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Finding the Missing Links among Metabolites, Microbes, and the Host
Open accessAbstract
The unexpected diversity of the human microbiome and metabolome far exceeds the complexity of the human genome. Although we now understand microbial taxonomic and genetic repertoires in some populations, we are just beginning to assemble the necessary computational and experimental tools to understand the metabolome in comparable detail. However, even with the limited current state of knowledge, individual connections between microbes and metabolites, between microbes and immune function, and between metabolites and immune function are being established. Here, we provide our perspective on these connections and outline a systematic research program that could turn these individual links into a broader network that allows us to understand how these components interact. This program will enable us to exploit connections among the microbiome, metabolome, and host immune system to maintain health and perhaps help us understand how to reverse the processes that lead to a wide range of immune and other diseases.
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“The gut microbiota influences the relative populations, migration, and function of various subsets of immune cells including Helper T cells, Regulatory T cells, mononuclear phagocytes and innate lymphoid cells (Dorrestein et al., 2014;Rooks and Garrett, 2016)”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Dorrestein et al., 2014
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“SCFAs have been shown to impact on T cell immune responses37.”
From Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer (2021) · cites this paper as [37]
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Metadata
- Authors
- Dorrestein, P. C., Mazmanian, S. K., & Knight, R.
- Affiliations
- University of California San Diego (US)
- California Institute of Technology (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Knight, Rob
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 40
- Issue
- 6
- Pages
- 824-832
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC4503329
- OpenAlex
- W2056978288
- Cited by
- 317
- References
- 76
- Citations by year
- 2026: 8 · 2025: 17 · 2024: 32 · 2023: 29 · 2022: 27 · 2021: 30 · 2020: 38 · 2019: 28 · 2018: 21 · 2017: 22 · 2016: 28 · 2015: 26 · 2014: 11
- FWCI
- 11.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of Mental Health (R01MH100556)
- National Human Genome Research Institute (U01HG004866, R01HG004872)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK078938, P01DK078669)
- National Institute of Neurological Disorders and Stroke (R01NS085910)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- human microbiome, human metabolome, host-microbe interactions, microbial metabolites, host immune function, microbial diversity, immune disorders, metabolomics
- MeSH terms
- Bacterial Proteins, Humans, Gastrointestinal Tract, Metagenome, Metabolome, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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