Fiber tractography reveals disruption of temporal lobe white matter tracts in schizophrenia

Phillips, Owen R.; Nuechterlein, Keith H.; Clark, Kristi A.; Hamilton, Liberty S.; Asarnow, Robert F.; Hageman, Nathan S.; Toga, Arthur W.; Narr, Katherine L.

doi:10.1016/j.schres.2008.10.019

Cited by 80Advanced Neuroimaging Techniques and ApplicationsSchizophrenia research and treatmentFunctional Brain Connectivity Studies

Fiber tractography reveals disruption of temporal lobe white matter tracts in schizophrenia

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Phillips, Owen R., Nuechterlein, Keith H., Clark, Kristi A., Hamilton, Liberty S., Asarnow, Robert F., Hageman, Nathan S., Toga, Arthur W., Narr, Katherine L.·2009·Schizophrenia Research

DOI 10.1016/j.schres.2008.10.019PMC PMC2655322

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Abstract

Diffusion tensor imaging (DTI) studies have demonstrated abnormal anisotropic diffusion in schizophrenia. However, examining data with low spatial resolution and/or a low number of gradient directions and limitations associated with analysis approaches sensitive to registration confounds may have contributed to mixed findings concerning the regional specificity and direction of results. This study examined three major white matter tracts connecting lateral and medial temporal lobe regions with neocortical association regions widely implicated in systems-level functional and structural disturbances in schizophrenia. Using DTIstudio, a previously validated regions of interest tractography method was applied to 30 direction diffusion weighted imaging data collected from demographically similar schizophrenia (n=23) and healthy control subjects (n=22). The diffusion tensor was computed at each voxel after intra-subject registration of diffusion-weighted images. Three-dimensional tract reconstruction was performed using the Fiber Assignment by Continuous Tracking (FACT) algorithm. Tractography results showed reduced fractional anisotropy (FA) of the arcuate fasciculi (AF) and inferior longitudinal fasciculi (ILF) in patients compared to controls. FA changes within the right ILF were negatively correlated with measures of thinking disorder. Reduced volume of the left AF was also observed in patients. These results, which avoid registration issues associated with voxel-based analyses of DTI data, support that fiber pathways connecting lateral and medial temporal lobe regions with neocortical regions are compromised in schizophrenia. Disruptions of connectivity within these pathways may potentially contribute to the disturbances of memory, language, and social cognitive processing that characterize the disorder.

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In schizophrenia, primary sensorimotor fasciculi appear comparatively unaffected, while structural abnormalities are consistently reported in frontal fasciculi connecting the frontal lobe with the rest of the brain, including the uncinate, arcuate, superior longitudinal, and cingulum bundle.
“Specifically, while the primary sensorimotor fasciculi appear to be comparatively unaffected in patients in schizophrenia, structural abnormalities have consistently been reported in the fasciculi connecting the frontal lobe with the rest of the brain, such as the uncinate fasciculus, 25,26 arcuate fasciculus, 27,28 superior longitudinal fasciculus, 29,30 and cingulum bundle.31,32”
From Schizophrenia, myelination, and delayed corollary discharges: a hypothesis (2012) · cites this paper as [25]

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Authors: Phillips, O. R., Nuechterlein, K. H., Clark, K. A., Hamilton, L. S., Asarnow, R. F., Hageman, N. S., Toga, A. W., & Narr, K. L.
Affiliations: University of California, Los Angeles (US)
ORCID: Phillips, Owen R.
Nuechterlein, Keith H.
Hamilton, Liberty S.
Asarnow, Robert F.
Toga, Arthur W.
Narr, Katherine L.
Venue: Schizophrenia Research
Publisher: Elsevier BV
Published: 2009-01
Volume: 107
Issue: 1
Pages: 30-38
ISSN: 0920-9964 (ISSN-L)
DOI: 10.1016/j.schres.2008.10.019
PMC: PMC2655322
OpenAlex: W2085041496
Cited by: 80
References: 93
Citations by year: 2025: 1 · 2024: 2 · 2022: 3 · 2021: 1 · 2020: 5 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 8 · 2015: 4 · 2014: 9 · 2013: 8 · 2012: 10
FWCI: 5.91
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Schizophrenia Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Simons Foundation
Institut National de la Santé et de la Recherche Médicale
National Institutes of Health
National Institute of Mental Health (R01MH071940, K01MH073990, R01MH060374, R01MH037705, P50MH066286, R01MH049716)
U.S. National Library of Medicine (R01LM005639)
National Center for Research Resources (P20RR020750, P41RR013642, U54RR021813)
Topics: Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords: schizophrenia, white matter tracts
MeSH terms: Adult, Female, Humans, Magnetic Resonance Imaging, Male, Nerve Fibers, Nerve Net, Neural Pathways, Brief Psychiatric Rating Scale, Schizophrenia, Temporal Lobe

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Fiber tractography reveals disruption of temporal lobe white matter tracts in schizophrenia

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