Cited by 158Advancements in Transdermal Drug DeliveryAir Quality and Health ImpactsDermatology and Skin Diseases

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The impact of urban particulate pollution on skin barrier function and the subsequent drug absorption

Pan, Tai-Long, Wang, Pei-Wen, Aljuffali, Ibrahim A., Huang, Chi-Ting, Lee, Chiang-Wen, Fang, Jia-You·2015·Journal of Dermatological Science

DOI 10.1016/j.jdermsci.2015.01.011

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Abstract

Background Ambient particulate matters (PMs) are known as inducers that adversely affect a variety of human organs.Objectives In this study, we aimed to evaluate the influence of PMs on the permeation of drugs and sunscreens via the skin. The role of skin-barrier properties such as the stratum corneum (SC) and tight junctions (TJs) during the delivery process was explored.Methods This work was conducted using both in vitro and in vivo experiments in pigs to check the responses of the skin to PMs. PMs primarily containing heavy metals (1648a) and polycyclic aromatic hydrocarbons (PAHs, 1649b) were employed to treat the skin.Results According to the transepidermal water loss (TEWL), 1649b but not 1648a significantly disrupted the SC integrity by 2-fold compared to the PBS control. The immunohistochemistry (IHC) of cytokeratin, filaggrin, and E-cadherin exhibited that 1649b mildly damaged TJs. The cytotoxicity of keratinocytes and skin fibroblasts caused by 1649b was stronger than that caused by 1648a. The 1649b elicited apoptosis via caspase-3 activation. The proteomic profiles showed that PMs upregulated Annexin A2 by >5-fold, which can be a biomarker of PM-induced barrier disruption. We found that the skin uptake of ascorbic acid, an extremely hydrophilic drug, was increased from 74 to 112 μg/g by 1649b treatment. The extremely lipophilic drug tretinoin also showed a 2.6-fold increase of skin accumulation. Oxybenzone and dextran absorption was not affected by PMs. The in vivo dye distribution visualized by fluorescence microscopy had indicated that 1649b intervention promoted permeant partitioning into SC.Conclusions Caution should be taken in exposing the skin to airborne dust due to its ability to reduce barrier function and increase the risk of drug overabsorption, although this effect was not very marked.

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Furuse, M., Hata, M., Furuse, K., Yoshida, Y., Haratake, A., Sugitani, Y., Noda, T., Kubo, A., & Tsukita, S. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200110122 · Cited by 1,512
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Tunggal, J. A., Helfrich, I., Schmitz, A., Schwarz, H., Günzel, D., Fromm, M., Kemler, R., Krieg, T., & Niessen, C. M. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600605 · Cited by 491
Airborne Particle Exposure and Extrinsic Skin Aging
Vierkötter, A., Schikowski, T., Ranft, U., Sugiri, D., Matsui, M., Krämer, U., & Krutmann, J. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.204 · Cited by 473
Déjà vu in proteomics. A hit parade of repeatedly identified differentially expressed proteins
Petrák, J., Ivánek, R., Toman, O., Čmejla, R., Čmejlová, J., Vyoral, D., Živný, J., & Vulpe, C. D. (2008) · PROTEOMICS · doi:10.1002/pmic.200700919 · Cited by 362
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Martinelli, N., Olivieri, O., & Girelli, D. (2013) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2013.04.001 · Cited by 327
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Authors: Pan, T.-L., Wang, P.-W., Aljuffali, I. A., Huang, C.-T., Lee, C.-W., & Fang, J.-Y.
Affiliations: Chang Gung University (TW)
Chang Gung University of Science and Technology (TW)
King Saud University (SA)
Corresponding author: Lee, Chiang-Wen
Fang, Jia-You
ORCID: Pan, Tai-Long
Wang, Pei-Wen
Lee, Chiang-Wen
Fang, Jia-You
Venue: Journal of Dermatological Science
Publisher: Elsevier BV
Published: 2015-04
Volume: 78
Issue: 1
Pages: 51-60
ISSN: 0923-1811 (ISSN-L)
DOI: 10.1016/j.jdermsci.2015.01.011
OpenAlex: W1986353412
Cited by: 158
References: 49
Citations by year: 2026: 6 · 2025: 10 · 2024: 22 · 2023: 11 · 2022: 11 · 2021: 15 · 2020: 18 · 2019: 22 · 2018: 17 · 2017: 14 · 2016: 11 · 2015: 1
FWCI: 7.96
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Dermatological Science (publishedVersion)
PubMed (publishedVersion)
Funders: Chang Gung University
Chang Gung Memorial Hospital (EMRPD1D901, CMRPD1B0332, and CMRPF6A0083)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Keywords: urban particulate matter, skin barrier function, stratum corneum integrity, tight junctions, polycyclic aromatic hydrocarbons, heavy metals, drug permeation, vitamin C, all-trans retinoic acid, benzophenone-3, filaggrin, E-cadherin, keratinocyte cytotoxicity, caspase-3 apoptosis, annexin A2, transepidermal water loss, skin proteomics, airborne dust exposure
MeSH terms: Filaggrin Proteins, Administration, Cutaneous, Air Pollutants, Animals, Ascorbic Acid, Benzophenones, Cell Survival, Cells, Cultured, Dextrans, Pharmaceutical Preparations, Fibroblasts, Male, Permeability, Polycyclic Aromatic Hydrocarbons, Skin, Skin Absorption, Tretinoin, Water Loss, Insensible, Keratinocytes, Apoptosis, Tight Junctions, Metals, Heavy, Models, Animal, Sus scrofa, Particulate Matter

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The impact of urban particulate pollution on skin barrier function and the subsequent drug absorption

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