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Cited by 37Neuroendocrine regulation and behaviorNeurotransmitter Receptor Influence on BehaviorBullying, Victimization, and Aggression

Effect of the interaction between oxytocin receptor gene polymorphism (rs53576) and stressful life events on aggression in Chinese Han adolescents

Shao, Di, Zhang, Hui-Hui, Long, Zhou-Ting, Li, Jie, Bai, Hua-Yu, Li, Jing-Jing, Cao, Feng-Lin·2018·Psychoneuroendocrinology
DOI 10.1016/j.psyneuen.2018.06.002
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Abstract

Objectives Accumulating evidence suggests that stressful life events are associated with increased risk for aggressive behavior in adolescents; however, aggressive reactions to life stressors exhibit large individual differences. The present study sought to examine whether the interaction between a single nucleotide polymorphism (SNP [rs53576]) within the oxytocin receptor gene (OXTR) and stressful life events is related to aggression in Chinese Han adolescents.Methods A total of 197 Chinese Han adolescents (14-17 years of age) were included in this study. Aggression was assessed using the 12-item short version of Buss and Perry Aggression Questionnaire. Stressful life events during the past 12 months were assessed using the Adolescent Self-Rating Life Events Checklist. Genomic DNA was extracted from saliva and buccal cells from each individual.Results Multivariate analysis of variance yielded a significant interaction between OXTR rs53576 SNP and life stress (F = 2.449, p = 0.043, partial η2 = 0.051) and of sex × SNP × life stress (F = 3.144, p = 0.016, partial η2 = 0.064). High life stress during the past 12 months was associated with high levels of physical aggression and hostility in OXTR rs53576 homozygous AA adolescents but not in G-carrier adolescents. In boys, homozygous AA individuals in the high life stress group reported significantly higher levels of physical aggression than participants in the other three groups; the interaction, however, was not significant in girls.Conclusions This study, which analyzed a specific gene-environment interaction, demonstrated that AA OXTR rs53576 homozygosity may correlate with higher levels of aggression under high life stress conditions with a sample of healthy Chinese Han adolescents. These findings promote the etiological understanding of adolescent aggression, highlighting the complex effect of stressful life events on aggression, and adding evidence supporting the relationship between the oxytocin system and aggressive behavior in adolescents.

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  • High life stress during the past 12 months was associated with high levels of physical aggression and hostility in OXTR rs53576 homozygous AA adolescents but not in G-carrier adolescents.

    “High life stress during the past 12 months was associated with high levels of physical aggression and hostility inOXTR rs53576 homozygous AA adolescents but not in G-carrier adolescents.”

    From Genetics of child aggression, a systematic review (2024) · cites this paper as Shao [107]

  • In boys, homozygous AA individuals in the high life stress group had significantly higher levels of physical aggression.

    “In boys, homozygous AA individuals in the high life stress group had significantly higher levels of physical aggression.”

    From Genetics of child aggression, a systematic review (2024) · cites this paper as Shao [107]

  • There was no significant effect for girls.

    “NS for girls.”

    From Genetics of child aggression, a systematic review (2024) · cites this paper as Shao [107]

  • There was a significant interaction between OXTR rs53576 and life stress (F = 2.449, p = 0.043, partial η2 = 0.051) and of sex × SNP × life stress (F = 3.144, p = 0.016, partialη2 = 0.064).

    “Significant interaction between OXTR rs53576 and life stress (F = 2.449, p = 0.043, partial η2 = 0.051) and of sex × SNP × life stress (F = 3.144, p = 0.016, partialη2 = 0.064).”

    From Genetics of child aggression, a systematic review (2024) · cites this paper as Shao [107]

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Authors
Shao, D., Zhang, H.-H., Long, Z.-T., Li, J., Bai, H.-Y., Li, J.-J., & Cao, F.-L.
Affiliations
Shandong University (CN)
ORCID
Venue
Psychoneuroendocrinology
Publisher
Elsevier BV
Published
2018-10
Volume
96
Pages
35-41
ISSN
0306-4530 (ISSN-L)
DOI
10.1016/j.psyneuen.2018.06.002
OpenAlex
W2807450564
Cited by
37
References
68
Citations by year
2025: 1 · 2024: 7 · 2023: 8 · 2022: 5 · 2021: 3 · 2020: 6 · 2019: 6 · 2018: 1
FWCI
5.38
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Psychoneuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Office for Philosophy and Social Sciences (17BSH054)
  • Natural Science Foundation of Shandong Province (ZR2017MC070)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Social Psychology › Bullying, Victimization, and Aggression
Keywords
oxytocin receptor gene, OXTR rs53576, gene-environment interaction, life events, adolescent aggression, physical aggression, hostility, sex differences, oxytocinergic system
MeSH terms
Adolescent, Aggression, Alleles, China, Ethnicity, Female, Gene Frequency, Genotype, Humans, Life Change Events, Male, Oxytocin, Surveys and Questionnaires, Sex Factors, Stress, Psychological, Receptors, Oxytocin, Polymorphism, Single Nucleotide, Asian People, Gene-Environment Interaction

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