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Cited by 231Amyotrophic Lateral Sclerosis ResearchNeuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

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Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: Assessed with [11C]-PBR28

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Zürcher, Nicole R., Loggia, Marco L., Lawson, Robert, Chonde, Daniel B., Izquierdo-Garcia, David, Yasek, Julia E., Akeju, Oluwaseun, Catana, Ciprian, Rosen, Bruce R., Cudkowicz, Merit E., Hooker, Jacob M., Atassi, Nazem·2015·NeuroImage: Clinical
DOI 10.1016/j.nicl.2015.01.009PMC PMC4310932
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Abstract

Evidence from human post mortem, in vivo and animal model studies implicates the neuroimmune system and activated microglia in the pathology of amyotrophic lateral sclerosis. The study aim was to further evaluate in vivo neuroinflammation in individuals with amyotrophic lateral sclerosis using [(11)C]-PBR28 positron emission tomography. Ten patients with amyotrophic lateral sclerosis (seven males, three females, 38-68 years) and ten age- and [(11)C]-PBR28 binding affinity-matched healthy volunteers (six males, four females, 33-65 years) completed a positron emission tomography scan. Standardized uptake values were calculated from 60 to 90 min post-injection and normalized to whole brain mean. Voxel-wise analysis showed increased binding in the motor cortices and corticospinal tracts in patients with amyotrophic lateral sclerosis compared to healthy controls (p FWE < 0.05). Region of interest analysis revealed increased [(11)C]-PBR28 binding in the precentral gyrus in patients (normalized standardized uptake value = 1.15) compared to controls (1.03, p < 0.05). In patients those values were positively correlated with upper motor neuron burden scores (r = 0.69, p < 0.05), and negatively correlated with the amyotrophic lateral sclerosis functional rating scale (r = -0.66, p < 0.05). Increased in vivo glial activation in motor cortices, that correlates with phenotype, complements previous histopathological reports. Further studies will determine the role of [(11)C]-PBR28 as a marker of treatments that target neuroinflammation.

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Crossref · 10.1016/j.nicl.2015.01.009

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Fig. 1 [11C]-PBR28 SUVR60–90 min images and statistical maps for between-group differences. A. [11C]-PBR28 SUVR60–90 min for 10 individual ALS patients and 10 age- and binding affinity-matched healthy controls. SUVR60–90 min data are projected onto the MNI template in radiological orientation and shown at MNI coordinate z = +64. B. Mean [11C]-PBR28 SUVR60–90 min images for the ALS and control groups, including comparisons between limb- and bulbar-onset patients, shown at MNI coordinates x = −2, y = −20, and z = +64. C. Brain regions that exhibit significantly higher binding in ALS compared to the control group in the voxelwise whole brain analysis, pFWE < 0.05, shown at MNI coordinates x = −8, y = −20, and z = +64.
Fig. 1 [11C]-PBR28 SUVR60–90 min images and statistical maps for between-group differences. A. [11C]-PBR28 SUVR60–90 min for 10 individual ALS patients and 10 age- and binding affinity-matched healthy controls. SUVR60–90 min data are projected onto the MNI template in radiological orientation and shown at MNI coordinate z = +64. B. Mean [11C]-PBR28 SUVR60–90 min images for the ALS and control groups, including comparisons between limb- and bulbar-onset patients, shown at MNI coordinates x = −2, y = −20, and z = +64. C. Brain regions that exhibit significantly higher binding in ALS compared to the control group in the voxelwise whole brain analysis, pFWE < 0.05, shown at MNI coordinates x = −8, y = −20, and z = +64.CC BY-NC-ND · PubMed Central
Fig. 2 Increased glial activation in primary motor cortex in ALS. Boxplots for [11C]-PBR28 SUVR60–90 min for the precentral gyrus a priori ROI for individuals with ALS and healthy controls. Patients with ALS exhibit significantly increased binding in the motor cortex compared to healthy controls, *p < 0.05.
Fig. 2 Increased glial activation in primary motor cortex in ALS. Boxplots for [11C]-PBR28 SUVR60–90 min for the precentral gyrus a priori ROI for individuals with ALS and healthy controls. Patients with ALS exhibit significantly increased binding in the motor cortex compared to healthy controls, *p < 0.05.CC BY-NC-ND · PubMed Central
Fig. 3 Correlation between glial activation and ALS disease severity. Significant correlations between [11C]-PBR28 binding in the primary motor cortex and ALS disease severity assessed using UMNB and ALSFRS-R were observed. A. Patients with higher UMNB show increased binding in the motor cortex as shown by a positive correlation between UMNB scores and SUVR60–90 min in the right precentral gyrus a priori ROI. B. A negative correlation between the ALSFRS-R and SUVR60–90 min in the right precentral gyrus reflects the fact that patients with a higher disability (lower ALSFRS-R score) show increased PBR28 binding in the motor cortex.
Fig. 3 Correlation between glial activation and ALS disease severity. Significant correlations between [11C]-PBR28 binding in the primary motor cortex and ALS disease severity assessed using UMNB and ALSFRS-R were observed. A. Patients with higher UMNB show increased binding in the motor cortex as shown by a positive correlation between UMNB scores and SUVR60–90 min in the right precentral gyrus a priori ROI. B. A negative correlation between the ALSFRS-R and SUVR60–90 min in the right precentral gyrus reflects the fact that patients with a higher disability (lower ALSFRS-R score) show increased PBR28 binding in the motor cortex.CC BY-NC-ND · PubMed Central

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Metadata

Authors
Zürcher, N. R., Loggia, M. L., Lawson, R., Chonde, D. B., Izquierdo-Garcia, D., Yasek, J. E., Akeju, O., Catana, C., Rosen, B. R., Cudkowicz, M. E., Hooker, J. M., & Atassi, N.
Affiliations
Harvard University (US)
Corresponding author
  • Hooker, Jacob M.
  • Atassi, Nazem
ORCID
Venue
NeuroImage: Clinical
Publisher
Elsevier BV
Published
2015
Volume
7
Pages
409-414
ISSN
2213-1582 (ISSN-L)
DOI
10.1016/j.nicl.2015.01.009
PMC
PMC4310932
OpenAlex
W1969387798
Cited by
226
References
31
Citations by year
2026: 6 · 2025: 15 · 2024: 27 · 2023: 15 · 2022: 11 · 2021: 26 · 2020: 25 · 2019: 21 · 2018: 19 · 2017: 27 · 2016: 26 · 2015: 8
FWCI
18.79
Type
journal article
Language
en
Open access
Licence
Locations
  • NeuroImage Clinical (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • Harvard NeuroDiscovery Center
  • Muscular Dystrophy Association
  • American Academy of Neurology
  • Anne Young Fellowship
  • NINDS (1K23NS083715-01A1)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords
amyotrophic lateral sclerosis, glial activation, neuroinflammation, microglial activation, [11C]PBR28, positron emission tomography, motor cortex, corticospinal tract, ALSFRS-R, neuroimmune system
MeSH terms
Acetamides, Adult, Aged, Amyotrophic Lateral Sclerosis, Brain, Carbon Radioisotopes, Female, Humans, Male, Middle Aged, Neuroglia, Pyridines, Radiographic Image Interpretation, Computer-Assisted, Radiopharmaceuticals, Positron-Emission Tomography

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