The DOI matches its Crossref record; 1,341 of the 1,341 references it cites were found in a registry or an index.
Retinoic acid receptors: From molecular mechanisms to cancer therapy
Abstract
Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum of pleiotropic effects in cell growth and differentiation that are relevant for embryonic development and adult physiology. The RA activity is mediated primarily by members of the retinoic acid receptor (RAR) subfamily, namely RARα, RARβ and RARγ, which belong to the nuclear receptor (NR) superfamily of transcription factors. RARs form heterodimers with members of the retinoid X receptor (RXR) subfamily and act as ligand-regulated transcription factors through binding specific RA response elements (RAREs) located in target genes promoters. RARs also have non-genomic effects and activate kinase signaling pathways, which fine-tune the transcription of the RA target genes. The disruption of RA signaling pathways is thought to underlie the etiology of a number of hematological and non-hematological malignancies, including leukemias, skin cancer, head/neck cancer, lung cancer, breast cancer, ovarian cancer, prostate cancer, renal cell carcinoma, pancreatic cancer, liver cancer, glioblastoma and neuroblastoma. Of note, RA and its derivatives (retinoids) are employed as potential chemotherapeutic or chemopreventive agents because of their differentiation, anti-proliferative, pro-apoptotic, and anti-oxidant effects. In humans, retinoids reverse premalignant epithelial lesions, induce the differentiation of myeloid normal and leukemic cells, and prevent lung, liver, and breast cancer. Here, we provide an overview of the biochemical and molecular mechanisms that regulate the RA and retinoid signaling pathways. Moreover, mechanisms through which deregulation of RA signaling pathways ultimately impact on cancer are examined. Finally, the therapeutic effects of retinoids are reported.
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“To decrease the toxicity of the natural retinoids as well as to increase their stability and selectivity against a specific RAR subtype, several semi-synthetic and synthetic retinoids (including “atypical retinoids”) have been developed29,30.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [30]
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“At least four molecules have reached phase 4 clinical trials: bexarotene, tazarotene, adapalene, and trifarotene29–31.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [30]
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1 retracted
Items 201–400 of 1,341
Function of retinoic acid receptor γ in the mouse
Lohnes, D., Kastner, P., Dierich, A., Mark, M. P., LeMeur, M., & Chambon, P. (1993) · Cell · doi:10.1016/0092-8674(93)90246-m · Cited by 598
Vitamin A in Health and Disease
Blomhoff, R. (1994) · CRC Press eBooks · doi:10.1201/9781482277562 · Cited by 597
Sir2 Regulates Skeletal Muscle Differentiation as a Potential Sensor of the Redox State
Fulco, M., Schiltz, R. L., Iezzi, S., King, M. T., Zhao, P., Kashiwaya, Y., Hoffman, E. P., Veech, R. L., & Sartorelli, V. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00226-0 · Cited by 591
Baek, S. H., Ohgi, K., Rose, D., Koo, E., Glass, C., & Rosenfeld, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00809-7 · Cited by 591
Lundblad, J. R., Kwok, R. P. S., Laurance, M. E., Harter, M. L., & Goodman, R. H. (1995) · Nature · doi:10.1038/374085a0 · Cited by 588
Sirtuins: Sir2-related NAD-dependent protein deacetylases.
North, B. J., & Verdin, E. M. (2004) · Genome biology · doi:10.1186/gb-2004-5-5-224 · Cited by 586
Perissi, V., Aggarwal, A. K., Glass, C. K., Rose, D. W., & Rosenfeld, M. G. (2004) · Cell · doi:10.1016/s0092-8674(04)00133-3 · Cited by 584
Shen, Z., Shi, Z., Fang, J., Gu, B.-W., Li, J., Zhu, Y., Shi, J., Zheng, P., Yan, H., Liu, Y., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400053101 · Cited by 583
RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2
Li, H., Gomes, P. J., & Chen, J. D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.16.8479 · Cited by 583
Progress in molecular-based management of differentiated thyroid cancer
Xing, M., Haugen, B. R., & Schlumberger, M. J. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60109-9 · Cited by 576
Cheung, Y.-T., Lau, W. K.-W., Yu, M.-S., Lai, C. S.-W., Yeung, S.-C., So, K.-F., & Chang, R. C.-C. (2009) · NeuroToxicology · doi:10.1016/j.neuro.2008.11.001 · Cited by 576
Molecular Genetics of Adult Acute Myeloid Leukemia: Prognostic and Therapeutic Implications
Marcucci, G., Haferlach, T., & Döhner, H. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.30.2554 · Cited by 575
Dollé, P., Ruberte, E., Leroy, P., Morriss‐Kay, G. M., & Chambon, P. (1990) · Development · doi:10.1242/dev.110.4.1133 · Cited by 574
Prevention of Skin Cancer in Xeroderma Pigmentosum with the Use of Oral Isotretinoin
Kraemer, K. H., DiGiovanna, J. J., Moshell, A. N., Tarone, R. E., & Peck, G. L. (1988) · New England Journal of Medicine · doi:10.1056/nejm198806233182501 · Cited by 574
High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice.
Lufkin, T., Lohnes, D., Mark, M., Dierich, A., Gorry, P., Gaub, M., Lemeur, M., & Chambon, P. (1993) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.90.15.7225 · Cited by 573
Näär, A. M., Boutin, J. A., Lipkin, S. M., Yu, V. C. K., Holloway, J. M., Glass, C. K., & Rosenfeld, M. G. (1991) · Cell · doi:10.1016/0092-8674(91)90021-p · Cited by 568
Breitman, T. R., Collins, S., & Keene, B. R. (1981) · Blood · doi:10.1182/blood.v57.6.1000.1000 · Cited by 567
Distinct Lineage Specification Roles for NANOG, OCT4, and SOX2 in Human Embryonic Stem Cells
Wang, Z., Oron, E., Nelson, B., Razis, S., & Ivanova, N. B. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.02.016 · Cited by 565
Retinoic acid and thyroid hormone induce gene expression through a common responsive element
Umesono, K., Giguère, V., Glass, C. K., Rosenfeld, M. G., & Evans, R. M. (1988) · Nature · doi:10.1038/336262a0 · Cited by 554
Polarity-specific activities of retinoic acid receptors determined by a co-repressor
Kurokawa, R., Söderström, M., Hörlein, A., Halachmi, S., Brown, M. A., Rosenfeld, M. G., & Glass, C. K. (1995) · Nature · doi:10.1038/377451a0 · Cited by 550
Douarin, B. L., Nielsen, A. L., Garnier, J., Ichinose, H., Jeanmougin, F., Losson, R., & Chambon, P. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01060.x · Cited by 544
A Hierarchy of Self-Renewing Tumor-Initiating Cell Types in Glioblastoma
Chen, R., Nishimura, M. C., Bumbaca, S., Kharbanda, S., Forrest, W. F., Kasman, I. M., Greve, J. M., Soriano, R. H., Gilmour, L. L., Rivers, C. S., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.12.049 · Cited by 544
Retinoic acid treatment abrogates elastase-induced pulmonary emphysema in rats
Massaro, G. D. C., & Massaro, D. J. (1997) · Nature Medicine · doi:10.1038/nm0697-675 · Cited by 536
A Microenvironment-Induced Myeloproliferative Syndrome Caused by Retinoic Acid Receptor γ Deficiency
Walkley, C. R., Olsen, G. H., Dworkin, S., Fabb, S. A., Swann, J. B., McArthur, G. A., Westmoreland, S. V., Chambon, P., Scadden, D. T., & Purton, L. E. (2007) · Cell · doi:10.1016/j.cell.2007.05.014 · Cited by 535
Xu, J., Liao, L., Ning, G., Yoshida‐Komiya, H., Deng, C., & O’Malley, B. W. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.120166297 · Cited by 534
Treatment of acute myelocytic leukemia: a study by cancer and leukemia group B
Rai, K., Holland, J., Glidewell, O. J., Weinberg, V. E., Brunner, K. W., Obrecht, J., Preisler, H., Nawabi, I., Prager, D., Carey, R., et al. (1981) · Blood · doi:10.1182/blood.v58.6.1203.bloodjournal5861203 · Cited by 532
Deconstructing repression: evolving models of co-repressor action
Perissi, V., Jepsen, K., Glass, C. K., & Rosenfeld, M. G. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2736 · Cited by 532
Malignant melanoma: genetics and therapeutics in the genomic eraPreprint
Chin, L., Garraway, L. A., & Fisher, D. E. (2006) · Genes & Development · doi:10.1101/gad.1437206 · Cited by 524
Niederreither, K., McCaffery, P., Dräger, U. C., Chambon, P., & Dollé, P. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(96)00653-3 · Cited by 523
The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2
Krämer, O. H., Zhu, P., Ostendorff, H. P., Golebiewski, M., Tiefenbach, J., Peters, M. A., Brill, B., Groner, B., Bach, I., Heinzel, T., et al. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg315 · Cited by 523
Structure–function relationship of estrogen receptor α and β: Impact on human health
Ascenzi, P., Bocedi, A., & Marino, M. (2006) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2006.07.001 · Cited by 522
Self-citationThe SRC family of nuclear receptor coactivators
Leo, C., & Chen, J. D. (2000) · Gene · doi:10.1016/s0378-1119(00)00024-x · Cited by 519
RAR and RXR modulation in cancer and metabolic disease
Altucci, L., Leibowitz, M. D., Ogilvie, K. M., de Lera, A. R., & Gronemeyer, H. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2397 · Cited by 517
Ruberte, E., Dollé, P., Chambon, P., & Morriss‐Kay, G. M. (1991) · Development · doi:10.1242/dev.111.1.45 · Cited by 516
Molecular determinants of nuclear receptor-corepressor interactionPreprint
Perissi, V., Staszewski, L. M., McInerney, E. M., Kurokawa, R., Krones, A., Rose, D. W., L., L. M., Milburn, M. V., Glass, C. K., & Rosenfeld, M. G. (1999) · Genes & Development · doi:10.1101/gad.13.24.3198 · Cited by 514
Advanced Nutrition and Human Metabolism
Maroto, M. (2022) · Journal of Nutrition Education and Behavior · doi:10.1016/j.jneb.2022.02.001 · Cited by 513
Controlling nuclear receptors: the circular logic of cofactor cycles
Perissi, V., & Rosenfeld, M. G. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1680 · Cited by 507
CONTROL OF TRANSLATION INITIATION IN ANIMALS
Gray, N. K., & Wickens, M. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.399 · Cited by 500
Schüle, R., Umesono, K., Mangelsdorf, D. J., Bolado, J., Pike, J. W., & Evans, R. M. (1990) · Cell · doi:10.1016/0092-8674(90)90531-i · Cited by 498
International Union of Pharmacology. LXIII. Retinoid X receptors
Germain, P., Chambon, P., Eichele, G., Evans, R. M., Lazar, M. A., Leid, M., De Lera, A. R., Lotan, R., Mangelsdorf, D. J., & Gronemeyer, H. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.4.7 · Cited by 496
Severe Anemia in Malawian Children
Calis, J. C. J., Phiri, K. S., Faragher, E. B., Brabin, B. J., Bates, I., Cuevas, L. E., de Haan, R. J., Phiri, A., Malange, P., Khoka, M., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa072727 · Cited by 494
The genesis and evolution of homeobox gene clusters
García‐Fernàndez, J. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1723 · Cited by 490
Acute promyelocytic leukaemia: novel insights into the mechanisms of cure
de Thé, H., & Zhu, C. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2943 · Cited by 490
Topical Tretinoin Improves Photoaged Skin
Weiss, J. (1988) · JAMA · doi:10.1001/jama.1988.03720040019020 · Cited by 490
A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness
Guenther, M. G., Lane, W. S., Fischle, W., Verdin, E., Lazar, M. A., & Shiekhattar, R. (2000) · Genes & Development · doi:10.1101/gad.14.9.1048 · Cited by 489
WW and SH3 domains, two different scaffolds to recognize proline‐rich ligands
Macías, M. J., Wiesner, S., & Sudol, M. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)03290-2 · Cited by 488
Hormonal, cellular, and molecular control of prostatic development
Marker, P. C., Donjacour, A. A., Dahiya, R., & Cunha, G. R. (2003) · Developmental Biology · doi:10.1016/s0012-1606(02)00031-3 · Cited by 488
Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family
Xu, J., Wu, R., & O’Malley, B. W. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2695 · Cited by 487
Smith, M. A., Parkinson, D. R., Cheson, B. D., & Friedman, M. A. (1992) · Journal of Clinical Oncology · doi:10.1200/jco.1992.10.5.839 · Cited by 483
A Clinical Trial of Beta Carotene to Prevent Basal-Cell and Squamous-Cell Cancers of the Skin
Greenberg, E. R., Baron, J. A., Stukel, T. A., Stevens, M. M., Mandel, J. S., Spencer, S. K., Elias, P. M., Lowe, N., Nierenberg, D. W., Bayrd, G., et al. (1990) · New England Journal of Medicine · doi:10.1056/nejm199009203231204 · Cited by 482
Glass, C. K., Lipkin, S. M., Devary, O. V., & Rosenfeld, M. G. (1989) · Cell · doi:10.1016/0092-8674(89)90016-0 · Cited by 478
Radu, A., Moore, M. S., & Blobel, G. (1995) · Cell · doi:10.1016/0092-8674(95)90331-3 · Cited by 477
BCoR, a novel corepressor involved in BCL-6 repressionPreprint
Huynh, K. D., Fischle, W., Verdin, E. M., & Bardwell, V. J. (2000) · Genes & Development · doi:10.1101/gad.14.14.1810 · Cited by 475
Dollé, P., Ruberte, E., Kastner, P., Petkovich, M. P., Stoner, C. M., Gudas, L. J., & Chambon, P. (1989) · Nature · doi:10.1038/342702a0 · Cited by 474
Mandelli, F., Diverio, D., Avvisati, G., Luciano, A., Barbui, T., Bernasconi, C., Broccia, G., Cerri, R., Falda, M., Fioritoni, G., et al. (1997) · PubMed · doi:10.1182/blood.v90.3.1014 · Cited by 472
Characterization of a Zinc Finger Gene Disrupted by the t(15;17) in Acute Promyelocytic Leukemia
Goddard, A. D., Borrow, J., Freemont, P. S., et al. (1991) · Science · doi:10.1126/science.1720570 · Cited by 472
Garcia‐Manero, G., Kantarjian, H. M., Sánchez‐González, B., Yang, H., Rosner, G. L., Verstovšek, S., Rytting, M., Wierda, W. G., Ravandi, F., Koller, C. A., et al. (2006) · Blood · doi:10.1182/blood-2006-03-009142 · Cited by 470
Histone Deacetylase Is a Target of Valproic Acid-Mediated Cellular Differentiation
Gurvich, N., Tsygankova, O. M., Meinkoth, J. L., & Klein, P. S. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-0799 · Cited by 470
Hager, G. L., McNally, J. G., & Misteli, T. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.09.005 · Cited by 469
PML protein isoforms and the RBCC/TRIM motif
Jensen, K., Shiels, C., & Freemont, P. S. (2001) · Oncogene · doi:10.1038/sj.onc.1204765 · Cited by 465
A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1
Marshall, H., Studer, M., Pöpperl, H., Aparicio, S. A. J. R., Kuroiwa, A., Brenner, S., & Krumlauf, R. K. (1994) · Nature · doi:10.1038/370567a0 · Cited by 452
Differentiation of mouse embryonic stem cells into a defined neuronal lineage
Bibel, M., Richter, J., Schrenk, K., Tucker, K. L., Staiger, V., Korte, M., Goetz, M., & Barde, Y.-A. (2004) · Nature Neuroscience · doi:10.1038/nn1301 · Cited by 450
Goss, A., Tian, Y., Tsukiyama, T., Cohen, E. D., Zhou, D. D., Lu, M. M., Yamaguchi, T. P., & Morrisey, E. E. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.06.005 · Cited by 447
Yoon, H., Chan, D. W., Huang, Z., Li, J., Fondell, J. D., Qin, J., & Wong, J. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg120 · Cited by 444
Hepatic stellate cell lipid droplets: A specialized lipid droplet for retinoid storage
Blaner, W. S., O'Byrne, S. M., Wongsiriroj, N., Kluwe, J., D'Ambrosio, D. M., Jiang, H., Schwabe, R. F., Hillman, E. M. C., Piantedosi, R., & Libien, J. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2008.11.001 · Cited by 444
PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression.
Liu, W., Tanasa, B., Tyurina, O. V., Zhou, T. Y., Gassmann, R., Liu, W. T., Ohgi, K. A., Benner, C., Garcia-Bassets, I., Aggarwal, A. K., et al. (2010) · Nature · doi:10.1038/nature09272 · Cited by 441
Redner, R., Rush, E., Faas, S. J., Rudert, W. A., & Corey, S. (1996) · Blood · doi:10.1182/blood.v87.3.882.bloodjournal873882 · Cited by 437
The Human Tumor Antigen PRAME Is a Dominant Repressor of Retinoic Acid Receptor Signaling
Epping, M. T., Wang, L., Edel, M. J., Carlée, L., Hernandez, M., & Bernards, R. (2005) · Cell · doi:10.1016/j.cell.2005.07.003 · Cited by 432
Kastner, P., Mark, M. P., Ghyselinck, N. B., Krężel, W., Dupé, V., Grondona, J. M., & Chambon, P. (1997) · Development · doi:10.1242/dev.124.2.313 · Cited by 429
Zhu, J., Koken, M. H. M., Quignon, F., Chelbi‐Alix, M. K., Degos, L., Wang, Z. Y., Chen, Z., & de Thé, H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.3978 · Cited by 426
Molecular mechanisms of retinoid actions in skin
Fisher, G. J., & Voorhees, J. J. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.9.8801161 · Cited by 425
Hu, J., Liu, Y.-F., Wu, C.-F., Xu, F., Shen, Z.-X., Zhu, Y., Li, J., Tang, W., Zhao, W.-L., Wu, W., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813280106 · Cited by 425
Isolation of male embryonal carcinoma cells and their chromosome replication patterns
McBurney, M. W., & Rogers, B. J. (1982) · Developmental Biology · doi:10.1016/0012-1606(82)90338-4 · Cited by 423
Retinoid-binding proteins: mediators of retinoid action
NOY, N. (2000) · Biochemical Journal · doi:10.1042/bj3480481 · Cited by 422
Froeling, F. E. M., Feig, C., Chelala, C., Dobson, R., Mein, C. A., Tuveson, D. A., Clevers, H. C., Hart, I. R., & Kocher, H. M. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.06.047 · Cited by 421
Embryonic retinoic acid synthesis is essential for heart morphogenesis in the mouse
Niederreither, K., Vermot, J., Messaddeq, N., Schuhbaur, B., Chambon, P., & Dollé, P. (2001) · Development · doi:10.1242/dev.128.7.1019 · Cited by 418
Veronesi, U., Palo, G. D., Marubini, E., Costa, A. C., Formelli, F., Mariani, L., DeCensi, A., Camerini, T., Turco, M. R. D., Mauro, M. G. D., et al. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.21.1847 · Cited by 418
Crystal Structure of a Heterodimeric Complex of RAR and RXR Ligand-Binding Domains
Bourguet, W., Vivat, V., Wurtz, J., Chambon, P., Gronemeyer, H., & Moras, D. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80424-4 · Cited by 417
International Union of Pharmacology. LX. Retinoic Acid Receptors
Germain, P., Chambon, P., Gregor Eichele, C., Evans, R. M., Lazar, M. A., Leid, M. E., de Lera, Á. R., Lotan, R., Mangelsdorf, D. J., & Gronemeyer, H. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.4.4 · Cited by 416
Kastner, P., Perez, A., Lutz, Y., Rochette‐Egly, C., Gaub, M. P., Durand, B., Lanotte, M., Berger, R., & Chambon, P. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05095.x · Cited by 415
Self-citationMrózek, K., Marcucci, G., Nicolet, D., Maharry, K. S., Becker, H., Whitman, S. P., Metzeler, K. H., Schwind, S., Wu, Y.-Z., Kohlschmidt, J., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2012.43.4738 · Cited by 415
Early death rate in acute promyelocytic leukemia remains high despite all-trans retinoic acid
Park, J. H., Qiao, B., Panageas, K. S., Schymura, M. J., Jurcic, J. G., Rosenblat, T. L., Altman, J. K., Douer, D., Rowe, J. M., & Tallman, M. S. (2011) · Blood · doi:10.1182/blood-2011-04-346437 · Cited by 409
Vitamin A and retinoid signaling: genomic and nongenomic effects
Al Tanoury, Z., Piskunov, A., & Rochette-Egly, C. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r030833 · Cited by 408
Self-citationMuindi, J. R., Frankel, S., Miller, W. J., Jakubowski, A. A., Scheinberg, D., Cw, Y., Dmitrovsky, E., & Warrell, R. J. (1992) · Blood · doi:10.1182/blood.v79.2.299.bloodjournal792299 · Cited by 408
N-CoR Mediates DNA Methylation-Dependent Repression through a Methyl CpG Binding Protein Kaiso
Yoon, H.-G., Chan, D. W., Reynolds, A. B., Qin, J., & Wong, J. (2003) · Molecular Cell · doi:10.1016/j.molcel.2003.08.008 · Cited by 408
Dejean, A., Bougueleret, L., Grzeschik, K., & Tiollais, P. (1986) · Nature · doi:10.1038/322070a0 · Cited by 405
Lotan, R., Xu, X., Lippman, S. M., Ro, J. Y., Lee, J. S., Lee, J. J., & Hong, W. K. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505253322103 · Cited by 405
The B-DNA Dodecamer at High Resolution Reveals a Spine of Water on Sodium,
Shui, X., McFail-Isom, L., Hu, G. G., & Williams, L. D. (1998) · Biochemistry · doi:10.1021/bi973073c · Cited by 404
Wang, Z., Boudjelal, M., Kang, S., Voorhees, J. J., & Fisher, G. J. (1999) · Nature Medicine · doi:10.1038/10577 · Cited by 404
Baur, E. V., Zechel, C., Heery, D. M., Heine, M. J., Garnier, J., Vivat, V., Douarin, B. L., Gronemeyer, H., Chambon, P., & Losson, R. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00339.x · Cited by 403
Durand, B., Saunders, M., Leroy, P., Leid, M. E., & Chambon, P. (1992) · Cell · doi:10.1016/0092-8674(92)90267-g · Cited by 396
Differential expression and ligand regulation of the retinoic acid receptor alpha and beta genes.
de Thé, H., Marchio, A., Tiollais, P., & Dejean, A. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb03394.x · Cited by 394
MORTALITY IN ORAL CONTRACEPTIVE USERS
Vessey, M. P. (1981) · The Lancet · doi:10.1016/s0140-6736(81)92875-0 · Cited by 394
Soriano, A. O., Yang, H., Faderl, S. H., Estrov, Z. E., Giles, F. J., Ravandi, F., Cortes, J. E., Wierda, W. G., Ouzounian, S., Quezada, A., et al. (2007) · Blood · doi:10.1182/blood-2007-03-078576 · Cited by 394
Primary cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome)
Jawed, S. I., Myskowski, P. L., Horwitz, S. M., Moskowitz, A. J., & Querfeld, C. (2014) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2013.07.049 · Cited by 394
THE BIOLOGICAL FUNCTION OF VITAMIN A ACID.
Dowling, J., & Wald, G. (1960) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.46.5.587 · Cited by 393
Genetic Predisposition Directs Breast Cancer Phenotype by Dictating Progenitor Cell Fate
Proia, T. A., Keller, P. J., Gupta, P. B., Klebba, I., Jones, A. D., Sedic, M., Gilmore, H. L., Tung, N., Naber, S. P., Schnitt, S. J., et al. (2011) · Cell stem cell · doi:10.1016/j.stem.2010.12.007 · Cited by 393
van Zandwijk, N. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.12.977 · Cited by 393
THE NECESSITY OF CERTAIN LIPINS IN THE DIET DURING GROWTH
McCollum, E. V., & Davis, M. (1913) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)88553-2 · Cited by 390
Progesterone-binding Components of Chick Oviduct
Spelsberg, T. C., Steggles, A. W., & O’Malley, B. W. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62071-x · Cited by 390
Lippman, S. M., Parkinson, D. R., Itri, L. M., Weber, R. S., Schantz, S. P., Ota, D. M., Schusterman, M. A., Krakoff, I. H., Gutterman, J. U., & Hong, W. K. (1992) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/84.4.235 · Cited by 388
Estey, E. H., Garcia‐Manero, G., Ferrajoli, A., Faderl, S. H., Verstovšek, S., Jones, D. M., & Kantarjian, H. M. (2005) · Blood · doi:10.1182/blood-2005-10-4006 · Cited by 385
Retinoid pathway and cancer therapeutics
Bushue, N., & Wan, Y. Y. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.07.003 · Cited by 385
Crosstalk among Histone Modifications
Suganuma, T., & Workman, J. L. (2008) · Cell · doi:10.1016/j.cell.2008.10.036 · Cited by 385
Powell, B. L., Moser, B. K., Stock, W., Gallagher, R. E., Willman, C. L., Stone, R. M., Rowe, J. M., Coutre, S. E., Feusner, J. H., Gregory, J., et al. (2010) · Blood · doi:10.1182/blood-2010-02-269621 · Cited by 383
Zhao, Y., Lang, G., Ito, S., Bonnet, J., Metzger, E., Sawatsubashi, S., Suzuki, E., Le Guezennec, X., Stunnenberg, H. G., Krasnov, A., et al. (2008) · Molecular Cell · doi:10.1016/j.molcel.2007.12.011 · Cited by 382
Transcriptional regulation through Mediator-like coactivators in yeast and metazoan cells.
Malik, S., & Roeder, R. (2000) · TIBS -Trends in Biochemical Sciences. Regular ed · doi:10.1016/s0968-0004(00)01596-6 · Cited by 382
Leroy, P., Krust, A., Zelent, A., Mendelsohn, C. L., Garnier, J., Kastner, P., Dierich, A., & Chambon, P. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07921.x · Cited by 380
The histone deacetylase-3 complex contains nuclear receptor corepressors
Wen, Y.-D., Perissi, V., Staszewski, L. M., Yang, W.-M., Krones, A., Glass, C. K., Rosenfeld, M. G., & Seto, E. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.13.7202 · Cited by 378
Retinol and retinyl esters: biochemistry and physiology
O'Byrne, S. M., & Blaner, W. S. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r037648 · Cited by 378
Ravandi, F., Estey, E., Jones, D. M., Faderl, S. H., O'Brien, S. M., Fiorentino, J., Pierce, S. A., Blamble, D., Estrov, Z. E., Wierda, W. G., et al. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.18.6130 · Cited by 376
Takeshita, A., Cardona, G. R., Koibuchi, N., Suen, C. S., & Chin, W. W. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.44.27629 · Cited by 375
Developmental regulation of the Hox genes during axial morphogenesis in the mouse
Deschamps, J., & van Nes, J. (2005) · Development · doi:10.1242/dev.01897 · Cited by 375
Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity
van de Pavert, S. A., Ferreira, M., Domingues, R. G., Ribeiro, H., Molenaar, R., Moreira-Santos, L., Almeida, F. F., Ibiza, S., Barbosa, I., Goverse, G., et al. (2014) · Nature · doi:10.1038/nature13158 · Cited by 374
Zelent, A., Mendelsohn, C. L., Kastner, P., Krust, A., Garnier, J., Ruffenach, F., Leroy, P., & Chambon, P. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07922.x · Cited by 373
Interaction of proteins with transcriptionally active estrogen receptors.
Cavaillès, V., Dauvois, S., Danielian, P. S., & Parker, M. G. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.21.10009 · Cited by 373
Zhu, J., Gianni’, M., Kopf, E., Honoré, N., Chelbi‐Alix, M. K., Koken, M. H. M., Quignon, F., Rochette‐Egly, C., & de Thé, H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.14807 · Cited by 371
Self-citationNicholson, R. C., Mader, S., Nagpal, S., Leid, M. E., Rochette‐Egly, C., & Chambon, P. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07895.x · Cited by 369
Self-citationFunction of retinoic acid receptors during embryonic development
Mark, M., Ghyselinck, N. B., & Chambon, P. (2009) · Nuclear Receptor Signaling · doi:10.1621/nrs.07002 · Cited by 363
The super elongation complex (SEC) and MLL in development and diseasePreprint
Smith, E. R., Lin, C., & Shilatifard, A. (2011) · Genes & Development · doi:10.1101/gad.2015411 · Cited by 362
Degos, L., Dombret, H., Chomienne, C., Daniel, M., Micléa, J., Chastang, C., Castaigné, S., & Fenaux, P. (1995) · Blood · doi:10.1182/blood.v85.10.2643.bloodjournal85102643 · Cited by 361
Koh, S. S., Chen, D., Lee, Y., & Stallcup, M. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m004228200 · Cited by 360
Grimwade, D. J., Jovanovic, J. V., Hills, R. K., Nugent, E., Patel, Y., Flora, R., Diverio, D., Jones, K., Aslett, H., Batson, E., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.20.1533 · Cited by 356
Self-citationRelation of Serum Vitamins a and E and Carotenoids to the Risk of Cancer
Willett, W. C., Polk, B. F., Underwood, B. A., Stampfer, M. J., Pressel, S., ROSNER, B. A., Taylor, J. O., Schneider, K. A., & Hames, C. G. (1984) · New England Journal of Medicine · doi:10.1056/nejm198402163100705 · Cited by 356
Promoter Methylation and Silencing of the Retinoic Acid Receptor- Gene in Lung Carcinomas
Virmani, A. K., Rathi, A., Zöchbauer‐Müller, S., Sacchi, N., Fukuyama, Y., Bryant, D., Maitra, A., Heda, S., Fong, K. M., Thunnissen, E., et al. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.16.1303 · Cited by 355
Bertrand, S., Brunet, F., Escrivá, H., Parmentier, G., Laudet, V., & Robinson‐Rechavi, M. (2004) · Molecular Biology and Evolution · doi:10.1093/molbev/msh200 · Cited by 353
Giordano, S. H., Temin, S., Kirshner, J. J., Chandarlapaty, S., Crews, J. R., Davidson, N. E., Esteva, F. J., Gonzalez-Angulo, A. M., Krop, I. E., Levinson, J., et al. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2013.54.0948 · Cited by 352
Adjuvant treatment of stage I lung cancer with high-dose vitamin A.
Pastorino, U., Infante, M. V., Maioli, M., Chiesa, G., Buyse, M. E., Firket, P., Rosmentz, N., Clerici, M., Soresi, E., & Valente, M. (1993) · Journal of Clinical Oncology · doi:10.1200/jco.1993.11.7.1216 · Cited by 350
Impaired Locomotion and Dopamine Signaling in Retinoid Receptor Mutant Mice
Krężel, W., Ghyselinck, N. B., Samad, T. A., Dupé, V., Kastner, P., Borrelli, E., & Chambon, P. (1998) · Science · doi:10.1126/science.279.5352.863 · Cited by 349
Ruberte, E., Dollé, P., Krust, A., Zelent, A., Morriss‐Kay, G. M., & Chambon, P. (1990) · Development · doi:10.1242/dev.108.2.213 · Cited by 349
Primary cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome)
Jawed, S. I., Myskowski, P. L., Horwitz, S. M., Moskowitz, A. J., & Querfeld, C. (2014) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2013.08.033 · Cited by 349
Hepatic Vitamin A Depletion in Alcoholic Liver Injury
Leo, M. A., & Lieber, C. S. (1982) · New England Journal of Medicine · doi:10.1056/nejm198209023071006 · Cited by 345
Licht, J. D., Chomienne, C., Goy, A. H., Chen, A., Scott, A. A., Head, D. R., Jl, M., Wu, Y., DeBlasio, A., & Miller, W. H. (1995) · Blood · doi:10.1182/blood.v85.4.1083.bloodjournal8541083 · Cited by 343
Lehmann, S., Landtblom, A. R., Carlsson, L., Antunović, P., Deneberg, S., Möllgård, L., Derolf, Å. R., Stockelberg, D., Tidefelt, U., Wåhlin, A., et al. (2011) · Leukemia · doi:10.1038/leu.2011.78 · Cited by 343
Shao, W., Fanelli, M., Ferrara, F. F., Riccioni, R., Rosenauer, A., Davison, K. L., Lamph, W. W., Waxman, S., Pelicci, P. G., Lo‐Coco, F., et al. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.2.124 · Cited by 342
Self-citationBoehm, M. F., Zhang, L., Zhi, L., McClurg, M. R., Berger, E. M., WAGONER, M., Mais, D. E., Suto, C. M., Davies, P. J. A., Heyman, R. A., et al. (1995) · Journal of Medicinal Chemistry · doi:10.1021/jm00016a018 · Cited by 342
Altucci, L., Rossin, A., Raffelsberger, W., Reitmair, A., Chomienne, C., & Gronemeyer, H. (2001) · Nature Medicine · doi:10.1038/89050 · Cited by 340
Mathews, V., George, B., Lakshmi, K. M., Viswabandya, A., Bajel, A. R., Balasubramanian, P., Velayudhan, S. R., Srivastava, V. M., Srivastava, A., & Chandy, M. (2005) · Blood · doi:10.1182/blood-2005-08-3532 · Cited by 340
Shimeld, S. M., & Holland, P. W. H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.9.4449 · Cited by 339
Physiological insights into all-trans-retinoic acid biosynthesis
Napoli, J. L. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.05.004 · Cited by 338
Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma
Campbell, J. S., Hughes, S. D., Gilbertson, D. G., Palmer, T. E., Holdren, M. S., Haran, A. C., Odell, M. M., Bauer, R. L., Ren, H.-P., Haugen, H. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409722102 · Cited by 337
In vivo functional analysis of the Hoxa-1 3′ retinoic acid response element (3′ RARE)
Dupé, V., Davenne, M., Brocard, J., Dollé, P., Mark, M. P., Dierich, A., Chambon, P., & Rijli, F. M. (1997) · Development · doi:10.1242/dev.124.2.399 · Cited by 335
Nagpal, S., Saunders, M., Kastner, P., Durand, B., Nakshatri, H., & Chambon, P. (1992) · Cell · doi:10.1016/0092-8674(92)90250-g · Cited by 332
PML/RARA Oxidation and Arsenic Binding Initiate the Antileukemia Response of As2O3
Jeanne, M., Lallemand-Breitenbach, V., Ferhi, O., Koken, M. H. M., Bras, M. L., Duffort, S., Pérès, L., Berthier, C., Soilihi, H., Raught, B., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.06.003 · Cited by 332
Lo‐Coco, F., Avvisati, G., Vignetti, M., Breccia, M., Gallo, E., Rambaldi, A., Paoloni, F. P., Fioritoni, G., Ferrara, F., Specchia, G., et al. (2010) · Blood · doi:10.1182/blood-2010-03-276196 · Cited by 331
Self-citationThe Role of Corepressors in Transcriptional Regulation by Nuclear Hormone Receptors
Privalsky, M. L. (2004) · Annual Review of Physiology · doi:10.1146/annurev.physiol.66.032802.155556 · Cited by 330
Shen, Y., Zhu, Y., Fan, X., Shi, J.-Y., Wang, Q., Yan, X., Gu, Z., Wang, Y., Chen, B., Jiang, C.-L., et al. (2011) · Blood · doi:10.1182/blood-2011-03-343988 · Cited by 329
Liu, Y., Lee, M., Wang, H., Li, Y., Hashimoto, Y., Klaus, M., Reed, J. C., & Zhang, X.-K. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.3.1138 · Cited by 329
Surface Antigens Common to Mouse Cleavage Embryos and Primitive Teratocarcinoma Cells in Culture
Artzt, K., Dubois, P., Bennett, D., et al. (1973) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.70.10.2988 · Cited by 328
Iland, H. J., Bradstock, K. F., Supple, S. G., Catalano, A., Collins, M. L., Hertzberg, M., Browett, P., Grigg, A., Firkin, F. C., Hugman, A., et al. (2012) · Blood · doi:10.1182/blood-2012-02-410746 · Cited by 328
Maruyama, R., Toyooka, S., Toyooka, K. O., et al. (2002) · PubMed · Cited by 326
Hepatitis B virus, aflatoxins, and hepatocellular carcinoma in Southern Guangxi, China
Yeh, F.-S., Yu, M., Mo, C.-C., et al. (1990) · Health Policy · doi:10.1016/0168-8510(90)90389-u · Cited by 326
Huang, E. Y., Zhang, J., Miska, E. A., Guenther, M. G., Kouzarides, T., & Lazar, M. A. (2000) · Genes & Development · doi:10.1101/gad.14.1.45 · Cited by 326
Grimwade, D. J., Biondi, A., Mozziconacci, J., Hagemeijer, A., Berger, R., Neat, M. J., Howe, K. M., Dastugue, N., Jansen, J. H., Radford‐Weiss, I., et al. (2000) · PubMed · doi:10.1182/blood.v96.4.1297 · Cited by 325
Lippman, S. M., Lee, J. J., Karp, D. D., Vokes, E. E., Benner, S. E., Goodman, G. E., Khuri, F. R., Marks, R. S., Winn, R., Fry, W. A., et al. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.8.605 · Cited by 321
PML/RARα and FLT3-ITD induce an APL-like disease in a mouse model
Kelly, L. M., Kutok, J. L., Williams, I. R., Boulton, C. L., Amaral, S. M., Curley, D. P., Ley, T. J., & Gilliland, D. G. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122233699 · Cited by 320
Sidell, N., Altman, A., Haussler, M. R., & Seeger, R. C. (1983) · Experimental Cell Research · doi:10.1016/0014-4827(83)90184-2 · Cited by 318
Retinoids and retinoid-binding protein expression in rat adipocytes.
Tsutsumi, C., Okuno, M., Tannous, L., Piantedosi, R., Allan, M., Goodman, D. S., & Blaner, W. S. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)46017-6 · Cited by 317
Excessive Intake of Vitamin A as a Cause of Congenital Anomalies in the Rat
Cohlan, S. Q. (1953) · Science · doi:10.1126/science.117.3046.535 · Cited by 317
Muindi, J., Frankel, Sr., Miller, W. J., Jakubowski, A., Scheinberg, D., Young, C., Dmitrovsky, E., & Warrell, R. J. (1992) · Blood · doi:10.1182/blood.v79.2.299.299 · Cited by 314
Co-regulator recruitment and the mechanism of retinoic acid receptor synergy
Germain, P., Iyer, J., Zechel, C., & Gronemeyer, H. (2002) · Nature · doi:10.1038/415187a · Cited by 312
Differentiation Therapy Exerts Antitumor Effects on Stem-like Glioma Cells
Campos, B., Wan, F., Farhadi, M. R., Ernst, A., Zeppernick, F. A., Tagscherer, K. E., Ahmadi, R., Lohr, J., Dictus, C., Gdynia, G., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1800 · Cited by 310
Wärnmark, A., Treuter, E., Wright, A. P. H., & Gustafsson, J.-A. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0384 · Cited by 308
Cellular Retinoid-Binding Proteins
Ong, D. E. (1987) · Archives of Dermatology · doi:10.1001/archderm.1987.01660360140026 · Cited by 308
Rochette-Egly, C., Adam, S., Rossignol, M., Egly, J.-M., & Chambon, P. (1997) · Cell · doi:10.1016/s0092-8674(00)80317-7 · Cited by 308
Self-citationN-CoR controls differentiation of neural stem cells into astrocytes
Hermanson, O., Jepsen, K., & Rosenfeld, M. G. (2002) · Nature · doi:10.1038/nature01156 · Cited by 308
Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development
Qi, H. H., Sarkissian, M., Hu, G., Wang, Z., Bhattacharjee, A., Gordon, D. B., Gonzales, M., Lan, F., Ongusaha, P. P., Huarte, M., et al. (2010) · Nature · doi:10.1038/nature09261 · Cited by 305
Krug, U. O., Röllig, C., Koschmieder, A., Heinecke, A., Sauerland, M. C., Schaich, M. A., Thiede, C., Krämer, M., Braess, J., Spiekermann, K., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(10)62105-8 · Cited by 304
Manicassamy, S., Ravindran, R., Deng, J., Oluoch, H., Denning, T. L., Kasturi, S. P., Rosenthal, K. M., Evavold, B. D., & Pulendran, B. (2009) · Nature Medicine · doi:10.1038/nm.1925 · Cited by 303
Genomic Antagonism between Retinoic Acid and Estrogen Signaling in Breast Cancer
Hua, S., Kittler, R., & White, K. P. (2009) · Cell · doi:10.1016/j.cell.2009.04.043 · Cited by 301
Nagpal, S., Friant, S., Nakshatri, H., & Chambon, P. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05889.x · Cited by 300
A new world of Polycombs: unexpected partnerships and emerging functions
Schwartz, Y. B., & Pirrotta, V. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3603 · Cited by 299
Bollag, W. (1972) · European Journal of Cancer (1965) · doi:10.1016/0014-2964(72)90153-3 · Cited by 298
Murine isoforms of retinoic acid receptor gamma with specific patterns of expression.
Kastner, P., Krust, A., Mendelsohn, C. L., Garnier, J., Zelent, A., Leroy, P., Staub, A., & Chambon, P. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.7.2700 · Cited by 296
Vahdat, L. T., Maslak, P. G., Miller, W. J., Eardley, A., Heller, G., Scheinberg, D., & Warrell, R. J. (1994) · Blood · doi:10.1182/blood.v84.11.3843.bloodjournal84113843 · Cited by 294
Feeding experiments illustrating the importance of accessory factors in normal dietaries
Hopkins, F. G. (1912) · The Journal of Physiology · doi:10.1113/jphysiol.1912.sp001524 · Cited by 294
PMLRAR homodimers: distinct DNA binding properties and heteromeric interactions with RXR.
Perez, A., Kastner, P., Sethi, S., Lutz, Y., REIBEL, C., & Chambon, P. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05986.x · Cited by 292
Tissue distribution and metabolism of newly absorbed vitamin A in the rat
Goodman, D. S., Huang, H. S., & Shiratori, T. (1965) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39309-3 · Cited by 292
Nuclear receptors: integration of multiple signalling pathways through phosphorylation
Rochette-Egly, C. (2003) · Cellular Signalling · doi:10.1016/s0898-6568(02)00115-8 · Cited by 291
Self-citationIs there a code embedded in proteins that is based on post-translational modifications?
Sims, R. J., & Reinberg, D. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2502 · Cited by 289
Pandolfi, P. P., Grignani, F., Alcalay, M., et al. (1991) · PubMed · Cited by 289
Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects
di Masi, A., Marinis, E. D., Ascenzi, P., & Marino, M. (2009) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2009.04.002 · Cited by 288
Self-citationHamada, K., Gleason, S. L., Levi, B.-Z., Hirschfeld, S., Appella, E., & Ozato, K. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.21.8289 · Cited by 285
de Thé, H., Marchio, A., Tiollais, P., & Dejean, A. (1987) · Nature · doi:10.1038/330667a0 · Cited by 284
Oligomerization of RAR and AML1 Transcription Factors as a Novel Mechanism of Oncogenic Activation
Minucci, S., Maccarana, M., Cioce, M., Luca, P. D., Gelmetti, V., Segalla, S., Croce, L. D., Giavara, S., Matteucci, C., Gobbi, A., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80321-4 · Cited by 282
Self-citationThe RNA Polymerase II Machinery
Woychik, N. A., & Hampsey, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00646-3 · Cited by 281
Plzf regulates limb and axial skeletal patterning
Barna, M., Hawe, N., Niswander, L. A., & Pandolfi, P. P. (2000) · Nature Genetics · doi:10.1038/76014 · Cited by 279
Locking in stable states of gene expression: transcriptional control during Drosophila development
Simon, J. A. (1995) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(95)80093-x · Cited by 279
Retinoic acid signaling pathways in development and diseases
Das, B. C., Thapa, P., Karki, R., Das, S., Mahapatra, S., Liu, T.-C., Torregroza, I., Wallace, D. P., Kambhampati, S., Van Veldhuizen, P., et al. (2014) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2013.11.025 · Cited by 276
Wells, R. A., Catzavelos, C., & Kamel‐Reid, S. (1997) · Nature Genetics · doi:10.1038/ng0997-109 · Cited by 276
Plzf Regulates Germline Progenitor Self-Renewal by Opposing mTORC1
Hobbs, R. M., Seandel, M., Falciatori, I., Rafii, S., & Pandolfi, P. P. (2010) · Cell · doi:10.1016/j.cell.2010.06.041 · Cited by 275
Design of selective nuclear receptor modulators: RAR and RXR as a case study
de Lera, Á. R., Bourguet, W., Altucci, L., & Gronemeyer, H. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2398 · Cited by 272
Translocations, master genes, and differences between the origins of acute and chronic leukemias
Rabbitts, T. H. (1991) · Cell · doi:10.1016/0092-8674(91)90057-6 · Cited by 271
Dilworth, F. J., & Chambon, P. (2001) · Oncogene · doi:10.1038/sj.onc.1204329 · Cited by 269
Nup98 Is a Mobile Nucleoporin with Transcription-dependent Dynamics
Griffis, E. R., Altan, N., Lippincott‐Schwartz, J., et al. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-11-0538 · Cited by 268
Prevention of Second Primary Tumors by an Acyclic Retinoid in Patients with Hepatocellular Carcinoma
Muto, Y., Moriwaki, H., & Saito, A. M. (1999) · New England Journal of Medicine · doi:10.1056/nejm199904013401315 · Cited by 266
Pandolfi, P. P., Alcalay, M., Fagioli, M., Zangrilli, D., Mencarelli, A., Diverio, D., Biondi, A., Coco, F. L., Rambaldi, A., & Grignani, F. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05185.x · Cited by 266
Vellenga, E., Imhoff, G. W. V., & Aarnoudse, J. G. (1983) · The Lancet · doi:10.1016/s0140-6736(83)90209-x · Cited by 265
Joki, T., Heese, O., Nikas, D. C., Bello, L., Zhang, J., Kraeft, S., Seyfried, N. T., Abe, T., Chen, L. B., Carroll, R. S., et al. (2000) · PubMed · Cited by 265
Motzer, R. J., Murphy, B. A., Bacik, J., Schwartz, L. H., Nanus, D. M., Mariani, T. V., Loehrer, P. J., Wilding, G., Fairclough, D. L., Cella, D. F., et al. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.16.2972 · Cited by 264
Flagged first, then by citations
Research works printed but not linked: 11
- Delescluse, 1991, Selective high affinity retinoic acid receptor α or β-γ ligands, Mol. Pharmacol, 40, 556
- Fukutani, 1995, Isoforms of PML-retinoic acid receptor alpha fused transcripts affect neither clinical features of acute promyelocytic leukemia nor prognosis after treatment with all-trans retinoic acid, Leukemia, 9, 1478
- Funk, 1912, The etiology of the deficiency diseases, Beri-beri, polyneuritis in birds, epidemic dropsy, scurvy, experimental scurvy in animals, infantile scurvy, ship beri-beri, pellagra, J.State Med, XX, 341
- Grimwade, 2000, Blood, 96, 1297
- Maignan, 1987, Bicyclic naphthalenic derivatives, a process for their preparation and their use in pharmaceuticals and cosmetics, Eur. Pat. Appl, 220, 118
- Mandelli, 1997, Molecular remission in PML/RARα-positive acute promyelocytic leukemia by combined all-trans-retinoic acid and idarubicin (AIDA) therapy, Blood, 90, 1014
- Marasca, 1999, Missense mutations in the PML/RARα ligand binding domain in ATRA-resistant As2O3 sensitive relapsed acute promyelocytic leukemia, Haematologica, 84, 963
- Recchia, 2003, Low dose interleukin-2 and 13-cis-retinoic acid as maintenance therapy in patients with solid tumors responsive to chemotherapy, J. Exp. Clin. Cancer Res, 22, 135
- Sun, 1992, treated 32 cases of acute promyelocytic leukemia, Chin. J. Integrat. Chin. West. Med, 12, 170
- Thompson, 1997, Retinoic acid-responsive enhancers located 3′ of the hox A and hox B homeobox gene clusters. Functional analysis, J. Biol. Chem, 272, 2167, 10.1074/jbc.272.4.2167 · DOI
- Vogel, 1999, Retinoid uptake, metabolism and transport, vol. 139, 31
Cited by
Sorted by citations
Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine
Ferreira, R., Napoli, J., Enver, T., Bernardino, L., & Ferreira, L. (2020) · Nature Communications · doi:10.1038/s41467-020-18042-2 · Cited by 138
Regulation of RXR-RAR Heterodimers by RXR- and RAR-Specific Ligands and Their Combinations
le Maire, A., Teyssier, C., Balaguer, P., Bourguet, W., & Germain, P. (2019) · Cells · doi:10.3390/cells8111392 · Cited by 88
Melanoma Chemoprevention: Current Status and Future Prospects
Chhabra, G., Ndiaye, M. A., Garcia‐Peterson, L. M., & Ahmad, N. (2017) · Photochemistry and Photobiology · doi:10.1111/php.12749 · Cited by 51
Anti-tumour effects of all-trans retinoid acid on serous ovarian cancer
Lokman, N. A., Ho, R., Gunasegaran, K., Bonner, W. M., Oehler, M. K., & Ricciardelli, C. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-1017-7 · Cited by 39
Bama, E. S., Grace, V. M. B., Sundaram, V., & Jesubatham, P. D. (2019) · 3 Biotech · doi:10.1007/s13205-019-1692-x · Cited by 8
Metadata
- Authors
- di Masi, A., Leboffe, L., De Marinis, E., Pagano, F., Cicconi, L., Rochette-Egly, C., Lo-Coco, F., Ascenzi, P., & Nervi, C.
- Affiliations
- Roma Tre University (IT)
- Sapienza University of Rome (IT)
- University of Rome Tor Vergata (IT)
- Corresponding author
- Ascenzi, Paolo
- Nervi, Clara
- Venue
- Molecular Aspects of Medicine
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 41
- Pages
- 1-115
- ISSN
- 0098-2997 (ISSN-L)
- OpenAlex
- W2064402415
- Cited by
- 403
- References
- 1,341
- Citations by year
- 2026: 20 · 2025: 33 · 2024: 50 · 2023: 32 · 2022: 44 · 2021: 42 · 2020: 41 · 2019: 41 · 2018: 31 · 2017: 24 · 2016: 30 · 2015: 12
- FWCI
- 9.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Aspects of Medicine (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Iris (Roma Tre University) (submittedVersion)
- Funders
- Italian Association for Cancer Research
- Italian Foundation for Cancer Research (15142)
- University of Roma “La Sapienza”
- Fondazione Roma
- CNRS
- INSERM
- Agence Nationale pour la Recherche (ANR-05-BLAN-0390-02, ANR-09-BLAN-0297-01)
- Foundation pour la Recherche Medicale (DEQ20090515423)
- Institut National du Cancer (INCa-PLO7-96099, PL09-194)
- Association pour la Recherche sur le Cancer (3169, SL220110603474)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- retinoic acid receptor, retinoic acid signaling, retinoid X receptor, nuclear receptor superfamily, transcriptional regulation, non-genomic signaling, retinoids, cancer therapy, chemoprevention, leukemia, skin cancer, head and neck cancer, lung cancer, breast cancer, prostate cancer, differentiation therapy, apoptosis
- MeSH terms
- Retinoic Acid Receptor alpha, Retinoic Acid Receptor gamma, Animals, Antineoplastic Agents, Female, Humans, Male, Neoplasms, Tretinoin, Receptors, Retinoic Acid, Response Elements
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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