Cited by 335Spatial Cognition and NavigationMemory and Neural MechanismsMemory Processes and Influences

Navigation around London by a taxi driver with bilateral hippocampal lesions

Maguire, E. A., Nannery, R., Spiers, H. J.·2006·Brain

Abstract

The time-scale of hippocampal involvement in supporting episodic memory remains a keenly debated topic, with disagreement over whether its role is temporary or permanent. Recently, there has been interest in how navigation by hippocampally-compromised patients in environments learned long ago speaks to this issue. However, identifying patients with damage that is primarily hippocampal, control subjects matched for navigation experience, and testing their in situ navigation, present substantial problems. We met these challenges by using a highly accurate and interactive virtual reality simulation of central London (UK) to assess the navigation ability of a licensed London taxi driver who had sustained bilateral hippocampal damage. In this test, patient TT and matched control taxi drivers drove a virtual London taxi along the streets they had first learned 40 years before. We found that the hippocampus is not required for general orientation in the city either in first person or survey perspectives, detailed topographical knowledge of landmarks and their spatial relationships, or even for active navigation along some routes. However, in his navigation TT was very reliant on main artery or 'A' roads, and became lost when navigation depended instead on non-A roads. We conclude that the hippocampus in humans is necessary for facilitating navigation in places learned long ago, particularly where complex large-scale spaces are concerned, and successful navigation requires access to detailed spatial representations.

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  • Neuropsychological evidence indicates that complex spatial memories acquired years in the past can become independent of the hippocampus.

    “Neuropsychological evidence indicates that complex spatial memories acquired years in the past can become independent of the hippocampus (Teng and Squire 1999; Rosenbaum et al. 2000, 2005; Maguire et al. 2006; Herdman et al. 2015).”
  • Several amnesic case studies have displayed impressive retention of spatial memories for environments learned before the onset of extensive hippocampal damage.

    “Several amnesic case studies have displayed impressive retention of spatial memories for environments learned before the onset of extensive hippocampal damage (Teng and Squire 1999; Rosenbaum et al. 2000; Maguire et al. 2006; Herdman et al. 2015).”

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Research works printed but not linked: 4

  1. Crawford JR, Howell DC. Comparing and individual's test score against norms derived from small samples. Clin Neuropsychol 1998; 12: 482-6.
  2. Knowlton BJ, Fanselow MS. The hippocampus, consolidation and online memory. Curr Opin Neurobiol 1998; 8: 293-6.
  3. Spiers HJ, Maguire EA, Burgess N. Hippocampal amnesia. Neurocase 2001a; 7: 357-82.
  4. Squire LR, Clark RE, Knowlton BJ. Retrograde amnesia. Hippocampus 2001; 11: 50-5.

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Authors
Maguire, E. A., Nannery, R., & Spiers, H. J.
Affiliations
UCL Queen Square Institute of Neurology (GB)
Corresponding author
Maguire, E. A.
Venue
Brain
Published
2006-09-29
Volume
129
Issue
11
Pages
2894-2907
ISSN
  • 0006-8950 (ISSN-L)
  • 1460-2156
OpenAlex
W2116524658
Cited by
335
References
44
Citations by year
2026: 7 · 2025: 12 · 2024: 21 · 2023: 11 · 2022: 10 · 2021: 23 · 2020: 21 · 2019: 40 · 2018: 15 · 2017: 20 · 2016: 14 · 2015: 11 · 2014: 18 · 2013: 12 · 2012: 17
FWCI
46.36
Type
journal article
Language
en
Open access
closed
Locations
  • Brain (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • HighWire Press Open Archive (submittedVersion)
Funders
Wellcome Trust (071173)
Topics
  • Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
hippocampus, spatial navigation, episodic memory, bilateral hippocampal lesions, taxi drivers, virtual reality navigation, landmark learning, spatial representation
MeSH terms
Aged, Amnesia, Automobile Driving, Hippocampus, Humans, Judgment, Learning, Magnetic Resonance Imaging, Male, Memory, Neuropsychological Tests, Orientation, Perceptual Disorders, Space Perception, Spatial Behavior, Limbic Encephalitis

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