Translaminar inhibitory cells recruited by layer 6 corticothalamic neurons suppress visual cortex
Open accessAbstract
In layer 6 (L6), a principal output layer of the mammalian cerebral cortex, a population of excitatory neurons defined by the NTSR1-Cre mouse line inhibit cortical responses to visual stimuli. Here we show that of the two major types of excitatory neurons existing in L6, the NTSR1-Cre line selectively targets those whose axons innervate both cortex and thalamus and not those whose axons remain within the cortex. These corticothalamic neurons mediate widespread inhibition across all cortical layers by recruiting fast-spiking inhibitory neurons whose cell body resides in deep cortical layers yet whose axons arborize throughout all layers. This study reveals a circuit by which L6 modulates cortical activity and identifies an inhibitory neuron able to regulate the strength of cortical responses throughout cortical depth.
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Presynaptic NMDA receptors likely make translaminar PV cells more responsive to local pyramidal cell inputs.
“which likely participates in making them more responsive to local pyramidal cell inputs”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Bortone et al., 2014
The Results and Discussion (page unavailable) report that layer 6 corticothalamic pyramidal cells strongly excite translaminar fast-spiking cells, which the paper associates with PV expression. They do not say that presynaptic NMDA receptors make those cells more responsive to local pyramidal-cell inputs; NMDA receptors appear only in a cited reference’s title. (LLM, conf=0.83)
Experimental — accuracy not yet measuredLaminar and columnar biases in axonal and dendritic arbors and connectivity correlate with somatic laminar location.
“laminar and columnar biases in axonal and dendritic arbors and connectivity have been observed to correlate with somatic laminar location”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Bortone et al., 2014
The Results (page unavailable) describe layer-specific axonal and dendritic arborization in the studied interneurons, and the Discussion identifies their somata as being in layer 6. The paper does not establish columnar biases or a general correlation between somatic laminar location and arborization and connectivity. (LLM, conf=0.84)
Experimental — accuracy not yet measuredIntracortical axons of layer 6 corticothalamic neurons preferentially target interneurons rather than excitatory cells.
“and intracortical axons of L6 corticothalamic neurons show a preference for targeting interneurons over excitatory cells (Bortone et al., 2014; McGuire et al., 1984; White and Keller, 1987).”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Bortone et al., 2014
PV+ translaminar interneurons are relatively rare fast-spiking interneurons that are particularly abundant in layers 5 and 6 and target pyramidal cells across several layers.
“PV+ translaminar interneurons constitute a relatively rare type of fast-spiking interneurons that is particularly abundant in layers 5 and 6”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Bortone et al., 2014
Pvalb-MET-2 included fast-spiking cells that resembled locally projecting layer 6 cells and deep basket cells.
“and contained fast-spiking cells resembling locally-projecting L6 cells (Bortone et al., 2014) and deep basket cells (Markram et al., 2015; Jiang et al., 2015).”
From Integrated Morphoelectric and Transcriptomic Classification of Cortical GABAergic Cells (2020) · cites this paper as Bortone et al., 2014
The interlaminar or translaminar projections of these Pvalb met-types resemble projections previously reported for layer 6 fast-spiking neurons.
“These interlaminar or translaminar projections resemble those described previously for fast-spiking neurons in L6 (Frandolig et al., 2019; Bortone et al., 2014).”
From Integrated Morphoelectric and Transcriptomic Classification of Cortical GABAergic Cells (2020) · cites this paper as Bortone et al., 2014
Some cell types have been quantified, but those studies often relied on extra labels such as individual gene markers to define the types beforehand.
“Specific cell types have been characterized quantitatively9–11, but these studies frequently have used additional labels (individual gene markers) to pre-define cell types.”
From Classification of electrophysiological and morphological neuron types in the mouse visual cortex (2019) · cites this paper as [9]
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Self-citation
- Authors
- Bortone, D. S., Olsen, S. R., & Scanziani, M.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Scanziani, Massimo
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 82
- Issue
- 2
- Pages
- 474-485
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC4068343
- OpenAlex
- W1991180842
- Cited by
- 300
- References
- 50
- Citations by year
- 2026: 17 · 2025: 23 · 2024: 13 · 2023: 24 · 2022: 18 · 2021: 37 · 2020: 31 · 2019: 27 · 2018: 27 · 2017: 29 · 2016: 23 · 2015: 23 · 2014: 8
- FWCI
- 12.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- Vassar College
- National Institutes of Health (1f32ns076185-01a1, NS047101)
- U.S. Public Health Service (HHSN271200723701C)
- University of California, San Diego (#NS047101, P30 NS047101)
- National Institute of Neurological Disorders and Stroke (N01-NS-0-2331, 1F32 NS076185-01A1, NS047101, F32 NS076185, HHSN271200723701C, P30NS047101, R01 NS069010, N01 NS002331, RC1NS069010)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- cortical depth, thalamocortical neurons, cortical circuits, neurotensin receptor 1
- MeSH terms
- Channelrhodopsins, Action Potentials, Animals, Fluorescent Dyes, Glutamate Decarboxylase, Mice, Inbred C57BL, Mice, Transgenic, Neural Inhibition, Neurons, Photic Stimulation, Thalamus, Transduction, Genetic, Visual Cortex, Wakefulness, Receptors, Neurotensin, Patch-Clamp Techniques, Green Fluorescent Proteins, Mice, In Vitro Techniques
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