Oxytocin sharpens self-other perceptual boundary
Abstract
Recent cross-species research has demonstrated that the neurohormone oxytocin plays a key role in social interaction and cognitive processing of others' emotions. Whereas oxytocin has been shown to influence social approach, trust, and bond formation, a potential role of the oxytocinergic system in blurring or enhancing the ability to differentiate between one's self and other's related stimuli is unknown. Thus, we investigated whether oxytocin affects the ability to differentiate between self- and other-related stimuli using a facial morphing procedure. In a placebo-controlled, double-blind study, 44 healthy men received either 24 IU oxytocin or placebo intranasally. After 45 min, we measured participants' ability to differentiate their own identity while viewing a photo of themselves morphing into the photo of an unfamiliar face. Oxytocin administration shortened the latency of self-other differentiation. Additionally, when asked to rate the pleasantness of the unmorphed photos, the oxytocin-treated participants rated their own and the unfamiliar face as comparably pleasant. Oxytocin increases the ability to recognize differences between self and others and increases positive evaluation of others. Our findings are consistent with the hypothesis that impaired oxytocin signaling may be involved in the development and manifestation of human psychopathologies in which self-recognition is altered.
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Oxytocin sharpens self-other perceptual boundaries.
“The idea that OXT influences self-referential processing and interoception is further supported by a recent study that indicates that OXT sharpens self-other perceptual boundaries (117).”
From Dissecting the Role of Oxytocin in the Formation and Loss of Social Relationships (2016) · cites this paper as [117]
OT may serve to sharpen in/out group distinction.
“This suggests that OT may serve to sharpen in/out group distinction (Colonnello et al., 2013).”
From Approaching the biology of human parental attachment: Brain imaging, oxytocin and coordinated assessments of mothers and fathers (2014) · cites this paper as Colonnello et al., 2013
OXT may sharpen the self-other perceptual boundary by increasing the ability to discriminate between one's own face and that of an unfamiliar person.
“Another study has reported that OXT may sharpen self-other perceptual boundary by showing in a morphing paradigm that it increased the ability of subjects to discriminate between their own face (self) and that of an unfamiliar person (other) [Colonnello et al., 2013].”
From Oxytocin blurs the self-other distinction during trait judgments and reduces medial prefrontal cortex responses: Oxytocin Blurs Self-Other Distinction (2016) · cites this paper as Colonnello et al., 2013
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- Authors
- Colonnello, V., Chen, F. S., Panksepp, J., & Heinrichs, M.
- Affiliations
- University of Freiburg (DE)
- Washington State University (US)
- Corresponding author
- Colonnello, Valentina
- Heinrichs, Markus
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 38
- Issue
- 12
- Pages
- 2996-3002
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2073550554
- Cited by
- 58
- References
- 79
- Citations by year
- 2026: 4 · 2025: 1 · 2023: 3 · 2022: 1 · 2021: 6 · 2020: 9 · 2019: 6 · 2018: 4 · 2017: 5 · 2016: 6 · 2015: 4 · 2014: 8 · 2013: 1
- FWCI
- 9.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Research Bank (Australian Catholic University) (submittedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- oxytocin, self-other distinction, face morphing, self-face recognition, social cognition, self-other boundary, face perception, intranasal oxytocin, self-other perception
- MeSH terms
- Administration, Intranasal, Adult, Discrimination, Psychological, Face, Facial Expression, Humans, Male, Neuropsychological Tests, Oxytocin, Photic Stimulation, Self Concept, Social Perception, Young Adult
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