Human emotion and memory: Interactions of the amygdala and hippocampal complex

Phelps, Elizabeth A

doi:10.1016/j.conb.2004.03.015

Cited by 1,577Memory and Neural MechanismsMemory Processes and InfluencesPosttraumatic Stress Disorder Research

Human emotion and memory: Interactions of the amygdala and hippocampal complex

Phelps, Elizabeth A·2004·Current Opinion in Neurobiology

DOI 10.1016/j.conb.2004.03.015

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Abstract

The amygdala and hippocampal complex, two medial temporal lobe structures, are linked to two independent memory systems, each with unique characteristic functions. In emotional situations, these two systems interact in subtle but important ways. Specifically, the amygdala can modulate both the encoding and the storage of hippocampal-dependent memories. The hippocampal complex, by forming episodic representations of the emotional significance and interpretation of events, can influence the amygdala response when emotional stimuli are encountered. Although these are independent memory systems, they act in concert when emotion meets memory.

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The hippocampus has an established role in emotional memory encoding and retrieval.
“the hippocampus has an established role in emotional memory encoding and retrieval”
From The Functional Role of Dreaming in Emotional Processes (2019) · cites this paper as Phelps, 2004
Along with the amygdala, the hippocampal formation mediates the processing and execution of fear memories.
“Along with the amygdala, the hippocampal formation mediates the processing and execution of fear memories”
From The Functional Role of Dreaming in Emotional Processes (2019) · cites this paper as Phelps, 2004
Neurobiology research indicates that stress and stress hormones are critically involved in forming enduring memories.
“This assumption is in contrast with findings from the neurobiology field of learning and memory, showing that stress and stress hormones are critically involved in forming enduring memories.”
From Stress, stress-induced cortisol responses, and eyewitness identification performance (2016) · cites this paper as Phelps, 2004
Both the amygdala and hippocampus are known to mediate attentional and learning aspects of emotion.
“Both the amygdala and hippocampus are known to mediate attentional and learning aspects of emotion (Baxter and Murray, 2002, Calder et al., 2001; Phelps, 2004; Phelps and LeDoux, 2005).”
From Adolescent neurobiological susceptibility to social context (2016) · cites this paper as Phelps, 2004

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“Along with the amygdala, the hippocampal formation mediates the processing and execution of fear memories (Phelps, 2004).”
Background
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Authors: Phelps, E. A.
Affiliations: New York University (US)
Corresponding author: Phelps, Elizabeth A
ORCID: Phelps, Elizabeth A
Venue: Current Opinion in Neurobiology
Publisher: Elsevier BV
Published: 2004-04
Volume: 14
Issue: 2
Pages: 198-202
ISSN: 0959-4388 (ISSN-L)
DOI: 10.1016/j.conb.2004.03.015
OpenAlex: W2104637120
Cited by: 1,577
References: 33
Citations by year: 2026: 69 · 2025: 86 · 2024: 80 · 2023: 112 · 2022: 76 · 2021: 61 · 2020: 87 · 2019: 125 · 2018: 88 · 2017: 101 · 2016: 95 · 2015: 81 · 2014: 69 · 2013: 79 · 2012: 61
FWCI: 2.88
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Neurobiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Keywords: amygdala, hippocampal complex, emotional memory, medial temporal lobe, memory encoding, memory storage, episodic memory, emotional meaning
MeSH terms: Amygdala, Brain Mapping, Emotions, Hippocampus, Humans, Functional Laterality, Magnetic Resonance Imaging, Memory, Neural Pathways, Sex Characteristics

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Human emotion and memory: Interactions of the amygdala and hippocampal complex

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