Prolonged inactivation of the hippocampus reveals temporally graded retrograde amnesia for unreinforced spatial learning in rats
Abstract
We investigated whether systems consolidation of spatial memory could be detected in a non-navigational, spatial-learning test that takes advantage of rats' natural propensity to preferentially investigate an object that was displaced relative to spatial cues more than an object that remained stationary. Previous studies using navigational spatial-learning tests have generally failed to reveal temporally-graded retrograde amnesia, possibly because the hippocampus needs to be intact for the retrieval and/or processing of navigational information during the test. In the present study, the hippocampus of rats was kept inactivated, at two sites along its septo-temporal axis (dorsal and intermediate), for four consecutive days, beginning either 3h or 5 days after familiarization to two identical objects in an open field. Rats that had their hippocampus inactivated beginning 5 days but not 3h after familiarization showed evidence that they remembered the previous location of the displaced object. The results suggest that systems consolidation of spatial memories can be detected using a non-navigational test of spatial memory.
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Intra-hippocampal infusions of muscimol injected twice daily for 4 consecutive days, when injected 3 hours, but not 5 days, after the sample trial, impaired long-term OPP memory tested 2-4 days after the last infusion.
“Furthermore, when injected 3 hours, but not 5 days, after the sample trial, intra-hippocampal infusions of muscimol injected twice daily for 4 consecutive days, impaired long-term OPP memory which was tested 2–4 days after the last infusion of muscimol (Gaskin et al., 2011).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Gaskin et al., 2011
Pre-test intra-hippocampus infusions of muscimol disrupted OPP memory tested 24 hours later in rats, supporting a critical role of the hippocampus in the retrieval of long-term OPP memory.
“Pre-test intra-hippocampus infusions of muscimol also disrupted OPP memory tested 24 hours later in rats (Gaskin et al., 2011), supporting a critical role of the hippocampus in the retrieval of long-term OPP memory.”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Gaskin et al., 2011
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Tanninen, S. E. (2012) · TSpace (University of Toronto)
- Authors
- Gaskin, S., Tardif, M., & Mumby, D. G.
- Affiliations
- Concordia University (CA)
- Corresponding author
- Gaskin, Stéphane
- Venue
- Neurobiology of Learning and Memory
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 96
- Issue
- 2
- Pages
- 288-296
- ISSN
- 1074-7427 (ISSN-L)
- OpenAlex
- W2163339613
- Cited by
- 11
- References
- 69
- Citations by year
- 2021: 1 · 2020: 1 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 4
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Learning and Memory (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- hippocampal inactivation, retrograde amnesia, systems consolidation, spatial memory, object displacement, rats
- MeSH terms
- Amnesia, Retrograde, Animals, Hippocampus, Male, Reinforcement, Psychology, Retention, Psychology, Space Perception, Maze Learning, Rats, Long-Evans, Rats
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