Oxidative stress in early stage Bipolar Disorder and the association with response to lithium
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Background Several studies have described increased oxidative stress (OxS) parameters and imbalance of antioxidant enzymes in Bipolar Disorder (BD) but few is know about the impact of treatment at these targets. However, no study has evaluated OxS parameters in unmedicated early stage BD and their association with lithium treatment in bipolar depression.Methods Patients with BD I or II (n = 29) in a depressive episode were treated for 6 weeks with lithium. Plasma samples were collected at baseline and endpoint, and were also compared to age-matched controls (n = 28). The thiobarbituric acid reactive substances (TBARS), and the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities were measured.Results Subjects with BD depression at baseline presented a significant increase in CAT (p = 0.005) and GPx (p < 0.001) levels, with lower SOD/CAT ratio (p = 0.001) and no changes on SOD or TBARS compared to healthy controls. Regarding therapeutics, lithium only induced a decrease in TBARS (p = 0.023) and SOD (p = 0.029) levels, especially in BDII. Finally, TBARS levels were significantly lower at endpoint in lithium responders compared to non-responders (p = 0.018) with no difference in any biomarker regarding remission.Conclusion The present findings suggest a reactive increase in antioxidant enzymes levels during depressive episodes in early stage BD with minimal prior treatment. Also, decreased lipid peroxidation (TBARS) levels were observed, associated with lithium's clinical efficacy. Overall, these results reinforce the role for altered oxidative stress in the pathophysiology of BD and the presence of antioxidant effects of lithium in the prevention of illness progression and clinical efficacy.
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Several studies showed that oxidative stress in the affective disorders can also be inhibited by psychiatric disease therapy itself, as this was demonstrated to be a causative component.
“Therefore several studies showed that oxidative stress in the affective disorders can also be inhibited by psychiatric disease therapy itself, as this was demonstrated to be a causative component [11, 250, 251].”
From Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches (2016) · cites this paper as [251]
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Ghribi, O., Herman, M. M., Spaulding, N. K., & Savory, J. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00957.x · Cited by 94 · see citing works
RetractedHamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
A Rating Scale for Mania: Reliability, Validity and Sensitivity
Young, R. C., Biggs, J. T., Ziegler, V. E., & Meyer, D. A. (1978) · British Journal of Psychiatry · doi:10.1192/bjp.133.5.429 · Cited by 8,744 · see citing works
Structured Clinical Interview for DSM-IV Axis I Disorders
Spitzer, R. L., First, M. B., & Gibbon, M. (1997) · Medical Entomology and Zoology · Cited by 3,582 · see citing works
Yatham, L. N., & Malhi, G. S. (2011) · Oxford University Press eBooks · doi:10.1093/med/9780199562305.001.0001 · Cited by 3,515 · see citing works
Yatham, L. N., Kennedy, S. H., Parikh, S. V., Schaffer, A., Beaulieu, S., Alda, M., O’Donovan, C., MacQUEEN, G. M., McIntyre, R. S., Sharma, V., et al. (2012) · Bipolar Disorders · doi:10.1111/bdi.12025 · Cited by 1,209 · see citing works
Berk, M., Kapczinski, F., Andreazza, A. C., Dean, O. M., Giorlando, F., Maes, M., Yücel, M., Gama, C. S., Dodd, S., Dean, B., et al. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.10.001 · Cited by 1,178 · see citing works
Bilici, M., Efe, H., Köroğlu, M. A., Uydu, H. A., Bekaroğlu, M., & Değer, O. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00199-3 · Cited by 718 · see citing works
Berman, S. B., & Hastings, T. G. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0731127.x · Cited by 664 · see citing works
Mitochondrial disease in mouse results in increased oxidative stress
Esposito, L., Melov, S., Panov, A. V., Cottrell, B. A., & Wallace, D. C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.4820 · Cited by 637 · see citing works
GABAergic dysfunction in mood disorders
Brambilla, P., Pérez, J., Barale, F., Schettini, G., & Soares, J. C. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001362 · Cited by 567 · see citing works
Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections.
Hastings, T. G., Lewis, D. A., & Zigmond, M. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.5.1956 · Cited by 547 · see citing works
Oxidative stress markers in bipolar disorder: A meta-analysis
Andreazza, A. C., Kauer-Sant'Anna, M., Frey, B. N., Bond, D. J., Kapczinski, F., Young, L. T., & Yatham, L. N. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.04.013 · Cited by 526 · see citing works
Molecular Evidence for Mitochondrial Dysfunction in Bipolar Disorder
Konradi, C. L., Eaton, M. E., MacDonald, M. L., Walsh, J. P., Benes, F. M., & Heckers, S. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.3.300 · Cited by 499 · see citing works
Stork, C., & Renshaw, P. F. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001711 · Cited by 486 · see citing works
Impaired mitochondrial function in psychiatric disorders
Manji, H. K., Kato, T., Prospero, N. A. D., Ness, S. L., Beal, M. F., Krams, M., & Chen, G. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3229 · Cited by 478 · see citing works
Andreazza, A. C., Shao, L., Wang, J.-F., & Young, L. T. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.22 · Cited by 448 · see citing works
Nonaka, S., Hough, C. J., & Chuang, D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2642 · Cited by 430 · see citing works
Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia
Clay, H. B., Daws, S., & Konradi, C. (2011) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2010.08.007 · Cited by 399 · see citing works
Ranjekar, P. K., Hinge, A. S., Hegde, M. V., Ghate, M. R., Kale, A. A., Sitasawad, S. L., Wagh, U. V., Debsikdar, V. B., & Mahadik, S. P. (2003) · Psychiatry Research · doi:10.1016/s0165-1781(03)00220-8 · Cited by 395 · see citing works
Machado‐Vieira, R., Manji, H. K., & Zarate, C. A. (2009) · Bipolar Disorders · doi:10.1111/j.1399-5618.2009.00714.x · Cited by 370 · see citing works
Self-citationAntioxidant enzyme activities and oxidative stress in affective disorders
Erkan Ozcan, M., Gulec, M., Ozerol, E., Polat, R., & Akyol, O. (2004) · International Clinical Psychopharmacology · doi:10.1097/00004850-200403000-00006 · Cited by 368 · see citing works
Lipid peroxidation and antioxidant enzyme levels in patients with schizophrenia and bipolar disorder
Kuloglu, M., Ustundag, B., Atmaca, M., Canatan, H., Tezcan, A. E., & Cinkilinc, N. (2002) · Cell Biochemistry and Function · doi:10.1002/cbf.940 · Cited by 321 · see citing works
Machado‐Vieira, R., Andreazza, A. C., Viale, C. I., Zanatto, V. C., Ceresér, V. H., Vargas, R. D. S., Kapczinski, F. P., Portela, L. V., Souza, D. O., Salvador, M. M., et al. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.05.016 · Cited by 314 · see citing works
Self-citationSerum S100B and antioxidant enzymes in bipolar patients
Andreazza, A. C., Cassini, C., Rosa, A. R., Leite, M. C., de Almeida, L. M. V., Nardin, P., da Cunha, A. B., Ceresér, K. M. M., Santin, A. M. P., Gottfried, C., et al. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.07.013 · Cited by 307 · see citing works
Bianchi, P., Kunduzova, O., Masini, E., Cambon, C., Bani, D., Raimondi, L., Séguélas, M., Nistri, S., Colucci, W. S., Leducq, N., et al. (2005) · Circulation · doi:10.1161/circulationaha.104.528133 · Cited by 265 · see citing works
Sun, X., Wang, J., Tseng, M., & Young, L. T. (2006) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0623 · Cited by 238 · see citing works
Mahadik, S. P., Evans, D. R., & Lal, H. (2001) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(00)00181-0 · Cited by 229 · see citing works
Shao, L., Young, L. T., & Wang, J. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.052 · Cited by 218 · see citing works
Andreazza, A. C., Kapczinski, F. P., Kauer‐Sant’Anna, M., Walz, J. C., Bond, D. J., Gonçalves, C. A., Young, L. T., & Yatham, L. N. (2009) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0935 · Cited by 199 · see citing works
Lai, C., & Yu, P. H. (1997) · Biochemical Pharmacology · doi:10.1016/s0006-2952(96)00731-9 · Cited by 198 · see citing works
D'Addario, C., Dell'Osso, B., Palazzo, M. C., Benatti, B., Lietti, L., Cattaneo, E., Galimberti, D., Fenoglio, C., Cortini, F., Scarpini, E., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.10 · Cited by 192 · see citing works
DNA damage in bipolar disorder
Andreazza, A. C., Frey, B. N., Erdtmann, B., Salvador, M. M., Rombaldi, F., Santin, A. M. P., Gonçalves, C. A., & Kapczinski, F. P. (2007) · Psychiatry Research · doi:10.1016/j.psychres.2006.03.025 · Cited by 187 · see citing works
Lithium Treatment Prevents Neurocognitive Deficit Resulting from Cranial Irradiation
Yazlovitskaya, E. M., Edwards, E., Thotala, D. K., Fu, A., Osusky, K. L., Whetsell, W. O., Boone, B. E., Shinohara, E. T., & Hallahan, D. E. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-2740 · Cited by 187 · see citing works
Kuhn, D. M., Arthur, R. E., Thomas, D. M., & Elferink, L. A. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0731309.x · Cited by 183 · see citing works
Ozaki, N., & Chuang, D. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69062336.x · Cited by 179 · see citing works
Volterra, A., Trotti, D., & Racagni, G. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09843-8 · Cited by 176 · see citing works
Gsell, W., Conrad, R., Hickethier, M., Sofic, E., Frölich, L., Wichart, I., Jellinger, K. A., Moll, G. H., Ransmayr, G. N., Beckmann, H., et al. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64031216.x · Cited by 175 · see citing works
Nocito, A., Dahm, F., Jochum, W., Jang, J. H., Georgiev, P., Bäder, M., Renner, E. L., & Clavien, P. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.05.019 · Cited by 175 · see citing works
Abdalla, D. S. P., Monteiro, H., Oliveira, J., & Bechara, E. J. H. (1986) · Clinical Chemistry · doi:10.1093/clinchem/32.5.805 · Cited by 168 · see citing works
Dopaminergic neuron-specific oxidative stress caused by dopamine itself.
Miyazaki, I., & Asanuma, M. (2008) · PubMed · doi:10.18926/amo/30942 · Cited by 168 · see citing works
Montero, D., Walther, G., Pérez‐Martin, A., Roche, E., & Vinet, A. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00956.x · Cited by 166 · see citing works
Stage managing bipolar disorder
Berk, M., Berk, L., Dodd, S., Cotton, S., Macneil, C., Daglas, R., Conus, P., Bechdolf, A., Moylan, S., & Malhi, G. S. (2014) · Bipolar Disorders · doi:10.1111/bdi.12099 · Cited by 163 · see citing works
Enzymes of the antioxidant defense system in chronic schizophrenic patients
Reddy, R. D., Mahadik, S. P., Mukherjee, S., & Murthy, J. N. (1991) · Biological Psychiatry · doi:10.1016/0006-3223(91)90298-z · Cited by 156 · see citing works
Haque, M. E., Asanuma, M., Higashi, Y., Miyazaki, I., Tanaka, K.-I., & Ogawa, N. (2002) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(02)00440-3 · Cited by 151 · see citing works
SOUSA, R. T. D., van de Bilt, M. T., Diniz, B. S., Ladeira, R. B., Portela, L. V., Souza, D. O., Forlenza, O. V., Gattaz, W. F., & Machado‐Vieira, R. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.02.054 · Cited by 145 · see citing works
Self-citationLovell, M. A., Xie, C., & Markesbery, W. R. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00346-4 · Cited by 127 · see citing works
Effects of lithium therapy on Na+–K+-ATPase activity and lipid peroxidation in bipolar disorder
Banerjee, U., Dasgupta, A., Rout, J. K., & Singh, O. P. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.12.006 · Cited by 124 · see citing works
Effects of lithium on oxidative stress parameters in healthy subjects
Machado‐Vieira, R. (2011) · Molecular Medicine Reports · doi:10.3892/mmr.2011.732 · Cited by 121 · see citing works
Self-citationIncreased plasma levels of lipid hydroperoxides in patients with ischemic stroke
Polidori, M. C., Frei, B. B., Cherubini, A., Nelles, G., Rordorf, G. A., Keaney, J. F., Schwamm, L. H., Mecocci, P., Koroshetz, W. J., & Beal, M. F. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00085-9 · Cited by 107 · see citing works
Number of manic episodes is associated with elevated DNA oxidation in bipolar I disorder
Soeiro‐de‐Souza, M. G., Andreazza, A. C., Carvalho, A. F., Machado‐Vieira, R., Young, L. T., & Moreno, R. A. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000047 · Cited by 97 · see citing works
Self-citationReduced antioxidant defense systems in schizophrenia and bipolar I disorder
Raffa, M., Barhoumi, S., Atig, F., Fendri, C., Kerkeni, A., & Mechri, A. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.07.013 · Cited by 95 · see citing works
Schäfer, M., Goodenough, S., Moosmann, B., & Behl, C. (2004) · Brain Research · doi:10.1016/j.brainres.2004.01.037 · Cited by 93 · see citing works
Grintzalis, K., Zisimopoulos, D., Grune, T., Weber, D., & Georgiou, C. D. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.09.038 · Cited by 88 · see citing works
Chronic Lithium Treatment Attenuates Intracellular Calcium Mobilization
Wasserman, M. J., Corson, T. W., Sibony, D., Cooke, R. G., Parikh, S. V., Pennefather, P., Li, P. P., & Warsh, J. J. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300400 · Cited by 88 · see citing works
Oxidative Parameters Differences during Non-Lethal and Lethal Sepsis Development1
Andrades, M., Ritter, C., Moreira, J. C. F., & Dal-Pizzol, F. (2005) · Journal of Surgical Research · doi:10.1016/j.jss.2004.11.008 · Cited by 86 · see citing works
Ogita, K., Kitago, T., Nakamuta, H., Fukuda, Y., Koida, M., Ogawa, Y., & Yoneda, Y. (1986) · Life Sciences · doi:10.1016/0024-3205(86)90482-0 · Cited by 82 · see citing works
Varga, V., Jenei, Z., Janáky, R., Saransaari, P., & Oja, S. S. (1997) · Neurochemical Research · doi:10.1023/a:1027377605054 · Cited by 81 · see citing works
The platelet as a peripheral marker in psychiatric illness
Plein, H., & Berk, M. (2001) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.251 · Cited by 71 · see citing works
Machado‐Vieira, R., Soeiro‐de‐Souza, M. G., Richards, E. M., Teixeira, A. L., & Zarate, C. A. (2013) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2013.830775 · Cited by 70 · see citing works
Self-citationThe Effects of Lithium on Oxidative Stress Parameters in Healthy Subjects
Khairova, R. A., Pawar, R., Salvadore, G., Juruena, M. F., Salvador, M. M., Gattaz, W. F., Zarate, C. A., & Machado‐Vieira, R. (2011) · Biological Psychiatry · Cited by 58 · see citing works
Self-citationHäberle, A., Greil, W., Russmann, S., & Grohmann, R. (2012) · BMC Psychiatry · doi:10.1186/1471-244x-12-153 · Cited by 53 · see citing works
Receptor targets for antidepressant therapy in bipolar disorder: An overview
Fountoulakis, K. Ν., Kelsoe, J. R., & Akiskal, H. S. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.04.043 · Cited by 52 · see citing works
Liochev, S. I., & Fridovich, I. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00304-9 · Cited by 42 · see citing works
Palmeira, C. M., Santos, M. S., Carvalho, A. P., & Oliveira, C. R. (1993) · Brain Research · doi:10.1016/0006-8993(93)90863-i · Cited by 38 · see citing works
The interaction between BDNF and DRD2 in Bipolar II disorder but not in bipolar i disorder
Huang, C., Chang, Y., Lee, S.-Y., Chen, S., Chen, S., Chu, C., Huang, S., Tzeng, N., Lee, I. H., Yeh, T. L., et al. (2012) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32055 · Cited by 25 · see citing works
Defective Nitric Oxide–Cyclic Guanosine Monophosphate Signaling in Patients With Bipolar Disorder
Fontoura, P. C., Pinto, V. L. M., Matsuura, C., Resende, Â. C., de Bem, G. F., Ferraz, M. R., Cheniaux, E., Brunini, T. M. C., & Mendes‐Ribeiro, A. C. (2012) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3182689460 · Cited by 20 · see citing works
Kim, H. K., & Andreazza, A. C. (2012) · Expert Review of Neurotherapeutics · doi:10.1586/ern.12.64 · Cited by 20 · see citing works
Flagged first, then by citations
1 of the 69 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Liochev SI Fridovich I The relative importance of HO* and ONOO– in mediating the toxicity of O*– Free Radic Biol Med 1999 26 777 8 10218668
Cited by
Sorted by citations
Is depression associated with increased oxidative stress? A systematic review and meta-analysis
Black, C. N., Bot, M., Scheffer, P. G., Cuijpers, P., & Penninx, B. W. J. H. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.09.025 · Cited by 711 · see citing works
Forlenza, O. V., de Paula, V. D. J. R., & Diniz, B. S. (2014) · ACS Chemical Neuroscience · doi:10.1021/cn5000309 · Cited by 333 · see citing works
Markers of Oxidative Stress and Neuroprogression in Depression Disorder
Vaváková, M., Ďuračková, Z., & Trebatická, J. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/898393 · Cited by 324 · see citing works
Reliability of malondialdehyde as a biomarker of oxidative stress in psychological disorders
Ansarin, K., Khoubnasabjafari, M., & Jouyban, A. (2017) · BioImpacts · doi:10.15171/bi.2015.20 · Cited by 270 · see citing works
Biological hypotheses and biomarkers of bipolar disorder
Sigitova, E., Fišar, Z., Hroudová, J., Cikánková, T., & Raboch, J. (2016) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12476 · Cited by 247 · see citing works
Won, E., & Kim, Y. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122679 · Cited by 222 · see citing works
Jiménez‐Fernández, S., Gurpegui, M., Díaz-Atienza, F., Pérez-Costillas, L., Gerstenberg, M., & Correll, C. U. (2015) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.14r09179 · Cited by 230 · see citing works
Magnetic field effects in biology from the perspective of the radical pair mechanism
Zadeh-Haghighi, H., & Simon, C. (2022) · Journal of The Royal Society Interface · doi:10.1098/rsif.2022.0325 · Cited by 197 · see citing works
Rowland, T., Perry, B. I., Upthegrove, R., Barnes, N. M., Chatterjee, J., Gallacher, D., & Marwaha, S. (2018) · The British Journal of Psychiatry · doi:10.1192/bjp.2018.144 · Cited by 197 · see citing works
Mitochondria, Metabolism, and Redox Mechanisms in Psychiatric Disorders
Kim, Y., Vadodaria, K. C., Lenkei, Z., Kato, T., Gage, F. H., Marchetto, M. C., & Santos, R. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7606 · Cited by 189 · see citing works
Scaini, G., Rezin, G. T., Carvalho, A. F., STRECK, E. L., Berk, M., & Quevedo, J. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.06.040 · Cited by 184 · see citing works
A model of the mitochondrial basis of bipolar disorder
Morris, G., Walder, K., McGee, S. L., Dean, O. M., Tye, S. J., Maes, M., & Berk, M. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.014 · Cited by 162 · see citing works
Human Catalase, Its Polymorphisms, Regulation and Changes of Its Activity in Different Diseases
Kodydková, J., Vávřová, L., Kocik, M., & Žák, A. (2014) · Folia Biologica · doi:10.14712/fb2014060040153 · Cited by 158 · see citing works
Prasad, S., Tyagi, A. K., & Aggarwal, B. B. (2016) · Experimental Biology and Medicine · doi:10.1177/1535370216638770 · Cited by 146 · see citing works
The role of mitochondria in mood disorders: from physiology to pathophysiology and to treatment
Giménez-Palomo, A., Dodd, S., Anmella, G., Carvalho, A. F., Scaini, G., Quevedo, J., Pacchiarotti, I., Vieta, E., & Berk, M. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.546801 · Cited by 140 · see citing works
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Malhi, G. S., & Outhred, T. (2016) · CNS Drugs · doi:10.1007/s40263-016-0380-1 · Cited by 133 · see citing works
Jiménez‐Fernández, S., Manuel Gurpegui, A., Rojas, D. G., Gutiérrez-Rojas, L., Carretero, M. D., & Correll, C. U. (2020) · Bipolar Disorders · doi:10.1111/bdi.12980 · Cited by 122 · see citing works
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Das, T. K., Javadzadeh, A., Dey, A., Sabesan, P., Théberge, J., Raduà, J., & Palaniyappan, L. K. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.08.006 · Cited by 114 · see citing works
Balmus, I. M., Ciobica, A., Antioch, I., Dobrin, R., & Timofte, D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3975101 · Cited by 103 · see citing works
A new look at an old drug: neuroprotective effects and therapeutic potentials of lithium salts
Carmassi, C., Grande, C. D., Gesi, C., Musetti, L., & Dell’Osso, L. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s106479 · Cited by 97 · see citing works
Emerging roles of brain metabolism in cognitive impairment and neuropsychiatric disorders
Morella, I., Brambilla, R., & Morè, L. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104892 · Cited by 96 · see citing works
Machado‐Vieira, R., Zanetti, M. V., Otaduy, M. C. G., SOUSA, R. T. D., Soeiro‐de‐Souza, M. G., Costa, A. C., Carvalho, A. F., Leite, C. C., Busatto, G. F., Zarate, C. A., et al. (2016) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000616 · Cited by 87 · see citing works
Self-citationTsai, M.-C., & Huang, T. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.10.045 · Cited by 86 · see citing works
Mitochondrial dysfunction as a critical event in the pathophysiology of bipolar disorder
Scaini, G., Andrews, T., Lima, C. N. D. C., Benevenuto, D., STRECK, E. L., & Quevedo, J. (2020) · Mitochondrion · doi:10.1016/j.mito.2020.12.002 · Cited by 77 · see citing works
Dorsal Anterior Cingulate Lactate and Glutathione Levels in Euthymic Bipolar I Disorder:1H-MRS Study
Soeiro‐de‐Souza, M. G., Pastorello, B., Leite, C. D. C., Henning, A., Moreno, R. A., & Otaduy, M. C. G. (2016) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw032 · Cited by 70 · see citing works
SOUSA, R. T. D., STRECK, E. L., Zanetti, M. V., Ferreira, G. K., Diniz, B. S., Brunoni, A. R., Busatto, G. F., Gattaz, W. F., & Machado‐Vieira, R. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3655-6 · Cited by 70 · see citing works
Self-citationMadireddy, S., & Madireddy, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031844 · Cited by 71 · see citing works
Inhibition of glycogen synthase kinase 3 by lithium, a mechanism in search of specificity
Chatterjee, D., & Beaulieu, J. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1028963 · Cited by 65 · see citing works
Bipolar Disorder and the Vascular System: Mechanisms and New Prevention Opportunities
Goldstein, B. I. (2017) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2017.10.006 · Cited by 64 · see citing works
Lipid Peroxidation in Psychiatric Illness: Overview of Clinical Evidence
Joshi, Y. B., & Praticò, D. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/828702 · Cited by 63 · see citing works
Machado‐Vieira, R. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.12.026 · Cited by 62 · see citing works
Self-citationNew Advances in the Pharmacology and Toxicology of Lithium: A Neurobiologically Oriented Overview
Bortolozzi, A. A., Fico, G., Berk, M., Solmi, M., Fornaro, M., Quevedo, J., Zarate, C. A., Kessing, L. V., Vieta, E., & Carvalho, A. F. (2024) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000007 · Cited by 63 · see citing works
Self-citationValvassori, S. S., Bavaresco, D. V., Feier, G., Recco, K. C. C., Steckert, A. V., Varela, R. B., Borges, C. P., Carvalho‐Silva, M., Gomes, L. M., STRECK, E. L., et al. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.03.089 · Cited by 58 · see citing works
Fidélis, E. M., Savall, A. S. P., Abreu, E. D. L., de Carvalho, F. B., Teixeira, F. E. G., Haas, S. E., Sampaio, T. B., & Pinton, S. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.09.032 · Cited by 58 · see citing works
Jiménez‐Fernández, S., Manuel Gurpegui, A., Rojas, D. G., Gutiérrez-Rojas, L., Carretero, M. D., & Correll, C. U. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.07.015 · Cited by 57 · see citing works
Targeting mitochondrially mediated plasticity to develop improved therapeutics for bipolar disorder
de Sousa, R. T., Machado‐Vieira, R., Zarate, C. A., & Manji, H. K. (2014) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2014.940893 · Cited by 54 · see citing works
Self-citationSOUSA, R. T. D., Zanetti, M. V., Talib, L. L., Serpa, M. H., Chaim, T. M., Carvalho, A. F., Brunoni, A. R., Busatto, G. F., Gattaz, W. F., & Machado‐Vieira, R. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.01.016 · Cited by 52 · see citing works
Self-citationPutative neuroprotective pharmacotherapies to target the staged progression of mental illness
Robertson, O. D., Coronado, N. G., Sethi, R., Berk, M., & Dodd, S. (2019) · Early Intervention in Psychiatry · doi:10.1111/eip.12775 · Cited by 52 · see citing works
Machado‐Vieira, R., Gattaz, W. F., Zanetti, M. V., SOUSA, R. T. D., Carvalho, A. F., Soeiro‐de‐Souza, M. G., Leite, C. C., & Otaduy, M. C. G. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.08.023 · Cited by 49 · see citing works
Self-citationValvassori, S. S., Dal-Pont, G. C., Resende, W. R., Jornada, L. K., Peterle, B. R., Machado, A. G., Farias, H. R., de Souza, C. T., Carvalho, A. F., & Quevedo, J. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.10.015 · Cited by 47 · see citing works
Pisanu, C., Papadima, E. M., Zompo, M. D., & Squassina, A. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.06.045 · Cited by 45 · see citing works
Filho, A. J. M. C., Cunha, N. L., de Souza, A. G., Soares, M. V.-R., Jucá, P. M., de Queiroz, T., Oliveira, J. V. S., Valvassori, S. S., Barichello, T., Quevedo, J., et al. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109872 · Cited by 44 · see citing works
Lithium Pharmacogenetics: Where Do We Stand?
Pisanu, C., Melis, C., & Squassina, A. (2016) · Drug Development Research · doi:10.1002/ddr.21341 · Cited by 44 · see citing works
Mitochondria dysfunction and bipolar disorder: From pathology to therapy
Lam, X.-J., Xu, B., Yeo, P. L., Cheah, P.-S., & Ling, K. (2023) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2023.04.002 · Cited by 44 · see citing works
Debom, G. N., Gazal, M., Soares, M. S. P., do Couto, C. A. T., de Mattos, B. D. S., Lencina, C. L., Kaster, M. P., Ghisleni, G., Tavares, R. G., Braganhol, E., et al. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.10.008 · Cited by 43 · see citing works
Mitochondrial Agents for Bipolar Disorder
Pereira, C. L., Chavarria, V., Vian, J., Ashton, M. M., Berk, M., Marx, W., & Dean, O. M. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy018 · Cited by 41 · see citing works
Beyond the therapeutic shackles of the monoamines: new mechanisms in bipolar disorder biology
Data-Franco, J., Singh, A., Popovic, D., Ashton, M., Berk, M., Vieta, E., Figueira, M. L., & Dean, O. M. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.09.004 · Cited by 38 · see citing works
Mondin, T. C., Cardoso, T. D. A., Moreira, F. P., Wiener, C. D., Oses, J. P., Souza, L. D. D. M., Jansen, K., Magalhães, P. V. D. S., Kapczinski, F. P., & da Silva, R. A. (2016) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2016.10.012 · Cited by 38 · see citing works
Refractory bipolar disorder and neuroprogression
da Costa, S. C., Passos, I. C., Lowri, C., Soares, J. C., & Kapczinski, F. P. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.09.005 · Cited by 37 · see citing works
Lv, Q., Hu, Q., Zhang, W., Huang, X., Zhu, M., Geng, R., Cheng, X., Bao, C., Wang, Y., Zhang, C., et al. (2020) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaa003 · Cited by 37 · see citing works
Common biological mechanisms between bipolar disorder and type 2 diabetes: Focus on inflammation
Sharma, A. N., Bauer, I. E., Sanches, M., Galvez, J. F., Zunta‐Soares, G. B., Quevedo, J., Kapczinski, F. P., & Soares, J. C. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.06.005 · Cited by 36 · see citing works
Insulin resistance takes center stage: a new paradigm in the progression of bipolar disorder
Calkin, C. V. (2019) · Annals of Medicine · doi:10.1080/07853890.2019.1659511 · Cited by 35 · see citing works
Lithium and the Interplay Between Telomeres and Mitochondria in Bipolar Disorder
Lundberg, M., Millischer, V., Backlund, L., Martinsson, L., Stenvinkel, P., Sellgren, C. M., Lavebratt, C., & Schalling, M. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.586083 · Cited by 35 · see citing works
Antioxidant Effects of Resveratrol in Intervertebral Disk
Huo, Y., Yang, D., Lai, K., Tu, J., Zhu, Y., Ding, W., & Yang, S. (2021) · Journal of Investigative Surgery · doi:10.1080/08941939.2021.1988771 · Cited by 35 · see citing works
Fibromyalgia and Bipolar Disorder: Emerging Epidemiological Associations and Shared Pathophysiology
Bortolato, B., Berk, M., Maes, M. H. J., McIntyre, R. S., & Carvalho, A. F. (2016) · Current Molecular Medicine · doi:10.2174/1566524016666160126144027 · Cited by 34 · see citing works
Effects of Lithium Monotherapy for Bipolar Disorder on Gene Expression in Peripheral Lymphocytes
Anand, A., McClintick, J. N., Murrell, J. R., Karne, H. S., Nürnberger, J. I., & Edenberg, H. J. (2016) · Complex Psychiatry · doi:10.1159/000446348 · Cited by 34 · see citing works
Psychiatric comorbidity in Wilson’s disease
Mura, G., Zimbrean, P. C., Demelia, L., & Carta, M. G. (2017) · International Review of Psychiatry · doi:10.1080/09540261.2017.1311845 · Cited by 34 · see citing works
Mood Stabilizers in Psychiatric Disorders and Mechanisms Learnt from In Vitro Model Systems
Nayak, R., Rosh, I., Kustanovich, I. M., & Stern, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179315 · Cited by 34 · see citing works
Fornaro, M., Berardis, D. D., Anastasia, A., Novello, S., Fusco, A., Cattaneo, C. I., Solmi, M., Monaco, F., Veronese, N., Kim, Y., et al. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.08.034 · Cited by 33 · see citing works
Loch, A. A., Zanetti, M. V., SOUSA, R. T. D., Chaim, T. M., Serpa, M. H., Gattaz, W. F., Teixeira, A. L., & Machado‐Vieira, R. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.09.014 · Cited by 33 · see citing works
Self-citationMitochondrial Dysfunction as a Biomarker of Illness State in Bipolar Disorder: A Critical Review
Giménez‐Palomo, A., Gracia, H. A., de Juan, O., Olivier, L., Ochandiano, I., Ilzarbe, L., Valentí, M., Stoppa, A., Llach, C.-D., Pacenza, G., et al. (2024) · Brain Sciences · doi:10.3390/brainsci14121199 · Cited by 33 · see citing works
Poladian, N., Navasardyan, I., Narinyan, W., Orujyan, D., & Venketaraman, V. (2023) · Clinics and Practice · doi:10.3390/clinpract13040070 · Cited by 31 · see citing works
Malondialdehyde as a candidate biomarker for bipolar disorder: A meta-analysis
Capuzzi, E., Ossola, P., Caldiroli, A., Auxilia, A. M., & Buoli, M. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110469 · Cited by 31 · see citing works
Yusuf, M., Khan, M., Robaian, M. A., & Khan, R. A. (2017) · Biological Chemistry · doi:10.1515/hsz-2017-0250 · Cited by 31 · see citing works
Cruz, E. C. S., Madrid, K. C., Arruda, M. A. Z., & Sussulini, A. (2020) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2020.126467 · Cited by 31 · see citing works
Entangled radicals may explain lithium effects on hyperactivity
Zadeh‐Haghighi, H., & Simon, C. (2021) · Scientific Reports · doi:10.1038/s41598-021-91388-9 · Cited by 29 · see citing works
Yosaee, S., Keshtkaran, Z., Abdollahi, S., Shidfar, F., Sarris, J. J., & Soltani, S. (2021) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2021.04.006 · Cited by 29 · see citing works
The Link between Refractoriness and Neuroprogression in Treatment-Resistant Bipolar Disorder
Bauer, I. E., Soares, J. C., Selek, S., & Meyer, T. D. (2017) · Modern trends in psychiatry · doi:10.1159/000470803 · Cited by 28 · see citing works
Mini-review: The anti-aging effects of lithium in bipolar disorder
Salarda, E. M., Zhao, N. O., Lima, C. N. D. C., & Fries, G. R. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136051 · Cited by 29 · see citing works
Metabolic regulation to treat bipolar depression: mechanisms and targeting by trimetazidine
Khanra, S., Reddy, P. H., Giménez‐Palomo, A., Park, C. H. J., Panizzutti, B., McCallum, M., Arumugham, S. S., Shreekantiah, U., Debnath, M., Das, B., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02134-8 · Cited by 28 · see citing works
de Jesus, J. R., de Campos, B. K., Galazzi, R. M., Capelo, J. L., & Arruda, M. A. Z. (2014) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-014-8341-3 · Cited by 27 · see citing works
Lithium treatment in the era of personalized medicine
RYBAKOWSKI, J. K. (2020) · Drug Development Research · doi:10.1002/ddr.21660 · Cited by 26 · see citing works
Mechanisms Underpinning the Polypharmacy Effects of Medications in Psychiatry
Bortolasci, C. C., Spolding, B., Callaly, E., Martin, S., Panizzutti, B., Kidnapillai, S., Connor, T., Hasebe, K., Mohebbi, M., Dean, O. M., et al. (2018) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy014 · Cited by 25 · see citing works
Ghanizadeh, A. J., Singh, A., Berk, M., & Nami, M. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2015.1019866 · Cited by 24 · see citing works
Korkmaz, Ş. A., Kızgın, S., Oğuz, E. F., Neşelioğlu, S., & Erel, Ö. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.07.079 · Cited by 24 · see citing works
O’Donnell, C. M., Barrett, D. W., O’Connor, P., & Gonzalez-Lima, F. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1268955 · Cited by 22 · see citing works
Sheffield, Z., Paul, P., Krishnakumar, S., & Pan, D. (2024) · Advanced Science · doi:10.1002/advs.202411339 · Cited by 24 · see citing works
Forlenza, O. V., Coutinho, A. M., Aprahamian, I., Prando, S., Mendes, L. L., Diniz, B. S., Gattaz, W. F., & Buchpiguel, C. A. (2014) · ACS Chemical Neuroscience · doi:10.1021/cn5000315 · Cited by 22 · see citing works
Self-citationVošahlíková, M., Roubalová, L., Cechová, K., Kaufman, J., Musil, S., Mikšı́k, I., Alda, M., & Svoboda, P. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109953 · Cited by 22 · see citing works
Comorbid Bipolar Disorder and Migraine: From Mechanisms to Treatment
Duan, J., Yang, R., Lu, W., Zhao, L., Hu, S., & Hu, C. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.560138 · Cited by 22 · see citing works
Arent, C. O., Valvassori, S. S., Steckert, A. V., Resende, W. R., Dal-Pont, G. C., Lopes-Borges, J., Amboni, R. T., Bianchini, G., & Quevedo, J. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.04.011 · Cited by 21 · see citing works
Inhibition of GSK-3β on Behavioral Changes and Oxidative Stress in an Animal Model of Mania
Dal-Pont, G. C., Resende, W. R., Varela, R. B., Menegas, S., Trajano, K. S., Peterle, B. R., Quevedo, J., & Valvassori, S. S. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1226-2 · Cited by 21 · see citing works
Chitty, K. M., Lagopoulos, J., Hickie, I. B., & Hermens, D. F. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.01.021 · Cited by 20 · see citing works
Menegas, S., Dal-Pont, G. C., Cararo, J. H., Varela, R. B., Aguiar‐Geraldo, J. M., Della, T. P., Andersen, M. L., Quevedo, J., & Valvassori, S. S. (2019) · Metabolic Brain Disease · doi:10.1007/s11011-019-00503-3 · Cited by 20 · see citing works
GLP-1 agonist liraglutide improves ouabain-induced mania and depressive state via GSK-3β pathway
Çiçekli, M. N., Tiryaki, E. S., Altun, A., & Günaydın, C. (2022) · Journal of Receptors and Signal Transduction · doi:10.1080/10799893.2022.2032747 · Cited by 20 · see citing works
Inter‐relation between brain‐derived neurotrophic factor and antioxidant enzymes in bipolar disorder
Mansur, R. B., Santos, C. M., Rizzo, L. B., da Cunha, G. R., Asevedo, E. D. M., Noto, M. N., Pedrini, M., Zeni‐Graiff, M., Cordeiro, Q., McIntyre, R. S., et al. (2016) · Bipolar Disorders · doi:10.1111/bdi.12418 · Cited by 19 · see citing works
Lv, Q., Guo, Y., Zhu, M., Geng, R., Cheng, X., Bao, C., Wang, Y., Huang, X., Zhang, C., Hao, Y., et al. (2019) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2019.1663929 · Cited by 19 · see citing works
The immunomodulatory effect of lithium as a mechanism of action in bipolar disorder
Szałach, Ł. P., Lisowska, K. A., Cubała, W. J., Barbuti, M., & Perugi, G. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1213766 · Cited by 18 · see citing works
Chitty, K. M., Lagopoulos, J., Hickie, I. B., & Hermens, D. F. (2014) · Clinical Neurophysiology · doi:10.1016/j.clinph.2014.09.025 · Cited by 18 · see citing works
Gawlik-Kotelnicka, O., Mielicki, W. P., Rabe‐Jabłońska, J., Lazarek, J., & Strzelecki, D. (2015) · Acta Neuropsychiatrica · doi:10.1017/neu.2015.47 · Cited by 18 · see citing works
Intracellular Signaling Cascades in Bipolar Disorder
Jones, G. H., Rong, C., Shariq, A. S., Mishra, A. P., & Machado‐Vieira, R. (2020) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_157 · Cited by 18 · see citing works
Self-citationRegulation of Mitochondrial Dynamics in Parkinson’s Disease—Is 2-Methoxyestradiol a Missing Piece?
Bastian, P., Dulski, J., Roszmann, A., Jacewicz, D., Kuban‐Jankowska, A., Sławek, J. W., Woźniak, M., & Górska‐Ponikowska, M. (2021) · Antioxidants · doi:10.3390/antiox10020248 · Cited by 17 · see citing works
Atagün, M. İ., & Canbek, Ö. (2021) · ALPHA PSYCHIATRY · doi:10.5152/alphapsychiatry.2021.21584 · Cited by 17 · see citing works
Malondialdehyde and bipolar disorder: A short comprehensive review of available literature
Caldiroli, A., Auxilia, A. M., Capuzzi, E., Clerici, M., & Buoli, M. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.05.001 · Cited by 16 · see citing works
Impaired coronary microvascular reactivity in youth with bipolar disorder
Kennedy, K. G., Ghugre, N. R., Roifman, I., Qi, X., Saul, K., McCrindle, B. W., Macgowan, C. K., MacIntosh, B. J., & Goldstein, B. I. (2023) · Psychological Medicine · doi:10.1017/s0033291723003021 · Cited by 15 · see citing works
The Protective Influence of Selenium on Oxidant Disturbances in Brain of Rats Exposed to Lithium
Kiełczykowska, M., Kocot, J., Lewandowska, A., Żelazowska, R., & Musik, I. (2015) · Physiological Research · doi:10.33549/physiolres.932910 · Cited by 15 · see citing works
Cao, T., Xu, B., Li, S., Qiu, Y., Chen, J., Wu, H., & Cai, H. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03367-7 · Cited by 14 · see citing works
Dal-Pont, G. C., Resende, W. R., Bianchini, G., Gava, F. F., Peterle, B. R., Trajano, K. S., Varela, R. B., Quevedo, J., & Valvassori, S. S. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.03.020 · Cited by 14 · see citing works
Emerging Drugs and Indications for Cardio-Metabolic Disorders in People with Severe Mental Illness
Kouidrat, Y., Amad, A., & Binder, M. D. (2015) · Current Pharmaceutical Design · doi:10.2174/1381612821666150619093128 · Cited by 14 · see citing works
- Authors
- de Sousa, R. T., Zarate, C. A., Zanetti, M. V., Costa, A. C., Talib, L. L., Gattaz, W. F., & Machado-Vieira, R.
- Affiliations
- National Institutes of Health (US)
- Universidade de São Paulo (BR)
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 50
- Pages
- 36-41
- ISSN
- 0022-3956 (ISSN-L)
- PMC
- PMC4052827
- OpenAlex
- W2085273391
- Cited by
- 169
- References
- 69
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 15 · 2023: 9 · 2022: 10 · 2021: 16 · 2020: 19 · 2019: 12 · 2018: 11 · 2017: 10 · 2016: 22 · 2015: 15 · 2014: 15 · 2012: 1
- FWCI
- 12.28
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Associação Beneficente Alzira Denise Hertzog da Silva (ABADHS)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- bipolar disorder, oxidative stress, lithium, bipolar depression, lipid peroxidation, antioxidant enzymes, superoxide dismutase, catalase, glutathione peroxidase, treatment response, biomarkers
- MeSH terms
- Adult, Bipolar Disorder, Catalase, Depression, Female, Glutathione Peroxidase, Humans, Male, Superoxide Dismutase, Time Factors, Lithium Carbonate, Treatment Outcome, Thiobarbituric Acid Reactive Substances, Oxidative Stress, Antimanic Agents
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