GABAergic interneurons form transient layer-specific circuits in early postnatal neocortex
Open accessAbstract
GABAergic interneurons play key roles in cortical circuits, yet little is known about their early connectivity. Here we use glutamate uncaging and a novel optogenetic strategy to track changes in the afferent and efferent synaptic connections of developing neocortical interneuron subtypes. We find that Nkx2-1-derived interneurons possess functional synaptic connections before emerging pyramidal cell networks. Subsequent interneuron circuit maturation is both subtype and layer dependent. Glutamatergic input onto fast spiking (FS), but not somatostatin-positive, non-FS interneurons increases over development. Interneurons of both subtype located in layers (L) 4 and 5b engage in transient circuits that disappear after the somatosensory critical period. These include a pathway mediated by L5b somatostatin-positive interneurons that specifically targets L4 during the first postnatal week. The innervation patterns of immature cortical interneuron circuits are thus neither static nor progressively strengthened but follow a layer-specific choreography of transient connections that differ from those of the adult brain.
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During the first postnatal week, interneurons receive most of their inputs from local pyramidal cells.
“Since interneurons receive most of their inputs from local pyramidal cells during the first postnatal week (Anastasiades et al., 2016), it is perhaps not surprising that these cells play a critical role in the survival of cortical interneurons (Figure 6B).”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Anastasiades et al., 2016
Interneurons demonstrate AMPAR-mediated synaptic currents by the first postnatal day.
“interneurons demonstrate AMPAR-mediated synaptic currents by the first postnatal day”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [34]
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Interneurons of the neocortical inhibitory system
Markram, H., Toledo-Rodriguez, M., Wang, Y., Gupta, A., Silberberg, G., & Wu, C. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1519 · Cited by 2,954 · see citing works
Critical period plasticity in local cortical circuits
Hensch, T. K. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1787 · Cited by 2,323 · see citing works
Neuronal Diversity and Temporal Dynamics: The Unity of Hippocampal Circuit Operations
Klausberger, T., & Somogyi, P. (2008) · Science · doi:10.1126/science.1149381 · Cited by 2,050 · see citing works
A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex
Taniguchi, H., He, M., Wu, P., Kim, S., Paik, R., Sugino, K., Kvitsani, D., Fu, Y., Lu, J., Lin, Y., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.07.026 · Cited by 1,828 · see citing works
Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons
Rudy, B., Fishell, G., Lee, S., & Hjerling‐Leffler, J. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20853 · Cited by 1,420 · see citing works
GABAergic cell subtypes and their synaptic connections in rat frontal cortex
Kawaguchi, Y. (1997) · Cerebral Cortex · doi:10.1093/cercor/7.6.476 · Cited by 1,416 · see citing works
Pfeffer, C. K., Xue, M., He, M., Huang, Z. J., & Scanziani, M. (2013) · Nature Neuroscience · doi:10.1038/nn.3446 · Cited by 1,353 · see citing works
Interneuron dysfunction in psychiatric disorders
Marín, O. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3155 · Cited by 1,190 · see citing works
Disynaptic Inhibition between Neocortical Pyramidal Cells Mediated by Martinotti Cells
Silberberg, G., & Markram, H. (2007) · Neuron · doi:10.1016/j.neuron.2007.02.012 · Cited by 768 · see citing works
Equalizing excitation-inhibition ratios across visual cortical neurons
Xue, M., Atallah, B. V., & Scanziani, M. (2014) · Nature · doi:10.1038/nature13321 · Cited by 722 · see citing works
Inhibitory threshold for critical-period activation in primary visual cortex
Fagiolini, M., & Hensch, T. K. (2000) · Nature · doi:10.1038/35004582 · Cited by 716 · see citing works
GABAergic Hub Neurons Orchestrate Synchrony in Developing Hippocampal Networks
Bonifazi, P., Goldin, M., Picardo, M. A., Jorquera, I., Cattani, A., Bianconi, G., Represa, A., Ben-Ari, Y., & Cossart, R. (2009) · Science · doi:10.1126/science.1175509 · Cited by 695 · see citing works
The temporal and spatial origins of cortical interneurons predict their physiological subtype
Butt, S. J. B., Fuccillo, M., Nery, S., Noctor, S., Kriegstein, A., Corbin, J. G., & Fishell, G. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.034 · Cited by 587 · see citing works
Self-citationFate mapping Nkx2.1‐lineage cells in the mouse telencephalon
Xu, Q., Tam, M., & Anderson, S. A. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21529 · Cited by 560 · see citing works
Miyoshi, G., Hjerling-Leffler, J., Karayannis, T., Sousa, V. H., Butt, S. J. B., Battiste, J., Johnson, J. E., Machold, R. P., & Fishell, G. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4515-09.2010 · Cited by 559 · see citing works
Dense Inhibitory Connectivity in Neocortex
Fino, E., & Yuste, R. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.025 · Cited by 532 · see citing works
Packer, A. M., & Yuste, R. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3131-11.2011 · Cited by 506 · see citing works
Functional maps of neocortical local circuitry.
Thomson, A. M. (2007) · Frontiers in Neuroscience · doi:10.3389/neuro.01.1.1.002.2007 · Cited by 434 · see citing works
Xu, X., Roby, K. D., & Callaway, E. M. (2010) · Journal of Comparative Neurology · doi:10.1002/cne.22229 · Cited by 429 · see citing works
Supralinear increase of recurrent inhibition during sparse activity in the somatosensory cortex
Kapfer, C., Glickfeld, L. L., Atallah, B. V., & Scanziani, M. (2007) · Nature Neuroscience · doi:10.1038/nn1909 · Cited by 427 · see citing works
A critical period for experience-dependent synaptic plasticity in rat barrel cortex
Fox, K. D. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-05-01826.1992 · Cited by 420 · see citing works
Fogarty, M., Grist, M., Gelman, D., Marín, O., Pachnis, V., & Kessaris, N. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1629-07.2007 · Cited by 412 · see citing works
Photostimulation using caged glutamate reveals functional circuitry in living brain slices.
Callaway, E. M., & Katz, L. C. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.16.7661 · Cited by 401 · see citing works
Miyoshi, G., Butt, S. J. B., Takebayashi, H., & Fishell, G. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1807-07.2007 · Cited by 400 · see citing works
Self-citationKawaguchi, Y. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.69.2.416 · Cited by 390 · see citing works
Fine-scale specificity of cortical networks depends on inhibitory cell type and connectivity
Yoshimura, Y., & Callaway, E. M. (2005) · Nature Neuroscience · doi:10.1038/nn1565 · Cited by 390 · see citing works
The requirement of Nkx2-1 in the temporal specification of cortical interneuron subtypes
Butt, S. J. B., Sousa, V. H., Fuccillo, M. V., Hjerling-Leffler, J., Miyoshi, G., Kimura, S., & Fishell, G. (2008) · Neuron · doi:10.1016/j.neuron.2008.07.031 · Cited by 330 · see citing works
Self-citationCharacterization of Nkx6-2-Derived Neocortical Interneuron Lineages
Sousa, V. H., Miyoshi, G., Hjerling-Leffler, J., Karayannis, T., & Fishell, G. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp038 · Cited by 328 · see citing works
Jarvis, M. F., & Khakh, B. S. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.067 · Cited by 327 · see citing works
Laminar sources of synaptic input to cortical inhibitory interneurons and pyramidal neurons
Dantzker, J. L. M., & Callaway, E. M. (2000) · Nature Neuroscience · doi:10.1038/76656 · Cited by 303 · see citing works
Translaminar inhibitory cells recruited by layer 6 corticothalamic neurons suppress visual cortex
Bortone, D. S., Olsen, S. R., & Scanziani, M. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.021 · Cited by 300 · see citing works
GABA Regulates Excitatory Synapse Formation in the Neocortex via NMDA Receptor Activation
Wang, D. D., & Kriegstein, A. R. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5599-07.2008 · Cited by 299 · see citing works
Neuronal activity is required for the development of specific cortical interneuron subtypes
De Marco García, N. V., Karayannis, T., & Fishell, G. (2011) · Nature · doi:10.1038/nature09865 · Cited by 294 · see citing works
Sequential Generation of Two Distinct Synapse-Driven Network Patterns in Developing Neocortex
Allène, C., Cattani, A., Ackman, J. B., Bonifazi, P., Aniksztejn, L., Ben-Ari, Y., & Cossart, R. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3733-08.2008 · Cited by 281 · see citing works
Postnatal Differentiation of Basket Cells from Slow to Fast Signaling Devices
Doischer, D., Aurel Hosp, J., Yanagawa, Y., Obata, K., Jonas, P., Vida, I., & Bartos, M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2890-08.2008 · Cited by 248 · see citing works
Lodato, S., Rouaux, C., Quast, K. B., Jantrachotechatchawan, C., Studer, M., Hensch, T. K., & Arlotta, P. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.015 · Cited by 244 · see citing works
Zemelman, B. V., Nesnas, N., Lee, G. A., & Miesenböck, G. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242738899 · Cited by 244 · see citing works
The columnar and laminar organization of inhibitory connections to neocortical excitatory cells
Kätzel, D., Zemelman, B. V., Buetfering, C., Wölfel, M., & Miesenböck, G. (2011) · Nature Neuroscience · doi:10.1038/nn.2687 · Cited by 241 · see citing works
Self-citationLaminar specificity of functional input to distinct types of inhibitory cortical neurons
Xu, X., & Callaway, E. M. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4104-08.2009 · Cited by 218 · see citing works
Cell Type–Specific Thalamic Innervation in a Column of Rat Vibrissal Cortex
Meyer, H. S., Wimmer, V. C., Hemberger, M., Bruno, R. M., de Kock, C. P. J., Frick, A., Sakmann, B. J., & Helmstaedter, M. N. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq069 · Cited by 205 · see citing works
Columnar Architecture Sculpted by GABA Circuits in Developing Cat Visual Cortex
Hensch, T. K., & Stryker, M. P. (2004) · Science · doi:10.1126/science.1091031 · Cited by 189 · see citing works
Mouse cortical inhibitory neuron type that coexpresses somatostatin and calretinin
Xu, X., Roby, K. D., & Callaway, E. M. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21101 · Cited by 185 · see citing works
Kasyanov, A. M., Safiulina, V. F., Voronin, L. L., & Cherubini, E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305974101 · Cited by 183 · see citing works
Coordinated developmental recruitment of latent fast spiking interneurons in layer IV barrel cortex
Daw, M. I., Ashby, M. C., & Isaac, J. T. R. (2007) · Nature Neuroscience · doi:10.1038/nn1866 · Cited by 174 · see citing works
Pioneer GABA Cells Comprise a Subpopulation of Hub Neurons in the Developing Hippocampus
Picardo, M. A., Guigue, P., Bonifazi, P., Batista-Brito, R., Allene, C., Ribas, A., Fishell, G., Baude, A., & Cossart, R. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.018 · Cited by 167 · see citing works
Scanning laser photostimulation: a new approach for analyzing brain circuits
Katz, L. C., & Dalva, M. B. (1994) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(94)90194-5 · Cited by 158 · see citing works
Optogenetic Control of Cells and Circuits
Miesenböck, G. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100109-104051 · Cited by 158 · see citing works
Precise Development of Functional and Anatomical Columns in the Neocortex
Bureau, I., Shepherd, G. M., & Svoboda, K. (2004) · Neuron · doi:10.1016/j.neuron.2004.05.002 · Cited by 149 · see citing works
Interneurons set the tune of developing networks
Ben‐Ari, Y., Khalilov, I., Represa, A., & GOZLAN, H. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.05.002 · Cited by 149 · see citing works
Target-specific expression of presynaptic NMDA receptors in neocortical microcircuits
Buchanan, K. A., Blackman, A. V., Moreau, A. W., Elgar, D., Costa, R. P., Lalanne, T., Tudor Jones, A. A., Oyrer, J., & Sjöström, P. J. (2012) · Neuron · doi:10.1016/j.neuron.2012.06.017 · Cited by 144 · see citing works
Lineage-specific laminar organization of cortical GABAergic interneurons
Ciceri, G., Dehorter, N., Sols, I., Huang, Z. J., Maravall, M., & Marín, O. (2013) · Nature Neuroscience · doi:10.1038/nn.3485 · Cited by 124 · see citing works
A direct translaminar inhibitory circuit tunes cortical output
Pluta, S. R., Naka, A., Veit, J., Telian, G. I., Yao, L., Hakim, R., Taylor, D., & Adesnik, H. (2015) · Nature Neuroscience · doi:10.1038/nn.4123 · Cited by 103 · see citing works
Berger, T. K., Perin, R., Silberberg, G., & Markram, H. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.176552 · Cited by 94 · see citing works
Pangratz-Fuehrer, S., & Hestrin, S. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6655-10.2011 · Cited by 83 · see citing works
Apicella, A. J., Wickersham, I. R., Seung, H. S., & Shepherd, G. M. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0011-12.2012 · Cited by 82 · see citing works
Early GABAergic circuitry in the cerebral cortex
Luhmann, H. J., Kirischuk, S., Sinning, A., & Kilb, W. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.12.014 · Cited by 59 · see citing works
Anastasiades, P. G., & Butt, S. J. B. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.1262-12.2012 · Cited by 49 · see citing works
Experience-Dependent Rewiring of Specific Inhibitory Connections in Adult Neocortex
Kätzel, D., & Miesenböck, G. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001798 · Cited by 24 · see citing works
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Hippocampal GABAergic Inhibitory Interneurons
Pelkey, K. A., Chittajallu, R., Craig, M. T., Tricoire, L., Wester, J. C., & McBain, C. J. (2017) · Physiological Reviews · doi:10.1152/physrev.00007.2017 · Cited by 889 · see citing works
Development and Functional Diversification of Cortical Interneurons
Lim, L., Mi, D., Llorca, A., & Marín, O. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.009 · Cited by 714 · see citing works
“Since interneurons receive most of their inputs from local pyramidal cells during the first postnatal week (Anastasiades et al., 2016), it is perhaps not surprising that these cells play a critical role in the survival of cortical interneurons (Figure 6B).”
Ben-Shalom, R., Keeshen, C. M., Berrios, K. N., An, J. Y., Sanders, S. J., & Bender, K. J. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.01.009 · Cited by 288 · see citing works
Pyramidal cell regulation of interneuron survival sculpts cortical networks
Wong, F. K., Bercsenyi, K., Sreenivasan, V., Portalés, A., Fernández-Otero, M., & Marín, O. (2018) · Nature · doi:10.1038/s41586-018-0139-6 · Cited by 286 · see citing works
Marques-Smith, A., Lyngholm, D., Kaufmann, A.-K., Stacey, J. A., Hoerder-Suabedissen, A., Becker, E. B. E., Wilson, M. C., Molnár, Z., & Butt, S. J. B. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.015 · Cited by 173 · see citing works
Complementary networks of cortical somatostatin interneurons enforce layer specific control
Naka, A., Veit, J., Shababo, B., Chance, R. K., Risso, D., Stafford, D., Snyder, B., Egladyous, A., Chu, D., Sridharan, S., et al. (2019) · eLife · doi:10.7554/elife.43696 · Cited by 117 · see citing works
Developmental Dysfunction of VIP Interneurons Impairs Cortical Circuits
Batista-Brito, R., Vinck, M., Ferguson, K. A., Chang, J. T., Laubender, D., Lur, G., Mossner, J. M., Hernandez, V. G., Ramakrishnan, C., Deisseroth, K., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.034 · Cited by 135 · see citing works
Developmental Cell Death in the Cerebral Cortex
Wong, F. K., & Marín, Ó. (2019) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100818-125204 · Cited by 128 · see citing works
Layer I Interneurons Sharpen Sensory Maps during Neonatal Development
Che, A., Babij, R., Iannone, A. F., Fetcho, R. N., Ferrer, M., Liston, C., Fishell, G., & De Marco García, N. V. (2018) · Neuron · doi:10.1016/j.neuron.2018.06.002 · Cited by 91 · see citing works
Anastasiades, P. G., Boada, C. M., & Carter, A. G. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy299 · Cited by 106 · see citing works
GABAergic Restriction of Network Dynamics Regulates Interneuron Survival in the Developing Cortex
Duan, Z. R. S., Che, A., Chu, P., Modol, L., Bollmann, Y., Babij, R., Fetcho, R. N., Otsuka, T., Fuccillo, M. V., Liston, C., et al. (2020) · Neuron · doi:10.1016/j.neuron.2019.10.008 · Cited by 102 · see citing works
Vasistha, N. A., Pardo-Navarro, M., Gasthaus, J., Weijers, D., Müller, M., García‐González, D., Malwade, S., Korshunova, I., Pfisterer, U., von Engelhardt, J., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0539-5 · Cited by 92 · see citing works
Anastasiades, P. G., Marlin, J. J., & Carter, A. G. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.073 · Cited by 89 · see citing works
Hage, T. A., Bosma-Moody, A., Baker, C. A., Kratz, M. B., Campagnola, L., Jarsky, T., Zeng, H., & Murphy, G. J. (2022) · eLife · doi:10.7554/elife.71103 · Cited by 84 · see citing works
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Adolescent sleep and the foundations of prefrontal cortical development and dysfunction
Anastasiades, P. G., de Vivo, L., Bellesi, M., & Jones, M. W. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102338 · Cited by 82 · see citing works
Kourdougli, N., Suresh, A., Liu, B., Juárez, P., Lin, A., Chung, D. T., Sams, A. G., Gandal, M. J., Martínez‐Cerdeño, V., Buonomano, D. V., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.06.009 · Cited by 68 · see citing works
Butt, S. J. B., Stacey, J. A., Teramoto, Y., & Vagnoni, C. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.03.011 · Cited by 61 · see citing works
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Floßmann, T., Kaas, T., Rahmati, V., Kiebel, S. J., Witte, O. W., Holthoff, K., & Kirmse, K. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.02.061 · Cited by 47 · see citing works
Principles of GABAergic signaling in developing cortical network dynamics
Kirmse, K., & Zhang, C. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110568 · Cited by 46 · see citing works
Mòdol, L., Sousa, V. H., Malvache, A., Tressard, T., Baude, A., & Cossart, R. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx198 · Cited by 39 · see citing works
The impact of (ab)normal maternal environment on cortical development
Vasistha, N. A., & Khodosevich, K. V. (2021) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2021.102054 · Cited by 36 · see citing works
A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons
Moissidis, M., Abbasova, L., Selten, M. M., Alis, R., Bernard, C., Domínguez-Canterla, Y., Oozeer, F., Qin, S., Kelly, A., Mòdol, L., et al. (2025) · Cell · doi:10.1016/j.cell.2025.06.029 · Cited by 34 · see citing works
Regulation of the E/I-balance by the neural matrisome
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Early-life exposure to caffeine affects the construction and activity of cortical networks in mice
Fazeli, W., Zappettini, S., Marguet, S. L., Grendel, J., Esclapez, M., Bernard, C., & Isbrandt, D. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.05.013 · Cited by 33 · see citing works
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Studies of cortical connectivity using optical circuit mapping methods
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Pan, N. C., Fang, A., Shen, C., Sun, L., Wu, Q., & Wang, X. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy293 · Cited by 26 · see citing works
The Role of Inhibitory Interneurons in Circuit Assembly and Refinement Across Sensory Cortices
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Early-generated interneurons regulate neuronal circuit formation during early postnatal development
Wang, C., Ma, J., Jiang, S.-N., Chen, T.-Q., Xu, Y.-Q., Yuan, Z.-L., Mao, X., Zhang, S., Liu, L., Fu, Y., et al. (2019) · eLife · doi:10.7554/elife.44649 · Cited by 25 · see citing works
Baruchin, L. J., Ghezzi, F., Kohl, M. M., & Butt, S. J. B. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhab363 · Cited by 20 · see citing works
Serotonergic regulation of bipolar cell survival in the developing cerebral cortex
Wong, F. K., Selten, M. M., Rosés-Novella, C., Sreenivasan, V., Pallas‐Bazarra, N., Serafeimidou‐Pouliou, E., Hanusz-Godoy, A., Oozeer, F., Edwards, R. H., & Marín, Ó. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111037 · Cited by 19 · see citing works
Non-canonical role for Lpar1-EGFP subplate neurons in early postnatal mouse somatosensory cortex
Ghezzi, F., Marques-Smith, A., Anastasiades, P. G., Lyngholm, D., Vagnoni, C., Rowett, A., Parameswaran, G., Hoerder-Suabedissen, A., Nakagawa, Y., Molnár, Z., et al. (2021) · eLife · doi:10.7554/elife.60810 · Cited by 13 · see citing works
Iannone, A. F., & García, N. V. D. M. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.04.005 · Cited by 17 · see citing works
Neuronal activity controls the development of interneurons in the somatosensory cortex
Babij, R., & García, N. D. M. (2016) · Frontiers in Biology · doi:10.1007/s11515-016-1427-x · Cited by 17 · see citing works
In vivo Optogenetic Approach to Study Neuron-Oligodendroglia Interactions in Mouse Pups
Ortolani, D., Manot-Saillet, B., Orduz, D., Ortíz, F. C., & Angulo, M. C. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00477 · Cited by 17 · see citing works
Genetic and activity dependent-mechanisms wiring the cortex: Two sides of the same coin
Bragg-Gonzalo, L., de León-Reyes, N. S., & Nieto, M. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.05.011 · Cited by 15 · see citing works
Self-supervised predictive learning accounts for cortical layer-specificity
Nejad, K. K., Anastasiades, P. G., Hertäg, L., & Costa, R. P. (2025) · Nature Communications · doi:10.1038/s41467-025-61399-5 · Cited by 14 · see citing works
Pyramidal neurons proportionately alter cortical interneuron subtypes
Wu, S. J., Dai, M., Yang, S.-P., McCann, C., Qiu, Y., Kumar, V., Marrero, G. J., Tsyporin, J., Huang, S., Shin, D., et al. (2026) · Nature · doi:10.1038/s41586-025-09996-8 · Cited by 25 · see citing works
Development of Prefrontal Circuits and Cognitive AbilitiesPreprint
Pöpplau, J. A., & Hanganu‐Opatz, I. L. (2024) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041502 · Cited by 15 · see citing works
Inglis, G. A. S., Zhou, Y., Patterson, D. G., Scharer, C. D., Han, Y., Boss, J. M., Wen, Z., & Escayg, A. (2020) · Human Molecular Genetics · doi:10.1093/hmg/ddaa150 · Cited by 12 · see citing works
Synaptic Basis for the Generation of Response Variation in Auditory Cortex
Tao, C., Zhang, G., Zhou, C., Wang, L., Yan, S., Zhang, L. I., Zhou, Y., & Xiong, Y. (2016) · Scientific Reports · doi:10.1038/srep31024 · Cited by 11 · see citing works
Early-life maturation of the somatosensory cortex: sensory experience and beyond
Nwabudike, I., & Che, A. (2024) · Frontiers in Neural Circuits · doi:10.3389/fncir.2024.1430783 · Cited by 8 · see citing works
Asenjo-Martínez, A., Dragičević, K., Hou, W., Ozsvár, A., Hansen, N. W., Pfisterer, U., Rydbirk, R., Demharter, S., Møller, B. E., Gasthaus, J., et al. (2025) · Neuron · doi:10.1016/j.neuron.2025.08.028 · Cited by 9 · see citing works
Gamma oscillations provide insights into cortical circuit development
Bitzenhofer, S. H. (2023) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-023-02801-3 · Cited by 8 · see citing works
Highly local activation of inhibition at the seizure wavefront in vivo
Shah, P. T., Valiante, T. A., & Packer, A. M. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114189 · Cited by 7 · see citing works
Ogi, H., Nitta, N., Tando, S., Fujimori, A., Aoki, I., Fushiki, S., & Itoh, K. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.12.012 · Cited by 7 · see citing works
Deng, R., Kao, J. P. Y., & Kanold, P. O. (2021) · Scientific Reports · doi:10.1038/s41598-021-82679-2 · Cited by 7 · see citing works
Ontogeny of the VIP+ interneuron sensory-motor circuit prior to active whiskingPreprint
Vagnoni, C., Baruchin, L. J., Ghezzi, F., Ratti, S., Molnár, Z., & Butt, S. J. B. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.01.182238 · Cited by 7 · see citing works
Ocana-Santero, G., Warming, H., Munday, V., MacKay, H. A., Gibeily, C. R., Hemingway, C., Stacey, J. A., Saha, A., Lazarte, I. P., Bachetta, A., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59659-5 · Cited by 7 · see citing works
Complementary networks of cortical somatostatin interneurons enforce layer specific controlPreprint
Naka, A., Veit, J., Shababo, B., Chance, R. K., Risso, D., Stafford, D. A., Snyder, B. J., Egladyous, A., Chu, D., Sridharan, S., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/456574 · Cited by 5 · see citing works
Neural cell competition sculpting brain from cradle to grave
Li, Y., Gao, L., Sun, X., Duan, L., Jiang, M., & Wu, Q. (2025) · National Science Review · doi:10.1093/nsr/nwaf057 · Cited by 5 · see citing works
Plutino, S., Laghouati, E., Jarre, G., Depaulis, A., Guillemain, I., & Bureau, I. (2024) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2023.102564 · Cited by 4 · see citing works
Longitudinal tracking of neuronal activity from the same cells in the developing brain using Track2p
Majnik, J., Mantez, M., Zangila, S., Bugeon, S., Guignard, L., Platel, J., & Cossart, R. (2025) · eLife · doi:10.7554/elife.107540.3 · Cited by 4 · see citing works
Functional maturation of neocortical inhibitory interneurons
Larimer, P., & Hasenstaub, A. R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-823672-7.00019-3 · Cited by 4 · see citing works
Vasistha, N. A., Pardo-Navarro, M., Gasthaus, J., Weijers, D., Müller, M. K., García-González, D., Malwade, S., Korshunova, I., Pfisterer, U., von Engelhardt, J., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/412981 · Cited by 4 · see citing works
Ghezzi, F., Baruchin, L. J., Ha, N. T., Shah-Ostrowski, M. J., Chama, A. G. C., Stacey, J. A., & Butt, S. J. B. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.21.568139 · Cited by 4 · see citing works
Developmental trajectory of cortical somatostatin interneuron functionPreprint
Wang, A. Y., Ferguson, K., Gupta, J., Higley, M. J., & Cardin, J. A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.05.583539 · Cited by 5 · see citing works
Deng, R., Chang, M., Kao, J. P. Y., & Kanold, P. O. (2023) · Scientific Reports · doi:10.1038/s41598-023-27536-0 · Cited by 3 · see citing works
Interneuron Diversity: How Form Becomes FunctionPreprint
García, N. V. D. M., & Fishell, G. (2024) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041513 · Cited by 3 · see citing works
Delayed integration of somatostatin interneurons into visual circuits
Wang, A., Ferguson, K., Gupta, J., Fan, V. H., Sun, S., Barson, D. G., Higley, M. J., & Cardin, J. A. (2025) · Nature Communications · doi:10.1038/s41467-025-64628-z · Cited by 2 · see citing works
Szrinivasan, R., Trontti, K., Mathieu, R., Draia-Nicolau, T., Chazal, G., Loukasmäki, S., Celma, S. B., Achim, K., Uvarov, P., Khirug, S., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-67270-x · Cited by 2 · see citing works
Posterior brain sensorimotor recruitment for inhibition of delayed responses in children
Ciesielski, K. T. R., Bouchard, C., Solis, I., Coffman, B. A., Tofighi, D., & Pesko, J. C. (2021) · Experimental Brain Research · doi:10.1007/s00221-021-06191-9 · Cited by 2 · see citing works
Abusaada, A., Rosa, F. D., Luhmann, H. J., Kilb, W., & Sinning, A. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1556174 · Cited by 2 · see citing works
Ghezzi, F., Baruchin, L. J., Ha, N. T., Shah-Ostrowski, M. J., Chama, A. G. C., Stacey, J. A., & Butt, S. J. B. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116299 · Cited by 2 · see citing works
Longitudinal tracking of neuronal activity from the same cells in the developing brain using Track2pPreprint
Majnik, J., Mantez, M., Zangila, S., Bugeon, S., Guignard, L., Platel, J., & Cossart, R. (2025) · eLife · doi:10.7554/elife.107540 · Cited by 3 · see citing works
Dlx2 reprograms the transcriptome and laminar position of glia-derived Ascl1-induced interneuronsPreprint
Cooper, A., Garcia-Mora, A., Herrera-Oropeza, G., Beltrán-Arranz, A., Marichal, N., Shi, Y., Leaman, S., Gonzalez, K. L., Strom, M., Hamid, F., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.02.697435 · Cited by 2 · see citing works
Offermanns, A., Pöpplau, J. A., & Hanganu‐Opatz, I. L. (2025) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2025.102866 · Cited by 2 · see citing works
Optogenetic Mapping of Neuronal Connections and their Plasticity
Kohl, M. M., & Kätzel, D. (2017) · Cambridge University Press eBooks · doi:10.1017/9781107281875.018 · Cited by 1 · see citing works
Restoring Transient Connectivity During Development Improves Dysfunctions in Fragile X MicePreprint
Dumontier, D., Liebman, S. A., Le, V.-H., George, S., Valdemar, D., Aelst, L. V., & Pouchelon, G. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.08.611918 · Cited by 1 · see citing works
Kim, J. H., Vlachos, A., Mahadevan, V., Caccavano, A., Banke, T. G., Crawley, O., Navarro, A. I., Yuan, X. Q., Abebe, D. T., Hunt, S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.24.678342 · Cited by 1 · see citing works
Higginbotham, H. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814407-7.00024-9
Baruchin, L. J., Kohl, M. M., & Butt, S. J. B. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.18.431791
Duffin, J. (2017) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.732084138.793539459
Longitudinal tracking of neuronal activity from the same cells in the developing brain using Track2pPreprint
Majnik, J., Mantez, M., Zangila, S., Bugeon, S., Guignard, L., Platel, J., & Cossart, R. (2025) · eLife · doi:10.7554/elife.107540.1
Longitudinal tracking of neuronal activity from the same cells in the developing brain using Track2pPreprint
Majnik, J., Mantez, M., Zangila, S., Bugeon, S., Guignard, L., Platel, J., & Cossart, R. (2025) · eLife · doi:10.7554/elife.107540.2
Thalamic Activity Regulates Interneuron Density in the Developing Visual Thalamus
Huerga-Gómez, I., Torres, D., Castellano-Ruiz, P., Wilson, E. S., Martini, F. J., & López‐Bendito, G. (2026) · Journal of Neuroscience · doi:10.1523/jneurosci.0247-25.2026
Interneurons and network activity in the cerebral cortex: a developmental dialogue
Moissidis, M., & Marín, Ó. (2026) · Nature reviews. Neuroscience · doi:10.1038/s41583-026-01088-4
Postnatal development of inhibition associated with entorhinal cortex input to the CA1 hippocampus
Vazetdinova, A., Khalilov, I., Gainutdinov, A., Vinokurova, D., Shipkov, D., Kurmashova, E., Nasretdinov, A., Valeeva, G. R., & Khazipov, R. (2026) · The Journal of Physiology · doi:10.1113/jp289077
- Authors
- Anastasiades, P. G., Marques-Smith, A., Lyngholm, D., Lickiss, T., Raffiq, S., Kätzel, D., Miesenböck, G., & Butt, S. J. B.
- Affiliations
- Hammersmith Hospital (GB)
- University of Oxford (GB)
- Corresponding author
- Butt, Simon J. B.
- ORCID
- Venue
- Nature Communications
- Published
- 2016-02-04
- Volume
- 7
- Issue
- 1
- Pages
- 10584-10584
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC4743032
- OpenAlex
- W2417421956
- Cited by
- 87
- References
- 58
- Citations by year
- 2026: 5 · 2025: 15 · 2024: 8 · 2023: 5 · 2022: 6 · 2021: 10 · 2020: 6 · 2019: 8 · 2018: 9 · 2017: 10 · 2016: 5
- FWCI
- 5.95
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Strathprints: The University of Strathclyde institutional repository (University of Strathclyde) (acceptedVersion, other-oa)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- UCL Discovery (University College London) (submittedVersion)
- Bristol Research (University of Bristol) (submittedVersion)
- Explore Bristol Research (submittedVersion)
- Funders
- Dana Foundation
- Wellcome Trust (089286, 090309/Z/09/Z, 106988/Z/15/Z, 089286/Z/09/Z)
- Research Councils UK
- Imperial College London
- Boehringer Ingelheim Fonds
- National Institutes of Health
- Medical Research Council (MR/K004387/1)
- Fundação para a Ciência e a Tecnologia
- Office of Naval Research
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- GABAergic interneurons, neocortex development, postnatal development, fast-spiking interneurons, somatostatin interneurons, glutamate uncaging, optogenetics, glutamatergic afferents, efferent connections
- MeSH terms
- Thyroid Nuclear Factor 1, Animals, Animals, Newborn, Immunohistochemistry, Interneurons, Nerve Net, Nuclear Proteins, Synapses, Transcription Factors, Cluster Analysis, Pyramidal Cells, Patch-Clamp Techniques, Neocortex, Principal Component Analysis, Green Fluorescent Proteins, Mice, GABAergic Neurons, Optogenetics
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