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Naive and Primed Pluripotent States
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Citations
Cites
The ground state of embryonic stem cell self-renewal
Ying, Q.-L., Wray, J., Nichols, J., Batlle-Morera, L., Doble, B., Woodgett, J., Cohen, P., & Smith, A. (2008) · Nature · doi:10.1038/nature06968 · Cited by 3,442
Self-citationChazaud, C., Yamanaka, Y., Pawson, T., & Rossant, J. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.02.020 · Cited by 898
Reflections on the biology of embryonic stem (ES) cells
Gardner, R. L., & Brook, F. A. (1997) · The International Journal of Developmental Biology · doi:10.1387/ijdb.9184330 · Cited by 123
Cited by
Single-cell ChIP-seq reveals cell subpopulations defined by chromatin state
Rotem, A., Ram, O., Shoresh, N., Sperling, R. A., Goren, A., Weitz, D. A., & Bernstein, B. E. (2015) · Nature Biotechnology · doi:10.1038/nbt.3383 · Cited by 854
Wnt signaling in development and tissue homeostasis
Steinhart, Z., & Angers, S. (2018) · Development · doi:10.1242/dev.146589 · Cited by 821
Human iPSC-based modeling of late-onset disease via progerin-induced aging
Miller, J. D., Ganat, Y. M., Kishinevsky, S., Bowman, R. L., Liu, B., Tu, E. Y., Mandal, P. K., Vera, E., Shim, J.-W., Kriks, S., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.11.006 · Cited by 777
Single Cell RNA-Sequencing of Pluripotent States Unlocks Modular Transcriptional Variation
Kolodziejczyk, A. A., Kim, J. K., Tsang, J. C. H., Ilicic, T., Henriksson, J., Natarajan, K. N., Tuck, A. C., Gao, X., Bühler, M., Liu, P., et al. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.09.011 · Cited by 570
Dynamic stem cell states: Naive to primed pluripotency in rodents and humans
Weinberger, L., Ayyash, M., Novershtern, N., & Hanna, J. H. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2015.28 · Cited by 622
Chromatin modifiers and remodellers: regulators of cellular differentiation
Chen, T., & Dent, S. Y. R. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3607 · Cited by 619
The updated biology of hypoxia-inducible factor
Greer, S. N., Metcalf, J. L., Wang, Y., & Ohh, M. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.125 · Cited by 545
Induced Pluripotent Stem Cells Meet Genome Editing
Hockemeyer, D., & Jaenisch, R. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.04.013 · Cited by 499
“…the developmental stage that is captured in vitro from the outgrowth of the inner cell mass, where hPSCs cultured under standard conditions represent a later epiblast-like pluripotent state (Brons et al., 2007; Tesar et al., 2007; Theunissen et al., 2014) and (reviewed in (Nichols and Smith, 2009).”
BackgroundNaive pluripotency is associated with global DNA hypomethylation
Leitch, H. G., McEwen, K. R., Turp, A., Encheva, V., Carroll, T., Grabole, N., Mansfield, W., Nashun, B., Knezovich, J. G., Smith, A., et al. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2510 · Cited by 516
Self-citationReorganization of enhancer patterns in transition from naive to primed pluripotency
Buecker, C., Srinivasan, R., Wu, Z., Calo, E., Acampora, D., Faial, T., Simeone, A., Tan, M., Swigut, T., & Wysocka, J. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.04.003 · Cited by 507
Lin28: Primal Regulator of Growth and Metabolism in Stem Cells
Shyh-Chang, N., & Daley, G. Q. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.03.005 · Cited by 458
Molecular recording of mammalian embryogenesis
Chan, M. M., Smith, Z. D., Grosswendt, S., Kretzmer, H., Norman, T. M., Adamson, B., Jost, M., Quinn, J. J., Yang, D., Jones, M. G., et al. (2019) · Nature · doi:10.1038/s41586-019-1184-5 · Cited by 364
Human pluripotent stem cell culture: considerations for maintenance, expansion, and therapeutics
Chen, K. G., Mallon, B. S., McKay, R. D. G., & Robey, P. G. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2013.12.005 · Cited by 358
Epigenetics of Reprogramming to Induced Pluripotency
Papp, B., & Plath, K. (2013) · Cell · doi:10.1016/j.cell.2013.02.043 · Cited by 307
Kang, M., Piliszek, A., Artus, J., & Hadjantonakis, A.-K. (2013) · Development · doi:10.1242/dev.084996 · Cited by 284
Inhibition of mTOR induces a paused pluripotent state
Bulut-Karslioglu, A., Biechele, S., Jin, H., Macrae, T. A., Hejna, M., Gertsenstein, M., Song, J. S., & Ramalho-Santos, M. (2016) · Nature · doi:10.1038/nature20578 · Cited by 283
Cell Therapy: Types, Regulation, and Clinical Benefits
El-Kadiry, A. E.-H., Rafei, M., & Shammaa, R. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.756029 · Cited by 256
Enhancer priming by H3K4 methyltransferase MLL4 controls cell fate transition
Wang, C., Lee, J.-E., Lai, B., Macfarlan, T. S., Xu, S., Zhuang, L., Liu, C., Peng, W., & Ge, K. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1606857113 · Cited by 242
Insights into epigenetic patterns in mammalian early embryos
Xu, R., Li, C., Liu, X., & Gao, S. (2021) · Protein & Cell · doi:10.1007/s13238-020-00757-z · Cited by 216
Principles of signaling pathway modulation for enhancing human naive pluripotency induction
Bayerl, J., Ayyash, M., Shani, T., Manor, Y. S., Gafni, O., Massarwa, R., Kalma, Y., Aguilera-Castrejon, A., Zerbib, M., Amir, H., et al. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.04.001 · Cited by 165
FoxO maintains a genuine muscle stem-cell quiescent state until geriatric age
García-Prat, L., Perdiguero, E., Alonso-Martín, S., Dell’Orso, S., Ravichandran, S., Brooks, S. R., Juan, A. H., Campanario, S., Jiang, K., Hong, X., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-00593-7 · Cited by 161
Multi-omic Profiling Reveals Dynamics of the Phased Progression of Pluripotency
Yang, P., Humphrey, S. J., Cinghu, S., Pathania, R., Oldfield, A. J., Kumar, D., Perera, D., Yang, J. Y. H., James, D. E., Mann, M., et al. (2019) · Cell Systems · doi:10.1016/j.cels.2019.03.012 · Cited by 146
Single-cell analyses of X Chromosome inactivation dynamics and pluripotency during differentiation
Chen, G., Schell, J. P., Benitez, J. A., Petropoulos, S., Yilmaz, M., Reinius, B., Alekseenko, Z., Shi, L., Hedlund, E., Lanner, F., et al. (2016) · Genome Research · doi:10.1101/gr.201954.115 · Cited by 123
iPSC Preparation and Epigenetic Memory: Does the Tissue Origin Matter?
Scesa, G., Adami, R., & Bottai, D. (2021) · Cells · doi:10.3390/cells10061470 · Cited by 110
Do all roads lead to Oct4? The emerging concepts of induced pluripotency
Radzisheuskaya, A., & Silva, J. C. R. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.11.010 · Cited by 101
Gain of CTCF-Anchored Chromatin Loops Marks the Exit from Naive Pluripotency
Pękowska, A., Klaus, B., Xiang, W., Severino, J., Daigle, N., Klein, F. A., Oleś, M., Casellas, R., Ellenberg, J., Steinmetz, L. M., et al. (2018) · Cell Systems · doi:10.1016/j.cels.2018.09.003 · Cited by 74
CRISPR/Cas9 Nuclease-Mediated Gene Knock-In in Bovine-Induced Pluripotent Cells
Heo, Y. T., Quan, X., Xu, Y. N., Baek, S., Choi, H., Kim, N.-H., & Kim, J. (2015) · Stem Cells and Development · doi:10.1089/scd.2014.0278 · Cited by 73
Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism
Romitti, M., Tourneur, A., de Faria da Fonseca, B., Doumont, G., Gillotay, P., Liao, X.-H., Eski, S. E., Van Simaeys, G., Chomette, L., Lasolle, H., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34776-7 · Cited by 64
Biological effects of culture substrates on human pluripotent stem cells
Hayashi, Y., & Furue, M. K. (2016) · Stem Cells International · doi:10.1155/2016/5380560 · Cited by 50
AP-1 activity is a major barrier of human somatic cell reprogramming
Liu, Y., He, J., Chen, R., Liu, H., Chen, J., Liu, Y., Wang, B., Guo, L., Pei, D., Wang, J., et al. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03883-x · Cited by 10
Metadata
- Authors
- Nichols, J., & Smith, A.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2009-06
- Volume
- 4
- Issue
- 6
- Pages
- 487-492
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2088128367
- Cited by
- 1,859
- References
- 3
- FWCI
- 26.17
- Type
- journal article
- Language
- en
- Open access
- bronze
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