Implications of psychosocial stress on memory formation in a typical male versus female student sample.
Abstract
Stress is known to differentially modulate memory function. Memory can be impaired or strengthened by stress, depending on e.g. the memory type and phase under study, the emotional value of the learned information and the sex of the subjects. Here, we addressed the latter and investigated the impact of psychosocial stress on long-term memory for neutral and emotional pictures and working memory in typical samples of male versus female students. In total, 77 subjects (54 women of which 39 used oral contraceptives) were exposed to either the Trier Social Stress Test (TSST) or a control condition, and then engaged in a long-term memory task (emotionally arousing and neutral pictures; surprise recall after one week) and a working memory (n-back) task. During the experiment salivary cortisol and alpha-amylase levels as well as subjective affect state were assessed. As expected, stress hormone concentrations as well as subjective negative affect states increased significantly in response to the stress task. Men reacted more to the stressor in terms of cortisol responses than women, probably due to oral contraceptive use of the latter. Results show that, in male as well as in female students, memory for emotional arousing information was better than for neutral information, in both the stress and control condition. Stress enhanced recognition memory for emotional versus neutral pictures only in male subjects. Moreover, stress enhanced working memory, particularly in males, during the first block of a 2-back task. The lack of stress effects on memory in women might be explained by oral contraceptive use, leading to blunted HPA-axis responses and secondary to reduced stress effects on memory. The results emphasize that stress affects both long-term and working memory differentially in male versus female students.
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In humans experimental or pharmacological stress studies have reported inconsistent effects with impairments as well as enhancements.
“In humans experimental or pharmacological stress studies have reported inconsistent effects with impairments as well as enhancements being reported [42], [46], [47].”
From Dose-dependent effects of endotoxin on neurobehavioral functions in humans (2011) · cites this paper as [46]
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- Authors
- Cornelisse, S., van Stegeren, A. H., & Joëls, M.
- Affiliations
- University Medical Center Utrecht (NL)
- Corresponding author
- Cornelisse, Sandra
- ORCID
- Joëls, Marian
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2011-05
- Volume
- 36
- Issue
- 4
- Pages
- 569-578
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2142439223
- Cited by
- 133
- References
- 50
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 8 · 2021: 9 · 2020: 15 · 2019: 10 · 2018: 11 · 2017: 11 · 2016: 7 · 2015: 5 · 2014: 13 · 2013: 12 · 2012: 6
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- psychosocial stress, memory formation, sex differences, long-term memory, emotional pictures, working memory, n-back task, salivary cortisol, alpha-amylase, oral contraceptives, hypothalamic-pituitary-adrenal axis, Trier Social Stress Test, recognition memory, negative affect
- MeSH terms
- Adolescent, Adult, Algorithms, Female, Humans, Male, Memory, Neuropsychological Tests, Photic Stimulation, Mental Recall, Sex Characteristics, Stress, Psychological, Students, Recognition, Psychology, Young Adult, Memory, Long-Term
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