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Brain Expression, Physiological Regulation and Role in Motivation and Associative Learning of Peroxisome Proliferator-activated Receptor γ
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PPARγ regulates ABCA1, LXRα, LPL, and GYK.
“In addition to LRP1, other genes are regulated by PPARγ such as ABCA1, LXRα, LPL, and GYK [52,83,84], and all were found to be down-regulated in ApoE4 astrocytes (Figure 2 and Figure 5).”
From ApoE3 vs. ApoE4 Astrocytes: A Detailed Analysis Provides New Insights into Differences in Cholesterol Homeostasis (2022) · cites this paper as [84]
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Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies
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Thiazolidinediones: the forgotten diabetes medications
Lebovitz, H. E. (2019) · Current Diabetes Reports · doi:10.1007/s11892-019-1270-y · Cited by 388
Mandrekar-Colucci, S., Karlo, J. C., & Landreth, G. E. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5268-11.2012 · Cited by 355 · cited 2×
“…on the cognition-improving effects of PPARγ stimulation in 447 rodents (Heneka et al. 2005; Pedersen et al. 2006; Rodriguez-Rivera et al. 2011; Denner et al. 2012; 448 Jahrling et al. 2014; Mandrekar-Colucci et al. 2012; Searcy et al. 2012) and humans (Risner et al. 449 2006; Sato et al. 2011).”
BackgroundAging and Alzheimer's disease: comparison and associations from molecular to system level
Xia, X., Jiang, Q., McDermott, J., & Han, J. J. (2018) · Aging Cell · doi:10.1111/acel.12802 · Cited by 301
Searcy, J. L., Phelps, J. T., Pancani, T., Kadish, I., Popovic, J., Anderson, K. L., Beckett, T. L., Murphy, M. P., Chen, K.-C., Blalock, E. M., et al. (2012) · Journal of Alzheimer's Disease · doi:10.3233/jad-2012-111661 · Cited by 154
Woon, L. S.-C., Sidi, H. B., Ravindran, A., Gosse, P. J., Mainland, R. L., Kaunismaa, E. S., Hatta, N. H., Arnawati, P., Zulkifli, A. Y., Mustafa, N., et al. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02615-y · Cited by 63
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Sorted by citations
Staurenghi, E., Leoni, V., Lo Iacono, M., Sottero, B., Testa, G., Giannelli, S., Leonarduzzi, G., & Gamba, P. (2022) · Antioxidants · doi:10.3390/antiox11112168 · Cited by 24
Metadata
- Authors
- Moosecker, S., Pissioti, A., Leidmaa, E., Harb, M. R., Dioli, C., Gassen, N. C., Yu, S., Gazea, M., Catania, C., Anderzhanova, E., Patchev, A. V., Kühne, C., Stoffel, R., Sotiropoulos, I., & Almeida, O. F. X.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2021-12
- Volume
- 479
- Pages
- 91-106
- ISSN
- 0306-4522
- Cited by
- 12
- References
- 12
- Language
- en
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