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Differentiation and Persistence of Memory CD8+ T Cells Depend on T Cell Factor 1
Open accessAbstract
T cell factor 1 (TCF-1) is a transcription factor known to act downstream of the canonical Wnt pathway and is essential for normal T cell development. However, its physiological roles in mature CD8+ T cell responses are unknown. Here we showed that TCF-1 deficiency limited proliferation of CD8+ effector T cells and impaired their differentiation towards a central memory phenotype. Moreover, TCF-1-deficient memory CD8+ T cells were progressively lost over time, exhibiting reduced expression of the anti-apoptotic molecule Bcl-2, interleukin-2 receptor β chain and diminished IL-15-driven proliferation. TCF-1 was directly associated with the Eomes allele and the Wnt-TCF-1 pathway was necessary and sufficient for optimal Eomes expression in naïve and memory CD8+ T cells. Importantly, forced expression of Eomes partly protected TCF-1-deficient memory CD8+ T cells from time-dependent attrition. Our studies thus identify TCF-1 as a critical player in a transcriptional program that regulates memory CD8 differentiation and longevity.
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Metadata
- Authors
- Zhou, X., Yu, S., Zhao, D.-M., Harty, J. T., Badovinac, V. P., & Xue, H.-H.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 33
- Issue
- 2
- Pages
- 229-240
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2056100438
- Cited by
- 688
- References
- 6
- FWCI
- 9.48
- Type
- journal article
- Language
- en
- Open access
- bronze
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