Transcranial direct current stimulation in severe, drug-resistant major depression
Abstract
Background Though antidepressant drugs are the treatment of choice for severe major depression, a number of patients do not improve with pharmacologic treatment. This study aimed to assess the effects of transcranial direct current stimulation (tDCS) in patients with severe, drug-resistant depression. Methods Fourteen hospitalized patients aged 37-68, with severe major depressive disorder according to DSM-IV.TR criteria, drug resistant, with high risk of suicide and referred for ECT were included. Mood was evaluated using the Beck Depression Inventory (BDI), the Hamilton Depression Rating Scale (HDRS) and the Visual Analogue Scale (VAS). We also administered cognitive tasks to evaluate the possible cognitive effects on memory and attention. tDCS was delivered over the dorsolateral prefrontal cortex (DLPC) (2 mA, 20 min, anode left, cathode right) twice a day. Results After five days of treatment although cognitive performances remained unchanged, the BDI and HDRS scores improved more than 30% (BDI p=0.001; HDRS p=0.017). The mood improvement persisted and even increased at four (T2) weeks after treatment ended. The feeling of sadness and mood as evaluated by VAS improved after tDCS (Sadness p=0.007; Mood p=0.036). Conclusions We conclude that frontal tDCS is a simple, promising technique that can be considered in clinical practice as adjuvant treatment for hospitalized patients with severe, drug-resistant major depression.
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- Authors
- Ferrucci, R., Bortolomasi, M., Vergari, M., Tadini, L., Salvoro, B., Giacopuzzi, M., Barbieri, S., & Priori, A.
- Affiliations
- University of Milan (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Corresponding author
- Priori, A.
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 118
- Issue
- 1-3
- Pages
- 215-219
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W1978696437
- Cited by
- 228
- References
- 27
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 6 · 2021: 8 · 2020: 10 · 2019: 31 · 2018: 14 · 2017: 15 · 2016: 19 · 2015: 15 · 2014: 15 · 2013: 24 · 2012: 12
- FWCI
- 12.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Keywords
- transcranial direct current stimulation, drug-resistant depression, dorsolateral prefrontal cortex, adjuvant therapy, hospitalized patients, mood improvement, cognitive effects, attention and memory, suicide risk, electroconvulsive therapy
- MeSH terms
- Suicide Prevention, Adult, Aged, Antidepressive Agents, Chronic Disease, Major Depressive Disorder, Drug Resistance, Drug Therapy, Combination, Electroconvulsive Therapy, Electric Stimulation Therapy, Female, Follow-Up Studies, Hospitalization, Humans, Male, Middle Aged, Neuropsychological Tests, Personality Inventory, Treatment Outcome, Retreatment
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