Cited by 499Nutritional Studies and DietPhytochemicals and Antioxidant ActivitiesAntioxidant Activity and Oxidative Stress

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Fruit and Vegetable Consumption and Its Relation to Markers of Inflammation and Oxidative Stress in Adolescents

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Holt, Erica M., Steffen, Lyn M., Moran, Antoinette, Basu, Samar, Steinberger, Julia, Ross, Julie A., Hong, Ching-Ping, Sinaiko, Alan R.·2009·Journal of the American Dietetic Association

DOI 10.1016/j.jada.2008.11.036PMC PMC2676354

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Background Fruits and vegetables, foods rich in flavonoids and antioxidants, have been associated with lower risk of stroke, coronary heart disease, and markers of inflammation and oxidative stress in adults. Markers of inflammation and oxidative stress are predictors of coronary heart disease risk; however, it is unknown whether these markers are related to dietary flavonoid and antioxidant intake in youth.Objective To determine whether greater intakes of fruit and vegetables, antioxidants, folate, and total flavonoids were inversely associated with markers of inflammation and oxidative stress in 285 adolescent boys and girls aged 13 to 17 years.Design In this cross-sectional study conducted between February 1996 and January 2000, diet was assessed by a 127-item food frequency questionnaire. Height and weight measurements were obtained and a fasting blood sample drawn. Spearman partial correlation analyses evaluated the relation of intakes of fruit and vegetables, antioxidants, folate, and flavonoids with markers of inflammation (C-reactive protein, interleukin-6, tumor necrosis factor-alpha, and 15-keto-dihydro-PGF(2alpha) metabolite and oxidative stress (urinary 8-iso prostaglandin F(2alpha), an F(2)-isoprostane), adjusting for age, sex, race, Tanner stage, energy intake, and body mass index.Results Urinary F(2)-isoprostane was inversely correlated with intakes of total fruit and vegetables, vitamin C, beta carotene, and flavonoids. Serum C-reactive protein was significantly inversely associated with intakes of fruit (r=-0.19; P=0.004), vitamin C (r=-0.13, P=0.03), and folate (r=-0.18; P=0.004). Serum interleukin-6 was inversely associated with intakes of legumes, vegetables, beta carotene, and vitamin C. Serum tumor necrosis factor-alpha was inversely associated with beta carotene (r=-0.14, P=0.02) and luteolin (r=-0.15, P=0.02).Conclusion Study results show that the beneficial effects of fruit and vegetable intake on markers of inflammation and oxidative stress are already present by early adolescence and provide support for the Dietary Guidelines for Americans "to consume five or more servings per day" of fruits and vegetables to promote beneficial cardiovascular health.

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Authors: Holt, E. M., Steffen, L. M., Moran, A., Basu, S., Steinberger, J., Ross, J. A., Hong, C.-P., & Sinaiko, A. R.
Affiliations: University of Minnesota (US)
Uppsala University (SE)
Corresponding author: Steffen, Lyn M.
ORCID: Steffen, Lyn M.
Moran, Antoinette
Steinberger, Julia
Sinaiko, Alan R.
Venue: Journal of the American Dietetic Association
Publisher: Elsevier BV
Published: 2009-03
Volume: 109
Issue: 3
Pages: 414-421
ISSN: 0002-8223 (ISSN-L)
DOI: 10.1016/j.jada.2008.11.036
PMC: PMC2676354
OpenAlex: W2051281636
Cited by: 496
References: 80
Citations by year: 2026: 10 · 2025: 21 · 2024: 45 · 2023: 25 · 2022: 35 · 2021: 35 · 2020: 30 · 2019: 24 · 2018: 29 · 2017: 33 · 2016: 28 · 2015: 33 · 2014: 34 · 2013: 35 · 2012: 30
FWCI: 26.56
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of the American Dietetic Association (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL052851, HL-52851)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: fruit and vegetable intake, dietary flavonoids, antioxidants, folic acid, inflammatory markers, oxidative stress, C-reactive protein, interleukin-6, TNF-α, vitamin C, beta-carotene, adolescents, cardiovascular disease prevention, dietary guidelines, Fabaceae, luteolin, dietary habits, body mass index, sex differences
MeSH terms: Adolescent, Antioxidants, C-Reactive Protein, Cardiovascular Diseases, Cross-Sectional Studies, Diet, Diet Surveys, Female, Flavonoids, Folic Acid, Fruit, Humans, Inflammation, Male, Surveys and Questionnaires, Tumor Necrosis Factor-alpha, Vegetables, Dinoprost, Biomarkers, Interleukin-6, Body Mass Index, Oxidative Stress, Statistics, Nonparametric, F2-Isoprostanes

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Fruit and Vegetable Consumption and Its Relation to Markers of Inflammation and Oxidative Stress in Adolescents

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