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Vitamin-related phenotypic adaptation to exposomal factors: The folate-vitamin D-exposome triad

Lucock, Mark·2022·Molecular Aspects of Medicine
DOI 10.1016/j.mam.2021.100944
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Abstract

The biological role of two key vitamins, folic acid and vitamin D is so fundamental to life processes, it follows that their UV sensitivity, dietary abundance (both key exposomal factors) and variability in dependent genes will modify their functional efficacy, particularly in the context of maintaining the integrity and function of genome and epigenome. This article therefore examines folate and vitamin D-related phenotypic adaptation to environmental factors which vary across the human life cycle as well as over an evolutionary time-scale. Molecular mechanisms, key nutrigenomic factors, phenotypic maladaptation and evolutionary models are discussed.

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Authors
Lucock, M.
ORCID
Lucock, Mark
Venue
Molecular Aspects of Medicine
Publisher
Elsevier BV
Published
2022-10
Volume
87
Pages
100944
ISSN
0098-2997
DOI
10.1016/j.mam.2021.100944
Cited by
7
References
9
Language
en
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