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The Low Density Lipoprotein Receptor-related Protein LRP Is Regulated by Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) Proteolysis in Malignant Cells
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MT1-MMP efficiently mediated LRP1 shedding in fibroblastoid type but not the epithelioid variant of HT1080 cells.
“It has been reported that MT1-MMP efficiently mediated LRP1 shedding in fibroblastoid type but not the epithelioid variant of HT1080 cells21.”
From Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis (2021) · cites this paper as [21]
The Results report MT1-MMP-mediated LRP cleavage in HT1080 cells, and the Discussion says stimulation of MT1-MMP enhanced the release of LRP material. Neither passage distinguishes fibroblastoid from epithelioid HT1080 variants or supports the claim that shedding occurs in one but not the other. No page numbers are available in our copy. (LLM, conf=0.87)
Experimental — accuracy not yet measuredMT1-MMP has been reported to cleave transmembrane proteins such as death receptor-6, neuropilin-1, and LRP-1 in breast cancer cells.
“MT1-MMP has been reported to cleave transmembrane proteins such as death receptor-6, neuropilin-1, and LDLR-related protein 1 (LRP-1) in breast cancer cells20,21.”
From Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis (2021) · cites this paper as [21]
MT1-MMP plays an essential role in tissue remodelling by cleaving extracellular matrix components and many non-extracellular matrix substrates.
“MT1-MMP plays an essential role in tissue remodelling by cleaving extracellular matrix components and many non-extracellular matrix substrates16,20,21,43.”
From Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis (2021) · cites this paper as [21]
MT1-MMP has been shown to shed LRP1 in breast carcinoma MCF7 cells, vascular smooth muscle cells, and cartilage.
“Recently, MT1-MMP has been shown to shed LRP1 in breast carcinoma MCF7 cells as well as in vascular smooth muscle cells and in cartilage21,45,46.”
From Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis (2021) · cites this paper as [21]
Proteolysis of LRP by matrix metalloproteases was recently reported.
“proteolysis of LRP by matrix metalloproteases was recently reported (25);”
From The Low Density Lipoprotein Receptor-related Protein (LRP) Is a Novel β-Secretase (BACE1) Substrate (2005) · cites this paper as [25]
LRP-1 is a substrate of MT1-MMP.
“Since LRP-1 is a substrate of MT1-MMP, we specifically questioned here how the MT1-MMP-to-LRP-1 cell surface expression ratio might regulate in vitro LRP-1-mediated An2 internalization within a human glioblastoma cell model.”
From MT1-MMP Expression Levels and Catalytic Functions Dictate LDL Receptor-Related Protein-1 Ligand Internalization Capacity in U87 Glioblastoma Cells (2022) · cites this paper as [35]
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Citations
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Metadata
- Authors
- Rozanov, D. V., Hahn-Dantona, E., Strickland, D. K., & Strongin, A. Y.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2004-02
- Volume
- 279
- Issue
- 6
- Pages
- 4260-4268
- ISSN
- 0021-9258
- Cited by
- 130
- References
- 3
- Language
- en
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