Cited by 331Birth, Development, and HealthMaternal Mental Health During Pregnancy and PostpartumStress Responses and Cortisol

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Prenatal stress, development, health and disease risk: A psychobiological perspective—2015 Curt Richter Award Paper

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Entringer, Sonja, Buss, Claudia, Wadhwa, Pathik D.·2015·Psychoneuroendocrinology

DOI 10.1016/j.psyneuen.2015.08.019PMC PMC4674548

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Abstract

The long-term consequences of exposure to excess stress, particularly during sensitive developmental windows, on the initiation and progression of many complex, common physical and mental disorders that confer a major global burden of disease are well established. The period of intrauterine life represents among the most sensitive of these windows, at which time the effects of stress may be transmitted inter-generationally from a mother to her as-yet-unborn child. As explicated by the concept of fetal or developmental programming of health and disease susceptibility, a growing body of evidence supports the notion that health and disease susceptibility is determined by the dynamic interplay between genetic makeup and environment, particularly during intrauterine and early postnatal life. Except in extreme cases, an adverse intrauterine exposure may not, per se, 'cause' disease, but, instead, may determine propensity for disease(s) in later life (by shaping phenotypic responsivity to endogenous and exogenous disease-related risk conditions). Accumulating evidence suggests that maternal psychological and social stress during pregnancy represents one such condition that may adversely affect the developing child, with important implications for a diverse range of physical and mental health outcomes. In this paper we review primarily our own contributions to the field of maternal stress during pregnancy and child mental and physical health-related outcomes. We present findings on stress-related maternal-placental-fetal endocrine and immune/inflammatory processes that may mediate the effects of various adverse conditions during pregnancy on the developing human embryo and fetus. We enunciate conceptual and methodological issues related to the assessment of stress during pregnancy and discuss potential mechanisms of intergenerational transmission of the effects of stress. Lastly, we describe on-going research and some future directions of our program.

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See all 331

Authors: Entringer, S., Buss, C., & Wadhwa, P. D.
Affiliations: University of California, Irvine (US)
Corresponding author: Entringer, Sonja
Buss, Claudia
ORCID: Entringer, Sonja
Buss, Claudia
Wadhwa, Pathik D.
Venue: Psychoneuroendocrinology
Publisher: Elsevier BV
Published: 2015-12
Volume: 62
Pages: 366-375
ISSN: 0306-4530 (ISSN-L)
DOI: 10.1016/j.psyneuen.2015.08.019
PMC: PMC4674548
OpenAlex: W2156890246
Cited by: 324
References: 107
Citations by year: 2026: 17 · 2025: 21 · 2024: 32 · 2023: 29 · 2022: 34 · 2021: 49 · 2020: 40 · 2019: 26 · 2018: 26 · 2017: 29 · 2016: 18 · 2015: 1
FWCI: 3.74
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Psychoneuroendocrinology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: US PHS (NIH) (RO1HD-065825, RO1HD-06028, R01 MH-091351, R21 RDK-098765)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: prenatal stress, fetal programming, developmental programming, intergenerational transmission, placenta, child mental health outcomes, gene-environment interaction
MeSH terms: Awards and Prizes, Child, Child Development, Disease Susceptibility, Female, Humans, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Pregnancy, Prenatal Exposure Delayed Effects, Stress, Psychological, Fetal Development

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Prenatal stress, development, health and disease risk: A psychobiological perspective—2015 Curt Richter Award Paper

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