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Cited by 120Treatment of Major DepressionMental Health Treatment and AccessAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Presenting characteristics of depressed outpatients as a function of recurrence: Preliminary findings from the STAR*D clinical trial

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Hollon, Steven D., Shelton, Richard C., Wisniewski, Stephen, Warden, Diane, Biggs, Melanie M., Friedman, Edward S., Husain, Mustafa, Kupfer, David J. +4 more·2006·Journal of Psychiatric Research
DOI 10.1016/j.jpsychires.2005.07.008PMC PMC5886709
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Abstract

Objectives Recurrent depression predicts risk for subsequent episodes, but it is unclear how it relates to demographic features, course of illness, and clinical presentation.Methods We report on the baseline data for the first 1500 patients enrolled in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study (www.star-d.org). Patients were required to have a DSM-IV diagnosis of nonpsychotic major depression and to score > or = 14 on the 17-item Hamilton rating scale for depression. Status with respect to recurrent depression and other aspects of illness course and demographic features were ascertained at intake, along with measures of depression and concurrent general medical illness.Results Patients with recurrent depression were older, had an earlier age of onset, and were more likely to have a positive family history of depression than first episode patients. However, recurrent patients were less likely to be chronic and reported shorter current episodes than first episode patients, something that was largely confined to females. Recurrent patients were more likely than first episode patients to report non-essential aspects of mood, cognition, and somatic symptoms, although largely as a consequence of greater overall depressive symptom severity.Conclusions As compared to single episode depressions, recurrent depression was associated with greater symptom severity and illness characteristics suggestive of greater underlying risk, but not other demographic characteristics than age. Risk for recurrence appeared to be distinct from chronic depression. A subset of chronic first episode patients may lack the capacity to remit and may therefore be distinct from those with recurrent episodes.

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Authors
Hollon, S. D., Shelton, R. C., Wisniewski, S., Warden, D., Biggs, M. M., Friedman, E. S., Husain, M., Kupfer, D. J., Nierenberg, A. A., Petersen, T. J., Shores-Wilson, K., & Rush, A. J.
Affiliations
  • Vanderbilt University (US)
  • Vanderbilt University Medical Center (US)
  • University of Pittsburgh (US)
  • The University of Texas Southwestern Medical Center (US)
  • University of Pittsburgh Medical Center (US)
  • Harvard University (US)
Corresponding author
Hollon, Steven D.
ORCID
Venue
Journal of Psychiatric Research
Publisher
Elsevier BV
Published
2006-02
Volume
40
Issue
1
Pages
59-69
ISSN
0022-3956 (ISSN-L)
DOI
10.1016/j.jpsychires.2005.07.008
PMC
PMC5886709
OpenAlex
W2071986516
Cited by
120
References
23
Citations by year
2026: 2 · 2025: 3 · 2024: 7 · 2023: 5 · 2022: 3 · 2021: 3 · 2020: 7 · 2019: 5 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 3 · 2014: 6 · 2013: 5 · 2012: 8
FWCI
4.47
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Psychiatric Research (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (n01mh90003-26-0-0)
  • National Institute of Mental Health (N01 MH090003, K24 MH17401, K02 MH01697, K02MH001697)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
recurrent depression, first-episode depression, chronic depression, depression severity, age of onset, family history of depression, clinical course, sex differences, somatic symptoms, STAR*D trial, outpatients
MeSH terms
Adolescent, Adult, Age Factors, Aged, Ambulatory Care, Antidepressive Agents, Chronic Disease, Depressive Disorder, Major, Major Depressive Disorder, Humans, Middle Aged, Personality Inventory, Phenotype, Prospective Studies, Psychometrics, Recurrence, Socioeconomic Factors, Cognitive Behavioral Therapy, Outcome Assessment, Health Care, Risk Assessment, Genetic Predisposition to Disease

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