Mortality related to actigraphic long and short sleep

Kripke, Daniel F.; Langer, Robert D.; Elliott, Jeffrey A.; Klauber, Melville R.; Rex, Katharine M.

doi:10.1016/j.sleep.2010.04.016

Cited by 175Sleep and related disordersCircadian rhythm and melatoninSleep and Work-Related Fatigue

Mortality related to actigraphic long and short sleep

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Kripke, Daniel F., Langer, Robert D., Elliott, Jeffrey A., Klauber, Melville R., Rex, Katharine M.·2011·Sleep Medicine

DOI 10.1016/j.sleep.2010.04.016PMC PMC3010336

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Abstract

Background The folk belief that we should sleep 8 h seems to be incorrect. Numerous studies have shown that self-reported sleep longer than 7.5 h or shorter than 6.5 h predicts increased mortality risk. This study examined if prospectively-determined objective sleep duration, as estimated by wrist actigraphy, was associated with mortality risks.Methods From 1995-1999, women averaging 67.6 years of age provided one-week actigraphic recordings. Survival could be estimated from follow-up continuing until 2009 for 444 of the women, with an average of 10.5 years before censoring. Multivariate age-stratified Cox regression models were controlled for history of hypertension, diabetes, myocardial infarction, cancer, and major depression.Results Adjusted survival functions estimated 61% survival (54-69%, 95% C.I.) for those with sleep less than 300 min and 78% survival (73-85%, 95% C.I.) for those with actigraphic sleep longer than 390 min, as compared with survival of 90% (85-94%, 95% C.I.) for those with sleep of 300-390 min. Time-in-bed, sleep efficiency and the timing of melatonin metabolite excretion were also significant mortality risk factors.Conclusion This study confirms a U-shaped relationship between survival and actigraphically measured sleep durations, with the optimal objective sleep duration being shorter than the self-report optimums. People who sleep five or six hours may be reassured. Further studies are needed to identify any modifiable factors for this mortality and possible approaches to prevention.

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Sleep disorders are associated with increased mortality.
“sleep disorders have been associated with increased mortality.(Kripke, Langer, Elliott, Klauber, and Rex 2011)”
From Successful aging: Advancing the science of physical independence in older adults (2015) · cites this paper as Kripke et al. 2011

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Authors: Kripke, D. F., Langer, R. D., Elliott, J. A., Klauber, M. R., & Rex, K. M.
Affiliations: University of California San Diego (US)
Corresponding author: Kripke, Daniel F.
ORCID: Kripke, Daniel F.
Elliott, Jeffrey A.
Venue: Sleep Medicine
Publisher: Elsevier BV
Published: 2011-01
Volume: 12
Issue: 1
Pages: 28-33
ISSN: 1389-9457 (ISSN-L)
DOI: 10.1016/j.sleep.2010.04.016
PMC: PMC3010336
OpenAlex: W2036038249
Cited by: 175
References: 21
Citations by year: 2026: 2 · 2025: 5 · 2024: 6 · 2023: 10 · 2022: 13 · 2021: 8 · 2020: 11 · 2019: 22 · 2018: 8 · 2017: 11 · 2016: 14 · 2015: 11 · 2014: 11 · 2013: 24 · 2012: 8
FWCI: 17.91
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Sleep Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: NIH HL55983
HL071123
NO1-WH-3-2120
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords: sleep duration, mortality, actigraphy, U-shaped relationship, time in bed, sleep efficiency, women, self-reported sleep
MeSH terms: Aged, Female, Humans, Mortality, Prospective Studies, Risk Factors, Sleep, Time Factors, Multivariate Analysis, Proportional Hazards Models, Actigraphy

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Mortality related to actigraphic long and short sleep

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