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Regulation of LRP-1 expression: Make the point

Emonard, H., Théret, L., Bennasroune, A.H., Dedieu, S.·2014·Pathologie Biologie
DOI 10.1016/j.patbio.2014.02.002
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Abstract

The low-density lipoprotein receptor-related protein-1 (LRP-1) is a membrane receptor displaying both scavenging and signaling functions. The wide variety of extracellular ligands and of cytoplasmic scaffolding and signaling proteins interacting with LRP-1 gives it a major role not only in physiological processes, such as embryogenesis and development, but also in critical pathological situations, including cancer and neurological disorders. In this review, we describe the molecular mechanisms involved at distinct levels in the regulation of LRP-1, from its expression to the proper location and stability at the cell surface.

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Metadata

Authors
Emonard, H., Théret, L., Bennasroune, A. H., & Dedieu, S.
Venue
Pathologie Biologie
Publisher
Elsevier BV
Published
2014-04
Volume
62
Issue
2
Pages
84-90
ISSN
0369-8114
DOI
10.1016/j.patbio.2014.02.002
Cited by
53
References
6
Language
en

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