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New Rabies Virus Variants for Monitoring and Manipulating Activity and Gene Expression in Defined Neural Circuits
Open accessAbstract
SUMMARY Glycoprotein-deleted (ΔG) rabies virus is a powerful tool for studies of neural circuit structure. Here we describe the development and demonstrate the utility of new resources that allow experiments directly investigating relationships between the structure and function of neural circuits. New methods and reagents allowed efficient production of twelve novel ΔG rabies variants from plasmid DNA. These new rabies viruses express useful neuroscience tools, including: the Ca++ indicator GCaMP3, for monitoring activity; Channelrhodopsin-2, for photoactivation; allatostatin receptor, for inactivation by ligand application; rtTA, ERT2CreERT2, or FLPo, for control of gene expression. These new tools allow neurons targeted based on their connectivity, to have their function assayed or their activity or gene expression manipulated. Combining these tools with in vivo imaging and optogenetic methods, and/or inducible gene expression in transgenic mice, will facilitate experiments investigating neural circuit development, plasticity, and function that have not been possible with existing reagents.
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Self-citation
Metadata
- Authors
- Osakada, F., Mori, T., Cetin, A. H., Marshel, J. H., Virgen, B., & Callaway, E. M.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2011-08
- Volume
- 71
- Issue
- 4
- Pages
- 617-631
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2030337024
- Cited by
- 318
- References
- 9
- FWCI
- 10.84
- Type
- journal article
- Language
- en
- Open access
- bronze
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