solution fit.
“Q5 Are the proposed solutions feasible (scalable, economical, implementable)?”
“| Q5 Problem solution fit |”
Study 8 has both a defined and an undefined consensus algorithm
MinorTable 7 lists study 8 under Practical Byzantine Fault Tolerance and again under "Not defined" for its consensus algorithm.
“| Practical Byzantine Fault Tolerance | 6 | 5, 8, 14, 21, 24, 37 |”
“| Not defined | 16 | 1, 7, 8, 11-13, 16, 17, 25-28, |”
Cites
Bitcoin: A Peer-to-Peer Electronic Cash SystemPreprint
Nakamoto, S. (2019) · SSRN Electronic Journal · doi:10.2139/ssrn.3440802 · Cited by 14,600 · cited 6× · see citing works
“The public blockchain is widely used in cryptocurrencies, and the two largest cryptocurrencies: Bitcoin [1] and Ethereum [5] (the main chain), are categorized as public permissionless chains.”
BackgroundMethodInfluentialAn Overview of Blockchain Technology: Architecture, Consensus, and Future Trends
Zheng, Z., Xie, S., Dai, H., Chen, X., & Wang, H. (2017) · 2017 IEEE International Congress on Big Data (BigData Congress) · doi:10.1109/bigdatacongress.2017.85 · Cited by 4,515 · see citing works
MedRec: Using Blockchain for Medical Data Access and Permission Management
Azaria, A., Ekblaw, A., Vieira, T., & Lippman, A. (2016) · 2016 2nd International Conference on Open and Big Data (OBD) · doi:10.1109/obd.2016.11 · Cited by 2,526 · see citing works
Levy, Y. M., & Ellis, T. J. (2006) · Informing Science The International Journal of an Emerging Transdiscipline · doi:10.28945/479 · Cited by 1,581 · cited 2× · see citing works
“As an important part of the review process a meticulous quality assessment of included publications was conducted [17].”
BackgroundMethodMeDShare: Trust-Less Medical Data Sharing Among Cloud Service Providers via Blockchain
Xia, Q., Sifah, E. B., Asamoah, K. O., Gao, J., Du, X., & Guizani, M. (2017) · IEEE Access · doi:10.1109/access.2017.2730843 · Cited by 1,148 · cited 1× · see citing works
“…control, data integrity, interoperability 12 [30] Electronic health records Sharing healthcare data between health institutions Data integrity 13 [31] Electronic health records Sharing healthcare data between health institutions Data integrity, access control 14 [32] Administrative systems…”
BackgroundPPCoin: Peer-to-Peer Crypto-Currency with Proof-of-Stake
King, S., & Nadal, S. (2012) · Cited by 984 · see citing works
Healthcare blockchain system using smart contracts for secure automated remote patient monitoring
Griggs, K. N., Ossipova, O., Kohlios, C. P., Baccarini, A. N., Howson, E. A., & Hayajneh, T. (2018) · Journal of Medical Systems · doi:10.1007/s10916-018-0982-x · Cited by 926 · cited 2× · see citing works
“…20 [38] Electronic health records Patient data management and storage in a cloud environment Access control, data integrity, data provenance 21 [39] Population health management system Collection and storage of sensor data for remote patient monitoring purposes Data integrity, data provenance…”
BackgroundDagher, G. G., Mohler, J., Milojkovic, M., & Marella, P. B. (2018) · Sustainable Cities and Society · doi:10.1016/j.scs.2018.02.014 · Cited by 854 · cited 2× · see citing works
“…health data/Electronic health records Managing access to personal health data and electronic health records Access control, data integrity 23 [41] Electronic health records Patients’ collection, archiving and sharing of healthcare data for clinical purposes Access control, data integrity,…”
BackgroundMethodFhirchain: applying blockchain to securely and scalably share clinical data
Zhang, P., White, J., Schmidt, D. C., Lenz, G., & Rosenbloom, S. T. (2018) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2018.07.004 · Cited by 796 · cited 3× · see citing works
“1 [19] Electronic health records Shared decision making Interoperability, access control, data integrity 2 [20] Electronic health records Health data recording, storing and sharing Access control, interoperability 3 [21] Knowledge infrastructures Aid decision-making by presenting knowledge Data integrity, repudiation…”
BackgroundA Systematic Review of the Use of Blockchain in Healthcare
Hölbl, M., Kompara, M., Kamišalić, A., & Nemec Zlatolas, L. (2018) · Symmetry · doi:10.3390/sym10100470 · Cited by 780 · cited 3× · see citing works
“To this end, parts of the method presented by Hölbl et al. were used and modified as appropriate [18].”
BackgroundMethodInfluentialComputer Security Technology Planning Study
Anderson, J. P. (1972) · Cited by 660 · see citing works
MedBlock: Efficient and Secure Medical Data Sharing Via Blockchain
Fan, K., Wang, S., Ren, Y., Li, H., & Yang, Y. (2018) · Journal of Medical Systems · doi:10.1007/s10916-018-0993-7 · Cited by 631 · cited 1× · see citing works
“Interoperability 18 [36] Electronic health records Sharing healthcare data for clinical and research purposes.”
BackgroundTowards secure and privacy-preserving data sharing in e-Health systems via consortium blockchain
Zhang, A., & Lin, X. (2018) · Journal of Medical Systems · doi:10.1007/s10916-018-0995-5 · Cited by 606 · cited 2× · see citing works
“Four publications [25,27,28,48] proposed to use blockchain for building a personal health record system that could bridge the gap between the patient and institution-specific EHRs.”
BackgroundBBDS: Blockchain-Based Data Sharing for Electronic Medical Records in Cloud Environments
Xia, Q., Sifah, E. B., Smahi, A., Amofa, S. K., & Zhang, X. (2017) · Information · doi:10.3390/info8020044 · Cited by 579 · cited 1× · see citing works
“…of telemedicine services Data integrity 34 [52] Electronic health records Retrieving information in the EHR Access control, data integrity 35 [53] Electronic health records Sharing healthcare data for clinical and research purposes Access control, security, interoperability 36 [54] Personal…”
BackgroundBitcoin Mining and its Energy Footprint
O'Dwyer, K. J., & Malone, D. (2014) · doi:10.1049/cp.2014.0699 · Cited by 569 · cited 1× · see citing works
“This is illustrated by the fact that the current electricity consumed for Bitcoin mining is comparable to the electricity requirements of a smaller country [10].”
BackgroundA Quantitative Measure of Continuity of Care
Bice, T. W., & Boxerman, S. B. (1977) · Medical Care · doi:10.1097/00005650-197704000-00010 · Cited by 529 · cited 1× · see citing works
“This is an alternative take on the use of health information to fix a broken healthcare system and improve the continuity of care [59] which builds on the patient in a more empowered and controlling role.”
BackgroundGuo, R., Shi, H., Zhao, Q., & Zheng, D. (2018) · IEEE Access · doi:10.1109/access.2018.2801266 · Cited by 505 · cited 1× · see citing works
“Access control, data integrity, interoperability 12 [30] Electronic health records Sharing healthcare data between health institutions Data integrity 13 [31] Electronic health records Sharing healthcare data between health institutions Data integrity, access control 14 [32] Administrative systems…”
BackgroundMamoshina, P., Ojomoko, L., Yanovich, Y., Ostrovski, A., Botezatu, A., Prikhodko, P., Izumchenko, E., Aliper, A., Romantsov, K., Zhebrak, A., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.22345 · Cited by 471 · see citing works
OmniPHR: a distributed architecture model to integrate personal health records
Roehrs, A., da Costa, C. A., & da Rosa Righi, R. (2017) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2017.05.012 · Cited by 428 · cited 3× · see citing works
“4 [22] 2016 1 1 2 2 1 7 7 [25] 2016 2 1 0 2 0 5 15 [33] 2016 1 1 1 0 2 5 28 [46] 2016 0 0 1 0 0 1 5 [23] 2017 1 0 1 2 1 5 8 [26] 2017 1 2 0 2 1 6 9 [27] 2017 0 1 0 1 2 4 12 [30] 2017 2 0 1 2 1 6”
BackgroundMethodCoiera, E. W. (2015) · CRC Press eBooks · doi:10.1201/b13617 · Cited by 421 · cited 1× · see citing works
“Healthcare institutions currently experience an increased demand of real-world data from industry and research organizations [16].”
BackgroundSecure cloud-based EHR system using attribute-based cryptosystem and blockchain
Wang, H., & Song, Y. (2018) · Journal of Medical Systems · doi:10.1007/s10916-018-0994-6 · Cited by 409 · cited 2× · see citing works
“…health records/ Administrative system Sharing healthcare data for administrative or economic purposes Identity management, access control 20 [38] Electronic health records Patient data management and storage in a cloud environment Access control, data integrity, data provenance 21 [39]…”
BackgroundMethodBlocHIE: A BLOCkchain-Based Platform for Healthcare Information Exchange
Jiang, S., Cao, J., Wu, H., Yang, Y., Ma, M., & He, J. (2018) · IEEE International Conference on Smart Computing · doi:10.1109/smartcomp.2018.00073 · Cited by 397 · see citing works
A framework for secure and decentralized sharing of medical imaging data via blockchain consensus
Patel, V. N. (2018) · Health Informatics Journal · doi:10.1177/1460458218769699 · Cited by 394 · see citing works
A secure system for pervasive social network-based healthcare
Zhang, J., Xue, N., & Huang, X. (2016) · IEEE Access · doi:10.1109/access.2016.2645904 · Cited by 361 · cited 2× · see citing works
“…storing and sharing Data integrity, data provenance 6 [24] Picture archiving and communications systems Exchange of medical images Access control 7 [25] IoT data management/Personal health data Remote collection and storage of health data Data integrity, access control 8 [26] Personal health…”
BackgroundBlockchain-based data preservation system for medical data
Li, H., Zhu, L., Shen, M., Gao, F., Tao, X., & Liu, S. (2018) · Journal of Medical Systems · doi:10.1007/s10916-018-0997-3 · Cited by 347 · cited 2× · see citing works
“Data integrity was enhanced by storing hashed medical data or hash pointer on chain [49,41,38].”
BackgroundMethodImproving data transparency in clinical trials using blockchain smart contracts
Nugent, T., Upton, D., & Cimpoesu, M. (2016) · F1000Research · doi:10.12688/f1000research.9756.1 · Cited by 309 · cited 4× · see citing works
“Other examples were found in the concepts addressing clinical trials, where data provenance issues are targeted by providing a tracking system of data used in the trials [44,46].”
BackgroundMethodInfluentialTamper-Resistant Mobile Health Using Blockchain Technology.
Ichikawa, D., Kashiyama, M., & Ueno, T. (2017) · JMIR mHealth and uHealth · doi:10.2196/mhealth.7938 · Cited by 298 · cited 2× · see citing works
“Five of the publications addressed the m-health domain and patient-controlled collection, storage and sharing of sensor data [23,27,35,39,32].”
BackgroundContinuous patient monitoring with a patient centric agent: a block architecture
Uddin, M. A., Stranieri, A., Gondal, I., & Balasubramanian, V. (2018) · IEEE Access · doi:10.1109/access.2018.2846779 · Cited by 264 · cited 2× · see citing works
“29 [47] 2018 2 1 2 2 2 9 30 [48] 2018 0 1 2 2 1 6 31 [49] 2018 1 0 1 2 1 5 33 [51] 2018 1 1 1 2 2 7 34 [52] 2018 0 1 1 2 1 5 36 [54] 2018 2 1 2 2 2 9 37 [55] 2018 0 1 1 2 2 6 38 [56] 2018 1 1 1 2 1 6”
BackgroundMIStore: a Blockchain-Based Medical Insurance Storage System
Zhou, L., Wang, L., & Sun, Y. (2018) · Journal of Medical Systems · doi:10.1007/s10916-018-0996-4 · Cited by 217 · cited 4× · see citing works
“Access control, data integrity, interoperability 12 [30] Electronic health records Sharing healthcare data between health institutions Data integrity 13 [31] Electronic health records Sharing healthcare data between health institutions Data integrity, access control 14 [32] Administrative systems Sharing healthcare in…”
BackgroundInfluentialHussein, A. F., ArunKumar, N., Ramirez-Gonzalez, G., Abdulhay, E., Tavares, J. M. R. S., & de Albuquerque, V. H. C. (2018) · Cognitive Systems Research · doi:10.1016/j.cogsys.2018.05.004 · Cited by 212 · see citing works
Privacy and data security in E-health: Requirements from the user’s perspective
Wilkowska, W., & Ziefle, M. (2012) · Health Informatics Journal · doi:10.1177/1460458212442933 · Cited by 207 · cited 1× · see citing works
“With stronger emphasis on team-based care and continuity of care across institutional borders, and identity management and access control across different health systems, the processes of sharing becomes important [58].”
BackgroundSoK of used cryptography in blockchain
Raikwar, M., Gligoroski, D., & Kralevska, K. (2019) · IEEE Access · doi:10.1109/access.2019.2946983 · Cited by 153 · cited 1× · see citing works
“These blocks are, upon acceptance to the blockchain linked to the previous and future blocks with cryptographic protocols [60].”
BackgroundSelf-citationOn the Design of a Blockchain-Based System to Facilitate Healthcare Data Sharing
Theodouli, A., Arakliotis, S., Moschou, K., Votis, K., & Tzovaras, D. K. (2018) · IEEE International Conference on Trust, Security and Privacy in Computing and Communications (TrustCom) · doi:10.1109/trustcom/bigdatase.2018.00190 · Cited by 150 · cited 1× · see citing works
“Data integrity, data provenance 26 [44] Clinical Trial Support Systems Recruitment of patients to clinical trials Data integrity, data provenance 27 [45] Electronic health records Sharing healthcare data for clinical and research purposes Interoperability, data provenance 28 [46] Clinical Trial…”
A Decentralizing Attribute-Based Signature for Healthcare Blockchain
Sun, Y., Zhang, R., Wang, X., Gao, K., & Liu, L. (2018) · International Conference on Computer Communications and Networks (ICCCN) · doi:10.1109/icccn.2018.8487349 · Cited by 140 · see citing works
Identity and Access Management with Blockchain in Electronic Healthcare Records
Mikula, T., & Jacobsen, R. H. (2018) · Euromicro Conference on Digital System Design (DSD) · doi:10.1109/dsd.2018.00008 · Cited by 135 · cited 2× · see citing works
“Access control, interoperability 19 [37] Electronic health records/ Administrative system Sharing healthcare data for administrative or economic purposes Identity management, access control”
BackgroundJi, Y., Zhang, J., Ma, J., Yang, C., & Yao, X. (2018) · Journal of Medical Systems · doi:10.1007/s10916-018-0998-2 · Cited by 123 · see citing works
A Blockchain-Based Notarization Service for Biomedical Knowledge Retrieval
Kleinaki, A.-S., Mytis-Gkometh, P., Drosatos, G., Efraimidis, P. S., & Kaldoudi, E. (2018) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2018.08.002 · Cited by 108 · cited 2× · see citing works
“1 [19] Electronic health records Shared decision making Interoperability, access control, data integrity 2 [20] Electronic health records Health data recording, storing and sharing Access control, interoperability 3 [21] Knowledge infrastructures Aid decision-making by presenting knowledge Data integrity, repudiation…”
BackgroundApplying Software Patterns to Address Interoperability in Blockchain-based Healthcare AppsPreprint
Zhang, P., White, J., Schmidt, D. C., & Lenz, G. (2017) · arXiv (Cornell University) · doi:10.48550/arxiv.1706.03700 · Cited by 91 · cited 1× · see citing works
“…38 [56] Electronic health records Patient-controlled sharing of health data between healthcare providers Access control, interoperability 39 [57] Electronic health records Exchange of healthcare data for clinical and research purposes Access control, interoperability example, in the paper…”
BackgroundRahmadika, S., & Rhee, K.-H. (2018) · International Journal of Engineering Business Management · doi:10.1177/1847979018790589 · Cited by 87 · cited 1× · see citing works
“…sensor data Access control, data integrity 37 [55] Electronic health records Sharing healthcare data between health institutions Data provenance 38 [56] Electronic health records Patient-controlled sharing of health data between healthcare providers Access control, interoperability 39 [57]…”
BackgroundSpatial blockchain-based secure mass screening framework for children with dyslexia
Rahman, M. A., Hassanain, E., Rashid, M. M., Barnes, S. J., & Hossain, M. S. (2018) · IEEE Access · doi:10.1109/access.2018.2875242 · Cited by 68 · cited 2× · see citing works
“…10 [28] Personal health records Sharing of health data for use by more than one healthcare institution Access control, interoperability 11 [29] Automated diagnostic service for patients Collection and storage of data about symptoms of dyslexia for the purpose of automated diagnostics,…”
BackgroundA Blockchain-Based Scheme for Access Control in e-Health Scenarios
Dias, J. P., Ferreira, H. S., & Martins, Â. (2019) · Advances in intelligent systems and computing · doi:10.1007/978-3-030-17065-3_24 · Cited by 65 · cited 1× · see citing works
“…Population health management system Collection and storage of sensor data for remote patient monitoring purposes Data integrity, data provenance 22 [40] Personal health data/Electronic health records Managing access to personal health data and electronic health records Access control, data…”
BackgroundTowards Decentralized Accountability and Self-sovereignty in Healthcare Systems
Liang, X., Shetty, S. S., Zhao, J., Bowden, D., Li, D., & Liu, J. (2018) · Lecture notes in computer science · doi:10.1007/978-3-319-89500-0_34 · Cited by 58 · see citing works
A Blockchain Application for Medical Information Sharing
Chen, J., Ma, X., Mingxiao, D., & Wang, Z. (2018) · IEEE International Symposium on Innovation and Entrepreneurship (TEMS-ISIE) · doi:10.1109/tems-isie.2018.8478645 · Cited by 39 · see citing works
Privacy preserving data management in recruiting participants for digital clinical trials
Angeletti, F., Chatzigiannakis, I., & Vitaletti, A. (2017) · doi:10.1145/3144730.3144733 · Cited by 31 · cited 4× · see citing works
“Other examples were found in the concepts addressing clinical trials, where data provenance issues are targeted by providing a tracking system of data used in the trials [44,46].”
BackgroundMethodInfluentialA Blockchain-Enabled Participatory Decision Support Framework
Laskowski, M. (2017) · Lecture notes in computer science · doi:10.1007/978-3-319-60240-0_40 · Cited by 9 · see citing works
Flagged first, then by citations
1 of the 46 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- blockchain.com [cited 2019 09.03]. Available from: https://www.blockchain.com/charts/n-transactions-total.
- Courtney, 1989, Some informal comments about integrity and the integrity workshop
Cited by
Sorted by citations
Smart wearable devices in cardiovascular care: Where we are and how to move forward
Bayoumy, K., Gaber, M., Elshafeey, A., Mhaimeed, O., Dineen, E. H., Marvel, F. A., Martin, S. S., Muse, E. D., Turakhia, M. P., Tarakji, K. G., et al. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00522-7 · Cited by 829 · see citing works
Blockchain for healthcare data management: opportunities, challenges, and future recommendations
Yaqoob, I., Salah, K., Jayaraman, R., & Al-Hammadi, Y. (2021) · Neural Computing and Applications · doi:10.1007/s00521-020-05519-w · Cited by 687 · see citing works
Medical 4.0 technologies for healthcare: Features, capabilities, and applications
Haleem, A., Javaid, M., Pratap Singh, R., & Suman, R. (2022) · Internet of Things and Cyber-Physical Systems · doi:10.1016/j.iotcps.2022.04.001 · Cited by 468 · see citing works
Blockchain for the Internet of Vehicles Towards Intelligent Transportation Systems: A Survey
Mollah, M. B., Zhao, J., Niyato, D., Guan, Y. L., Yuen, C., Sun, S., Lam, K.-Y., & Koh, L. H. (2020) · IEEE Internet of Things Journal · doi:10.1109/jiot.2020.3028368 · Cited by 464 · see citing works
“A substantial effort has been highlighted to converge blockchain with smart health system in [39]–[44].”
BackgroundTandon, A., Dhir, A., Islam, A. K. M. N., & Mäntymäki, M. (2020) · Computers in Industry · doi:10.1016/j.compind.2020.103290 · Cited by 439 · see citing works
“While these SLRs have contributed to the extant body of knowledge, their focus has primarily been on synthesizing or delineating trends (e. g. Hasselgren et al., 2020) and areas of blockchain application (see Risius & Spohrer, 2017; Hölbl et al. 2018; Agbo et al. 2019; Jaoude & Saade, 2019 .”
The Recent Progress and Applications of Digital Technologies in Healthcare: A Review
Senbekov, M., Saliev, T. M., Bukeyeva, Z., Almabayeva, A., Zhanaliyeva, M., Джамбуловна, А. Н., Toishibekov, Y., & Fakhradiyev, I. R. (2020) · International Journal of Telemedicine and Applications · doi:10.1155/2020/8830200 · Cited by 471 · see citing works
“The third problem is abuses in the healthcare ecosystem that share the same trust (e.g., problems with fake drugs, procedures, skills, and patients) [60].”
BackgroundTripathi, G., Ahad, M. A., & Casalino, G. (2023) · Decision Analytics Journal · doi:10.1016/j.dajour.2023.100344 · Cited by 393 · see citing works
Blockchain applications in management: A bibliometric analysis and literature review
Tandon, A., Kaur, P., Mäntymäki, M., & Dhir, A. (2021) · Technological Forecasting and Social Change · doi:10.1016/j.techfore.2021.120649 · Cited by 327 · see citing works
Rauniyar, A., Hagos, D. H., Jha, D., Håkegård, J. E., Bagci, U., Rawat, D. B., & Vlassov, V. (2024) · IEEE Internet of Things Journal · doi:10.1109/jiot.2023.3329061 · Cited by 315 · see citing works
“In healthcare, blockchain’s capabilities offer secure management of electronic health records (EHRs) [67] and have prompted extensive research exploration [1], [68], [69], [70], [71], [71], [72], [73].”
BackgroundA Comparative Study: Blockchain Technology Utilization Benefits, Challenges and Functionalities
Ali, O., Jaradat, A., Kulakli, A., & Abuhalimeh, A. (2021) · IEEE Access · doi:10.1109/access.2021.3050241 · Cited by 314 · see citing works
“The challenges are caused by variation and may be related to the absence of data standards, which reduces interoperability as a consequence of non-compatibility between systems that are meant to be improved by blockchain technology in the healthcare sector [100], [104].”
BackgroundThe role of blockchain technology in telehealth and telemedicine
Ahmad, R. W., Salah, K., Jayaraman, R., Yaqoob, I., Ellahham, S. H., & Omar, M. (2021) · International Journal of Medical Informatics · doi:10.1016/j.ijmedinf.2021.104399 · Cited by 299 · see citing works
“have been extensively practiced in existing systems that are proposed to digitize healthcare services [20].”
BackgroundBlockchain and AI-Based Solutions to Combat Coronavirus (COVID-19)-Like Epidemics: A Survey
Nguyen, D. C., Ding, M., Pathirana, P. N., & Seneviratne, A. (2021) · IEEE Access · doi:10.1109/access.2021.3093633 · Cited by 286 · see citing works
“Up to date, blockchain has proved its success in healthcare and biomedical applications with promising performances in terms of healthcare data security [49], secure data management [50], [51], and transparent medical data storage [52], [53].”
BackgroundBlockchain in education management: present and future applications
Bhaskar, P., Tiwari, C. K., & Joshi, A. (2020) · Interactive Technology and Smart Education · doi:10.1108/itse-07-2020-0102 · Cited by 293 · see citing works
Blockchain technology in healthcare: A systematic review
Saeed, H., Malik, H., Bashir, U., Ahmad, A., Riaz, S., Ilyas, M., Bukhari, W. A., & Khan, M. I. A. (2022) · PLoS ONE · doi:10.1371/journal.pone.0266462 · Cited by 276 · see citing works
“Recently [14] reviewed 39 studies to present an overview on common channels and other areas where blockchain technology is utilized for healthcare enhancement.”
BackgroundMiyachi, K., & Mackey, T. K. (2021) · Information Processing & Management · doi:10.1016/j.ipm.2021.102535 · Cited by 236 · see citing works
Blockchain technology in the healthcare industry: Trends and opportunities
Hussien, H. M., Yasin, S. M., Udzir, N. I., Ninggal, M. I. H., & Salman, S. (2021) · Journal of Industrial Information Integration · doi:10.1016/j.jii.2021.100217 · Cited by 237 · see citing works
Understanding the Blockchain Oracle Problem: A Call for Action
Caldarelli, G. (2020) · Information · doi:10.3390/info11110509 · Cited by 223 · see citing works
“Discussing the oracle problem in the case of health records, which, according to a recent literature review, has received most of the academic contributions [95], the outcome is quite controversial.”
BackgroundMassaro, M. (2021) · Technovation · doi:10.1016/j.technovation.2021.102386 · Cited by 220 · see citing works
Smart healthcare in smart cities: wireless patient monitoring system using IoT
Poongodi, M., Sharma, A., Hamdi, M., Ma, M., & Chilamkurti, N. (2021) · The Journal of Supercomputing · doi:10.1007/s11227-021-03765-w · Cited by 197 · see citing works
Blockchain Application in Healthcare Systems: A Review
Ghosh, P. K., Chakraborty, A., Hasan, M., Rashid, K., & Siddique, A. H. (2023) · Systems · doi:10.3390/systems11010038 · Cited by 204 · see citing works
“We observe that practical Byzantine fault tolerance is now used in Hyperledger Fabric [29].”
Jabarulla, M. Y., & Lee, H.-N. (2021) · Healthcare · doi:10.3390/healthcare9081019 · Cited by 183 · see citing works
“Blockchain’s immutable and decentralized nature [53] has demonstrated its promising potential in healthcare applications, such as secure data management [54], transparent medical data storage [55], and healthcare data privacy [16,56].”
BackgroundReegu, F. A., Abas, H., Gulzar, Y., Xin, Q., Alwan, A. A., Jabbari, A., Sonkamble, R. G., & Dziyauddin, R. A. (2023) · Sustainability · doi:10.3390/su15086337 · Cited by 194 · see citing works
“6 [19] A framework for secure and decentralized sharing of medical imaging data via blockchain consensus DICOM”
MethodBlockchain Technology in Renovating Healthcare
Singh, B. P. (2023) · Advances in healthcare information systems and administration book series · doi:10.4018/978-1-6684-5422-0.ch012 · Cited by 171 · see citing works
A Systematic Review of Blockchain Applications
Sunny, F. A., Hájek, P., Munk, M., Abedin, M. Z., Satu, M. S., Efat, M. I. A., & Islam, M. J. (2022) · IEEE Access · doi:10.1109/access.2022.3179690 · Cited by 175 · see citing works
“Blockchain technology is used to mitigate these kinds of mismanagement issues related to additional costs and services [112], [113].”
MethodNegro‐Calduch, E., Muscat, N. A., Krishnamurthy, R. S., & Novillo-Ortiz, D. (2021) · International Journal of Medical Informatics · doi:10.1016/j.ijmedinf.2021.104507 · Cited by 163 · see citing works
Blockchain technology and gender equality: A systematic literature review
Vaio, A. D., Hassan, R., & Palladino, R. (2022) · International Journal of Information Management · doi:10.1016/j.ijinfomgt.2022.102517 · Cited by 153 · see citing works
Shynu, P. G., Menon, V. G., Kumar, R. L., Kadry, S., & Nam, Y. (2021) · IEEE Access · doi:10.1109/access.2021.3065440 · Cited by 147 · see citing works
“That ensures the level to which the intended data quality is achieved or surpassed decides the validity of the report [36].”
BackgroundData Sharing Under the General Data Protection Regulation
Vlahou, A., Hallinan, D., Apweiler, R., Argilés, À., Beige, J., Benigni, A., Bischoff, R., Black, P. C., Boehm, F., Céraline, J., et al. (2021) · Hypertension · doi:10.1161/hypertensionaha.120.16340 · Cited by 134 · see citing works
Alugubelli, N. R., Abuissa, H. S., & Róka, A. (2022) · Sensors · doi:10.3390/s22228903 · Cited by 139 · see citing works
Sustainable finance and blockchain: A systematic review and research agenda
Ren, Y., Ma, C., Chen, X.-Q., Lei, Y.-T., & Wang, Y. (2023) · Research in International Business and Finance · doi:10.1016/j.ribaf.2022.101871 · Cited by 135 · see citing works
Investigating the barriers of blockchain technology integrated food supply chain: a BWM approach
Khan, S., Kaushik, M. K., Kumar, R., & Khan, W. (2022) · Benchmarking An International Journal · doi:10.1108/bij-08-2021-0489 · Cited by 120 · see citing works
A Survey on Blockchain for Healthcare: Challenges, Benefits, and Future Directions
Arbabi, M. S., Lal, C., Veeraragavan, N. R., Marijan, D., Nygård, J. F., & Vitenberg, R. M. (2022) · IEEE Communications Surveys & Tutorials · doi:10.1109/comst.2022.3224644 · Cited by 123 · see citing works
“Asthe authors assert in [43], the activities within the mentioned six interactions require constant interchange of consent-and other patient-related sensitive HD, which effectively entails exchanging data across multi-institutional borders.”
BackgroundMauro, M., Noto, G., Prenestini, A., & Sarto, F. (2024) · Technological Forecasting and Social Change · doi:10.1016/j.techfore.2024.123781 · Cited by 153 · see citing works
Tahir, M., Sardaraz, M., Muhammad, S., & Khan, M. S. (2020) · Sustainability · doi:10.3390/su12176960 · Cited by 113 · see citing works
Blockchain Personal Health Records: Systematic Review
Fang, H. S. A., Tan, T. H., Tan, C. Y. F., & Tan, M. C. J. (2021) · Journal of Medical Internet Research · doi:10.2196/25094 · Cited by 104 · see citing works
“In the health care industry, EHRs were found to be the most commonly used case for blockchain applications [11-14].”
BackgroundA Review of Blockchain-Based Secure Sharing of Healthcare Data
Peng, X., Zhang, X., Wang, L. Y., Liu, W., & Peng, S. (2022) · Applied Sciences · doi:10.3390/app12157912 · Cited by 98 · see citing works
“However, this review did not summarize the techniques [11].”
Assessing the feasibility of blockchain technology in industries: evidence from Turkey
Erol, I., Ar, I. M., Ozdemir, A., Peker, I., Asgary, A., Medeni, I. T., & Medeni, T. (2020) · Journal of Enterprise Information Management · doi:10.1108/jeim-09-2019-0309 · Cited by 80 · see citing works
Javaid, M., Haleem, A., & Singh, R. P. (2024) · Informatics and Health · doi:10.1016/j.infoh.2024.05.001 · Cited by 121 · see citing works
Leveraging 6G, extended reality, and IoT big data analytics for healthcare: A review
Ahmad, H. F., Rafique, W., Rasool, R. U., Alhumam, A., Anwar, Z., & Qadir, J. (2023) · Computer Science Review · doi:10.1016/j.cosrev.2023.100558 · Cited by 96 · see citing works
Applications of Blockchain in the Medical Field: Narrative Review
Xie, Y., Zhang, J., Wang, H., Liu, P., Liu, S., Huo, T., Duan, Y.-Y., Dong, Z., Lu, L., & Ye, Z. (2021) · Journal of Medical Internet Research · doi:10.2196/28613 · Cited by 98 · see citing works
“Hasselgren et al [15] counted the current medical use of various types of blockchains and frameworks, and found that the consortium chain is the most widely used.”
Karandikar, N., Chakravorty, A., & Rong, C. (2021) · Sensors · doi:10.3390/s21113822 · Cited by 96 · see citing works
“[44] identified access control, data provenance and data integrity as crucial in order to maintain the patient’s privacy during data exchanges between institutions in the healthcare ecosystem.”
BackgroundDecentralised provenance for healthcare data
Margheri, A., Masi, M., Miladi, A., Vladimiro Sassone, C., & Rosenzweig, J. (2020) · International Journal of Medical Informatics · doi:10.1016/j.ijmedinf.2020.104197 · Cited by 94 · see citing works
“Tracking the provenance of healthcare data stored across distributed EHRs would support such data-informed medical decision-making and clinical research [2, 3, 4].”
BackgroundBlockchain Applications in Health Care and Public Health: Increased Transparency
Velmovitsky, P. E., Bublitz, F. M., Fadrique, L. X., & Morita, P. P. (2021) · JMIR Medical Informatics · doi:10.2196/20713 · Cited by 89 · see citing works
“Hasselgren et al [21] conducted a scoping review of blockchain in health care and, while focusing on peer-reviewed publications rather than the industry, they found that both the number and quality of blockchain research is growing.”
BackgroundGovindan, K., Nasr, A. K., Heidary, M. S., Nosrati-Abarghooee, S., & Mina, H. (2022) · International Journal of Production Research · doi:10.1080/00207543.2021.2013560 · Cited by 88 · see citing works
“A review of the related literature reveals that some studies have addressed the concepts of blockchain in healthcare, the benefits, opportunities, and challenges arising from the application of blockchain in healthcare, as well as the frameworks used to design BT-based systems in the healthcare industry (Agbo,Mahmoud,…”
MethodBlockchain-based privacy and security preserving in electronic health: a systematic review
Kiania, K., Jameii, S. M., & Rahmani, A. M. (2023) · Multimedia Tools and Applications · doi:10.1007/s11042-023-14488-w · Cited by 92 · see citing works
“The authors of [18] reviewed 39 papers that used Blockchain in healthcare approaches published between 2018 and 2020.”
BackgroundBlockchain research in healthcare: a bibliometric review and current research trends
Rejeb, A., Treiblmaier, H., Rejeb, K., & Zailani, S. H. M. (2021) · Journal of Data Information and Management · doi:10.1007/s42488-021-00046-2 · Cited by 87 · see citing works
“Numerous academic researchers have investigated the possibilities and challenges that BCT provides with regard to healthcare information systems (Stafford & Treiblmaier, 2020; Hasselgren et al., 2020; Tanwar et al., 2020a; Farouk et al., 2020; Khatoon, 2020; Alam Khan et al., 2020).”
BackgroundKnowledge, diffusion and interest in blockchain technology in SMEs
Bracci, E., Tallaki, M., Ievoli, R., & Diplotti, S. (2021) · Journal of Knowledge Management · doi:10.1108/jkm-02-2021-0099 · Cited by 88 · see citing works
Hajian, A., Prybutok, V. R., & Chang, H. (2022) · Computers in Human Behavior · doi:10.1016/j.chb.2022.107471 · Cited by 83 · see citing works
Hiwale, M., Walambe, R. A., Potdar, V. M., & Kotecha, K. V. (2023) · Healthcare Analytics · doi:10.1016/j.health.2023.100192 · Cited by 88 · see citing works
Lu, W., Wu, L., Zhao, R., Li, X., & Xue, F. (2021) · Journal of Construction Engineering and Management · doi:10.1061/(asce)co.1943-7862.0002148 · Cited by 82 · see citing works
Popoola, O. J., Rodrigues, M., Marchang, J., Shenfield, A., Ikpehai, A., & Popoola, J. (2023) · Blockchain Research and Applications · doi:10.1016/j.bcra.2023.100178 · Cited by 82 · see citing works
Blockchain for business management: Applications, challenges and potentials
Pal, A., Tiwari, C. K., & Haldar, N. (2021) · The Journal of High Technology Management Research · doi:10.1016/j.hitech.2021.100414 · Cited by 84 · see citing works
Kumar, R., Arjunaditya, Singh, D., Srinivasan, K., & Hu, Y. (2022) · Healthcare · doi:10.3390/healthcare11010081 · Cited by 88 · see citing works
“Another important contribution that blockchain makes towards maintaining EHRs is interoperability [89].”
BackgroundAn Overview of Blockchain and IoT Integration for Secure and Reliable Health Records Monitoring
Alam, S., Bhatia, S., Shuaib, M., Khubrani, M. M., Alfayez, F., Malibari, A., & Ahmad, S. (2023) · Sustainability · doi:10.3390/su15075660 · Cited by 79 · see citing works
Thantharate, P., & Thantharate, A. (2023) · Big Data and Cognitive Computing · doi:10.3390/bdcc7040165 · Cited by 79 · see citing works
Blockchain in Health Care: Hope or Hype?
El-Gazzar, R. F., & Stendal, K. (2020) · Journal of Medical Internet Research · doi:10.2196/17199 · Cited by 80 · see citing works
“We did not attempt to conduct a thorough literature review on the topic, as there are already comprehensive literature reviews on blockchain in health care [8-10 , Thus, we aim to answer our research question: What implications may blockchain technology bring to the health care sector?”
BackgroundMethodInfluentialGautam, N., Ghanta, S. N., Mueller, J. M., Mansour, M. M., Chen, Z., Puente, C., Ha, Y., Tarun, T., Dhar, G., Sivakumar, K., et al. (2022) · Diagnostics · doi:10.3390/diagnostics12122964 · Cited by 88 · see citing works
Platt, M., & McBurney, P. (2023) · Algorithms · doi:10.3390/a16010034 · Cited by 82 · see citing works
Erol, İ., Öztel, A., Searcy, C., & Medeni, İ. T. (2022) · Technological Forecasting and Social Change · doi:10.1016/j.techfore.2022.122132 · Cited by 76 · see citing works
Privacy and Security of Blockchain in Healthcare: Applications, Challenges, and Future Perspectives
Taherdoost, H. (2023) · Sci · doi:10.3390/sci5040041 · Cited by 84 · see citing works
“Hasselgren et al. [13] carried out a scoping assessment on the healthcare use of blockchain technology.”
BackgroundOmboni, S., Panzeri, E., & Campolo, L. (2020) · Current Hypertension Reports · doi:10.1007/s11906-020-01056-y · Cited by 72 · see citing works
Industry 5.0: Ethereum blockchain technology based DApp smart contract
Rupa, C., Midhunchakkaravarthy, D., Hasan, M. K., Alhumyani, H. A., & Saeed, R. A. (2021) · Mathematical Biosciences & Engineering · doi:10.3934/mbe.2021349 · Cited by 70 · see citing works
Influential Usage of Big Data and Artificial Intelligence in Healthcare
Yang, Y. C., Islam, S. U., Noor, A., Khan, S., Afsar, W., & Nazir, S. (2021) · Computational and Mathematical Methods in Medicine · doi:10.1155/2021/5812499 · Cited by 68 · see citing works
“The purpose of this study is to systematically acquire startup publications and evaluate the Turkish position of the use/offer of blockchain to improve processes and services in healthcare, health sciences, and services sanitary [47].”
RetractedImpact of blockchain in healthcare system
David, S., Duraipandian, K., Chandrasekaran, D., Pandey, D., Sindhwani, N., & Pandey, B. K. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-99481-1.00004-3 · Cited by 69 · see citing works
Blockchain technologies to mitigate COVID-19 challenges: A scoping review
Abd-Alrazaq, A. A., Alajlani, M., Alhuwail, D., Erbad, A., Giannicchi, A., Shah, Z., Hamdi, M., & Househ, M. S. (2020) · Computer Methods and Programs in Biomedicine Update · doi:10.1016/j.cmpbup.2020.100001 · Cited by 67 · see citing works
Sammeta, N., & Parthiban, L. (2021) · Complex & Intelligent Systems · doi:10.1007/s40747-021-00549-w · Cited by 68 · see citing works
A survey of blockchain-based IoT eHealthcare: Applications, research issues, and challenges
Rahman, M. S., Islam, A., Uddin, M. A., & Stea, G. (2022) · Internet of Things · doi:10.1016/j.iot.2022.100551 · Cited by 72 · see citing works
Blockchain for Increased Trust in Virtual Health Care: Proof-of-Concept Study
Hasselgren, A., Rensaa, J.-A. H., Kralevska, K., Gligoroski, D., & Faxvaag, A. (2021) · Journal of Medical Internet Research · doi:10.2196/28496 · Cited by 65 · see citing works
“The use cases of blockchain in the health domain are increasing exponentially, as shown by Hasselgren et al [7], among others.”
MethodSelf-citationA Blockchain-Enabled Framework for mHealth Systems
Ţarălungă, D. D., & Florea, B. C. (2021) · Sensors · doi:10.3390/s21082828 · Cited by 66 · see citing works
Erol, İ., Ar, İ. M., & Peker, İ. (2021) · Applied Soft Computing · doi:10.1016/j.asoc.2021.108331 · Cited by 64 · see citing works
Theoretical and practical applications of blockchain in healthcare information management
Sadeghi, J., Prybutok, V. R., & Sauser, B. J. (2022) · Information & Management · doi:10.1016/j.im.2022.103649 · Cited by 64 · see citing works
Aloini, D., Benevento, E., Stefanini, A., & Zerbino, P. (2022) · Technovation · doi:10.1016/j.technovation.2022.102557 · Cited by 65 · see citing works
Blockchain-Empowered Service Management for the Decentralized Metaverse of Things
Maksymyuk, T., Gazda, J., Bugár, G., Gazda, V., Liyanage, M., & Döhler, M. (2022) · IEEE Access · doi:10.1109/access.2022.3205739 · Cited by 66 · see citing works
“To unleash the full potential of the Internet of 195 Skills concept in the MoT environment, we need to extend 196 the traditional concept of the tactile internet with haptic 197 communications providing immersive user engagement by 198 enriching the sensory experience in many critical aspects of 199 industries [10].”
BackgroundBlockchain for applications of clinical trials: Taxonomy, challenges, and future directions
Hang, L., Chen, C., Zhang, L., & Yang, J. G. (2022) · IET Communications · doi:10.1049/cmu2.12488 · Cited by 62 · see citing works
Enhancing EHR Interoperability and Security through Distributed Ledger Technology: A Review
Ferreira, J. C., Elvas, L. B., Correia, R., & Mascarenhas, M. (2024) · Healthcare · doi:10.3390/healthcare12191967 · Cited by 67 · see citing works
“Recent technological advancements, particularly in blockchain and DLT, have shown promise in addressing interoperability issues [17].”
BackgroundA Hierarchical Multi Blockchain for Fine Grained Access to Medical Data
Malamas, V., Kotzanikolaou, P., Dasaklis, T. K., & Burmester, M. V. D. (2020) · IEEE Access · doi:10.1109/access.2020.3011201 · Cited by 58 · see citing works
“Several existing solutions rely on cloud-based architectures (e.g., [3], [4]), although during the last couple of years blockchain-based architectures have also been proposed (e.g., [5]).”
BackgroundSarno, L. D., Caroselli, A., Tonin, G., Graglia, B., Pansini, V., Causio, F. A., Gatto, A., & Chiaretti, A. (2024) · Biomedicines · doi:10.3390/biomedicines12061220 · Cited by 58 · see citing works
“Blockchain is a technology characterized by the decentralization of entries, meaning that inputs are agreed upon by a peer-to-peer network through various consensus protocols, rather than a central authority controlling the content [24].”
InfluentialGDPR Compliance for Blockchain Applications in Healthcare
Hasselgren, A., Wan, P. K., Horn, M., Kralevska, K., & Gligoroski, D. (2020) · doi:10.5121/csit.2020.101303 · Cited by 55 · see citing works
Self-citationHussien, H. M., Yasin, S. M., Udzir, N. I., & Ninggal, M. I. H. (2021) · Sensors · doi:10.3390/s21072462 · Cited by 54 · see citing works
Liu, X., Shah, R., Shandilya, A., Shah, M., & Pandya, A. (2024) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2024.141371 · Cited by 52 · see citing works
Chang, S. E., & Chen, Y. (2020) · Journal of Medical Internet Research · doi:10.2196/19480 · Cited by 57 · see citing works
“Researchers have conducted literature reviews to report on the current challenges [48,49].”
BackgroundBlockchain Technology in Healthcare Big Data Management: Benefits, Applications and Challenges
Bazel, M. A., Mohammed, F., & Ahmad, M. B. (2021) · International Conference on Emerging Smart Technologies and Applications (eSmarTA) · doi:10.1109/esmarta52612.2021.9515747 · Cited by 50 · see citing works
Blockchain Technology, Structure, and Applications: A Survey
Moosavi, N., Taherdoost, H., Mohamed, N. A., Madanchian, M., Farhaoui, Y., & Khan, I. U. (2024) · Procedia Computer Science · doi:10.1016/j.procs.2024.05.150 · Cited by 57 · see citing works
Implementing blockchain in information systems: a review
Lu, Y. (2021) · Enterprise Information Systems · doi:10.1080/17517575.2021.2008513 · Cited by 79 · see citing works
“…such as electronic health data, as well as malicious data processing and management, pharmaceutical analytics, and hospitality management (Kuo, Kim, and Ohno-Machado 2017; Kuo, Zavaleta Rojas, and Ohno-Machado 2019; Agbo, Mahmoud, and Eklund 2019; McGhin et al. 2019; Hasselgren et al. 2020).”
BackgroundSEMRES - A Triple Security Protected Blockchain Based Medical Record Exchange Structure
Lee, Y.-L., Lee, H.-A., Hsu, C., Kung, H.-H., & Chiu, H. (2021) · Computer Methods and Programs in Biomedicine · doi:10.1016/j.cmpb.2021.106595 · Cited by 49 · see citing works
Esmaeilzadeh, P. (2022) · BMC Medical Informatics and Decision Making · doi:10.1186/s12911-022-01815-8 · Cited by 49 · see citing works
“The unauthorized sharing of sensitive health information can erode public trust in healthcare systems [41].”
BackgroundExploring applications of blockchain in healthcare: road map and future directions
Singh, Y., Jabbar, M. A., Shandilya, S. K., Вовк, О., & Hnatiuk, Y. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1229386 · Cited by 60 · see citing works
“Examples of such apps for the EMR use cases are, Hyperledger Fabric-based Healthchain (118), Acile (119), and MedRec (33), both of which were created on the Ethereum platform and Other instances include MeDShare (96), BlockHIE (88), FHIRChain (81), and MedBlock (25).”
Blockchain in radiology research and clinical practice: current trends and future directions
Tagliafico, A. S., Campi, C., Bignotti, B., Bortolotto, C., Buccicardi, D., Coppola, F., Prost, R., Rengo, M., & Faggioni, L. (2022) · La radiologia medica · doi:10.1007/s11547-022-01460-1 · Cited by 48 · see citing works
“Online resources are available to acquire deeper knowledge of blockchain details which are outside the purpose of this review [3–6, 8, 10–15].”
BackgroundA Secure and Privacy-Preserving Medical Data Sharing via Consortium Blockchain
Zhang, D., Wang, S., Zhang, Y., Zhang, Q., & Zhang, Y. (2022) · Security and Communication Networks · doi:10.1155/2022/2759787 · Cited by 49 · see citing works
“Previous studies [15] have explored the efficacy of blockchain to achieve electronic medical record sharing with security and privacy preservation.”
BackgroundBlockchain technology in pharmaceutical supply chains: a transaction cost perspective
Gruchmann, T., Elgazzar, S. H., & Ali, A. H. (2023) · Modern Supply Chain Research and Applications · doi:10.1108/mscra-10-2022-0023 · Cited by 49 · see citing works
Blockchain in healthcare: A comprehensive review of applications and security concerns
Atadoga, A., Elufioye, O. A., Omaghomi, T. T., Akomolafe, O. O., Odilibe, I. P., & Owolabi, O. R. (2024) · International Journal of Science and Research Archive · doi:10.30574/ijsra.2024.11.1.0244 · Cited by 47 · see citing works
Towards roadmap to implement blockchain in healthcare systems based on a maturity model
Akbar, M. A., Leiva, V., Rafi, S., Qadri, S. F., Mahmood, S., & Alsanad, A. (2022) · Journal of Software Evolution and Process · doi:10.1002/smr.2500 · Cited by 48 · see citing works
“6 The access con-trol system of blockchain makes the trustful settings to the patients as they can control the volume of their data sharing with a third party (for example, the researcher needs to access all data or subset of their medical reports, etc. 6 ).”
BackgroundElectronic health records in Brazil: Prospects and technological challenges
Barbalho, I. M. P., Fernandes, F. R. D. S., Barros, D. M. S., de Paiva, J. C., Henriques, J. M. O., de Morais, A. H. F., Coutinho, K. D., Neto, G. C. C., Chioro, A., & Valentim, R. A. D. M. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.963841 · Cited by 53 · see citing works
Construction cost management using blockchain and encryption
Cheng, J. C. P., Liu, H., Gan, V. J. L., Das, M., Tao, X., & Zhou, S. (2023) · Automation in Construction · doi:10.1016/j.autcon.2023.104841 · Cited by 48 · see citing works
Lee, D., & Song, M. (2021) · IEEE Access · doi:10.1109/access.2021.3130552 · Cited by 47 · see citing works
“Healthcare stakeholders are attempting to address security and privacy issues in HIE through blockchain adoption [5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16].”
BackgroundWMTDBC: An unsupervised multivariate analysis model for fraud detection in health insurance claims
Settipalli, L., & Gangadharan, G. R. (2022) · Expert Systems with Applications · doi:10.1016/j.eswa.2022.119259 · Cited by 44 · see citing works
Blockchain-based solutions for clinical trial data management: a systematic review
Zhang, W. (2022) · Metaverse Basic and Applied Research · doi:10.56294/mr202217 · Cited by 44 · see citing works
Mishra, A. R., Rani, P., Alrasheedi, A. F., & Dwivedi, R. (2023) · Engineering Applications of Artificial Intelligence · doi:10.1016/j.engappai.2023.107112 · Cited by 44 · see citing works
Al-Aswad, H., Elmedany, W. M., Balakrishna, C., Ababneh, N., & Curran, K. (2021) · Arab Journal of Basic and Applied Sciences · doi:10.1080/25765299.2020.1870812 · Cited by 44 · see citing works
“The results of the conduct review in Hasselgren, Kralevska, Gligoroski, Pedersen, and Faxvaag (2019) indicate that the electronic health record is the most targeted area in healthcare using blockchain technology.”
ResultComprehensive review for healthcare data quality challenges in blockchain technology
Abuhalimeh, A., & Ali, O. (2023) · Frontiers in Big Data · doi:10.3389/fdata.2023.1173620 · Cited by 47 · see citing works
- Authors
- Hasselgren, A., Kralevska, K., Gligoroski, D., Pedersen, S. A., & Faxvaag, A.
- Affiliations
- Norwegian University of Science and Technology (NO)
- Corresponding author
- Hasselgren, Anton
- Venue
- International Journal of Medical Informatics
- Publisher
- Elsevier BV
- Published
- 2020-02
- Volume
- 134
- Pages
- 104040
- ISSN
- 1386-5056 (ISSN-L)
- OpenAlex
- W2996452324
- Semantic Scholar
- e21700b05fc480d4f2c18462dbeaaf90dadb378d
- Cited by
- 676
- References
- 46
- Citations by year
- 2026: 58 · 2025: 98 · 2024: 123 · 2023: 135 · 2022: 127 · 2021: 109 · 2020: 26
- FWCI
- 11.40
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- International Journal of Medical Informatics (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- NORA - Norwegian Open Research Archives (submittedVersion, cc-by-nc-nd)
- Topics
- Physical Sciences › Computer Science › Information Systems › Blockchain Technology Applications and Security
- Health Sciences › Health Professions › Health Information Management › Electronic Health Records Systems
- Physical Sciences › Computer Science › Information Systems › Blockchain Technology in Education and Learning
- Keywords
- blockchain, health care, electronic health records, personal health records, interoperability, data integrity, access control, provenance, Ethereum, Hyperledger Fabric, health education
- MeSH terms
- Blockchain, Delivery of Health Care, Humans, Health Records, Personal, Electronic Health Records, Quality Improvement, Health Information Exchange
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Claims read by deepseek-v4.1-flash under definition version 3 (extract-v3) on 2026-10-09.
Classified by jev-1.13-20260917 (gold-guideline-v0.2) on 2026-10-09.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review