Limbic and cortical information processing in the nucleus accumbens
Open accessAbstract
The nucleus accumbens regulates goal-directed behaviors by integrating information from limbic structures and the prefrontal cortex. Here, we review recent studies in an attempt to provide an integrated view of the control of information processing in the nucleus accumbens in terms of the regulation of goal-directed behaviors and how disruption of these functions might underlie the pathological states in drug addiction and other psychiatric disorders. We propose a model that could account for the results of several studies investigating limbic-system interactions in the nucleus accumbens and their modulation by dopamine and provide testable hypotheses for how these might relate to the pathophysiology of major psychiatric disorders.
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Nucleus accumbens dysfunction has been heavily implicated in schizophrenia.
“In ventral striatum, nucleus accumbens (NAc) dysfunction has been heavily implicated in schizophrenia [19, 20].”
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- Authors
- Goto, Y., & Grace, A. A.
- Affiliations
- McGill University (CA)
- University of Pittsburgh (US)
- Corresponding author
- Goto, Yukiori
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2008-11
- Volume
- 31
- Issue
- 11
- Pages
- 552-558
- ISSN
- 0166-2236 (ISSN-L)
- PMC
- PMC2884964
- OpenAlex
- W2070712548
- Cited by
- 332
- References
- 60
- Citations by year
- 2026: 11 · 2025: 10 · 2024: 9 · 2023: 8 · 2022: 10 · 2021: 17 · 2020: 17 · 2019: 23 · 2018: 17 · 2017: 16 · 2016: 19 · 2015: 22 · 2014: 18 · 2013: 26 · 2012: 26
- FWCI
- 2.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health (2r01mh057440-26a1)
- National Institute of Mental Health (R01-MH057440, R37MH057440)
- National Institute on Drug Abuse (R01DA015408)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- nucleus accumbens, limbic system, prefrontal cortex, goal-directed behavior, drug addiction, dopamine, mental illness, information processing
- MeSH terms
- Animals, Cerebral Cortex, Humans, Limbic System, Mental Processes, Models, Biological, Neural Pathways, Nucleus Accumbens
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