Oxytocin effects on neural correlates of self-referential processing
Abstract
Oxytocin (OT) influences how humans process information about others. Whether OT affects the processing of information about oneself remains unknown. Using a double-blind, placebo-controlled within-subject design, we recorded event-related potentials (ERPs) from adults during trait judgments about oneself and a celebrity and during judgments on word valence, after intranasal OT or placebo administration. We found that OT vs. placebo treatment reduced the differential amplitudes of a fronto-central positivity at 220-280 ms (P2) during self- vs. valence-judgments. OT vs. placebo treatment tended to reduce the differential amplitude of a late positive potential at 520-1000 ms (LPP) during self-judgments but to increase the differential LPP amplitude during other-judgments. OT effects on the differential P2 and LPP amplitudes to self- vs. celebrity-judgments were positively correlated with a measure of interdependence of self-construals. Thus OT modulates the neural correlates of self-referential processing and this effect varies as a function of interdependence.
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OXT was found to decrease the differential amplitudes of a frontocentral positivity at 220 to 280 ms (P200) in the area of the mPFC and ACC during self-vs.-valence judgments.
“In another event related potential study, OXT was found to decrease the differential amplitudes of a frontocentral positivity at 220 to 280 ms (P200) in the area of the mPFC and ACC during self-vs.valence-judgments (self-referential processing) [Liu et al., 2013].”
From Oxytocin blurs the self-other distinction during trait judgments and reduces medial prefrontal cortex responses: Oxytocin Blurs Self-Other Distinction (2016) · cites this paper as Liu et al., 2013
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- Authors
- Liu, Y., Sheng, F., Woodcock, K. A., & Han, S.
- Affiliations
- Peking University (CN)
- Corresponding author
- Han, Shihui
- Venue
- Biological Psychology
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 94
- Issue
- 2
- Pages
- 380-387
- ISSN
- 0301-0511 (ISSN-L)
- OpenAlex
- W2165708796
- Semantic Scholar
- 598969a0c9099850b7e34498c5d2c6b7016cad44
- Cited by
- 55
- References
- 66
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 8 · 2019: 7 · 2018: 2 · 2017: 6 · 2016: 8 · 2015: 5 · 2014: 3
- FWCI
- 7.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychology (publishedVersion)
- PubMed (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Research Portal (Queen's University Belfast) (submittedVersion)
- Funders
- Beijing Municipal Natural Science Foundation (Z111107067311058)
- National Key Research and Development Program of China (2010CB833903)
- National Natural Science Foundation of China (91224008, 81161120539, 91024032)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- oxytocin, self-referential processing, self-construal, interdependence, trait judgments, word valence, P2 component, late positive potential, event-related potentials, social cognition, intranasal administration
- MeSH terms
- Administration, Intranasal, Analysis of Variance, Brain Mapping, Double-Blind Method, Electroencephalography, Evoked Potentials, Humans, Judgment, Male, Oxytocics, Oxytocin, Reaction Time, Self Concept, Social Perception, Young Adult
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