Cited by 335Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesNeuroscience and Neuropharmacology Research

Limbic and cortical information processing in the nucleus accumbens

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Goto, Yukiori, Grace, Anthony A.·2008·Trends in Neurosciences

Abstract

The nucleus accumbens regulates goal-directed behaviors by integrating information from limbic structures and the prefrontal cortex. Here, we review recent studies in an attempt to provide an integrated view of the control of information processing in the nucleus accumbens in terms of the regulation of goal-directed behaviors and how disruption of these functions might underlie the pathological states in drug addiction and other psychiatric disorders. We propose a model that could account for the results of several studies investigating limbic-system interactions in the nucleus accumbens and their modulation by dopamine and provide testable hypotheses for how these might relate to the pathophysiology of major psychiatric disorders.

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Crossref · 10.1016/j.tins.2008.08.002

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Authors
Goto, Y., & Grace, A. A.
Affiliations
  • McGill University (CA)
  • University of Pittsburgh (US)
Corresponding author
Goto, Yukiori
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
2008-11
Volume
31
Issue
11
Pages
552-558
ISSN
0166-2236 (ISSN-L)
OpenAlex
W2070712548
Cited by
332
References
60
Citations by year
2026: 11 · 2025: 10 · 2024: 9 · 2023: 8 · 2022: 10 · 2021: 17 · 2020: 17 · 2019: 23 · 2018: 17 · 2017: 16 · 2016: 19 · 2015: 22 · 2014: 18 · 2013: 26 · 2012: 26
FWCI
2.37
Type
journal article
Language
en
Open access
Locations
  • Trends in Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Alliance for Research on Schizophrenia and Depression
  • National Institutes of Health (2r01mh057440-26a1)
  • National Institute of Mental Health (R01-MH057440, R37MH057440)
  • National Institute on Drug Abuse (R01DA015408)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
nucleus accumbens, limbic system, prefrontal cortex, goal-directed behavior, drug addiction, dopamine, mental illness, information processing
MeSH terms
Animals, Cerebral Cortex, Humans, Limbic System, Mental Processes, Models, Biological, Neural Pathways, Nucleus Accumbens

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