Cited by 317Gut microbiota and healthMetabolomics and Mass Spectrometry StudiesOral microbiology and periodontitis research

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Finding the Missing Links among Metabolites, Microbes, and the Host

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Dorrestein, Pieter C., Mazmanian, Sarkis K., Knight, Rob·2014·Immunity

DOI 10.1016/j.immuni.2014.05.015PMC PMC4503329

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Abstract

The unexpected diversity of the human microbiome and metabolome far exceeds the complexity of the human genome. Although we now understand microbial taxonomic and genetic repertoires in some populations, we are just beginning to assemble the necessary computational and experimental tools to understand the metabolome in comparable detail. However, even with the limited current state of knowledge, individual connections between microbes and metabolites, between microbes and immune function, and between metabolites and immune function are being established. Here, we provide our perspective on these connections and outline a systematic research program that could turn these individual links into a broader network that allows us to understand how these components interact. This program will enable us to exploit connections among the microbiome, metabolome, and host immune system to maintain health and perhaps help us understand how to reverse the processes that lead to a wide range of immune and other diseases.

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Authors: Dorrestein, P. C., Mazmanian, S. K., & Knight, R.
Affiliations: University of California San Diego (US)
California Institute of Technology (US)
Howard Hughes Medical Institute (US)
Corresponding author: Knight, Rob
ORCID: Dorrestein, Pieter C.
Mazmanian, Sarkis K.
Knight, Rob
Venue: Immunity
Publisher: Elsevier BV
Published: 2014-06
Volume: 40
Issue: 6
Pages: 824-832
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2014.05.015
PMC: PMC4503329
OpenAlex: W2056978288
Cited by: 317
References: 76
Citations by year: 2026: 8 · 2025: 17 · 2024: 32 · 2023: 29 · 2022: 27 · 2021: 30 · 2020: 38 · 2019: 28 · 2018: 21 · 2017: 22 · 2016: 28 · 2015: 26 · 2014: 11
FWCI: 11.88
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 383 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: Howard Hughes Medical Institute
National Institute of Mental Health (R01MH100556)
National Human Genome Research Institute (U01HG004866, R01HG004872)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK078938, P01DK078669)
National Institute of Neurological Disorders and Stroke (R01NS085910)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords: human microbiome, human metabolome, host-microbe interactions, microbial metabolites, host immune function, microbial diversity, immune disorders, metabolomics
MeSH terms: Bacterial Proteins, Humans, Gastrointestinal Tract, Metagenome, Metabolome, Microbiota

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Finding the Missing Links among Metabolites, Microbes, and the Host

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