Investigating psychological and physiological responses to the Trier Social Stress Test in young adults with insomnia
Abstract
Objective Stress and hyperarousal both contribute to insomnia. Elevated stress-related sleep reactivity is associated with hyperarousal, and might constitute a vulnerability to future insomnia. The present study examined acute stress-induced arousal and its association with nocturnal sleep. Methods Participants were 30 healthy adults (66.7% female, M age = 26.7 years): 10 with insomnia (INS) and 20 good sleepers with high vulnerability (HV) or low vulnerability (LV) to insomnia. They underwent two consecutive nights of polysomnography. During the evening preceding the second night, the Trier Social Stress Test (TSST) was administered, and psychological and physiological arousal indices were assessed. Results The TSST elicited an increase in psychological and physiological arousal in all three groups. The INS group showed greater acute cortisol response (p < 0.05) and secretion at bedtime (p < 0.05), and higher pre-sleep cognitive arousal (p < 0.01) than the LV group; HV participants did not significantly differ from those in the INS or the LV group. Increased cortisol response and elevated sympathovagal imbalance (ie, low frequency/high frequency ratio) were each significantly associated with longer nocturnal awakenings (p = 0.048, p = 0.037, respectively). Heightened blood pressure was significantly associated with prolonged sleep onset latency, and reduced total sleep time and sleep efficiency (all ps < 0.05). Conclusions These findings support the hyperarousal conceptualization of insomnia and indirectly suggest that increased stress reactivity and bedtime hyperarousal might represent a trait-like vulnerability in certain good sleepers. More research is warranted to validate and expand these preliminary findings.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Several factors contribute to the transition from acute to chronic insomnia, including markers linked to the stress response such as blood pressure, respiratory rate, and activation of the HPA axis in those with a predisposition for insomnia.
“Several factors have been identified to contribute to the transition from acute to chronic insomnia [20], including markers linked to the stress response such as blood pressure, respiratory rate, and activation of the HPA axis in those with a predisposition for insomnia [21,22].”
From A systematic review and meta-analysis of poor sleep, insomnia symptoms and stress in undergraduate students (2022) · cites this paper as [22]
Cites
Eysenck, H. J. (1985) · Behaviour Research and Therapy · doi:10.1016/0005-7967(85)90087-7 · Cited by 32,026 · see citing works
“Stress: appraisal and coping,”
Folkman, S. (2013) · Encyclopedia of Behavioral Medicine · doi:10.1007/978-1-4419-1005-9_215 · Cited by 27,833 · see citing works
(1970) · Cited by 24,983 · see citing works
Heart Rate Variability: Standards of Measurement, Physiological Interpretation, and Clinical Use
Electrophysiology, T. F. O. T. E. S. O. C. T. N. A. (1996) · Circulation · doi:10.1161/01.cir.93.5.1043 · Cited by 17,159 · see citing works
Heart rate variability: Standards of measurement, physiological interpretation, and clinical use
Malik, M., Bigger, J. T., Camm, A. J., Kleiger, R. E., Malliani, A., Moss, A. J., & Schwartz, P. J. (1996) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a014868 · Cited by 15,289 · see citing works
Diagnostic and Statistical Manual of Mental Disorders(DSM)
Leong, F. T. L. (2008) · Sage eBooks · doi:10.4135/9781412963978.n182 · Cited by 10,858 · see citing works
Validation of the Insomnia Severity Index as an outcome measure for insomnia research
Bastien, C. (2001) · Sleep Medicine · doi:10.1016/s1389-9457(00)00065-4 · Cited by 8,067 · see citing works
(2007) · Cited by 6,530 · see citing works
Kirschbaum, C., Pirke, K.-M., & Hellhammer, D. H. (2008) · Neuropsychobiology · doi:10.1159/000119004 · Cited by 6,093 · see citing works
Dickerson, S. S., & Kemeny, M. E. (2004) · Psychological Bulletin · doi:10.1037/0033-2909.130.3.355 · Cited by 5,881 · see citing works
Physiology and neurobiology of stress and adaptation: central role of the brain
McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 4,981 · see citing works
Morin, C. M., Belleville, G., Bélanger, L., & Ivers, H. (2011) · Sleep · doi:10.1093/sleep/34.5.601 · Cited by 4,620 · see citing works
Self-citationFrom Psychological Stress to the Emotions: A History of Changing Outlooks
Lazarus, R. S. (1993) · Annual Review of Psychology · doi:10.1146/annurev.ps.44.020193.000245 · Cited by 2,596 · see citing works
Miller, G. E., Chen, E., & Zhou, E. S. (2007) · Psychological Bulletin · doi:10.1037/0033-2909.133.1.25 · Cited by 2,467 · see citing works
(1993) · Medical Entomology and Zoology · Cited by 2,324 · see citing works
Self-citationHarvey, A. G. (2002) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(01)00061-4 · Cited by 1,790 · see citing works
The hyperarousal model of insomnia: A review of the concept and its evidence
Riemann, D., Spiegelhalder, K., Feige, B., Voderholzer, U., Berger, M., Perlis, M., & Nissen, C. (2010) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2009.04.002 · Cited by 1,789 · see citing works
Kudielka, B. M., Hellhammer, D. H., & Wüst, S. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.10.004 · Cited by 963 · see citing works
Assessing salivary cortisol in large-scale, epidemiological research
Adam, E. K., & Kumari, M. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.06.011 · Cited by 936 · see citing works
Hyperarousal and insomnia: state of the science
Bonnet, M. H., & Arand, D. L. (2010) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2009.05.002 · Cited by 914 · see citing works
Morin, C. M., & Jarrin, D. C. (2022) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2022.03.003 · Cited by 907 · see citing works
Self-citationVgontzas, A. N., Bixler, E. O., Lin, H.-M., Prolo, P., Mastorakos, G., Vela-Bueno, A., Kales, A., & Chrousos, G. P. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.8.7778 · Cited by 884 · see citing works
Psychophysiological insomnia: the behavioural model and a neurocognitive perspective
PERLIS, M. L., GILES, D. E., MENDELSON, W. B., BOOTZIN, R. R., & WYATT, J. K. (1997) · Journal of Sleep Research · doi:10.1046/j.1365-2869.1997.00045.x · Cited by 795 · see citing works
Morin, C. M., Drake, C. L., Harvey, A. G., Krystal, A. D., Manber, R., Riemann, D., & Spiegelhalder, K. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.26 · Cited by 746 · see citing works
Self-citationRole of Stress, Arousal, and Coping Skills in Primary Insomnia
Morin, C. M., Rodrigue, S., & Ivers, H. (2003) · Psychosomatic Medicine · doi:10.1097/01.psy.0000030391.09558.a3 · Cited by 739 · see citing works
Self-citationThe phenomenology of the pre-sleep state: the development of the pre-sleep arousal scale
Nicassio, P. M., Mendlowitz, D. R., Fussell, J. J., & Petras, L. (1985) · Behaviour Research and Therapy · doi:10.1016/0005-7967(85)90004-x · Cited by 704 · see citing works
(2009) · Sleep · doi:10.5665/sleep/32.1.55 · Cited by 664 · see citing works
Self-citationMiller, G., Chen, E., & Cole, S. W. (2009) · Annual Review of Psychology · doi:10.1146/annurev.psych.60.110707.163551 · Cited by 591 · see citing works
Schommer, N. C., Hellhammer, D. H., & Kirschbaum, C. (2003) · Psychosomatic Medicine · doi:10.1097/01.psy.0000035721.12441.17 · Cited by 561 · see citing works
24-Hour Metabolic Rate in Insomniacs and Matched Normal Sleepers
Bonnet, M. H., & Arand, D. L. (1995) · Sleep · doi:10.1093/sleep/18.7.581 · Cited by 557 · see citing works
Assessment of Autonomic Function in Cardiovascular Disease
Lahiri, M. K., Kannankeril, P. J., & Goldberger, J. J. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.01.038 · Cited by 554 · see citing works
Heart rate variability, sleep and sleep disorders
Stein, P. K., & Pu, Y. (2011) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2011.02.005 · Cited by 528 · see citing works
Autonomic activity during human sleep as a function of time and sleep stage
Trinder, J., Kleiman, J., Carrington, M., Smith, S., Breen, S., Tan, N., & Kim, Y. (2001) · Journal of Sleep Research · doi:10.1046/j.1365-2869.2001.00263.x · Cited by 507 · see citing works
The Natural History of Insomnia: A Population-Based 3-Year Longitudinal Study
Morin, C. M., Bélanger, L., LeBlanc, M., Ivers, H., Savard, J., Espie, C. A., Mérette, C., Baillargeon, L., & Grégoire, J.-P. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2008.610 · Cited by 498 · see citing works
Diagnostic and Statistical Manual of Mental Disorders (DSM)
Keeley, J. W., Burgess, D. R., & Blashfield, R. K. (2008) · Sage eBooks · doi:10.4135/9781412956321.n79 · Cited by 478 · see citing works
Vulnerability to Stress-related Sleep Disturbance and Hyperarousal
Drake, C., Richardson, G., Roehrs, T., Scofield, H., & Roth, T. (2004) · Sleep · doi:10.1093/sleep/27.2.285 · Cited by 469 · see citing works
Foley, P., & Kirschbaum, C. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.01.010 · Cited by 455 · see citing works
Ohayon, M. M., & Reynolds, C. F. (2009) · Sleep Medicine · doi:10.1016/j.sleep.2009.07.008 · Cited by 432 · see citing works
Adaptation canadienne-française de la forme révisée du State-Trait Anxiety Inventory de Spielberger
Gauthier, J., & Bouchard, S. (1993) · Canadian Journal of Behavioural Science/Revue canadienne des sciences du comportement · doi:10.1037/h0078881 · Cited by 407 · see citing works
Chronic insomnia and activity of the stress system
Vgontzas, A. N., Tsigos, C., Bixler, E. O., Stratakis, C. A., Zachman, K., Kales, A., Vela-Bueno, A., & Chrousos, G. P. (1998) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(97)00302-4 · Cited by 401 · see citing works
von Dawans, B., Kirschbaum, C., & Heinrichs, M. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.08.004 · Cited by 387 · see citing works
Acute Stress Affects Heart Rate Variability During Sleep
Hall, M. H., Vasko, R., Buysse, D. J., Ombao, H., Chen, Q., Cashmere, J. D., Kupfer, D. J., & Thayer, J. F. (2004) · Psychosomatic Medicine · doi:10.1097/01.psy.0000106884.58744.09 · Cited by 378 · see citing works
Stress and Sleep Reactivity: A Prospective Investigation of the Stress-Diathesis Model of Insomnia
Drake, C. L., Pillai, V., & Roth, T. G. (2014) · SLEEP · doi:10.5665/sleep.3916 · Cited by 347 · see citing works
Insomnia and its Impact on Physical and Mental Health
Fernández‐Mendoza, J., & Vgontzas, A. N. (2013) · Current Psychiatry Reports · doi:10.1007/s11920-013-0418-8 · Cited by 339 · see citing works
The Bidirectional Association Between Depression and Insomnia
Sivertsen, B., Salo, P., Mykletun, A., Hysing, M., Pallesen, S., Krokstad, S., Nordhus, I. H., & Øverland, S. N. (2012) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3182648619 · Cited by 327 · see citing works
LeBlanc, M., Beaulieu‐Bonneau, S., Mérette, C., Savard, J., Ivers, H., & Morin, C. M. (2007) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2007.03.004 · Cited by 308 · see citing works
Self-citationHellhammer, J., & Schubert, M. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.05.012 · Cited by 304 · see citing works
Chronic Insomnia and the Stress System
Basta, M., Chrousos, G. P., Vela‐Bueno, A., & Vgontzas, A. N. (2007) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2007.04.002 · Cited by 294 · see citing works
Prevalence of Insomnia and its Treatment in Canada
Morin, C. M., LeBlanc, M., Bélanger, L., Ivers, H., Mérette, C., & Savard, J. (2011) · The Canadian Journal of Psychiatry · doi:10.1177/070674371105600905 · Cited by 294 · see citing works
Self-citationHan, K.-S., Kim, L., & Shim, I. (2012) · Experimental Neurobiology · doi:10.5607/en.2012.21.4.141 · Cited by 290 · see citing works
Cognitive-Emotional Hyperarousal as a Premorbid Characteristic of Individuals Vulnerable to Insomnia
Fernández-Mendoza, J., Vela-Bueno, A., Vgontzas, A. N., Ramos-Platón, M. J., Olavarrieta-Bernardino, S., Bixler, E. O., & De la Cruz-Troca, J. J. (2010) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181d75319 · Cited by 234 · see citing works
Effects of Stress on Sleep: The Moderating Role of Coping Style.
Sadeh, A., Keinan, G., & Daon, K. (2004) · Health Psychology · doi:10.1037/0278-6133.23.5.542 · Cited by 228 · see citing works
Heart rate and heart rate variability in subjectively reported insomnia
Spiegelhalder, K., FUCHS, L., Ladwig, J., Kyle, S. D., Nissen, C., Voderholzer, U., Feige, B., & Riemann, D. W. (2010) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2010.00863.x · Cited by 225 · see citing works
Roizen, M. F. (2010) · Yearbook of Anesthesiology and Pain Management · doi:10.1016/s1073-5437(10)79480-8 · Cited by 218 · see citing works
[Evaluation of insomnia: validity of 3 questionnaires].
Blais, F., Gendron, L., Mimeault, V., & Morin, C. M. (1997) · PubMed · Cited by 218 · see citing works
Self-citationMorin, C. M., & Jarrin, D. C. (2013) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2013.05.002 · Cited by 216 · see citing works
Self-citationRumination predicts longer sleep onset latency after an acute psychosocial stressor
Zoccola, P. M., Dickerson, S. S., & Lam, S. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181ae58e8 · Cited by 209 · see citing works
Kalmbach, D. A., Pillai, V., Cheng, P., Arnedt, J. T., & Drake, C. L. (2015) · Sleep Medicine · doi:10.1016/j.sleep.2015.09.007 · Cited by 205 · see citing works
Nocturnal cortisol and melatonin secretion in primary insomnia
Riemann, D., Klein, T., Rodenbeck, A., Feige, B., Horny, A., Hummel, R., Weske, G., Al-Shajlawi, A., & Voderholzer, U. (2002) · Psychiatry Research · doi:10.1016/s0165-1781(02)00249-4 · Cited by 202 · see citing works
Harvey, C., Gehrman, P., & Espie, C. A. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2013.11.004 · Cited by 201 · see citing works
Lanfranchi, P. A., Pennestri, M.-H., Fradette, L., Dumont, M., Morin, C. M., & Montplaisir, J. (2009) · Sleep · doi:10.1093/sleep/32.6.760 · Cited by 198 · see citing works
Self-citationFrankenhaeuser, M., Lundberg, U., & Forsman, L. (1980) · Biological Psychology · doi:10.1016/0301-0511(80)90029-0 · Cited by 169 · see citing works
Situational insomnia: consistency, predictors, and outcomes
Bonnet, M. H., & Arand, D. L. (2003) · SLEEP · doi:10.1093/sleep/26.8.1029 · Cited by 135 · see citing works
Heart rate variability in insomnia patients: A critical review of the literature
Dodds, K. L., Miller, C. B., Kyle, S. D., Marshall, N. S., & Gordon, C. J. (2016) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2016.06.004 · Cited by 134 · see citing works
The influence of pre-sleep cognitive arousal on sleep onset processes
Wuyts, J., Valck, E. D., Vandekerckhove, M. M. P., Pattyn, N., Bulckaert, A., Berckmans, D., Haex, B., Verbraecken, J. A., & Cluydts, R. (2011) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2011.09.016 · Cited by 133 · see citing works
Pillai, V., Roth, T. G., Mullins, H. M., & Drake, C. L. (2014) · SLEEP · doi:10.5665/sleep.3838 · Cited by 130 · see citing works
Sleep onset and cardiovascular activity in primary insomnia
de Zambotti, M., Covassin, N., Tona, G. D. M., Sarlo, M., & Stegagno, L. (2010) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2010.00871.x · Cited by 127 · see citing works
Maes, J., Verbraecken, J. A., Willemen, M., Volder, I. D., Gastel, A. V., Michiels, N., Verbeek, I., Vandekerckhove, M. M. P., Wuyts, J., Haex, B., et al. (2013) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2013.10.012 · Cited by 109 · see citing works
Jarrin, D. C., Chen, I. Y., Ivers, H., & Morin, C. M. (2014) · Journal of Sleep Research · doi:10.1111/jsr.12172 · Cited by 109 · see citing works
Self-citationHeart Rate and Heart Rate Variability Modification in Chronic Insomnia Patients
Farina, B., Dittoni, S., Colicchio, S., Testani, E., Losurdo, A., Gnoni, V., Blasi, C. D., Brunetti, R., Contardi, A., Mazza, S., et al. (2013) · Behavioral Sleep Medicine · doi:10.1080/15402002.2013.801346 · Cited by 105 · see citing works
Stress-related sleep disturbance and polysomnographic response to caffeine
Drake, C. L., Jefferson, C., Roehrs, T., & Roth, T. G. (2006) · Sleep Medicine · doi:10.1016/j.sleep.2006.03.019 · Cited by 100 · see citing works
Varkevisser, M., Dongen, H. P. A. V., & KERKHOF, G. A. (2005) · SLEEP · doi:10.1093/sleep/28.12.1588 · Cited by 95 · see citing works
Zhang, J., Lam, S.-P., Li, S. X., Ronald, C. W., Kong, A. P. S., Chan, M. H. M., Ho, C. S., Li, A. M., & Wing, Y. K. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3728 · Cited by 84 · see citing works
Heart rate changes in chronic insomnia
Stepanski, E. J., Glinn, M. A., Zorick, F. J., Roehrs, T., & Roth, T. G. (1994) · Stress Medicine · doi:10.1002/smi.2460100409 · Cited by 82 · see citing works
Fang, S., Huang, C.-J., Yang, T.-T., & Tsai, P.-S. (2008) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2008.02.003 · Cited by 80 · see citing works
Identifying At-Risk Individuals for Insomnia Using the Ford Insomnia Response to Stress Test
Kalmbach, D. A., Pillai, V., Arnedt, J. T., & Drake, C. L. (2016) · SLEEP · doi:10.5665/sleep.5462 · Cited by 80 · see citing works
Nakajima, S., Okajima, I., Sasai, T., Kobayashi, M., Furudate, N., Drake, C. L., Roth, T. G., & Inoue, Y. (2013) · Sleep Medicine · doi:10.1016/j.sleep.2013.09.022 · Cited by 58 · see citing works
The influence of pre-sleep cognitive arousal on sleep onset processes
Wuyts, J., Verhaert, V., Bulckaert, A., BRUYNE, G. D., Exadaktylos, V., Berckmans, D., Haex, B., Verbraecken, J. A., Valck, E. D., Pattyn, N., et al. (2010) · Journal of Sleep Research · Cited by 58 · see citing works
Fernández‐Mendoza, J., Shaffer, M. L., Olavarrieta‐Bernardino, S., Vgontzas, A. N., Calhoun, S. L., Bixler, E. O., & Vela‐Bueno, A. (2014) · Journal of Sleep Research · doi:10.1111/jsr.12168 · Cited by 56 · see citing works
Temporal Stability of the Ford Insomnia Response to Stress Test (FIRST)
Jarrin, D. C., Chen, I. Y., Ivers, H., Drake, C. L., & Morin, C. M. (2016) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.6192 · Cited by 39 · see citing works
Self-citationSleep-Related Arousal Versus General Cognitive Arousal in Primary Insomnia
Spiegelhalder, K., Regen, W., Feige, B., Hirscher, V., Unbehaun, T., Nissen, C., Riemann, D. W., & Baglioni, C. (2012) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.2040 · Cited by 38 · see citing works
Yang, C., Lin, S., & Cheng, C. (2013) · Journal of Clinical Psychology · doi:10.1002/jclp.22000 · Cited by 34 · see citing works
中島, 俊. (2014) · Institutional Repositories DataBase (IRDB) · Cited by 30 · see citing works
Gehrman, P., Hall, M. H., Barilla, H., Buysse, D. J., Perlis, M. L., Gooneratne, N. S., & Ross, R. J. M. (2014) · Behavioral Sleep Medicine · doi:10.1080/15402002.2014.940112 · Cited by 18 · see citing works
Chen, I., Jarrin, D. C., Rochefort, A., Lamy, M., Ivers, H., & Morin, C. M. (2015) · Sleep Medicine · doi:10.1016/j.sleep.2015.02.1510 · Cited by 13 · see citing works
Self-citation
Flagged first, then by citations
1 of the 86 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Kalmbach, D. A., Anderson, J. R., & Drake, C. L. (2018) · Journal of Sleep Research · doi:10.1111/jsr.12710 · Cited by 620 · see citing works
Gardani, M., Bradford, D. R. R., Russell, K., Allan, S., Beattie, L., Ellis, J. G., & Akram, U. (2022) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2021.101565 · Cited by 368 · see citing works
Insomnia disorder: State of the science and challenges for the future
Riemann, D. W., Benz, F., Dressle, R. J., Espie, C. A., Johann, A. F., Blanken, T. F., Leerssen, J., Wassing, R., Henry, A. L., Kyle, S. D., et al. (2022) · Journal of Sleep Research · doi:10.1111/jsr.13604 · Cited by 368 · see citing works
Hyperarousal and sleep reactivity in insomnia: current insights
Kalmbach, D. A., Cuamatzi-Castelan, A. S., Tonnu, C. V., Tran, K. M., Anderson, J. R., Roth, T. G., & Drake, C. L. (2018) · Nature and Science of Sleep · doi:10.2147/nss.s138823 · Cited by 343 · see citing works
Sleep in the anxiety-related disorders: A meta-analysis of subjective and objective research
Cox, R. C., & Olatunji, B. O. (2020) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2020.101282 · Cited by 235 · see citing works
Insomnia and hypertension: A systematic review
Jarrin, D. C., Alvaro, P. K., Bouchard, M.-A., Jarrin, S. D., Drake, C. L., & Morin, C. M. (2018) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2018.02.003 · Cited by 211 · see citing works
Self-citationDressle, R. J., Feige, B., Spiegelhalder, K., Schmucker, C., Benz, F., Mey, N. C., & Riemann, D. (2022) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2022.101588 · Cited by 161 · see citing works
Sleep Duration and Blood Pressure: Recent Advances and Future Directions
Makarem, N., Shechter, A., Carnethon, M. R., Mullington, J. M., Hall, M. H., & Abdalla, M. (2019) · Current Hypertension Reports · doi:10.1007/s11906-019-0938-7 · Cited by 117 · see citing works
Effect of Sleep Disturbances on Blood Pressure
Makarem, N., Alcántara, C., Williams, N., Bello, N. A., & Abdalla, M. (2021) · Hypertension · doi:10.1161/hypertensionaha.120.14479 · Cited by 114 · see citing works
Bathgate, C. J., & Fernández‐Mendoza, J. (2018) · Current Hypertension Reports · doi:10.1007/s11906-018-0850-6 · Cited by 99 · see citing works
Piber, D., Cho, H. J., Lee, O. S., Lamkin, D. M., Olmstead, R. E., & Irwin, M. R. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.08.004 · Cited by 95 · see citing works
Man, I. S. C., Shao, R., Hou, W. K., Li, S. X., Liu, F. Y., Lee, M., Wing, Y. K., Yau, S., & Lee, T. M. C. (2022) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2022.101050 · Cited by 56 · see citing works
Correia, A. T. L., Lipinska, G., Rauch, L., Forshaw, P. E., Roden, L. C., & Rae, D. E. (2022) · Sleep Medicine · doi:10.1016/j.sleep.2022.10.018 · Cited by 54 · see citing works
Yan, C.-Q., Liu, C., Wang, X., Huo, J., Zhou, P., Zhang, S., Fu, Q.-N., Zhang, J., Wang, Z., & Liu, Q. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00167 · Cited by 45 · see citing works
Insomnia Phenotypes, Cardiovascular Risk and Their Link to Brain Health
Fernández‐Mendoza, J. (2025) · Circulation Research · doi:10.1161/circresaha.125.325686 · Cited by 47 · see citing works
Kalmbach, D. A., Cheng, P., & Drake, C. L. (2021) · SLEEP · doi:10.1093/sleep/zsab028 · Cited by 43 · see citing works
Will daytime occupational noise exposures induce nighttime sleep disturbance?
Lin, C.-Y., Tsai, P., Lin, K.-Y., Chen, C.-Y., Chung, L.-H., Wu, J., & Guo, Y. L. (2018) · Sleep Medicine · doi:10.1016/j.sleep.2018.05.025 · Cited by 40 · see citing works
Vgontzas, A. N., Fernández‐Mendoza, J., Lenker, K. P., Basta, M., Bixler, E. O., & Chrousos, G. P. (2021) · Journal of Sleep Research · doi:10.1111/jsr.13526 · Cited by 37 · see citing works
How emotions impact sleep: A quantitative review of experiments
Križan, Z., Boehm, N., & Strauel, C. (2023) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2023.101890 · Cited by 33 · see citing works
Ballot, O., Daviaux, Y., Sanz-Arigita, E. J., Ivers, H., Micoulaud-Franchi, J. A., Bioulac, S., Philip, P., Morin, C. M., & Altena, E. (2021) · Sleep Medicine · doi:10.1016/j.sleep.2021.10.014 · Cited by 22 · see citing works
Self-citationMaiolino, G., Bisogni, V., Silvani, A., Pengo, M. F., Lombardi, C., & Parati, G. (2020) · Journal of Thoracic Disease · doi:10.21037/jtd-cus-2020-014 · Cited by 20 · see citing works
Is a blunted cortisol response to stress a premorbid risk for insomnia?
Reffi, A. N., Cheng, P., Kalmbach, D. A., Jovanović, T., Norrholm, S. D., Roth, T. G., & Drake, C. L. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105873 · Cited by 18 · see citing works
Hyperarousal dynamics reveal an overnight increase boosted by insomnia
Rösler, L., van Kesteren, E., Leerssen, J., van der Lande, G., Lakbila‐Kamal, O., Foster‐Dingley, J. C., Albers, A. C. W., & Someren, E. J. W. V. (2024) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2024.09.032 · Cited by 17 · see citing works
Consequences of child maltreatment: A glimpse at stress and sleep
Pfaff, A., & Schlarb, A. A. (2021) · Journal of Sleep Research · doi:10.1111/jsr.13456 · Cited by 16 · see citing works
Insomnia and cardiometabolic disease risk
Fernández‐Mendoza, J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815373-4.00029-0 · Cited by 13 · see citing works
Factors Influencing Sleep Quality and Effects of Sleep on Hypertension
Mirjat, A. A., Mirjat, A. A., Naveed, M., Majeed, F., & Chong, S. (2020) · Sleep and Vigilance · doi:10.1007/s41782-020-00094-5 · Cited by 15 · see citing works
Mu, L., Zhou, Y., Jamal, G. C., Wu, H. E., Wang, Y., Wang, Y., Wang, J., & Zhang, X. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.12.033 · Cited by 16 · see citing works
Cardiac vagal recovery following acute psychological stress in human adults: A scoping review
Roddick, C. M., Seo, Y. S., Barkovich, S.-L., Forrester, L., & Chen, F. S. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106268 · Cited by 16 · see citing works
Yüksel, D., Kiss, O., Prouty, D., Arra, N., Volpe, L., Baker, F. C., & de Zambotti, M. (2023) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2023.02.006 · Cited by 15 · see citing works
Feng, Y.-Z., Chen, J., Hu, Z., Liu, G.-X., Zhou, Y.-S., Zhang, P., Su, A.-X., Yang, S., Zhang, Y., Wei, R., et al. (2023) · Nature and Science of Sleep · doi:10.2147/nss.s415464 · Cited by 13 · see citing works
Candidate mechanisms linking insomnia disorder to Alzheimer’s disease risk
Chappel-Farley, M. G., Lui, K. K., Dave, A., Chen, I. Y., & Mander, B. A. (2020) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2020.01.010 · Cited by 12 · see citing works
Self-citationKater, M., Werner, A., Schlarb, A. A., & Lohaus, A. (2022) · Journal of Sleep Research · doi:10.1111/jsr.13591 · Cited by 12 · see citing works
Tsai, T. C., Mitchell, H., Zeitzer, J. M., Ting, A., Laurenceau, J., Spiegel, D., & Kim, Y. (2024) · Psychosomatic Medicine · doi:10.1097/psy.0000000000001283 · Cited by 9 · see citing works
Physiological responses to acute psychosocial stress in women with menopausal insomnia
Yüksel, D., de Zambotti, M., Sugarbaker, D. S., Schulte, T., Colrain, I. M., & Baker, F. C. (2021) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2021.02.019 · Cited by 9 · see citing works
Walther, L.-M., von Känel, R., Heimgartner, N., Zuccarella‐Hackl, C., Stirnimann, G., & Wirtz, P. H. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.824616 · Cited by 9 · see citing works
Mechanisms Linking Insomnia and Cardiometabolic Disease Risk
Fernández‐Mendoza, J. (2025) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.125.322880 · Cited by 9 · see citing works
Yu, K., Xia, L., Chen, H.-H., Zou, T.-T., Zhang, Y., Zhang, P., Yang, Y., Wei, R.-M., Su, Z.-F., & Chen, G.-H. (2024) · Nature and Science of Sleep · doi:10.2147/nss.s491040 · Cited by 7 · see citing works
Kim, H., Lee, K. H., Shin, J., Seo, W. W., Jeon, J. E., Lee, H. Y., You, J. H., Kim, S., Kim, S. J., & Lee, Y. J. (2024) · Sleep Medicine · doi:10.1016/j.sleep.2024.12.027 · Cited by 6 · see citing works
The interplay between relationship effectiveness, life stress, and sleep: A prospective study
Huelsnitz, C. O., Simpson, J. A., Rothman, A. J., & Englund, M. M. (2019) · Personal Relationships · doi:10.1111/pere.12266 · Cited by 4 · see citing works
Wang, H., Li, H., Kou, J., Fatemeh, N. N., Peng, Y., Qian, Y., Li, C., Chen, W., Zhou, Y., Zhang, M., et al. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.09.018 · Cited by 3 · see citing works
Zareba, M. R., Davydova, T., Palomar‐García, M., Adrián‐Ventura, J., Costumero, V., & Visser, M. (2025) · Sleep Medicine · doi:10.1016/j.sleep.2025.106527 · Cited by 4 · see citing works
Andorfer, A., Kraler, S., Kaufmann, P., Pollheimer, E., Spah, C., Fuchshuber, J., Rominger, C., Traunmüller, C., Schwerdtfeger, A. R., & Unterrainer, . (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1098122 · Cited by 2 · see citing works
Bigalke, J. A., Murvich, A. M., Brothers, R. M., & Carter, J. R. (2025) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00053.2025 · Cited by 2 · see citing works
Elucidating the Relationship Between Insomnia, Sex, and Cardiovascular Disease
Leeds, R., Shechter, A., Alcántara, C., Aggarwal, B., Usseglio, J., Abdalla, M., & Moise, N. (2020) · Gender and the Genome · doi:10.1177/2470289720980018 · Cited by 2 · see citing works
Yang, B., Zhao, H., Li, Z., Li, J., & Liu, X. (2025) · Indoor and Built Environment · doi:10.1177/1420326x251392075 · Cited by 1 · see citing works
Momayyezi, M., Fakhravari, L., Fallahzadeh, H., & Mirzaei, M. (2021) · Journal of Human Environment and Health Promotion · doi:10.52547/jhehp.7.2.90 · Cited by 1 · see citing works
Sleep and Cardiovascular Reactivity to an Acute Virtual Stressor
Tiani, A. G. (2022) · doi:10.33915/etd.11340 · Cited by 1 · see citing works
Ellis, J. D., Mun, C. J., & Finan, P. H. (2023) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780197618431.013.12
Scott, H., Gehrman, P., & Perlis, M. L. (2025) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780197602751.013.17
Cardiovascular reactivity to mental stress is associated with insomnia susceptibility
Valtadoros, L. E., Murvich, A. M., Talukdar, A., Carter, J. R., & Bigalke, J. A. (2025) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00554.2025 · Cited by 1 · see citing works
Stress and Affective Dysregulation in Depression and Insomnia
Vargas, I., Walker, J. L., Campbell, R. L., & Veilleux, J. C. (2025) · CBT: science into practice · doi:10.1007/978-3-031-92265-7_4
Insomnia and cardiometabolic disease risk
Fernández‐Mendoza, J., & Nyhuis, C. C. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-13954-3.00047-4
Schilbach, M., Baethge, A., Shoshan, H. N., & Rigotti, T. (2026) · Journal of Business and Psychology · doi:10.1007/s10869-026-10099-y
Insomnia symptom severity predicts blunted cortisol reactivity to a psychosocial stressor
Vargas, I., Dickens, H., Vance, A., Floyd, V., Walker, J. L., Egeler, M. E., Assar, A., Joslin, M. D. M., & Makhanova, A. (2026) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2026.108033
- Authors
- Chen, I. Y., Jarrin, D. C., Ivers, H., & Morin, C. M.
- Affiliations
- Institut Universitaire en Santé Mentale de Québec (CA)
- Corresponding author
- Chen, Ivy Y.
- Venue
- Sleep Medicine
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 40
- Pages
- 11-22
- ISSN
- 1389-9457 (ISSN-L)
- OpenAlex
- W2763612638
- Cited by
- 56
- References
- 86
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 4 · 2023: 5 · 2022: 10 · 2021: 8 · 2020: 5 · 2019: 4 · 2018: 6
- FWCI
- 4.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Sleep Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- insomnia, Trier Social Stress Test, acute stress, hyperarousal, cortisol response, sympathovagal imbalance, sleep reactivity, sleep latency, nocturnal awakenings, sleep efficiency, blood pressure, cognitive arousal
- MeSH terms
- Adult, Arousal, Female, Humans, Hydrocortisone, Sleep Initiation and Maintenance Disorders, Male, Stress, Psychological, Polysomnography, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
