Hedonic sensitivity in adolescent and adult rats: Taste reactivity and voluntary sucrose consumption
Open accessAbstract
Adolescents have been hypothesized to exhibit an age-related partial anhedonia that may lead them to seek out natural and drug rewards to compensate for this attenuated hedonic sensitivity. In the present series of experiments, taste reactivity (TR) and 2 bottle choice tests were used to assess hedonic reactions to sucrose. In Exp 1, total positive taste responses to 10% sucrose solution were significantly higher in adolescent than adult rats during the infusion period. In Exp 2, adolescent animals exhibited a concentration-effect shift that was consistent with a greater hedonic sensitivity compared to adults. Conversely, adolescents exhibited fewer negative responses to quinine. Using a shortened infusion period, adolescents in Exp 3 exhibited a trend for greater positive TR than adults in response to 10 and 34% sucrose. Consistent with the TR results of Exp 1-3, adolescents consumed significantly more sucrose solution (ml/kg) than adults, although no significant age difference in sucrose preference rates emerged. The results of the current series of experiments do not support the hypothesis that adolescents exhibit an age-related, partial anhedonia, with adolescent animals, under a number of test circumstances showing greater positive taste reactivity and reduced negative responding.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Adolescent rats are more sensitive than adults to the rewarding properties of food, palatable tastants, social peers, and novelty, as measured by conditioned place preference.
“Studies conducted in our laboratory and others likewise have found adolescent rats to be more sensitive than their adult counterparts to the rewarding properties of a variety of positively rewarding stimuli. These include food and palatable tastants (Vaidya et al, 2004; Wilmouth & Spear, 2009; Friemel et al, 2010), as well as the rewarding effects of social peers (Douglas et al, 2004) and novelty”
From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Wilmouth & Spear, 2009
Adolescent rats show greater hedonic liking responses to rewarding stimuli than adults in several circumstances, as indexed by consumption of sucrose or palatable substances and by taste reactivity.
“Using a variety of behavioral measures thought to reflect hedonic “liking”, adolescent rats as well have been found to exhibit greater “liking” responses to rewarding stimuli than adults under a number of circumstances, with adolescent rats exhibiting greater hedonic “liking” than their mature counterparts when indexed via such traditional measures as consumption of sucrose or other highly pal”
From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Wilmouth & Spear, 2009
Adolescents show elevated positive taste reactivity to certain concentrations of sucrose.
“conversely exhibiting adolescent-associated elevations in positive responding to certain concentrations of sucrose”
From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Wilmouth & Spear, 2009
Attenuated aversive sensitivity during adolescence is also evident with non-drug stimuli.
“These attenuations in aversive sensitivity during adolescence are also evident with non-drug stimuli”
From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Wilmouth & Spear, 2009
Adolescents show less negative taste reactivity to quinine than adults.
“adolescents consistently showed less negative taste reactivity to the aversive tastant quinine than adults”
From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Wilmouth & Spear, 2009
Adolescent rats are more sensitive than adults to the rewarding properties of a variety of positively rewarding stimuli, including food and palatable tastants, social peers, and novelty.
“adolescent rats to be more sensitive than their adult counterparts to the rewarding properties of a variety of positively rewarding stimuli. These include food and palatable tastants (Vaidya et al, 2004; Wilmouth & Spear, 2009; Friemel et al, 2010), as well as the rewarding effects of social peers (Douglas et al, 2004) and novelty (Douglas et al, 2003)”
From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Wilmouth & Spear, 2009
Adolescent rats exhibit greater hedonic liking responses to rewarding stimuli than adults under a number of circumstances, including consumption of sucrose or other highly palatable substances and taste reactivity to sucrose.
“adolescent rats as well have been found to exhibit greater “liking” responses to rewarding stimuli than adults under a number of circumstances, with adolescent rats exhibiting greater hedonic “liking” than their mature counterparts when indexed via such traditional measures as consumption of sucrose or other highly palatable substances (e.g., Vaidya et al, 2004; Wilmouth & Spear, 2009; Friemel et”
From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Wilmouth & Spear, 2009
Adolescents, more so than children or adults, show heightened activation in the ventral striatum following the receipt of hedonic rewards, including money, sucrose, and immediate rather than long-term rewards.
“human and rodent research has shown that adolescents, more so than children or adults, show heightened activation in the ventral striatum following the receipt of hedonic rewards, including money, sucrose, and immediate rather than long-term rewards (7, 15, 19, 20).”
From Neural sensitivity to eudaimonic and hedonic rewards differentially predict adolescent depressive symptoms over time (2014) · cites this paper as [19]
Risky behavior during the adolescent period is not specific to humans; adolescent compared with adult rats show increased risk-taking, novelty seeking, and voluntary alcohol consumption.
“risky behavior during the adolescent period is not specific to humans; for example, adolescent as compared to adult rats show increased risk-taking, novelty seeking, and voluntary alcohol consumption (Doremus et al., 2005; Spear, 2011; Wilmouth & Spear, 2009).”
From Neural networks involved in adolescent reward processing: an activation likelihood estimation meta-analysis of functional neuroimaging studies (2015) · cites this paper as Wilmouth & Spear, 2009
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Guide for the Care and Use of Laboratory Animals: Eighth Edition
(2011) · doi:10.17226/12910 · Cited by 16,199 · see citing works
The adolescent brain and age-related behavioral manifestations
Spear, L. P. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00014-2 · Cited by 5,433 · see citing works
Self-citationWhat is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127 · see citing works
Willner, P., Towell, A., Sampson, D., Sophokleous, S., & Muscat, R. (1987) · Psychopharmacology · doi:10.1007/bf00187257 · Cited by 1,993 · see citing works
Food reward: brain substrates of wanting and liking
Berridge, K. C. (1996) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(95)00033-b · Cited by 1,901 · see citing works
Chambers, R. A., Taylor, J. R., & Potenza, M. N. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.6.1041 · Cited by 1,719 · see citing works
Galvan, A., Hare, T. A., Parra, C. E., Penn, J., Voss, H., Glover, G., & Casey, B. J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1062-06.2006 · Cited by 1,282 · see citing works
The taste reactivity test. I. Mimetic responses to gustatory stimuli in neurologically normal rats
Grill, H. J., & Norgren, R. (1978) · Brain Research · doi:10.1016/0006-8993(78)90568-1 · Cited by 1,203 · see citing works
The Guide for the Care and Use of Laboratory Animals
(2016) · ILAR Journal · doi:10.1093/ilar/ilw013 · Cited by 956 · see citing works
Petersen, A. C., Compas, B. E., Brooks-Gunn, J., Stemmler, M., Ey, S., & Grant, K. E. (1993) · American Psychologist · doi:10.1037/0003-066x.48.2.155 · Cited by 788 · see citing works
The ecology of adolescent activity and experience
Csikszentmihalyi, M., Larson, R., & Prescott, S. (1977) · Journal of Youth and Adolescence · doi:10.1007/bf02138940 · Cited by 781 · see citing works
Steiner, J. E., Glaser, D., Hawilo, M. E., & Berridge, K. C. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00051-8 · Cited by 752 · see citing works
Berridge, K. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00072-x · Cited by 721 · see citing works
Triadic model of the neurobiology of motivated behavior in adolescence.
ERNST, M., PINE, D. S., & HARDIN, M. (2006) · Psychological Medicine · doi:10.1017/s0033291705005891 · Cited by 718 · see citing works
Neuroleptic-Induced "Anhedonia" in Rats: Pimozide Blocks Reward Quality of Food
Wise, R. A., Spindler, J., de Wit, H., & Gerberg, G. J. (1978) · Science · doi:10.1126/science.566469 · Cited by 636 · see citing works
Incentive-elicited brain activation in adolescents: Similarities and differences from young adults
Bjork, J. M., Knutson, B., Fong, G. W., Caggiano, D. M., Bennett, S. M., & Hommer, D. W. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4862-03.2004 · Cited by 567 · see citing works
Hedonic Hot Spots in the Brain
Peciña, S., Smith, K. S., & Berridge, K. C. (2006) · The Neuroscientist · doi:10.1177/1073858406293154 · Cited by 441 · see citing works
Berridge, K. C., Venier, I. L., & Robinson, T. E. (1989) · Behavioral Neuroscience · doi:10.1037/0735-7044.103.1.36 · Cited by 356 · cited 1× · see citing works
“Additionally, 6-hydroxydopamine lesions are known to produce aphagia and adipsia, but do not alter hedonic or aversive taste reactions (Berridge et al., 1989).”
Drug addiction as dopamine-dependent associative learning disorder
Chiara, G. D. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00372-6 · Cited by 317 · see citing works
Presence of cannabinoid binding sites in the brain from early postnatal ages
de Fonseca, F. R., Ramos, J. A., Bonnin, A., & Fernández‐Ruíz, J. (1993) · Neuroreport · doi:10.1097/00001756-199302000-00005 · Cited by 297 · see citing works
Opiate reward: Sites and substrates
Wise, R. A. (1989) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(89)80021-1 · Cited by 286 · see citing works
Adolescent stress: causes and consequences
(1992) · Choice Reviews Online · doi:10.5860/choice.29-3016 · Cited by 272 · see citing works
Pellis, S. M., & Pellis, V. C. (1990) · Developmental Psychobiology · doi:10.1002/dev.420230303 · Cited by 255 · see citing works
Action of drugs of abuse on brain reward systems: An update with specific attention to opiates
Wise, R. A., & Bozarth, M. A. (1982) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(82)90076-4 · Cited by 194 · see citing works
Differential effects of delta9-THC on learning in adolescent and adult rats
Cha, Y. M., White, A. M., Kuhn, C. M., Wilson, W. A., & Swartzwelder, H. S. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.03.006 · Cited by 149 · see citing works
Peciña, S. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(97)00044-0 · Cited by 148 · see citing works
Primus, R. J., & Kellogg, C. K. (1989) · Developmental Psychobiology · doi:10.1002/dev.420220608 · Cited by 146 · see citing works
Anger, worry, and hurt in early adolescence: An enlarging world of negative emotions.
Larson, R. W., & Asmussen, L. (2017) · doi:10.4324/9781315083025-2 · Cited by 140 · see citing works
Berridge, K. C., & Grill, H. J. (1983) · Behavioral Neuroscience · doi:10.1037//0735-7044.97.4.563 · Cited by 132 · see citing works
Berridge, K. C., & Grill, H. J. (1983) · Behavioral Neuroscience · doi:10.1037/0735-7044.97.4.563 · Cited by 123 · see citing works
Adolescent stress: Causes and consequences
Faust, J. (1992) · Journal of Anxiety Disorders · doi:10.1016/0887-6185(92)90018-3 · Cited by 119 · see citing works
A comparison of benzodiazepine, serotonin, and dopamine agents in the taste-reactivity paradigm
Treit, D., & Berridge, K. C. (1990) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(90)90011-6 · Cited by 116 · see citing works
Comparing personality constructs of risk-taking behavior
Trimpop, R. M., Kerr, J., & Kirkcaldy, B. D. (1998) · Personality and Individual Differences · doi:10.1016/s0191-8869(98)00048-8 · Cited by 114 · see citing works
Cha, Y. M., Jones, K. H., Kuhn, C. M., Wilson, W. A., & Swartzwelder, S. H. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282ee7b7e · Cited by 108 · see citing works
Post, G. B., & Kemper, H. C. G. (1993) · PubMed · Cited by 56 · see citing works
Social interactions and 50kHz ultrasonic vocalizations in adolescent and adult rats
Willey, A. R., Varlinskaya, E. I., & Spear, L. P. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.03.025 · Cited by 52 · see citing works
Self-citationNance, D. (1983) · Neuroscience and Biobehavioral Reviews · doi:10.1016/0149-7634(83)90015-5 · Cited by 47 · see citing works
A new taste reactivity analysis of the integration of taste and physiological state information
Grill, H. J., Roitman, M. F., & Kaplan, J. M. (1996) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1996.271.3.r677 · Cited by 37 · see citing works
Kang-Park, M.-H., Wilson, W. A., Kuhn, C. M., Moore, S. D., & Swartzwelder, H. S. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00091.2007 · Cited by 30 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Doremus-Fitzwater, T. L., Varlinskaya, E. I., & Spear, L. P. (2010) · Brain and Cognition · doi:10.1016/j.bandc.2009.08.008 · Cited by 397 · see citing works
Self-citationSpear, L. P. (2011) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2011.08.001 · Cited by 292 · see citing works
Self-citationTelzer, E. H. (2016) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2015.10.010 · Cited by 274 · see citing works
Silverman, M. H., Jedd, K., & Luciana, M. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.07.083 · Cited by 277 · see citing works
The impact of sugar consumption on stress driven, emotional and addictive behaviors
Jacques, A., Chaaya, N., Beecher, K., Ali, S. A., Belmer, A., & Bartlett, S. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.05.021 · Cited by 271 · see citing works
Making Sense of Rodent Models of Anhedonia
Scheggi, S., Montis, M. G. D., & Gambarana, C. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy083 · Cited by 209 · see citing works
Telzer, E. H., Fuligni, A. J., Lieberman, M. D., & Galván, A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1323014111 · Cited by 183 · see citing works
Kundaković, M., Lim, S. C., Gudsnuk, K. M., & Champagne, F. A. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00078 · Cited by 172 · see citing works
Juvenile mice show greater flexibility in multiple choice reversal learning than adults
Johnson, C. V., & Wilbrecht, L. (2011) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2011.05.008 · Cited by 143 · see citing works
Adolescent brain maturation and smoking: What we know and where we’re headed
Lydon‐Staley, D. M., Wilson, S. J., Child, A. E., & Geier, C. F. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.07.003 · Cited by 133 · see citing works
Doremus-Fitzwater, T. L., & Spear, L. P. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.08.015 · Cited by 125 · see citing works
Self-citationSPEAR, L. P., & Varlinskaya, E. I. (2010) · Developmental Psychobiology · doi:10.1002/dev.20457 · Cited by 120 · see citing works
Self-citationReward sensitivity for a palatable food reward peaks during pubertal developmental in rats
Friemel (2010) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2010.00039 · Cited by 117 · see citing works
Adolescents and alcohol: Acute sensitivities, enhanced intake, and later consequences
SPEAR, L. P. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2013.11.006 · Cited by 116 · see citing works
Self-citationStrong, M. N., Yoneyama, N., Fretwell, A. M., Snelling, C., Tanchuck, M. A., & Finn, D. A. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.10.008 · Cited by 110 · see citing works
The impact of junk foods on the adolescent brain
Reichelt, A. C., & Rank, M. M. (2017) · Birth Defects Research · doi:10.1002/bdr2.1173 · Cited by 102 · see citing works
Ethanol‐induced conditioned taste aversion in male Sprague‐Dawley rats: impact of age and stress
Anderson, R. I., Varlinskaya, E. I., & Spear, L. P. (2010) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01307.x · Cited by 96 · see citing works
Self-citationReichelt, A. C. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00189 · Cited by 93 · see citing works
Kendig, M. D., Boakes, R. A., Rooney, K. B., & Corbit, L. H. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.08.012 · Cited by 87 · see citing works
The Neuroscience of Adolescence
Galván, A. (2017) · Cambridge University Press eBooks · doi:10.1017/9781316106143 · Cited by 82 · see citing works
The Functional and Neurobiological Properties of Bad Taste
Schier, L. A., & Spector, A. C. (2018) · Physiological Reviews · doi:10.1152/physrev.00044.2017 · Cited by 75 · see citing works
Abush, H., & Akirav, I. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.51 · Cited by 77 · see citing works
SPEAR, L. P. (2011) · Child Development Perspectives · doi:10.1111/j.1750-8606.2011.00182.x · Cited by 70 · see citing works
Self-citationAdolescents exhibit behavioral differences from adults during instrumental learning and extinction
Sturman, D. A., Mandell, D. R., & Moghaddam, B. (2010) · Behavioral Neuroscience · doi:10.1037/a0018463 · Cited by 69 · see citing works
Exercise to reduce the escalation of cocaine self-administration in adolescent and adult rats
Zlebnik, N. E., Anker, J. J., & Carroll, M. E. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2760-7 · Cited by 62 · see citing works
Peters, K. Z., & Naneix, F. (2022) · Frontiers in Neural Circuits · doi:10.3389/fncir.2022.939235 · Cited by 61 · see citing works
The developmental psychopathology of motivation in adolescence
Fairchild, G. (2011) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2011.07.009 · Cited by 53 · see citing works
The Teenage Brain: Adolescents and Alcohol
Spear, L. (2013) · Current Directions in Psychological Science · doi:10.1177/0963721412472192 · Cited by 49 · see citing works
Self-citationRiaz, M. S., Bohlen, M. O., Gunter, B. W., Henry, Q., Stockmeier, C. A., & Paul, I. A. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.09.005 · Cited by 49 · see citing works
Quality of life and animal behaviour
Yeates, J. W. (2016) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2016.04.018 · Cited by 43 · see citing works
Naneix, F., Darlot, F., Coutureau, É., & Cador, M. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13149 · Cited by 40 · see citing works
Anderson, R. I., & SPEAR, L. P. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.01.004 · Cited by 38 · see citing works
Self-citationLukkes, J. L., Thompson, B. S., Freund, N., & Andersen, S. L. (2015) · Developmental Psychobiology · doi:10.1002/dev.21368 · Cited by 36 · see citing works
Willey, A. R., & SPEAR, L. P. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.10.001 · Cited by 34 · see citing works
Self-citationArenas, M. C., Aguilar, M. A., Montagud‐Romero, S., Mateos-García, A., Navarro-Francés, C. I., Miñarro, J., & Rodríguez‐Arias, M. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666150921112841 · Cited by 33 · see citing works
The phosphodiesterase-4 inhibitor roflumilast decreases ethanol consumption in C57BL/6J mice
Liu, X. B., Hao, P., Yang, M., Sun, J., Mao, L., Fan, C., Zhang, Z., Li, D.-W., Yang, X., Sun, B., et al. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4631-8 · Cited by 32 · see citing works
Burton, C. L., Noble, K., & Fletcher, P. J. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.44 · Cited by 32 · see citing works
Sex-specific enhancement of palatability-driven feeding in adolescent rats
Marshall, A. T., Liu, A. T., Murphy, N. P., Maidment, N. T., & Ostlund, S. B. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180907 · Cited by 31 · see citing works
Harvey, R. C., Dembro, K. A., Rajagopalan, K., Mutebi, M. M., & Kantak, K. M. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1579-3 · Cited by 29 · see citing works
Yip, S. W., & Potenza, M. N. (2016) · Clinical Psychology Review · doi:10.1016/j.cpr.2016.11.003 · Cited by 28 · see citing works
Neural Systems Underlying Reward and Approach Behaviors in Childhood and Adolescence
Galván, A. (2013) · Current topics in behavioral neurosciences · doi:10.1007/7854_2013_240 · Cited by 30 · see citing works
Age differences in appetitive Pavlovian conditioning and extinction in rats
Meyer, H. C., & Bucci, D. J. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.10.004 · Cited by 27 · see citing works
Protracted motivational dopamine-related deficits following adolescence sugar overconsumption
Naneix, F., Darlot, F., Smedt, V. D., Pape, J., Coutureau, É., & Cador, M. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.11.021 · Cited by 25 · see citing works
Fam, J. P., Clemens, K. J., Westbrook, R. F., Morris, M. J., & Kendig, M. D. (2021) · Appetite · doi:10.1016/j.appet.2021.105742 · Cited by 21 · see citing works
Marcolin, M. L., Hodges, T. E., Baumbach, J. L., & McCormick, C. M. (2018) · Developmental Psychobiology · doi:10.1002/dev.21800 · Cited by 20 · see citing works
Hankosky, E. R., Westbrook, S. R., Haake, R. M., Marinelli, M., & Gulley, J. M. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4804-5 · Cited by 20 · see citing works
Tenk, C. M., & Felfeli, T. (2017) · Appetite · doi:10.1016/j.appet.2017.07.016 · Cited by 18 · see citing works
Neural Systems Underlying Reward and Approach Behaviors in Childhood and Adolescence
Galván, A. (2013) · Current topics in behavioral neurosciences · doi:10.1007/978-3-662-45758-0_240 · Cited by 17 · see citing works
Stolyarova, A., & Izquierdo, A. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00115 · Cited by 16 · see citing works
Archer, T., Kostrzewa, R. M., Beninger, R. J., & Palomo, T. (2010) · Neurotoxicity Research · doi:10.1007/s12640-010-9162-6 · Cited by 16 · see citing works
Reward-predictive cues elicit excessive reward seeking in adolescent rats
Marshall, A. T., Munson, C., Maidment, N., & Ostlund, S. B. (2020) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2020.100838 · Cited by 16 · see citing works
Evaluation of Parameters Which Influence Voluntary Ingestion of Supplements in Rats
Ruvira, S., Rodríguez‐Rodríguez, P., Cañas, S., Ramiro‐Cortijo, D., Aguilera, Y., Muñoz-Valverde, D., & Arribas, S. M. (2023) · Animals · doi:10.3390/ani13111827 · Cited by 14 · see citing works
Increased sign‐tracking behavior in adolescent rats
DeAngeli, N. E., Miller, S., Meyer, H. C., & Bucci, D. J. (2017) · Developmental Psychobiology · doi:10.1002/dev.21548 · Cited by 15 · see citing works
Differential rearing alters taste reactivity to ethanol, sucrose, and quinine
Wukitsch, T. J., Brase, E. C., Moser, T. J., Kiefer, S. W., & Cain, M. E. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05394-x · Cited by 13 · see citing works
Galván, A., & Tottenham, N. (2016) · Wiley eBooks · doi:10.1002/9781119125556.devpsy218 · Cited by 13 · see citing works
Doherty, J. M., & Gonzales, R. A. (2015) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12630 · Cited by 13 · see citing works
Stratford, J. M., & Thompson, J. A. (2016) · Chemical Senses · doi:10.1093/chemse/bjv082 · Cited by 12 · see citing works
Carrara‐Nascimento, P. F., Hoffmann, L. B., Contó, M. B., Marcourakis, T., & Camarini, R. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00046 · Cited by 10 · see citing works
Gano, A., Pautassi, R. M., Doremus‐Fitzwater, T. L., Barney, T. M., Vore, A. S., & Terrence Deak, B. (2019) · Experimental Biology and Medicine · doi:10.1177/1535370219831709 · Cited by 9 · see citing works
Adolescent female rats recovered from the activity‐based anorexia display blunted hedonic responding
Hurley, M. M., Nawari, A. N., Chen, V. X., O’Brien, S. C., Sabir, A. I., Goodman, E. J., Wiles, L. J., Biswas, A., Aston, S. A., Khambadkone, S. G., et al. (2022) · International Journal of Eating Disorders · doi:10.1002/eat.23752 · Cited by 6 · see citing works
Unlocking the age-old secrets of reward and substance use
Liu, C., & Filbey, F. M. (2024) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2024.173766 · Cited by 7 · see citing works
Kähäri, A. (2021) · British Food Journal · doi:10.1108/bfj-12-2020-1109 · Cited by 7 · see citing works
LaMagna, S., Olsson, K., Warshaw, D., Fazilov, G., Iskhakov, B., Buras, A., & Bodnar, R. J. (2018) · Nutritional Neuroscience · doi:10.1080/1028415x.2018.1436216 · Cited by 6 · see citing works
Salazar, M. G., Nguyen, C. H., Oak, S., Jackson, J., & Rincón‐Cortés, M. (2025) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2025.1659339 · Cited by 5 · see citing works
Clasen, M. M., Wetzell, B., & Riley, A. L. (2016) · Learning & Behavior · doi:10.3758/s13420-016-0227-0 · Cited by 4 · see citing works
Preference for Palatable Food, Impulsivity, and Relation to Drug Addiction in Rats
Carroll, M. E., Zlebnik, N. E., & Holtz, N. A. (2020) · Neuromethods · doi:10.1007/978-1-0716-0924-8_12 · Cited by 4 · see citing works
Wukitsch, T. J., & Cain, M. E. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05805-y · Cited by 4 · see citing works
Gámiz, F., Expósito, A. N., Vázquez‐Ágredos, A., Menchén-Márquez, S., & Gallo, M. (2023) · Psicothema · doi:10.7334/psicothema2022.256 · Cited by 4 · see citing works
Saccharin Preference in Rats: Relation to Impulsivity and Drug Abuse
Carroll, M. E., Holtz, N. A., & Zlebnik, N. E. (2012) · Neuromethods · doi:10.1007/978-1-62703-104-2_13 · Cited by 3 · see citing works
Adolescent and Adult Age Differences in Palatable Food Learning and Consumption
Shteyn, R., & Petrovich, G. D. (2025) · Physiology & Behavior · doi:10.1016/j.physbeh.2025.115074 · Cited by 3 · see citing works
Behavioral responses to natural rewards in developing male and female rats
Oak, S., Nguyen, C. P., Rodney‐Hernández, P., & Rincón‐Cortés, M. (2023) · Developmental Psychobiology · doi:10.1002/dev.22448 · Cited by 2 · see citing works
Galván, A. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316106143.008 · Cited by 2 · see citing works
Fractionating impulsivity and reward-related phenotypes in adolescent mice
Albert‐Lyons, R., Desrochers, S. S., Fengler, C., & Nautiyal, K. M. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115396 · Cited by 1 · see citing works
Cody, C. R., Hennessy, R. R., Brenhouse, H. C., & Davidow, J. Y. (2025) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2025.101620 · Cited by 1 · see citing works
Galván, A. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316106143.006 · Cited by 1 · see citing works
Galván, A. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316106143.002 · Cited by 1 · see citing works
EFECTO EN EL CONSUMO DE ALIMENTO Y PESO CORPORAL EN CRÍAS DESNUTRIDAS
Martínez, A., & de Tomasi, E. B. (2021) · Revista Mexicana de Análisis de la Conducta · doi:10.5514/rmac.v47.i2.81167 · Cited by 1 · see citing works
Differential behavioral effects of ketamine between adolescent and adult Sprague-Dawley rats
Greenwood, M. A. (2013) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/xrxb-ft46 · Cited by 1 · see citing works
(2018) · Cambridge University Press eBooks · doi:10.1017/9781316106143.011 · Cited by 1 · see citing works
The Implications of Adolescent Neuroscience on Policy
Galván, A. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316106143.009
Galván, A. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316106143.010
Cognitive Neuroscience Methods to Study the Adolescent Brain
Galván, A. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316106143.004
Current awareness in flavour and fragrance
(2009) · Flavour and Fragrance Journal · doi:10.1002/ffj.1956
Hankosky, E. R., Westbrook, S. R., Haake, R. M., Marinelli, M., & Gulley, J. M. (2017) · doi:10.31219/osf.io/z9hb6
Galván, A. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316106143.001
Galván, A. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316106143.005
Pérez-Valenzuela, E., & Laviolette, S. R. (2022) · Neuromethods · doi:10.1007/978-1-0716-2799-0_9
Galván, A. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316106143.003
Galván, A. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316106143.007
Adolescent exposure to sucrose increases cocaine‐mediated behaviours in adulthood via Smad3
Gancarz, A. M., Parmar, R., Shwani, T., Cobb, M. M., Crawford, M. N., Watson, J. R., Evans, L., Kausch, M. A., Werner, C. T., & Dietz, D. (2023) · Addiction Biology · doi:10.1111/adb.13346
Graney, P. L., Sarno, E. L., Miller, J. E., & Wagner, C. K. (2024) · Developmental Psychobiology · doi:10.1002/dev.22536
Taste disorders due to unilateral upper molar extraction in juvenile and adult albino rats
Paúl, A. G.-P., & Aguirre-Siancas, E. (2025) · Neurology Perspectives · doi:10.1016/j.neurop.2025.100203
Matic, V. M., Huynh, M., Bishnoi, I. R., Kavaliers, M., & Ossenkopp, K. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115771
Is sugar addictive? Integrating evidence across addiction frameworks
Hascher, S., Kendig, M., & Pontes, H. M. (2026) · Addiction Research & Theory · doi:10.1080/16066359.2026.2703032
Nelson, T., Gutierrez, A., Minanov, K., Seferge, M., Addy, N., & Bağdaş, D. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1955253
- Authors
- Wilmouth, C. E., & Spear, L. P.
- Affiliations
- Binghamton University (US)
- Corresponding author
- Spear, Linda P.
- ORCID
- Spear, Linda P.
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 2009-06
- Volume
- 92
- Issue
- 4
- Pages
- 566-573
- ISSN
- 0091-3057 (ISSN-L)
- PMC
- PMC3385517
- OpenAlex
- W2028866842
- Cited by
- 96
- References
- 41
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 15 · 2017: 10 · 2016: 9 · 2015: 7 · 2014: 2 · 2013: 8 · 2012: 2
- FWCI
- 2.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (DA 019071, R01DA019071)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- anhedonia, adolescence, age differences, taste reactivity, sucrose intake, sucrose preference, quinine, concentration-dependent effects, rats
- MeSH terms
- Adolescent, Animals, Appetitive Behavior, Behavior, Animal, Humans, Male, Reward, Sucrose, Taste, Rats, Sprague-Dawley, Models, Animal, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
