Comparative distribution of nicotinic receptor subtypes during development, adulthood and aging: an autoradiographic study in the rat brain
Open accessAbstract
The distribution in the rat brain of high affinity nicotinic heteromeric acetylcholine receptors and of low affinity nicotinic, alpha7-containing, homomeric receptors was studied using in vitro light microscopic autoradiography. As ligands, we used [3H]epibatidine, or [125I]epibatidine, and [125I]alpha-bungarotoxin, respectively. In adult animals, the two types of binding sites were widely distributed in many different brain structures, including the brainstem, cerebellum, mesencephalic structures, limbic system and cortex, but their anatomical distribution differed markedly. Only in rare instances could a co-localization be observed, for example in the superficial layer of the superior colliculus. In developing animals, both types of labeling were strongly expressed during embryonic and postnatal phases. Their distributions were qualitatively similar to those observed in adult animals, with a few noticeable exceptions in the cerebral cortex, hippocampus and brain stem. In aging animals, neither the distribution nor the density of nicotinic binding sites was significantly altered. Our conclusions are the following. (a) There is little overlap in the distribution of heteromeric and alpha7-containing homomeric nicotinic receptors in the rat brain. (b) The abundance of neuronal nicotinic receptors during embryonic and postnatal development suggests that they may play a role in the establishment of neuronal connectivity. (c) The expression of neuronal nicotinic receptors is unaltered in middle aged animals, suggesting that in the rat these receptors do not play any major role in aging process.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Receptors, transporters as well as synthesizing enzymes are already expressed (~E10 rodent and week 4-5 human) even when the actual axonal projections have not yet arrived in the PFC.
“Receptors, transporters as well as synthesizing enzymes are already expressed (~E10 rodent and week 4–5 human) even when the actual axonal projections have not yet arrived in the PFC [236–240].”
From Development of prefrontal cortex (2022) · cites this paper as [239]
Cites
The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959 · see citing works
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Interneurons of the hippocampus
Freund, T. F., & Buzsáki, G. (1998) · Hippocampus · doi:10.1002/(sici)1098-1063(1996)6:4 · Cited by 3,423 · see citing works
Picciotto, M. R., Zoli, M., Rimondini, R., Léna, C., Marubio, L. M., Pich, E. M., Fuxe, K., & Changeux, J.-P. (1998) · Nature · doi:10.1038/34413 · Cited by 1,320 · see citing works
Presynaptic nicotinic ACh receptors
Wonnacott, S. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10073-4 · Cited by 1,308 · see citing works
Wada, E., Wada, K., Boulter, J., Deneris, E. S., Heinemann, S., Patrick, J., & Swanson, L. W. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902840212 · Cited by 1,044 · see citing works
Clarke, P. B. S., Schwartz, R., Paul, S. M., Cb, P., & Pert, A. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-05-01307.1985 · Cited by 1,037 · see citing works
Physiological Diversity of Nicotinic Acetylcholine Receptors Expressed by Vertebrate Neurons
McGehee, D. S., & Role, L. W. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.002513 · Cited by 1,022 · see citing works
Hippocampal synaptic transmission enhanced by low concentrations of nicotine
Gray, R. G. F., Rajan, A. S., Radcliffe, K. A., Yakehiro, M., & Dani, J. A. (1996) · Nature · doi:10.1038/383713a0 · Cited by 947 · see citing works
Emerging structure of the Nicotinic Acetylcholine receptors
Karlin, A. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn731 · Cited by 921 · see citing works
Elgoyhen, A. B., Johnson, D. S., Boulter, J., Vetter, D. E., & Heinemann, S. (1994) · Cell · doi:10.1016/0092-8674(94)90555-x · Cited by 899 · see citing works
Neuronal nicotinic receptors in the human brain
Paterson, D., & Nordberg, A. K. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00045-3 · Cited by 782 · see citing works
Nicotinic Receptors in the Development and Modulation of CNS Synapses
Role, L. W., & Berg, D. K. (1996) · Neuron · doi:10.1016/s0896-6273(00)80134-8 · Cited by 762 · see citing works
PRESYNAPTIC IONOTROPIC RECEPTORS AND THE CONTROL OF TRANSMITTER RELEASE
MacDermott, A. B., Role, L. W., & Siegelbaum, S. A. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.443 · Cited by 570 · see citing works
Reduced antinociception in mice lacking neuronal nicotinic receptor subunits
Marubio, L. M., Jiménez, M. D. M. A., Cordero‐Erausquin, M., Léna, C., Novère, N. G. L., d’Exaerde, A. D. K., Huchet, M., Damaj, M. I., & Changeux, J. (1999) · Nature · doi:10.1038/19756 · Cited by 533 · see citing works
Nicotinic acetylcholine receptors: from structure to brain function
Hogg, R. C., Raggenbass, M., & Bertrand, D. (2003) · Springer eBooks · doi:10.1007/s10254-003-0005-1 · Cited by 529 · see citing works
Self-citationOrr‐Urtreger, A., Göldner, F. M., Saeki, M., Lorenzo, I., Goldberg, L. B., Biasi, M. D., Dani, J. A., Patrick, J. W., & Beaudet, A. L. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-23-09165.1997 · Cited by 494 · see citing works
Nicotinic acetylcholine receptors in health and disease
Lindstrom, J. (1997) · Molecular Neurobiology · doi:10.1007/bf02740634 · Cited by 443 · see citing works
Timing and Location of Nicotinic Activity Enhances or Depresses Hippocampal Synaptic Plasticity
Ji, D., Lape, R., & Dani, J. A. (2001) · Neuron · doi:10.1016/s0896-6273(01)00332-4 · Cited by 419 · see citing works
Le Novère, N., Corringer, P., & Changeux, J. (2002) · Journal of Neurobiology · doi:10.1002/neu.10153 · Cited by 411 · see citing works
Identification of Four Classes of Brain Nicotinic Receptors Using β2 Mutant Mice
Zoli, M., Léna, C., Picciotto, M. R., & Changeux, J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-12-04461.1998 · Cited by 401 · see citing works
Identification of four classes of brain nicotinic receptors using beta2 mutant mice.
Zoli, M., Léna, C., Picciotto, M. R., & Changeux, J. (1998) · PubMed Central · doi:10.1523/jneurosci.18-12-04461.1996 · Cited by 387 · see citing works
Frazier, C. J., Rollins, Y. D., Breese, C. R., Leonard, S., Freedman, R., & Dunwiddie, T. V. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-04-01187.1998 · Cited by 374 · see citing works
Swanson, L. W., Simmons, D. M., Whiting, P. J., & Lindström, J. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-10-03334.1987 · Cited by 342 · see citing works
Alkondon, M., Pereira, E. F. R., Barbosa, C. T. F., & Albuquerque, E. X. (1997) · PubMed · Cited by 326 · see citing works
Brain nicotinic receptors: structure and regulation, role in learning and reinforcement
Changeux, J.-P., Bertrand, D., Corringer, P.-J., Dehaene, S., Edelstein, S., Léna, C., Le Novère, N., Marubio, L., Picciotto, M., & Zoli, M. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00040-4 · Cited by 322 · see citing works
Self-citationProgesterone modulates a neuronal nicotinic acetylcholine receptor.
Valera, S., Ballivet, M., & Bertrand, D. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.20.9949 · Cited by 277 · see citing works
Self-citationFunctional nicotinic ACh receptors on interneurones in the rat hippocampus
Jones, S., & Yakel, J. L. (1997) · The Journal of Physiology · doi:10.1111/j.1469-7793.1997.603bd.x · Cited by 271 · see citing works
Nicotinic Stimulation Produces Multiple Forms of Increased Glutamatergic Synaptic Transmission
Radcliffe, K. A., & Dani, J. A. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-18-07075.1998 · Cited by 271 · see citing works
Synaptic Plasticity and Nicotine Addiction
Dani, J. A., Ji, D., & Zhou, F.-M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00379-8 · Cited by 266 · see citing works
Alkondon, M., Pereira, E. F. R., & Albuquerque, E. X. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00880-4 · Cited by 263 · see citing works
Perry, D. C., Xiao, Y., Nguyen, H. N., Musachio, J. L., Dávila‐García, M. I., & Kellar, K. J. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00951.x · Cited by 246 · see citing works
Ji, D., & Dani, J. A. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.5.2682 · Cited by 231 · see citing works
Atlas of the Developing Rat Nervous System
(1994) · Elsevier eBooks · doi:10.1016/c2009-0-02416-7 · Cited by 221 · see citing works
A Novel Human Nicotinic Receptor Subunit, α10, That Confers Functionality to the α9-Subunit
Sgard, F., Charpantier, E., Bertrand, S., Walker, N., Caput, D., Graham, D., Bertrand, D., & Besnard, F. (2002) · Molecular Pharmacology · doi:10.1124/mol.61.1.150 · Cited by 212 · see citing works
Self-citationNicotinic receptors in aging and dementia
Picciotto, M. R., & Zoli, M. (2002) · Journal of Neurobiology · doi:10.1002/neu.10102 · Cited by 207 · see citing works
Chen, D., & Patrick, J. W. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.38.24024 · Cited by 206 · see citing works
Roerig, B., Nelson, D. A., & Katz, L. C. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-21-08353.1997 · Cited by 192 · see citing works
[3H]epibatidine labels nicotinic receptors in rat brain: an autoradiographic study.
Perry, D. C., & Kellar, K. J. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12091-0 · Cited by 163 · see citing works
Hefft, S., Hulo, S., Bertrand, D., & Müller, D. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.769ab.x · Cited by 152 · see citing works
Self-citationParadiso, K. G., Zhang, J., & Steinbach, J. H. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-17-06561.2001 · Cited by 144 · see citing works
Picone, T., Allen, L., Olsen, P., & Ferris, M. (1982) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/36.6.1214 · Cited by 133 · see citing works
Zhang, X., Liu, C., Miao, H., Gong, Z., & Nordberg, A. K. (1998) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(98)00044-6 · Cited by 123 · see citing works
Broide, R. S., Robertson, R. T., & Leslie, F. M. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-09-02956.1996 · Cited by 123 · see citing works
A critical period for nicotine-induced disruption of synaptic development in rat auditory cortex
Aramakis, V. B., Hsieh, C. Y., Leslie, F. M., & Metherate, R. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-16-06106.2000 · Cited by 120 · see citing works
Identification of a novel nicotinic binding site in mouse brain using [125I]‐epibatidine
Whiteaker, P., Jimenez, M., McIntosh, J. M., Collins, A. C., & Marks, M. J. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703616 · Cited by 105 · see citing works
The behaviour of infants whose mothers smoke in pregnancy
Saxton, D. W. (1978) · Early Human Development · doi:10.1016/0378-3782(78)90063-4 · Cited by 102 · see citing works
Han, Z., Zoli, M., Cardona, A., Bourgeois, J., Changeux, J., & Novère, N. G. L. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10659 · Cited by 99 · see citing works
Potentiation of Human α4β2 Neuronal Nicotinic Acetylcholine Receptor by Estradiol
Curtis, L., Buisson, B., Bertrand, S., & Bertrand, D. (2002) · Molecular Pharmacology · doi:10.1124/mol.61.1.127 · Cited by 94 · see citing works
Self-citationRobinson, D. M., Peebles, K. C., Kwok, H. C. K., Adams, B. M., Clarke, L., Woollard, G. A., & Funk, G. D. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.012705 · Cited by 83 · see citing works
Nicotinic receptors in circuit excitability and epilepsy
Raggenbass, M., & Bertrand, D. (2002) · Journal of Neurobiology · doi:10.1002/neu.10152 · Cited by 82 · see citing works
Self-citationFrazier, C. J., Strowbridge, B. W., & Papke, R. L. (2003) · Journal of Neurophysiology · doi:10.1152/jn.01036.2002 · Cited by 80 · see citing works
Nicotinic Acetylcholine Receptors
Wiley, J., York, N., Colquhoun, D., Unwin, P. N. T., Shelley, C., Hatton, C., & Sivilotti, L. G. (2004) · Encyclopedic Dictionary of Genetics, Genomics and Proteomics · doi:10.1002/0471684228.egp08474 · Cited by 79 · see citing works
Synaptic Potentials Mediated by α7 Nicotinic Acetylcholine Receptors in Supraoptic Nucleus
Hatton, G. I., & Yang, Q. Z. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-01-00029.2002 · Cited by 63 · see citing works
Tizabi, Y., Russell, L. T., Nespor, S. M., Perry, D. C., & Grunberg, N. E. (2000) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(00)00171-4 · Cited by 55 · see citing works
The α7 nicotinic receptors in human fetal brain and spinal cord
Falk, L. L., Nordberg, A. K., Seiger, Å., Kjældgaard, A., & Hellström‐Lindahl, E. (2002) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2001.00714.x · Cited by 49 · see citing works
Nicotinic receptor expression following nicotine exposure via maternal milk
Narayanan, U., Birru, S., Vaglenova, J., & Breese, C. R. (2002) · Neuroreport · doi:10.1097/00001756-200205240-00012 · Cited by 48 · see citing works
Agulhon, C., Charnay, Y., Vallet, P. G., Bertrand, D., & Malafosse, A. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00113-2 · Cited by 43 · see citing works
Self-citationTizabi, Y., & Perry, D. C. (2000) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(00)00379-8 · Cited by 43 · see citing works
Higher expression of α7 nicotinic acetylcholine receptors in human fetal compared to adult brain
Falk, L. L., Nordberg, A. K., Seiger, Å., Kjældgaard, A., & Hellström‐Lindahl, E. (2003) · Developmental Brain Research · doi:10.1016/s0165-3806(03)00063-4 · Cited by 42 · see citing works
Localization of mRNA for CHRNA7 in human fetal brain.
Agulhon, C., Abitbol, M. M., Bertrand, D., & Malafosse, A. (1999) · PubMed · Cited by 31 · see citing works
Self-citationSubunit and region-specific decreases in nicotinic acetylcholine receptor mRNA in the aged rat brain
Ferrari, R., Pedrazzi, P., Algeri, S., Agnati, L. F., & Zoli, M. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00015-9 · Cited by 28 · see citing works
Interaction of maternal smoking and other in-pregnancy exposures Analytic considerations
Mattson, S. N. (2002) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(02)00198-8 · Cited by 12 · see citing works
Flagged first, then by citations
1 of the 64 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Neuronal nicotinic receptors: from structure to pathology
Gotti, C., & Clementi, F. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.09.006 · Cited by 970 · see citing works
The dynamic effects of nicotine on the developing brain
Dwyer, J. B., McQuown, S. C., & Leslie, F. M. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.02.003 · Cited by 559 · see citing works
Nicotinic acetylcholine receptors: From basic science to therapeutics
Hurst, R. S., Rollema, H., & Bertrand, D. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.08.012 · Cited by 525 · see citing works
Self-citationDevelopment of prefrontal cortex
Kolk, S. M., & Rakic, P. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01137-9 · Cited by 378 · see citing works
Nicotine and brain development
Dwyer, J. B., Broide, R. S., & Leslie, F. M. (2008) · Birth Defects Research Part C: Embryo Today: Reviews · doi:10.1002/bdrc.20118 · Cited by 256 · see citing works
Targeting the nicotinic alpha7 acetylcholine receptor to enhance cognition in disease
Wallace, T. L., & Porter, R. H. P. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.06.034 · Cited by 225 · see citing works
Elevations of Endogenous Kynurenic Acid Produce Spatial Working Memory Deficits
Chess, A. C., Simoni, M. K., Alling, T. E., & Bucci, D. J. (2006) · Schizophrenia Bulletin · doi:10.1093/schbul/sbl033 · Cited by 225 · see citing works
Hajós, M., Hurst, R. S., Hoffmann, W. E., Krause, M., Wall, T. M., Higdon, N. R., & Groppi, V. E. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.076968 · Cited by 225 · see citing works
Layer-Specific Modulation of the Prefrontal Cortex by Nicotinic Acetylcholine Receptors
Poorthuis, R. B., Bloem, B., Schak, B., Wester, J., de Kock, C. P. J., & Mansvelder, H. D. (2013) · Cerebral Cortex · doi:10.1093/cercor/bhr390 · Cited by 176 · see citing works
Biton, B., Bergis, O. E., Galli, F., Alain, N., Lochead, A. W., Jegham, S., Godet, D., Lanneau, C., Santamaria, R., Chesney, F., et al. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301189 · Cited by 174 · see citing works
Alteration of the in vivo nicotinic receptor density in ADNFLE patients: a PET study
Picard, F., Bruel, D., Servent, D., Saba, W., Fruchart‐Gaillard, C., Peyronneau, M., Roumenov, D., Brodtkorb, E., Zuberi, S. M., Gambardella, A., et al. (2006) · Brain · doi:10.1093/brain/awl156 · Cited by 168 · see citing works
Developmental aspects of the cholinergic system
Abreu‐Villaça, Y., Filgueiras, C. C., & Manhães, A. C. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.12.049 · Cited by 166 · see citing works
Picciotto, M. R., Lewis, A. S., van Schalkwyk, G. I., & Mineur, Y. S. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.12.028 · Cited by 157 · see citing works
Guidetti, P., Hoffman, G. E., Meléndez‐Ferro, M., Albuquerque, E. X., & Schwarcz, R. M. (2006) · Glia · doi:10.1002/glia.20432 · Cited by 156 · see citing works
Alpha 7 nicotinic acetylcholine receptor and its effects on Alzheimer's disease
Ma, K., & Qian, Y. (2018) · Neuropeptides · doi:10.1016/j.npep.2018.12.003 · Cited by 143 · see citing works
Therapeutic Potential of α7 Nicotinic Acetylcholine Receptors
Bertrand, D., Lee, C., Flood, D. G., Marger, F., & Donnelly‐Roberts, D. L. (2015) · Pharmacological Reviews · doi:10.1124/pr.113.008581 · Cited by 139 · see citing works
Self-citationCellular, Synaptic and Network Effects of Acetylcholine in the Neocortex
Colangelo, C., Shichkova, P., Keller, D. X., Markram, H., & Ramaswamy, S. (2019) · Frontiers in Neural Circuits · doi:10.3389/fncir.2019.00024 · Cited by 134 · see citing works
Altered map of visual space in the superior colliculus of mice lacking early retinal waves
Mrsic-Flogel, T. D., Hofer, S. B., Creutzfeldt, C., Cloëz-Tayarani, I., Changeux, J.-P., Bonhoeffer, T., & Hübener, M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1555-05.2005 · Cited by 131 · see citing works
Nucleus incertus—An emerging modulatory role in arousal, stress and memory
Ryan, P. J., Ma, S., Olucha-Bordonau, F. E., & Gundlach, A. L. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.02.004 · Cited by 131 · see citing works
Developmental Excitation of Corticothalamic Neurons by Nicotinic Acetylcholine Receptors
Kassam, S. M., Herman, P. M., Goodfellow, N. M., Alves, N. C., & Lambe, E. K. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2645-08.2008 · Cited by 100 · see citing works
Cholinergic influences on cortical development and adult neurogenesis
Bruel‐Jungerman, E., Lucassen, P. J., & Francis, F. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.01.021 · Cited by 110 · see citing works
Nicotinic receptors regulate the survival of newborn neurons in the adult olfactory bulb
Mechawar, N., Saghatelyan, A., Grailhe, R., Scoriels, L., Gheusi, G., Gabellec, M.-M., Lledo, P.-M., & Changeux, J.-P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403361101 · Cited by 104 · see citing works
Guseva, M., Hopkins, D. M., Scheff, S. W., & Pauly, J. R. (2008) · Journal of Neurotrauma · doi:10.1089/neu.2008.0516 · Cited by 97 · see citing works
The Developmental Decrease in REM Sleep: The Role of Transmitters and Electrical Coupling
García‐Rill, E., Charlesworth, A. G., Heister, D. S., Ye, M., & Hayar, A. M. (2008) · SLEEP · doi:10.1093/sleep/31.5.673 · Cited by 96 · see citing works
α7 Nicotinic acetylcholine receptors and their role in cognition
Lendvai, B., Kassai, F., Szájli, Á., & Némethy, Z. (2012) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2012.11.003 · Cited by 95 · see citing works
Scientific Opinion on the developmental neurotoxicity potential of acetamiprid and imidacloprid
(PPR), E. P. O. P. P. P. A. T. R. (2013) · EFSA Journal · doi:10.2903/j.efsa.2013.3471 · Cited by 97 · see citing works
Nicotinic α 7 Receptors as a New Target for Treatment of Cannabis Abuse
Solinas, M., Scherma, M., Fattore, L., Stroik, J., Wertheim, C. E., Tanda, G., Fratta, W., & Goldberg, S. R. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0027-07.2007 · Cited by 86 · see citing works
Acetylcholine excites neocortical pyramidal neurons via nicotinic receptors
Hedrick, T. P., & Waters, J. (2015) · Journal of Neurophysiology · doi:10.1152/jn.00716.2014 · Cited by 86 · see citing works
Regional Brain Activity Correlates of Nicotine Dependence
Rose, J. E., Behm, F. M., Salley, A. N., Bates, J. E., Coleman, R. E., Hawk, T. C., & Turkington, T. G. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301379 · Cited by 78 · see citing works
Chess, A. C., & Bucci, D. J. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.03.006 · Cited by 78 · see citing works
Nicotinic mechanisms influencing synaptic plasticity in the hippocampus
Placzek, A. N., Zhang, T. A., & Dani, J. A. (2009) · Acta Pharmacologica Sinica · doi:10.1038/aps.2009.39 · Cited by 77 · see citing works
Gozzi, A., Schwarz, A. J., Reese, T., Bertani, S., Crestan, V., & Bifone, A. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300955 · Cited by 77 · see citing works
Targeting α7 Nicotinic Acetylcholine Receptors in the Treatment of Schizophrenia
Hajós, M., & Rogers, B. N. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210790361434 · Cited by 73 · see citing works
Alpha7 neuronal nicotinic receptors as a drug target in schizophrenia
Wallace, T. L., & Bertrand, D. (2012) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2013.736498 · Cited by 72 · see citing works
Self-citationKunii, Y., Zhang, W., Xu, Q., Hyde, T. M., McFadden, W. C., Shin, J. H., Deep‐Soboslay, A., Ye, T., Li, C., Kleinman, J. E., et al. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.14080978 · Cited by 70 · see citing works
Bailey, C. D. C., Alves, N. C., Nashmi, R., De Biasi, M., & Lambe, E. K. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.09.011 · Cited by 69 · see citing works
Attention and working memory deficits in a perinatal nicotine exposure mouse model
Zhang, L., Spencer, T., Biederman, J., & Bhide, P. (2018) · PLoS ONE · doi:10.1371/journal.pone.0198064 · Cited by 65 · see citing works
The septo-hippocampal system, learning and recovery of function
Niewiadomska, G., Baksalerska-Pazera, M., & Riedel, G. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.03.039 · Cited by 67 · see citing works
Beinat, C., Banister, S. D., Herrera, M., Law, V., & Kassiou, M. (2015) · CNS Drugs · doi:10.1007/s40263-015-0260-0 · Cited by 71 · see citing works
Mathew, S., Law, A. J., Lipska, B. K., Dávila‐García, M. I., Zamora, E. D., Mitkus, S. N., Vakkalanka, R., Straub, R. E., Weinberger, D. R., Kleinman, J. E., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm253 · Cited by 63 · see citing works
Magueresse, C. L., Safiulina, V. F., Changeux, J., & Cherubini, E. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.117572 · Cited by 59 · see citing works
Nicotine improves performance in an attentional set shifting task in rats.
Allison, C., & Shoaib, M. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.06.055 · Cited by 63 · see citing works
Proulx, É., Piva, M., Tian, M. K., Bailey, C. D. C., & Lambe, E. K. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1481-3 · Cited by 57 · see citing works
Son, J., & Winzer‐Serhan, U. H. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21828 · Cited by 58 · see citing works
Hascup, K. N., & Hascup, E. R. (2016) · Journal of Alzheimer's Disease · doi:10.3233/jad-160041 · Cited by 57 · see citing works
Ricceri, L., Filippis, B. D., Fuso, A., & Giovanni Laviola, A. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.03.051 · Cited by 55 · see citing works
Maggi, L., Sola, E., Minneci, F., Magueresse, C. L., Changeux, J., & Cherubini, E. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.067041 · Cited by 56 · see citing works
Anderson, D. J., Bunnelle, W. H., Surber, B. W., Du, J. Y., Surowy, C. S., Tribollet, E., Marguerat, A., Bertrand, D., & Gopalakrishnan, M. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.130062 · Cited by 52 · see citing works
Self-citationHuang, L. Z., Abbott, L. C., & Winzer‐Serhan, U. H. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.03.008 · Cited by 54 · see citing works
Cholinergic Control in Developing Prefrontal–Hippocampal Networks
Janiesch, P. C., Krüger, H.-S., Pöschel, B., & Hanganu-Opatz, I. L. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2644-11.2011 · Cited by 49 · see citing works
Huang, L. Z., & Winzer‐Serhan, U. H. (2006) · Brain Research · doi:10.1016/j.brainres.2006.06.084 · Cited by 52 · see citing works
Slater, C. L., Liu, Y., Weiss, E., Yu, K., & Wang, Q. (2022) · Brain Sciences · doi:10.3390/brainsci12070890 · Cited by 49 · see citing works
Distribution of α7 Nicotinic Acetylcholine Receptor Subunit mRNA in the Developing Mouse
Broide, R. S., Winzer‐Serhan, U. H., Chen, Y., & Leslie, F. M. (2019) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2019.00076 · Cited by 50 · see citing works
Matta, S. G., & Elberger, A. J. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0767-2 · Cited by 48 · see citing works
Christensen, D. Z., Mikkelsen, J. D., Hansen, H. H., & Thomsen, M. S. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06845.x · Cited by 46 · see citing works
Skoubis, P. D., Hradil, V. P., Chin, C.-L., Luo, Y., Fox, G. B., & McGaraughty, S. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.08.072 · Cited by 46 · see citing works
Regulation of hippocampal inhibitory circuits by nicotinic acetylcholine receptors
Griguoli, M., & Cherubini, E. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.220095 · Cited by 44 · see citing works
Aznavour, N., Watkins, K. C., & Descarries, L. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20501 · Cited by 45 · see citing works
Expression of mutant β2 nicotinic receptors during development is crucial for epileptogenesis
Manfredi, I., Zani, A. D., Rampoldi, L., Pegorini, S., Bernascone, I., Moretti, M., Gotti, C., Croci, L., Consalez, G. G., Ferini‐Strambi, L., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp004 · Cited by 43 · see citing works
Mukherjee, J., Lao, P. J., Betthauser, T. J., Samra, G. K., Pan, M., Patel, I. H., Liang, C., Metherate, R., & Christian, B. T. (2017) · The Journal of Comparative Neurology · doi:10.1002/cne.24320 · Cited by 43 · see citing works
Neurochemistry of the Kölliker‐Fuse nucleus from a respiratory perspective
Varga, A. G., Maletz, S. N., Bateman, J. T., Reid, B. T., & Levitt, E. S. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15041 · Cited by 43 · see citing works
Involvement of cholinergic mechanisms in the behavioral effects of dietary fat consumption
Morganstern, I., Ye, Z., Liang, S., Fagan, S. E., & LEIBOWITZ, S. F. (2012) · Brain Research · doi:10.1016/j.brainres.2012.06.004 · Cited by 42 · see citing works
Griguoli, M., Maul, A., Nguyen, C., Giorgetti, A., Carloni, P., & Cherubini, E. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.2446-10.2010 · Cited by 41 · see citing works
Hansen, H. H., Timmermann, D. B., Peters, D., Walters, C. L., Damaj, M. I., & Mikkelsen, J. D. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21293 · Cited by 40 · see citing works
Otvos, R. A., Still, K. B. M., Somsen, G. W., Smit, A. B., & Kool, J. (2019) · SLAS DISCOVERY · doi:10.1177/2472555218822098 · Cited by 39 · see citing works
Authority), E. (. F. S., Hernandez‐Jerez, A., Coja, T., Paparella, M., Price, A., Henri, J., Focks, A., Louisse, J., Terron, A., Binaglia, M., et al. (2024) · EFSA Journal · doi:10.2903/j.efsa.2024.8759 · Cited by 37 · see citing works
Centeno, M. L., Henderson, J. A., Pau, K. ‐. F., & Bethea, C. L. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21026 · Cited by 38 · see citing works
Murakami, Y., Imamura, Y., Kasahara, Y., Yoshida, C., Momono, Y., Fang, K., Sakai, D., Konishi, Y., & Nishiyama, T. (2023) · Cells · doi:10.3390/cells12071087 · Cited by 36 · see citing works
Time-dependent alterations of cholinergic markers after experimental traumatic brain injury
Donat, C. K., Schuhmann, M. U., Voigt, C., Nieber, K., Deuther‐Conrad, W., & Brust, P. (2008) · Brain Research · doi:10.1016/j.brainres.2008.09.059 · Cited by 37 · see citing works
α7 nicotinic acetylcholine receptor agonist properties of tilorone and related tricyclic analogues
Briggs, C. A., Schrimpf, M. R., Anderson, D. J., Gubbins, E. J., Grønlien, J. H., Håkerud, M., Ween, H., Thorin‐Hagene, K., Malysz, J., Li, J., et al. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707649 · Cited by 36 · see citing works
Thany, S. H., & Tricoire-Leignel, H. (2011) · Current Neuropharmacology · doi:10.2174/157015911798376343 · Cited by 34 · see citing works
Vivekanandarajah, A., Chan, Y. L., Chen, H., & Machaalani, R. (2015) · NeuroToxicology · doi:10.1016/j.neuro.2015.12.017 · Cited by 36 · see citing works
Scientific Opinion on the developmental neurotoxicity potential of acetamiprid and imidacloprid
Ockleford, C. (2013) · Cited by 36 · see citing works
Nicotine regulates mRNA expression of feeding peptides in the arcuate nucleus in neonatal rat pups
Huang, L. Z., & Winzer‐Serhan, U. H. (2007) · Developmental Neurobiology · doi:10.1002/dneu.20348 · Cited by 36 · see citing works
Kim, J. H., Perry, C. J., Ganella, D. E., & Madsen, H. B. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.10.018 · Cited by 35 · see citing works
Duncan, J. R., Paterson, D. S., & Kinney, H. C. (2008) · Autonomic Neuroscience · doi:10.1016/j.autneu.2008.09.006 · Cited by 35 · see citing works
Tőkés, T., Tuboly, E., Varga, G., Major, L., Ghyczy, M., Kaszaki, J., & Boros, M. (2014) · European Journal of Nutrition · doi:10.1007/s00394-014-0691-2 · Cited by 35 · see citing works
Neuronal α7 Nicotinic Receptors as a Target for the Treatment of Schizophrenia
Wallace, T. L., & Bertrand, D. (2015) · International review of neurobiology · doi:10.1016/bs.irn.2015.08.003 · Cited by 33 · see citing works
Self-citationDallanoce, C., Magrone, P., Matera, C., Frigerio, F., Grazioso, G., Amici, M. D., Fucile, S., Piccari, V., Frydenvang, K., Pucci, L., et al. (2011) · ChemMedChem · doi:10.1002/cmdc.201000514 · Cited by 33 · see citing works
Damborsky, J. C., & Winzer‐Serhan, U. H. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.09.002 · Cited by 33 · see citing works
Magueresse, C. L., & Cherubini, E. (2007) · Hippocampus · doi:10.1002/hipo.20271 · Cited by 33 · see citing works
Machaalani, R., Kashi, P. K., & Waters, K. A. (2010) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2010.05.009 · Cited by 32 · see citing works
Tian, M. K., Bailey, C. D. C., & Lambe, E. K. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12622 · Cited by 28 · see citing works
Section I. The Cholinergic System
Smythies, J. (2005) · International review of neurobiology · doi:10.1016/s0074-7742(05)64001-9 · Cited by 32 · see citing works
Kroker, K. S., Rast, G. F., & Rosenbrock, H. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.09.167 · Cited by 31 · see citing works
Hoffmeister, P.-G., Donat, C. K., Schuhmann, M. U., Voigt, C., Walter, B. L., Nieber, K., Meixensberger, J., Bauer, R., & Brust, P. (2010) · NeuroMolecular Medicine · doi:10.1007/s12017-010-8136-4 · Cited by 31 · see citing works
Son, J., & Winzer‐Serhan, U. H. (2009) · Brain Research · doi:10.1016/j.brainres.2009.04.046 · Cited by 31 · see citing works
Selectivity of ABT-089 for α4β2* and α6β2* nicotinic acetylcholine receptors in brain
Marks, M. J., Wageman, C. R., Grady, S. R., Gopalakrishnan, M., & Briggs, C. A. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.05.022 · Cited by 30 · see citing works
The possible contribution of neuronal nicotinic acetylcholine receptors in depression
Bertrand, D. (2005) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2005.7.3/dbertrand · Cited by 30 · see citing works
Self-citationSchulz, K. M., Andrud, K. M., Burke, M. B., Pearson-Smith, J. N., Kreisler, A. D., Stevens, K. E., Leonard, S. S., & Adams, C. E. (2013) · Developmental Neurobiology · doi:10.1002/dneu.22097 · Cited by 29 · see citing works
Smoking during pregnancy: Postnatal effects on arousal and attentional brain systems
García‐Rill, E., Buchanan, R., McKeon, K., Skinner, R. D., & Wallace, T. (2007) · NeuroToxicology · doi:10.1016/j.neuro.2007.01.007 · Cited by 27 · see citing works
Mok, M. H. S., & Kew, J. N. C. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.104794 · Cited by 28 · see citing works
Nakauchi, S., Malvaez, M., Su, H., Kleeman, E., Dang, R., Wood, M. A., & Sumikawa, K. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.12.007 · Cited by 27 · see citing works
Heister, D. S., Hayar, A. M., & García‐Rill, E. (2009) · SLEEP · doi:10.1093/sleep/32.9.1135 · Cited by 27 · see citing works
Morris, K. A., & Gold, P. E. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.11.010 · Cited by 27 · see citing works
Impact of ageing on postsynaptic neuronal nicotinic neurotransmission in auditory thalamus
Sottile, S. Y., Ling, L. L., Cox, B. C., & Caspary, D. M. (2017) · The Journal of Physiology · doi:10.1113/jp274467 · Cited by 27 · see citing works
Aging Affects Nicotinic Acetylcholine Receptors in Brain
Utkin, Y. N. (2019) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/1871524919666190320102834 · Cited by 26 · see citing works
Muscarinic and nicotinic responses in the developing pedunculopontine nucleus (PPN)
Good, C. H., Bay, K. D., Buchanan, R., Skinner, R. D., & García‐Rill, E. (2006) · Brain Research · doi:10.1016/j.brainres.2006.10.046 · Cited by 25 · see citing works
Martin, M. M., McCarthy, D. M., Schatschneider, C. W., Trupiano, M. X., Jones, S. K., Kalluri, A., & Bhide, P. G. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz207 · Cited by 25 · see citing works
Ghimire, M., Cai, R., Ling, L. L., Hackett, T. A., & Caspary, D. M. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.0093-20.2020 · Cited by 25 · see citing works
- Authors
- Tribollet, E., Bertrand, D., Marguerat, A., & Raggenbass, M.
- Affiliations
- University of Geneva (CH)
- ORCID
- Bertrand, D
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2004-01
- Volume
- 124
- Issue
- 2
- Pages
- 405-420
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2140445474
- Cited by
- 199
- References
- 64
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 8 · 2018: 7 · 2017: 6 · 2016: 3 · 2015: 13 · 2014: 8 · 2013: 9 · 2012: 18
- FWCI
- 5.80
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Keywords
- nicotinic acetylcholine receptors, alpha7 nicotinic acetylcholine receptor, receptor distribution, brain development, aging, embryonic development, postnatal development, receptor binding sites, epibatidine binding, alpha-bungarotoxin binding, neuronal connectivity, rat brain
- MeSH terms
- Age Factors, Aging, Animals, Animals, Newborn, Autoradiography, Binding Sites, Brain, Brain Chemistry, Bungarotoxins, Embryo, Mammalian, Female, Iodine Isotopes, Male, Pyridines, Receptors, Nicotinic, Tissue Distribution, Tritium, Rats, Sprague-Dawley, Rats, Wistar, Nicotinic Agonists, Bridged Bicyclo Compounds, Heterocyclic, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review