Both oxytocin and vasopressin may influence alloparental behavior in male prairie voles
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Neuropeptides, especially oxytocin (OT) and arginine vasopressin (AVP), have been implicated in several features of monogamy including alloparenting. The purpose of the present study was to examine the role of OT and AVP in alloparental behavior in reproductively naïve male prairie voles. Males received intracerebroventricular (ICV) injections of artificial cerebrospinal fluid (aCSF), OT, an OT receptor antagonist (OTA), AVP, an AVP receptor antagonist (AVPA), or combinations of OTA and AVPA and were subsequently tested for parental behavior. Approximately 45 min after treatment, animals were tested for behavioral responses to stimulus pups. In a 10-min test, spontaneous alloparental behavior was high in control animals. OT and AVP did not significantly increase the number of males that showed parental behavior, although more subtle behavioral changes were observed. Combined treatment with AVPA and OTA (10 ng each) significantly reduced male parental behavior and increased attacks; following a lower dose (1 ng OTA/1 ng AVPA), males were less likely to display kyphosis and tended to be slower to approach pups than controls. Since treatment with only one antagonist did not interfere with the expression of alloparenting, these results suggest that access to either OT or AVP receptors may be sufficient for the expression of alloparenting.
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Male prairie voles appear to facilitate infant care behavior through either the oxytocin or arginine vasopressin system.
“Males appear to facilitate infant care behavior through either the OT or AVP system (34).”
From Chronic intranasal oxytocin causes long-term impairments in partner preference formation in male prairie voles (2013) · cites this paper as [34]
Studies in numerous species provide converging evidence that oxytocin during development can have permanent effects on the brain and behavior.
“Yet, in the last 12 years, there has been a resurgence of research in this area, with studies in numerous species providing converging evidence that Oxt during development can have permanent effects on the brain and behavior (3, 13–29) (see Table 1).”
From Oxytocin during Development: Possible Organizational Effects on Behavior (2015) · cites this paper as [13]
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“The relationship between oxytocin and alloparenting behavior has also been established in adult male prairie volves (Bales et al., 2004a).”
BackgroundVasopressinergic Neurocircuitry Regulating Social Attachment in a Monogamous Species
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Self-citation
- Authors
- Bales, K. L., Kim, A. J., Lewis-Reese, A. D., & Sue Carter, C.
- Affiliations
- University of Illinois Chicago (US)
- Corresponding author
- Bales, Karen L
- ORCID
- Bales, Karen L
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 2004-05
- Volume
- 45
- Issue
- 5
- Pages
- 354-361
- ISSN
- 0018-506X (ISSN-L)
- OpenAlex
- W2056925553
- Cited by
- 217
- References
- 62
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 9 · 2023: 3 · 2022: 27 · 2021: 7 · 2020: 22 · 2019: 9 · 2018: 8 · 2017: 20 · 2016: 12 · 2015: 15 · 2014: 13 · 2013: 6 · 2012: 15
- FWCI
- 6.95
- Type
- journal article
- Language
- en
- Open access
- green
- escholarship.org
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
- Funders
- Institute for Research on Unlimited Love
- National Institutes of Health
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01 HD 38490, P01HD038490, F32 HD08702, F32HD008702)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, vasopressin, Microtus ochrogaster, monogamy, neuropeptides, oxytocin receptor antagonist, vasopressin receptor antagonists, male parental behavior, intracerebroventricular administration, kyphosis
- MeSH terms
- Aggression, Animals, Arvicolinae, Injections, Intraventricular, Male, Nesting Behavior, Oxytocin, Paternal Behavior, Vasopressins, Vasotocin, Receptors, Oxytocin, Antidiuretic Hormone Receptor Antagonists
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