The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.
Impacts of polystyrene microplastic on the gut barrier, microbiota and metabolism of mice
Abstract
Microplastics (MPs), which are new environmental pollutants with a diameter of <5 mm, have received wide attention in recent years. However, there are still very limited data regarding the risks of MPs to animals, especially higher mammals. In this study, we exposed male mice to 5 μm pristine and fluorescent polystyrene MP for six weeks. The results showed that the polystyrene MP was observed in the guts of mice and could reduce the intestinal mucus secretion and cause damage the intestinal barrier function. In addition, high-throughput sequencing of the V3-V4 region of the 16S rRNA gene was used to explore the change of the gut microbiota composition in the cecal content. At the phylum level, the content of Actinobacteria decreased significantly in the polystyrene MP-treated group. The PD whole-tree indexes of the alpha diversity and principal component analysis (PCA) of the beta diversity indicated that the diversity of gut microbiota was altered after polystyrene MP exposure. At the genus level, a total of 15 types of bacteria changed significantly after exposure to polystyrene MP. Furthermore, the predicted KEGG (Kyoto Encyclopedia of Genes and Genomes) metabolic pathway differences indicated that the main metabolic pathways of the functional genes in the microbial community were significantly influenced by the polystyrene MP. In addition, indexes of amino acid metabolism and bile acid metabolism in the serum were analyzed after polystyrene MP exposure. These results indicated that polystyrene MP caused metabolic disorders. In conclusion, the polystyrene MP induced gut microbiota dysbiosis, intestinal barrier dysfunction and metabolic disorders in mice. This study provided more data on the toxicity of MPs in a terrestrial organism to aid in the assessment of the health risks of polystyrene MP to animals.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“and metabolic disorders (5-μm polystyrene microplastics at concentrations of 1.456×106 particles/L and 1.456×107 particles/L).31”
From Microplastics and Anthropogenic Particles in Recreationally Caught Freshwater Fish from an Urbanized Region of the North American Great Lakes (2024) · cites this paper as [31]
In the citing paper
“Although some in vitro and in vivo studies examining impacts of microplastics on mammals show effects, such as intestinal barrier disfunction and alteration of biomarkers,30,31”
From Microplastics and Anthropogenic Particles in Recreationally Caught Freshwater Fish from an Urbanized Region of the North American Great Lakes (2024) · cites this paper as [31]
In the citing paper
“However, it is unclear if toxicological effects from either of these mechanisms are occurring in humans, and at what thresholds effects occur.”
From Microplastics and Anthropogenic Particles in Recreationally Caught Freshwater Fish from an Urbanized Region of the North American Great Lakes (2024) · cites this paper as [31]
In the citing paper
“Smaller nanoparticles exhibit a higher surface area-to-volume ratio, enhancing their chemical reactivity, biological interactions, cellular uptake, and tissue penetration (Jin et al., 2019; Shin et al., 2023; Teng et al., 2022).”
From Deciphering the toxic effects of polystyrene nanoparticles on erythropoiesis at single-cell resolution (2025) · cites this paper as Jin et al., 2019
Citations
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Plastic waste inputs from land into the ocean
Jambeck, J. R., Geyer, R., Wilcox, C., Siegler, T. R., Perryman, M., Andrady, A., Narayan, R., & Law, K. L. (2015) · Science · doi:10.1126/science.1260352 · Cited by 13,163
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726
Lost at sea: where is all the plastic?
Thompson, R. C., Olsen, Y., Mitchell, R. P., Davis, A., Rowland, S. J., John, A. W. G., McGonigle, D., & Russell, A. E. (2004) · Science · doi:10.1126/science.1094559 · Cited by 7,765
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176
Accumulation and fragmentation of plastic debris in global environments
Barnes, D. K. A., Galgani, F., Thompson, R. C., & Barlaz, M. (2009) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0205 · Cited by 6,126
Metagenomic Analysis of the Human Distal Gut Microbiome
Gill, S. R., Pop, M., DeBoy, R. T., Eckburg, P. B., Turnbaugh, P. J., Samuel, B. S., Gordon, J. I., Relman, D. A., Fraser-Liggett, C. M., & Nelson, K. E. (2006) · Science · doi:10.1126/science.1124234 · Cited by 4,699
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572
The Physical Impacts of Microplastics on Marine Organisms: A Review
Wright, S. L., Thompson, R. C., & Galloway, T. S. (2013) · Environmental Pollution · doi:10.1016/j.envpol.2013.02.031 · Cited by 4,524
Horton, A. A., Walton, A., Spurgeon, D. J., Lahive, E., & Svendsen, C. (2017) · Science of The Total Environment · doi:10.1016/j.scitotenv.2017.01.190 · Cited by 3,756
Life in the “plastisphere”: microbial communities on plastic marine debris
Zettler, E. R., Mincer, T. J., & Amaral-Zettler, L. A. (2013) · Environmental Science & Technology · doi:10.1021/es401288x · Cited by 3,368
Normal gut microbiota modulates brain development and behavior
Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., Hibberd, M. L., Forssberg, H., & Pettersson, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010529108 · Cited by 3,228
Eerkes-Medrano, D., Thompson, R. C., & Aldridge, D. C. (2015) · Water Research · doi:10.1016/j.watres.2015.02.012 · Cited by 2,638
Microplastics as an emerging threat to terrestrial ecosystems
Machado, A. A. D. S., Kloas, W., Zarfl, C., Hempel, S., & Rillig, M. C. (2017) · Global Change Biology · doi:10.1111/gcb.14020 · Cited by 2,468
EGU General Assembly Conference Abstracts
Bell, A., Main, I. G., Atkinson, M., Vicente, R. F., Meredith, P. G., & Boon, S. A. (2013) · Cited by 2,408
Browne, M. A., Dissanayake, A., Galloway, T. S., Lowe, D. M., & Thompson, R. C. (2008) · Environmental Science & Technology · doi:10.1021/es800249a · Cited by 2,263
Lu, Y., Zhang, Y., Deng, Y., Jiang, W., Zhao, Y., Geng, J., Ding, L., & Ren, H. (2016) · Environmental Science & Technology · doi:10.1021/acs.est.6b00183 · Cited by 2,125
Microplastics in bivalves cultured for human consumption
Cauwenberghe, L. V., & Janssen, C. (2014) · Environmental Pollution · doi:10.1016/j.envpol.2014.06.010 · Cited by 2,105
Lusher, A. L., McHugh, M., & Thompson, R. C. (2013) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2012.11.028 · Cited by 2,075
Microplastic pollution in the surface waters of the Laurentian Great Lakes
Eriksen, M., Mason, S., Wilson, S., Box, C., Zellers, A., Edwards, W., Farley, H., & Amato, S. (2013) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2013.10.007 · Cited by 1,937
Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice
Devkota, S., Wang, Y., Musch, M. W., Leone, V., Fehlner-Peach, H., Nadimpalli, A., Antonopoulos, D. A., Jabri, B., & Chang, E. B. (2012) · Nature · doi:10.1038/nature11225 · Cited by 1,904
Oyster reproduction is affected by exposure to polystyrene microplastics
Sussarellu, R., Suquet, M., Thomas, Y., Christophe Lambert, B., Fabioux, C., Arsenault-Pernet, E.-J., Goïc, N. L., Quillien, V., Mingant, C., Epelboin, Y., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1519019113 · Cited by 1,896
Duis, K., & Coors, A. (2016) · Environmental Sciences Europe · doi:10.1186/s12302-015-0069-y · Cited by 1,878
von Moos, N., Burkhardt-Holm, P., & Köhler, A. (2012) · Environmental Science & Technology · doi:10.1021/es302332w · Cited by 1,697
The present and future of microplastic pollution in the marine environment
do Sul, J. A. I., & da Costa, M. F. (2013) · Environmental Pollution · doi:10.1016/j.envpol.2013.10.036 · Cited by 1,663
Contributing to marine pollution by washing your face: Microplastics in facial cleansers
Fendall, L. S., & Sewell, M. A. (2009) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2009.04.025 · Cited by 1,525
Microplastic is an Abundant and Distinct Microbial Habitat in an Urban River
McCormick, A. R., Hoellein, T. J., Mason, S. A., Schluep, J., & Kelly, J. J. (2014) · Environmental Science & Technology · doi:10.1021/es503610r · Cited by 1,486
Mucins in the mucosal barrier to infection
Lindén, S. K., SUTTON, P. R. N., Karlsson, N. G., Korolik, V., & McGuckin, M. A. (2008) · Mucosal Immunology · doi:10.1038/mi.2008.5 · Cited by 1,257
Jeong, C.-B., Won, E.-J., Kang, H.-M., Lee, M.-C., Hwang, D.-S., Hwang, U.-K., Zhou, B., Souissi, S., Lee, S.-J., & Lee, J.-S. (2016) · Environmental Science & Technology · doi:10.1021/acs.est.6b01441 · Cited by 1,233
Microplastic pollution, a threat to marine ecosystem and human health: a short review
Sharma, S., & Chatterjee, S. (2017) · Environmental Science and Pollution Research · doi:10.1007/s11356-017-9910-8 · Cited by 1,191
Microplastic Pollution in Table Salts from China
Yang, D., Shi, H., Li, L., Li, J., Jabeen, K., & Kolandhasamy, P. (2015) · Environmental Science & Technology · doi:10.1021/acs.est.5b03163 · Cited by 1,129
Polystyrene Spherules in Coastal Waters
Carpenter, E. J., Anderson, S. J., Harvey, G. R., Miklas, H. P., & Peck, B. B. (1972) · Science · doi:10.1126/science.178.4062.749 · Cited by 1,115
Lu, L., Wan, Z., Luo, T., Fu, Z., & Jin, Y. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.03.051 · Cited by 1,095
Self-citationGlobal warming releases microplastic legacy frozen in Arctic Sea ice
Obbard, R. W., Sadri, S., Wong, Y. Q., Khitun, A. A., Baker, I. A., & Thompson, R. C. (2014) · Earth s Future · doi:10.1002/2014ef000240 · Cited by 1,091
Schell, M. A., Karmirantzou, M., Snel, ., Vilanova, D., Berger, B. W., Pessi, G., Zwahlen, M.-C., Desiere, F., Peer Bork, B., Delley, M., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212527599 · Cited by 942
Size-Dependent Effects of Micro Polystyrene Particles in the Marine Copepod Tigriopus japonicus
Lee, K.-W., Shim, W. J., Kwon, O. Y., & Kang, J.-H. (2013) · Environmental Science & Technology · doi:10.1021/es401932b · Cited by 923
The role of microbial amino acid metabolism in host metabolism
Neis, E., Dejong, C., & Rensen, S. (2015) · Nutrients · doi:10.3390/nu7042930 · Cited by 920
Polystyrene microplastics induce microbiota dysbiosis and inflammation in the gut of adult zebrafish
Jin, Y., Xia, J., Pan, Z., Yang, J., Wang, W., & Fu, Z. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2017.12.088 · Cited by 896
Self-citationPeng, G., Xu, P., Zhu, B., Bai, M., & Li, D. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2017.11.034 · Cited by 724
Synthetic fibers as an indicator of land application of sludge
Zubris, K. A. V., & Richards, B. K. (2005) · Environmental Pollution · doi:10.1016/j.envpol.2005.04.013 · Cited by 723
Effects of environmental pollutants on gut microbiota
Jin, Y., Wu, S., Zeng, Z., & Fu, Z. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2016.11.045 · Cited by 683
Self-citationHussain, N. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00152-1 · Cited by 682
A critical perspective on early communications concerning human health aspects of microplastics
Rist, S., Almroth, B. C., Hartmann, N. B., & Karlsson, T. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.01.092 · Cited by 601
Amino acid metabolism in intestinal bacteria: links between gut ecology and host health
Dai, Z. (2010) · Frontiers in bioscience · doi:10.2741/3820 · Cited by 580
Microplastics in Livers of European Anchovies (Engraulis encrasicolus, L.)
Collard, F., Gilbert, B., Compère, P., Eppe, G., Das, K., Jauniaux, T., & Parmentier, E. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2017.07.089 · Cited by 438
Forsythe, P., Sudo, N., Dinan, T., Taylor, V. H., & Bienenstock, J. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.05.058 · Cited by 429
The biogeography of the Plastisphere: implications for policy
Amaral‐Zettler, L., Zettler, E., Slikas, B., Boyd, G. D., Melvin, D. W., Morrall, C. E., Proskurowski, G., & Mincer, T. J. (2015) · Frontiers in Ecology and the Environment · doi:10.1890/150017 · Cited by 427
Microbes and the gut‐brain axis
Bercik, P., Collins, S. M., & Verdu, E. F. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2012.01906.x · Cited by 417
Zhao, S., Zhu, L., & Li, D. (2016) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2016.01.112 · Cited by 369
Microplastic-associated bacterial assemblages in the intertidal zone of the Yangtze Estuary
Jiang, P., Zhao, S., Zhu, L., & Li, D. (2017) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2017.12.105 · Cited by 367
Ramos, L., Berenstein, G. A., Hughes, E. A., Zalts, A., & Montserrat, J. M. (2015) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2015.03.142 · Cited by 301
Effects of polystyrene microplastics on the fitness of earthworms in an agricultural soil
Cao, D., Xiao, W., Luo, X., Liu, G., & Zheng, H. (2017) · IOP Conference Series Earth and Environmental Science · doi:10.1088/1755-1315/61/1/012148 · Cited by 291
Coordination of tolerogenic immune responses by the commensal microbiota
Round, J. L., O’Connell, R. M., & Mazmanian, S. K. (2009) · Journal of Autoimmunity · doi:10.1016/j.jaut.2009.11.007 · Cited by 269
Interactions Between Microorganisms and Marine Microplastics: A Call for Research
Harrison, J. P., Sapp, M., Schratzberger, M., & Osborn, A. M. (2011) · Marine Technology Society Journal · doi:10.4031/mtsj.45.2.2 · Cited by 253
Propionic acid affects immune status and metabolism in adipose tissue from overweight subjects
Al-Lahham, S., Roelofsen, H., Rezaee, F., Weening, D., Hoek, A., Vonk, R. J., & Venema, K. (2011) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2011.02590.x · Cited by 241
Schmidt, C., Lautenschläger, C., Collnot, E.-M., Schümann, M., Bojarski, C., Schulzke, J., Lehr, C., & Stallmach, A. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.10.019 · Cited by 236
Weber, A., Scherer, C., Brennholt, N., Reifferscheid, G., & Wagner, M. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2017.11.014 · Cited by 233
Subchronic Exposure of Mice to Cadmium Perturbs Their Hepatic Energy Metabolism and Gut Microbiome
Zhang, S., Jin, Y., Zeng, Z., Liu, Z., & Fu, Z. (2015) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.5b00237 · Cited by 220
Self-citationBa, Q., Li, M., Chen, P., Huang, C., Duan, X., Lu, L., Li, J., Chu, R., Xie, D., Song, H., et al. (2016) · Environmental Health Perspectives · doi:10.1289/ehp360 · Cited by 189
Self-citationQuantitative Tar and Plastic Waste Distributions in the Pacific Ocean
Wong, C. S., Green, D. R., & Cretney, W. J. (1974) · Nature · doi:10.1038/247030a0 · Cited by 185
Xia, J., Jin, C., Pan, Z., Sun, L., Fu, Z., & Jin, Y. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.03.053 · Cited by 184
Self-citationEffects of short term lead exposure on gut microbiota and hepatic metabolism in adult zebrafish
Xia, J., Lu, L., Jin, C., Wang, S., Zhou, J., Ni, Y., Fu, Z., & Jin, Y. (2018) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2018.03.007 · Cited by 181
Self-citationNorkina, O., Burnett, T. G., & Lisle, R. C. D. (2004) · Infection and Immunity · doi:10.1128/iai.72.10.6040-6049.2004 · Cited by 175
Kokalj, A. J., Horvat, P., Skalar, T., & Kržan, A. (2017) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2017.10.020 · Cited by 165
Profiling of Serum Bile Acids in a Healthy Chinese Population Using UPLC–MS/MS
Xie, G., Wang, Y., Wang, X., Zhao, A., Chen, T., Ni, Y., Wong, L. L., Zhang, H., Zhang, J., Liu, C., et al. (2015) · Journal of Proteome Research · doi:10.1021/pr500920q · Cited by 160
Jin, Y., Zeng, Z., Wu, Y., Zhang, S., & Fu, Z. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv115 · Cited by 152
Self-citationBhatia, S., Prabhu, P. N., Benefiel, A. C., Miller, M. J., Chow, J., Davis, S. R., & Gaskins, H. R. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400639 · Cited by 148
Atrazine and its main metabolites alter the locomotor activity of larval zebrafish (Danio rerio)
Liu, Z., Wang, Y., Zhu, Z., Yang, E., Feng, X., Fu, Z., & Jin, Y. (2016) · Chemosphere · doi:10.1016/j.chemosphere.2016.01.007 · Cited by 147
Self-citationKong, W., Huang, C., Tang, Y., Zhang, D., Wu, Z., & Chen, X. (2017) · Scientific Reports · doi:10.1038/s41598-017-01336-9 · Cited by 130
Cellular and Molecular Basis of Intestinal Barrier Dysfunction in the Irritable Bowel Syndrome
Martínez, C., González-Castro, A. M., Vicario, M., & Santos, J. (2012) · Gut and Liver · doi:10.5009/gnl.2012.6.3.305 · Cited by 117
Clinical, biochemical, and molecular spectrum of hyperargininemia due to arginase I deficiency
Scaglia, F., & Lee, B. (2006) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.30091 · Cited by 113
Exposure to the fungicide propamocarb causes gut microbiota dysbiosis and metabolic disorder in mice
Wu, S., Jin, C., Wang, Y., Fu, Z., & Jin, Y. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2017.10.129 · Cited by 93
Self-citationSanz, Y., & de Palma, G. (2009) · International Reviews of Immunology · doi:10.3109/08830180903215613 · Cited by 92
Evidence for intestinal chloride secretion
Murek, M. K., Kopic, S., & Geibel, J. P. (2010) · Experimental Physiology · doi:10.1113/expphysiol.2009.049445 · Cited by 90
Lynch, S. V., Goldfarb, K. C., Wild, Y. K., Kong, W., De Lisle, R. C., & Brodie, E. L. (2013) · Gut Microbes · doi:10.4161/gmic.22430 · Cited by 87
Jin, C., Xia, J., Wu, S., Tu, W., Pan, Z., Fu, Z., Wang, Y., & Jin, Y. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfx227 · Cited by 84
Self-citationMagera, M. J., Gunawardena, N. D., Hahn, S. H., Tortorelli, S., Mitchell, G. A., Goodman, S. I., Rinaldo, P., & Matern, D. (2006) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2005.12.005 · Cited by 66
Chen, Y., Zhang, H.-S., Fong, G., Xi, Q., Wu, G., Bai, C., Ling, Z., Li, F., Xu, Y., Qin, Y.-Q., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.653584 · Cited by 64
Cholestasis and Endogenous Opioids
Davis, M. P. (2007) · Clinical Pharmacokinetics · doi:10.2165/00003088-200746100-00002 · Cited by 53
A translational view on the biliary lipid secretory network
Sasso, G. L., Petruzzelli, M., & Moschetta, A. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2007.12.002 · Cited by 38
In vitro evaluation of intestinal epithelial TLR activation in preventing food allergic responses
de Kivit, S., Tobin, M. C., DeMeo, M. T., Fox, S., Garssen, J., Forsyth, C. B., Keshavarzian, A., & LANDAY, A. L. (2014) · Clinical Immunology · doi:10.1016/j.clim.2014.07.002 · Cited by 36
Prevotella copri and the microbial pathogenesis of rheumatoid arthritis
Moreno, J. G. (2014) · Reumatología Clínica · doi:10.1016/j.reuma.2014.11.001 · Cited by 22
Trauner, M. A., Fickert, P., & Tilg, H. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.02.029 · Cited by 16
Huerta, E., Mendoza‐Vega, J., Kú-Quej, V. M., Angeles, J. D. L., del Cid, L. S., Quijano, C., Escalona‐Segura, G., Gertsen, H., Salánki, T., van der Ploeg, M. J., et al. (2017) · EGU General Assembly Conference Abstracts · Cited by 7
Flagged first, then by citations
Cited by
Sorted by citations
Risk assessment of microplastic particles
Koelmans, A. A., Redondo‐Hasselerharm, P. E., Nor, N. H. M., de Ruijter, V. N., Mintenig, S. M., & Kooi, M. (2022) · Nature Reviews Materials · doi:10.1038/s41578-021-00411-y · Cited by 1,204
Impact of Microplastics and Nanoplastics on Human Health
Yee, M. S.-L., Hii, L., Looi, C.-K., Lim, W., Wong, S. F., Kok, Y.-Y., Tan, B.-K., Wong, C.-Y., & Leong, C. (2021) · Nanomaterials · doi:10.3390/nano11020496 · Cited by 1,119
Ecotoxicity and genotoxicity of polystyrene microplastics on higher plant Vicia faba
Jiang, X., Chen, H., Liao, Y., Ye, Z., Li, M., & Klobučar, G. I. V. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.04.055 · Cited by 1,008
Akdiş, C. A. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00538-7 · Cited by 1,066
Toxicity of Microplastics and Nanoplastics in Mammalian Systems
Yong, C., Valiyaveettil, S., & Tang, B. L. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17051509 · Cited by 925
“Pathological changes to the gut include a reduction in mucus secretion [90], gut barrier dysfunction [104,106], intestinal inflammation [107] and gut microbiota dysbiosis [90,104,106,107].”
Background
Metadata
- Authors
- Jin, Y., Lu, L., Tu, W., Luo, T., & Fu, Z.
- Affiliations
- Zhejiang University of Technology (CN)
- Jiangxi Academy of Sciences (CN)
- Corresponding author
- Fu, Zhengwei
- Venue
- Science of The Total Environment
- Publisher
- Elsevier BV
- Published
- 2019-02
- Volume
- 649
- Pages
- 308-317
- ISSN
- 0048-9697 (ISSN-L)
- OpenAlex
- W2889479406
- Cited by
- 1,100
- References
- 84
- Citations by year
- 2026: 152 · 2025: 189 · 2024: 193 · 2023: 161 · 2022: 181 · 2021: 102 · 2020: 73 · 2019: 39
- FWCI
- 20.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Science of The Total Environment (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Zhejiang Provincial Natural Science Foundation of China (LR16B070002, 21777146)
- National Natural Science Foundation of China
- Topics
- Physical Sciences › Environmental Science › Pollution › Microplastics and Plastic Pollution
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
- Keywords
- polystyrene microplastics, gut dysbiosis, intestinal barrier dysfunction, microbial metabolic pathways, amino acid metabolism, bile acid metabolism, cecal microbiota, actinobacteria
- MeSH terms
- Gastrointestinal Microbiome, Animals, Environmental Pollutants, Male, Metabolic Diseases, Mice, Inbred ICR, Particle Size, Polystyrenes, Gastrointestinal Tract, Mice, Particulate Matter, Dysbiosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
